Lee, W., Nanou, A., Rikkert, L., Coumans, F. A. W., Otto, C., Terstappen, L. W. M. M., & Offerhaus, H. L. (2018). Characterization of Extracellular Vesicles using Raman Spectroscope for Label-free Cancer Detection. Poster session presented at International Society for Extracellular Vesicles Annual Meeting 2018, Barcelona, Spain.
Lee, W., & Offerhaus, H. L. (2018). Classifying Raman Spectra of Extracellular Vesicles using a Convolutional Neural Network. Poster session presented at The 26th International Conference on Raman Spectroscopy 2018, Jeju, Korea, Republic of.
Lee, W., Nanou, A., Rikkert, L. G., Enciso Martinez, A., Coumans, F. A. W., Otto, C., ... Offerhaus, H. L. (2017). Characterization of Extracellular Vesicles using Raman Spectroscope for Label-free Prostate Cancer Detection. Poster session presented at NLSEV kickoff meeting 2017, Utrecht, Netherlands.
UT Research Information System
Tumor-derived extracellular vesicles (tdEVs) may contain information important for the management of cancer patients. Their presence in biofluids of cancer patients renders them a promising biomarker for the diagnosis of cancer, the monitoring of therapy and the profiling of the tumor leading to a therapy tailored to the individual. Within the framework of the Cancer-ID program, novel techniques for the detection, isolation and characterization of tdEVs are being developed. EVs of different origins have been prepared and are being characterized with Raman spectroscopy, fluorescence microscopy and electrical impedance spectroscopy. Functionalized microfluidics and microsieves approaches are being developed to isolate them specifically from heterogeneous patient samples.