About Me
My research is in the cancer-on-a-chip field. I focus on mimicking several in vivo conditions in a chip to have a better understanding and prediction of drug efficacy in man and animals.
Expertise
Medicine & Life Sciences
# Heterografts
# Lab-On-A-Chip Devices
Engineering & Materials Science
# Cell Culture
# Cell Death
# Cells
# Heterografts
# Microfluidics
# Pharmacokinetics
Publications
Recent
Komen, J.
, van den Berg, A.
, van der Meer, A., & Van Vuurden, D. (2022).
Effect of dynamic, intracerebral-like, doxorubicin concentrations on brain stem cancer cells on-chip. Abstract from Microphysiological Systems World Summit, MPS 2022, New Orleans, Louisiana, United States.
Komen, J. (2022).
Mimicking and surpassing the cancer xenograft model with dynamic, in vivo-like, drug concentrations on-chip. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente.
https://doi.org/10.3990/1.9789036553971
Komen, J., van Neerven, S., Bossink, E. G. B. M., de Groot, N., Nijman, L.
, van den Berg, A., Vermeulen, L.
, & van der Meer, A. (2022).
The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts.
Micromachines,
13(5), [739].
https://doi.org/10.3390/mi13050739
Komen, J., Bossink, E. G. B. M.
, van den Berg, A.
, & van der Meer, A. (2021).
Comparing on-chip colorectal cancer spheroid drug response to xenografts. Poster session presented at EUROoCS Annual conference 2021, Uppsala, Sweden.
Komen, J., van Neerven, S. M.
, van den Berg, A., Vermeulen, L.
, & van der Meer, A. D. (2021).
Mimicking and surpassing the xenograft model with cancer-on-chip technology.
EBioMedicine,
66, [103303].
https://doi.org/10.1016/j.ebiom.2021.103303
Komen, J., Westerbeek, E. Y.
, Kolkman, R. W., Roesthuis, J.
, Lievens, C.
, van den Berg, A.
, & van der Meer, A. D. (2020).
Controlled pharmacokinetic anti-cancer drug concentration profiles lead to growth inhibition of colorectal cancer cells in a microfluidic device.
Lab on a chip,
20(17), 3167-3178.
https://doi.org/10.1039/d0lc00419g
Komen, J., Westerbeek, E. Y.
, van der Meer, A.
, & van den Berg, A. (2019).
A microfluidic device for testing static and dynamic, in vivo like, drug concentration effects on cancer cells. In
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Contact Details
Visiting Address
University of Twente
Drienerlolaan 5
7522 NB Enschede
The Netherlands
Mailing Address
University of Twente
P.O. Box 217
7500 AE Enschede
The Netherlands
Additional Contact Information
Room C3407