prof.dr. C. von Birgelen (Clemens)

Medicine & Life Sciences

# Drug-Eluting Stents
# Everolimus
# Myocardial Infarction
# Percutaneous Coronary Intervention
# Polymers
# St Elevation Myocardial Infarction
# Stents
# Zotarolimus

Faculty of Behavioural, Management and Social Sciences (BMS), Health Technology & Services Research (HTSR)

Medisch Spectrum Twente
cardiologist, interventional cardiologist
foundation CRE Enschede
board member of a foundation

e-ULTIMASTER investigators (2023). Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study). The American journal of cardiology, 186, 71-79. https://doi.org/10.1016/j.amjcard.2022.10.023

De Luca, G., Manzo-Silberman, S., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Busljetik, O., Cercek, M., Okkels, L., Loh, P. H., Calmac, L., Ferrer, G. R. I., Quadros, A., Milewski, M., Scotto di Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., ... Verdoia, M. (2023). Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry. Journal of Clinical Medicine, 12(3), [896]. https://doi.org/10.3390/jcm12030896

Fabris, E., Berta, B., Hommels, T., Roleder, T., Hermanides, R. S., Rivero, F. , von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., Reith, S., Roleder-Dylewska, M., Gasior, P., Malinowski, K. P., De Luca, G., Garcia-Garcia, H. M., ... Kedhi, E. (2023). Long-term outcomes of patients with normal fractional flow reserve and thin-cap fibroatheroma. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 18(13), e1099-e1107. https://doi.org/10.4244/EIJ-D-22-00306

Pinxterhuis, T. H. , Ploumen, E. H. , Zocca, P. , Doggen, C. J. M., Schotborgh, C. E., Anthonio, R. L., Roguin, A., Danse, P. W., Benit, E., Aminian, A., Stoel, M. G., Linssen, G. C. M. , Geelkerken, R. H. , & von Birgelen, C. (2023). Risk of bleeding after percutaneous coronary intervention and its impact on further adverse events in clinical trial participants with comorbid peripheral arterial disease. International journal of cardiology, 374, 27-32. https://doi.org/10.1016/j.ijcard.2022.12.009

Ploumen, E. H., Pinxterhuis, T. H., Buiten, R. A. , Zocca, P., Danse, P. W., Schotborgh, C. E., Scholte, M., Tjon Joe Gin, R. M., Somi, S., van Houwelingen, K. G., Stoel, M. G., de Man, H. A. F. , Hartmann, M., Linssen, G. C. M. , van der Heijden, L. C. , Kok, M. M. , Doggen, C. J. M. , & von Birgelen, C. (2022). Final 5-Year Report of the Randomized BIO-RESORT Trial Comparing 3 Contemporary Drug-Eluting Stents in All-Comers. Journal of the American Heart Association, 11(22), [e026041]. https://doi.org/10.1161/JAHA.122.026041

De Luca, G., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Zimbakov, Z., Cercek, M., Jensen, L. O., Loh, P. H., Calmac, L., Ferrer, G. R. I., Quadros, A., Milewski, M., Scotto D’Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., Wong Sung Lung, A., ... Verdoia, M. (2022). Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS–STEMI COVID-19 Registry. Journal of Clinical Medicine, 11(22), [6722]. https://doi.org/10.3390/jcm11226722

De Luca, G., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Zimbakov, Z., Cercek, M., Okkels Jensen, L., Loh, P. H., Calmac, L., Roura i Ferrer, G., Quadros, A., Milewski, M., Scotto Di Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., Wong Sung Lung, A., ... Verdoia, M. (2022). SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion. Angiology. https://doi.org/10.1177/00033197221129351

Konigstein, M., Redfors, B., Zhang, Z., Kotinkaduwa, L. N., Mintz, G. S., Smits, P. C., Serruys, P. W. , von Birgelen, C., Madhavan, M. V., Golomb, M., Ben-Yehuda, O., Mehran, R., Leon, M. B., & Stone, G. W. (2022). Utility of the ACC/AHA Lesion Classification to Predict Outcomes After Contemporary DES Treatment: Individual Patient Data Pooled Analysis From 7 Randomized Trials. Journal of the American Heart Association, 11(24), [e025275]. https://doi.org/10.1161/JAHA.121.025275

Roleder-Dylewska, M., Gasior, P., Hommels, T. M., Roleder, T., Berta, B., Ang, H. Y., Ng, J. C. K., Hermanides, R. S., Fabris, E., IJsselmuiden, A., Kauer, F., Alfonso, F. , von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., ... Kedhi, E. (2022). Morphological characteristics of lesions with thin cap fibroatheroma: A substudy from the COMBINE (OCT-FFR) trial . European Heart Journal Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jeac218

Haude, M., Toelg, R., Lemos, P. A., Christiansen, E. H., Abizaid, A. , von Birgelen, C., Neumann, F. J., Wijns, W., Ince, H., Kaiser, C., Lim, S. T., Escaned, J., Eeckhout, E., Garcia-Garcia, H. M., & Waksman, R. (2022). Sustained Safety and Performance of a Second-Generation Sirolimus-Eluting Absorbable Metal Scaffold: Long-Term Data of the BIOSOLVE-II First-in-Man Trial at 5 Years. Cardiovascular Revascularization Medicine, 38, 106-110. https://doi.org/10.1016/j.carrev.2021.07.017

Fabris, E., Berta, B., Roleder, T., Hermanides, R. S., Ijsselmuiden, A. J. J., Kauer, F., Alfonso, F. , Von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., Reith, S., Roleder-Dylewska, M., Gasior, P., Malinowski, K., De Luca, G., ... Kedhi, E. (2022). Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights from the COMBINE OCT-FFR Trial. Circulation: Cardiovascular Interventions, 15(5), 430-438. https://doi.org/10.1161/CIRCINTERVENTIONS.121.011728

Ploumen, E. H. , & von Birgelen, C. (2022). Search for Holy Grail of Stent Coating Will Go On. Cardiovascular Revascularization Medicine, 42, 100-101. https://doi.org/10.1016/j.carrev.2022.06.019

Burrello, J., Gallone, G., Burrello, A., Pagliari, D. J. , Ploumen, E. H., Iannaccone, M., De Luca, L. , Zocca, P., Patti, G., Cerrato, E., Wojakowski, W., Venuti, G., De Filippo, O., Mattesini, A., Ryan, N., Helft, G., Muscoli, S., Kan, J., Sheiban, I., ... D’ascenzo, F. (2022). Prediction of All-Cause Mortality Following Percutaneous Coronary Intervention in Bifurcation Lesions Using Machine Learning Algorithms. Journal of Personalized Medicine, 12(6), [990]. https://doi.org/10.3390/jpm12060990

De Luca, G., Nardin, M., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Zimbakov, Z., Cercek, M., Okkels Jensen, L., Loh, P. H., Calmac, L., Roura Ferrer, G., Quadros, A., Milewski, M., Scotto di Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., ... Verdoia, M. (2022). Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry. Respiratory research, 23(1), [207]. https://doi.org/10.1186/s12931-022-02128-0

Pinxterhuis, T. H. , Ploumen, E. H. , Zocca, P. , Doggen, C. J. M., Schotborgh, C. E., Anthonio, R. L., Roguin, A., Danse, P. W., Benit, E., Aminian, A., Stoel, M. G., Linssen, G. C. M. , Geelkerken, R. H. , & von Birgelen, C. (2022). Outcome after percutaneous coronary intervention with contemporary stents in patients with concomitant peripheral arterial disease: A patient-level pooled analysis of four randomized trials. Atherosclerosis, 355, 52-59. https://doi.org/10.1016/j.atherosclerosis.2022.05.002

PIONEER IV trial investigator (2022). Angiography-derived physiology guidance vs usual care in an All-comers PCI population treated with the healing-targeted supreme stent and Ticagrelor monotherapy: PIONEER IV trial design. American heart journal, 246, 32-43. https://doi.org/10.1016/j.ahj.2021.12.018

ISACS-STEMI COVID-19, & Collaborators (2022). COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction. Heart (British Cardiac Society), 108(6), 458-466. https://doi.org/10.1136/heartjnl-2021-319750

Ploumen, E. H. , Halfwerk, F. R., van der Kolk, R. , Grandjean, J. G. , von Birgelen, C. , & van Til, J. A. (2022). Use of the left radial artery as vascular access for coronary angiography and as a bypass conduit: A clinical dilemma? Cardiovascular Revascularization Medicine, 34, 134-139. https://doi.org/10.1016/j.carrev.2021.01.014

Claassens, D. M. F., Gimbel, M. E., Bergmeijer, T. O., Vos, G. J. A., Hermanides, R. S., van der Harst, P., Barbato, E., Morisco, C., Tjon Joe Gin, R. M., de Vrey, E. A., Heestermans, T. A. C. M., Jukema, J. W. , von Birgelen, C., Waalewijn, R. A., Hofma, S. H., den Hartog, F. R., Voskuil, M., van't Hof, A. W. J., Asselbergs, F. W., ... ten Berg, J. M. (2021). Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients. International journal of cardiology, 334, 10-17. https://doi.org/10.1016/j.ijcard.2021.04.029

Janssens, G. N., Lemkes, J. S., van der Hoeven, N. W., van Leeuwen, M. A. H., Everaars, H., van de Ven, P. M., Brinckman, S. L., Timmer, J. R., Meuwissen, M., Meijers, J. C. M., van der Weerdt, A. P., ten Cate, T. J. F., Piek, J. J. , von Birgelen, C., Diletti, R., Escaned, J., van Rossum, A. C., Nijveldt, R., & van Royen, N. (2021). Transient ST-elevation myocardial infarction versus persistent ST-elevation myocardial infarction. An appraisal of patient characteristics and functional outcome. International journal of cardiology, 336, 22-28. https://doi.org/10.1016/j.ijcard.2021.05.018

Kedhi, E., Berta, B., Roleder, T., Hermanides, R. S., Fabris, E., IJsselmuiden, A. J. J., Kauer, F., Alfonso, F. , von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., Reith, S., Al Nooryani, A., Rivero, F., Malinowski, K., ... Wojakowski, W. (2021). Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial. European heart journal, 42(45), 4671-4679. https://doi.org/10.1093/eurheartj/ehab433

Ploumen, E. , Zocca, P., Buiten, R. A. , Doggen, C., Aminian, A., Schotborgh, C., Jessurun, G. A. J., Roguin, A., Danse, P. W., Benit, E. , & von Birgelen, C. (2021). Three-year outcome of all-comer patiens treated with resolute onyx zotarolimus-eluting versus orsiro sirolimus-eluting stens in the randomized bionyx trial. Journal of the American College of Cardiology, 77(18), 1026-1026.

Ploumen, E. H., Pinxterhuis, T. H. , Zocca, P., Roguin, A., Anthonio, R. L., Schotborgh, C. E., Benit, E., Aminian, A., Danse, P. W. , Doggen, C. J. M. , von Birgelen, C. , & Kok, M. M. (2021). Impact of prediabetes and diabetes on 3-year outcome of patients treated with new-generation drug-eluting stents in two large-scale randomized clinical trials. Cardiovascular diabetology, 20(1), [217]. https://doi.org/10.1186/s12933-021-01405-4

Ploumen, E. H. (2021). New-generation drug-eluting stents in various patient populations. [PhD Thesis - Research external, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036552523

van der Maten, G., Reimer, J. M. B., Meijs, M. F. L. , von Birgelen, C. , Brusse-Keizer, M. G. J., & den Hertog, H. M. (2021). Detection of major cardioembolic sources in real-world patients with ischemic stroke or transient ischemic attack of undetermined cause. Cerebrovascular Diseases Extra, 11(1), 22-28. https://doi.org/10.1159/000512743

Publications in scientific journals

A complete list of all manuscripts published in scientific journals is provided on the homepage of PubMed.gov (https://www.ncbi.nlm.nih.gov/pubmed/). Please use the search term: von Birgelen C[AU] .

Alternatively, you may copy and paste this direct link into your Internet browser: https://www.ncbi.nlm.nih.gov/pubmed/?term=von+Birgelen+C%5BAU%5D .

Ph.D. supervised at the University of Twente

M.M. Kok. Percutaneous coronary interventions from various perspectives. Ph.D. (cum laude), 13-12-2018. Supervisor: von Birgelen C.

L.C. van der Heijden. Second-generation drug-eluting stents and beyond. Ph.D., 06-12-2017. Supervisor: von Birgelen C.

J.J. Kandhai-Ragunath. Peripheral endothelial function after ST-segment elevation myocardial infarction. Ph.D., 06-12-2017. Supervisor: von Birgelen C.

M.K. Lam. Lesion morphology, vessel anatomy and the outcome of coronary stenting: Insight from the TWENTE trials. Ph.D., 17-06-2015. Supervisors: von Birgelen C. and IJzerman M.J.

H. Sen. Drug-eluting stent use in patients with increased risk. Ph.D., 19-12-2014. Supervisor: von Birgelen C.

K. Tandjung. Clinical assessment of drug-eluting stents: TWENTE trial and beyond. Ph.D. (cum laude), 25-06-2014. Supervisor: von Birgelen C.

M.A.G.M. Olimulder. Utility of cardiovascular magnetic resonance imaging with contrast- enhancement beyond the scope of viability. Ph.D., 25-06-2014. Supervisor: von Birgelen C.

M.G. Stoel. Angiography and coronary function – a clinical approach. Ph.D., 11-10-2013. Supervisors: von Birgelen C. and Zijlstra F.

M.W.Z. Basalus. Drug-eluting stents: from bench-top to clinical research. Ph.D., 11-10-2013. Supervisor: von Birgelen C.

M. Hartmann. Serial intravascular ultrasound assessment of coronary atherosclerosis progression and remodeling. Ph.D., 27-11-2008. Supervisor: von Birgelen C.