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dr. P.R. Kuninty (Praneeth)

Researcher

About Me

Praneeth Reddy Kuninty was born on the 4th of December 1988 in Adilabad, India. He obtained his Bachelor of Pharmacy from J.S.S College of Pharmacy, Mysore in 2010. In 2013, he graduated from the University of Groningen with a Master in Medical Pharmaceutical Sciences. During his masters, he did his first research project on the “Characterization of Inulin Nanocrystals” in the department of Pharmaceutical Technology and Biopharmacy under the guidance of dr. Wouter Hinrichs. Later he did his second research project on the “SAINT-Lipid Polycation particles, a novel carrier for an improved delivery of siRNA to activated primary endothelial cells” in the department of Endothelial Biomedicine & Vascular Drug Targeting under the guidance of dr. Jam Kamps. Since July 2013, he is working towards his Ph.D. in the department of Biomaterials Science and Technology on investigating novel targets in pancreatic tumor stroma and targeted delivery of small RNAs/-inhibitors for cancer therapy under the guidance of dr. Jai Prakash.

Expertise

Neoplasms
Micrornas
Pancreatic Stellate Cells
Peptide Nucleic Acids
Tumor Microenvironment
Stromal Cells
Fibroblasts
Pancreatic Neoplasms

Research

Pancreatic cancer is the most aggressive tumor type with a 5-year overall survival of only 8% and the median survival time is about 6 months. Chemotherapy is the only option for patients with advanced pancreatic cancer, as only less than 20% tumors are resectable. The progression of pancreatic cancer is mainly supported by abundant fibrosis or desmoplasia or tumor stroma. In tumor stroma, cancer-associated fibroblasts (CAFs) mostly originate from pancreatic stellate cells (PSCs), which are shown to elicit tumor promoting activities by secreting different cytokines and growth factors . PSCs produce the abundant extracellular matrix in the tumor stroma, which acts as a physical barrier for drug delivery to the tumor tissue. PSCs interact closely with tumor cells to create a tumor-promoting microenvironment that facilitates tumor growth, angiogenesis, and metastasis, which indicates a role for PSCs in tumor progression. I nvestigating novel targets in pancreatic tumor stroma and developing targeted delivery strategies for small RNAs/-inhibitors for cancer therapy. 

Publications

Other Contributions

Kowalski PS, Kuninty PR, Bijlsma KT, Stuart MC, Leus NG, Ruiters MH, Molema G, Kamps JA. SAINT-liposome-polycation particles, a new carrier for improved delivery of siRNAs to inflamed endothelial cells”. Eur J Pharm Biopharm. 2015

UT Research Information System

Google Scholar Link

Education

MSc. Medical Pharmaceutical Sciences

University of Groningen, 2011-2013

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst - Zuidhorst (building no. 28), room 255
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst - Zuidhorst  255
P.O. Box 217
7500 AE Enschede
The Netherlands

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