dr.ir. A.M. Leferink (Anne)


About Me

Anne is a senior lecturer in the BSc and MSc program Technical Medicine (University of Twente) in modules including Cell Biology (theory and practical course),  Biomaterials for clinical interventions (also module-coordinator) and in the mastercourse Clinical Biotechnology (also course coordinator). Since 2020 she also teaches Cell Biology in the program ATLAS University College.

Since August 2021, Anne started for 0.2 FTE as teaching fellow on Challenge Based Learning. This fellowship will allow her to gain experience and to conduct research on Challenge Based Learning methods in her education.

Furthermore, Anne conducts research in the field of Organ-on-a-chip technology. She is embedded in the Applied Stem Cell Technologies group and is a member of the Organ On a chip Centre Twente (OoCCT),

Moreover, Anne has a general interest in the development of biomedical devices and tools for medical interventions and diagnostics for both in vivo and extracorporeal applications. She works with several clinical and industrial partners in setting up clinical trials and optimizing designs of medical devices.
She has gained expertise in a broad range of biomedical related topics ranging from the molecular cell biology level up to the functional level of the musculoskeletal system at the macro-scale.


Engineering & Materials Science
Blood-Brain Barrier
Tissue Engineering
Medicine & Life Sciences
Mesenchymal Stem Cells
Tissue Engineering


  • Development of tumor-on-a-chip models to study processes involved in tissue invasion and metastasis.
  • BBB-on-a-chip
  • Lymph-on-a-chip consortium (NWA)
  • Development and testing of medical devices for per- and post-operative treatment.


Avgidis, F. , Tibbe, M. , Leferink, A. , & Segerink, L. (2019). Assessing barrier properties using impedance spectroscopy in a semi-circular, blood-brain barrier on-chip. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 422-423). (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019). The Chemical and Biological Microsystems Society.
de Pinho, A. R. G., Odila, I. , Leferink, A. , van Blitterswijk, C., Camarero-Espinosa, S. , & Moroni, L. (2019). Hybrid polyester-hydrogel electrospun scaffolds for tissue engineering applications. Frontiers in bioengineering and biotechnology, 7(SEP), [231]. https://doi.org/10.3389/fbioe.2019.00231
Minol, J. P., Reinsch, I., Luik, M. , Leferink, A., Barth, M., Assmann, A., Lichtenberg, A., & Akhyari, P. (2018). Reaktive Sauerstoffspezies und Gefäßdegeneration. Zeitschrift fur Herz-, Thorax- und Gefasschirurgie, 32(3), 242-247. https://doi.org/10.1007/s00398-018-0227-9
Tibbe, M. P. , Le The, H. , Leferink, A. M. , Eijkel, J. C. T. , & Segerink, L. I. (2018). Porous sbum-micrometer PDMS membranes as cell culture substrates in a microfludiic chip. Poster session presented at 9th International Conference on Microtechnologies in Medicine and Biology, MMB 2018, Monterey, California, United States.
Tibbe, M. , Le The, H. , Eijkel, J. , van den Berg, A. , Leferink, A. , & Segerink, L. (2018). Transwell integrated porous sub-micrometer PDMS membranes as alternative cell culture platform. Poster session presented at EMBS Micro and Nantechnology in Medicine Conference, MNMC 2018, Kauai, Hawaii, United States.
Other Contributions

Peer-reviewer for several journals including: Biomaterials, Advanced Technologies, Journal of Tissue Engineering and Regenerative Medicine, Integrative Biology and Acta Biomaterialia.


Google Scholar Link


Module or course coordinator:

  • MOD11 TM "Biomaterials and Ethics"
  • MSc. course TM: Clinical Biotechnology
  • ATLAS Elective: Cell Biology


  • MOD01 TM "Bouwstenen van de Mens" Introduction to Cell Biology and Project
  • MOD02 TM "Zicht op ziekte" Project Assessor
  • MOD11 TM "Biomaterials and Ethics" Biomaterials and Project


  • Chairman of the OLC-TG (educational quality committee)
  • Teaching fellow on Challenge Based Learning
  • Internship supervisor BME and TM

Affiliated Study Programmes



Courses Academic Year  2022/2023

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2021/2022


  • Tumor-on-a-chip models to study secretion factors involved in cancer metastasis (in collaboration with i3S, Porto, Portugal)
  • Development of an oxygen delivery device to prevent anastomotic leakage after esophageal tumor resection (in collaboration with ZGT, MST and UMCG).
  • Development of a Blood-Brain-Barrier on a chip (BIOS/ Lab on a chip group)
  • Development of a Lymph-on-a-chip model (NWA consortium)


In the press


Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst Complex (building no. 20), room ZH112
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst Complex  ZH112
P.O. Box 217
7500 AE Enschede
The Netherlands

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