dr.ir. A.M. Leferink (Anne)


About Me

Anne is a senior lecturer in the BSc and MSc program Technical Medicine (University of Twente) in modules including Cell Biology (theory and practical course),  Biomaterials for clinical interventions (also module-coordinator) and in the mastercourse Clinical Biotechnology (also course coordinator). Furthermore, she is involved in the Minor ICR&TIST in which she teaches a micro-module on 'Practices in the natural Sciences'. 

From August 2021 till December 2022, Anne was appointed 0.2 FTE as teaching fellow on Challenge Based Learning. This fellowship allowed her to gain experience and to conduct research on Challenge Based Learning methods in education.

Anne is embedded in the Applied Stem Cell Technologies group in the faculty of Science and Technology. She conducts research in the field of Organ-on-a-chip technology. She is involved in the national LymphChip Consortium. and is a member of the Organ On a chip Centre Twente (OoCCT), the dutch Human Organ And Disease Model Technologies (hDMT) consortium and the European Organ on a chip Society (EUROoCS).

Moreover, Anne has a general interest in the development of biomedical devices and tools for medical interventions and diagnostics for both in vivo and extracorporeal applications. She works with several clinical and industrial partners in setting up clinical trials and optimizing designs of medical devices. She has gained expertise in a broad range of biomedical related topics ranging from the molecular cell biology level up to the functional level of the musculoskeletal system at the macro-scale.


Engineering & Materials Science
Blood-Brain Barrier
Tissue Engineering
Medicine & Life Sciences
Mesenchymal Stem Cells
Tissue Engineering


  • Lymph-on-a-chip consortium (NWA)
  • Development and testing of medical devices for per- and post-operative treatment.

Educational Research:

  • The role of the 'teacher' in Challenge-Based Learning
  • Peer-Feedback and Peer-Assessment in bachelor courses
  • From 'push-to-pull': how to increase students' autonomy on learning.


Paul, A., van Dorp, T. , Leferink, A. M. , Vollertsen, A. R. , van der Meer, A. , & Odijk, M. (2023). 3D Porous Microfluidic Architectures for Heart-on-Chip. Poster session presented at 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023, Katowice, Poland.
Conceição, F., Sousa, D. M. , Loessberg-Zahl, J. , Vollertsen, A. R., Neto, E., Søe, K., Paredes, J. , Leferink, A., & Lamghari, M. (2022). A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis. Materials Today Bio, 13, Article 100219. https://doi.org/10.1016/j.mtbio.2022.100219
Avgidis, F. , Tibbe, M. , Leferink, A. , & Segerink, L. (2019). Assessing barrier properties using impedance spectroscopy in a semi-circular, blood-brain barrier on-chip. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 422-423). (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019). The Chemical and Biological Microsystems Society.
de Pinho, A. R. G., Odila, I. , Leferink, A. , van Blitterswijk, C., Camarero-Espinosa, S. , & Moroni, L. (2019). Hybrid polyester-hydrogel electrospun scaffolds for tissue engineering applications. Frontiers in bioengineering and biotechnology, 7(SEP), Article 231. https://doi.org/10.3389/fbioe.2019.00231
Minol, J. P., Reinsch, I., Luik, M. , Leferink, A., Barth, M., Assmann, A., Lichtenberg, A., & Akhyari, P. (2018). Reaktive Sauerstoffspezies und Gefäßdegeneration. Zeitschrift fur Herz-, Thorax- und Gefasschirurgie, 32(3), 242-247. https://doi.org/10.1007/s00398-018-0227-9
Tibbe, M. P. , Le The, H. , Leferink, A. M. , Eijkel, J. C. T. , & Segerink, L. I. (2018). Porous sbum-micrometer PDMS membranes as cell culture substrates in a microfludiic chip. Poster session presented at 9th International Conference on Microtechnologies in Medicine and Biology, MMB 2018, Monterey, California, United States.
Tibbe, M. , Le The, H. , Eijkel, J. , van den Berg, A. , Leferink, A. , & Segerink, L. (2018). Transwell integrated porous sub-micrometer PDMS membranes as alternative cell culture platform. Poster session presented at EMBS Micro and Nantechnology in Medicine Conference, MNMC 2018, Kauai, Hawaii, United States.
Other Contributions

Peer-reviewer for several journals including: Biomaterials, Biofabrication, Advanced Technologies, Journal of Tissue Engineering and Regenerative Medicine, Integrative Biology and Acta Biomaterialia.


Google Scholar Link


Module or course coordinator:

  • MOD11 TM "Biomaterials"
  • MSc. course TM: Clinical Biotechnology
  • Orthopedics Workshop for Master TM


  • MOD01 TM "Bouwstenen van de Mens" Introduction to Cell Biology and Project
  • MOD02 TM "Zicht op ziekte" Project Assessor
  • MOD11 TM "Biomaterials" Biomaterials and Project
  • MSc. course TM: Clinical Biotechnology
  • Micro-module lecturer in ICR&TIST minor


  • Personal Pursuit supervisor at ATLAS (University College Twente)
  • Internship supervisor BME and TM

Affiliated Study Programmes



Courses Academic Year  2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2022/2023


  • Tumor-on-a-chip models to study secretion factors involved in cancer metastasis (in collaboration with i3S, Porto, Portugal)
  • Development of an oxygen delivery device to prevent anastomotic leakage after esophageal tumor resection (in collaboration with ZGT, MST and UMCG)
  • Development of a Lymph-on-a-chip model (NWA consortium)

For education project, see 'education'


In the press


Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst Complex (building no. 20), room ZH112
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst Complex  ZH112
P.O. Box 217
7500 AE Enschede
The Netherlands

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