prof.dr. C. von Birgelen (Clemens)

Medicine & Life Sciences

# Drug-Eluting Stents
# Everolimus
# Myocardial Infarction
# Percutaneous Coronary Intervention
# Polymers
# St Elevation Myocardial Infarction
# Stents
# Zotarolimus

Faculty of Behavioural, Management and Social Sciences (BMS), Health Technology & Services Research (HTSR)

Medisch Spectrum Twente
cardiologist, interventional cardiologist
foundation CRE Enschede
board member of a foundation

ULTRA Collaborators (2023). Predictors of target lesion failure after treatment of left main, bifurcation, or chronic total occlusion lesions with ultrathin-strut drug-eluting coronary stents in the ULTRA registry. Catheterization and cardiovascular interventions, 102(2), 221-232. https://doi.org/10.1002/ccd.30696

Spirito, A., Itchhaporia, D., Sartori, S., Camenzind, E., Chieffo, A., Dangas, G. D., Galatius, S., Jeger, R. V., Kandzari, D. E., Kastrati, A., Kim, H. S., Kimura, T., Leon, M. B., Mehta, L. S., Mikhail, G. W., Morice, M. C., Nicolas, J., Pileggi, B., Serruys, P. W., ... Mehran, R. (2023). Impact of chronic kidney disease and diabetes on clinical outcomes in women undergoing PCI. EuroIntervention, 19(6), 493-501. https://doi.org/10.4244/EIJ-D-23-00086

van der Maten, G., Meijs, M. F. L., Timmer, J. R., Brouwers, P. J. A. M. , von Birgelen, C., Coutinho, J. M., Bouma, B. J., Kerkhoff, H., Helming, A. M., van Tuijl, J. H., van der Meer, N. A., Saxena, R., Ebink, C. , van der Palen, J., & den Hertog, H. M. (2023). Routine transthoracic echocardiography in ischaemic stroke or transient ischaemic attack of undetermined cause: a prospective multicentre study. Netherlands heart journal. Advance online publication. https://doi.org/10.1007/s12471-023-01819-7

Pinxterhuis, T. H. , Ploumen, E. H. , Zocca, P. , Doggen, C. J. M., Schotborgh, C. E., Anthonio, R. L., Roguin, A., Danse, P. W., Benit, E., Aminian, A. , Hartmann, M., Linssen, G. C. M. , & von Birgelen, C. (2023). Impact of premature coronary artery disease on adverse event risk following first percutaneous coronary intervention. Frontiers in Cardiovascular Medicine, 10, Article 1160201. https://doi.org/10.3389/fcvm.2023.1160201

van der Maten, G., Meijs, M. F. L. , van der Palen, J., Brouwers, P. J. A. M. , von Birgelen, C., van Opstal, J., & den Hertog, H. M. (2023). Atrial fibrillation detected with outpatient cardiac rhythm monitoring in patients with ischemic stroke or TIA of undetermined cause. Journal of Stroke and Cerebrovascular Diseases, 32(12), Article 107400. Advance online publication. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107400

Pinxterhuis, T. H. , Ploumen, E. H. , Zocca, P. , Doggen, C. J. M., Schotborgh, C. E., Anthonio, R. L., Roguin, A., Danse, P. W., Benit, E., Aminian, A., van Houwelingen, K. G., Linssen, G. C. M. , Geelkerken, R. H. , & von Birgelen, C. (2023). Outcome of percutaneous coronary intervention using ultrathin-strut biodegradable polymer sirolimus-eluting versus thin-strut durable polymer zotarolimus-eluting stents in patients with comorbid peripheral arterial disease: a post-hoc analysis from two randomized trials. Cardiovascular diagnosis and therapy, 13(4), 673-685. https://doi.org/10.21037/cdt-22-584

Pinxterhuis, T. H. , Ploumen, E. H. , Doggen, C. J. M. , Hartmann, M., Schotborgh, C. E., Anthonio, R. L., Roguin, A., Danse, P. W., Benit, E., Aminian, A., Linssen, G. C. M. , & Von birgelen, C. (2023). First Myocardial Infarction in Patients with Premature Coronary Artery Disease: Insights into Patient Characteristics and Outcome after Treatment with Contemporary Stents. European Heart Journal: Acute Cardiovascular Care. Advance online publication. https://doi.org/10.1093/ehjacc/zuad098

e-ULTIMASTER investigators (2023). Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study). The American journal of cardiology, 186, 71-79. Advance online publication. https://doi.org/10.1016/j.amjcard.2022.10.023

De Luca, G., Manzo-Silberman, S., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Busljetik, O., Cercek, M., Okkels, L., Loh, P. H., Calmac, L., Ferrer, G. R. I., Quadros, A., Milewski, M., Scotto di Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., ... Verdoia, M. (2023). Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry. Journal of Clinical Medicine, 12(3), Article 896. https://doi.org/10.3390/jcm12030896

Fabris, E., Berta, B., Hommels, T., Roleder, T., Hermanides, R. S., Rivero, F. , von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., Reith, S., Roleder-Dylewska, M., Gasior, P., Malinowski, K. P., De Luca, G., Garcia-Garcia, H. M., ... Kedhi, E. (2023). Long-term outcomes of patients with normal fractional flow reserve and thin-cap fibroatheroma. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 18(13), e1099-e1107. https://doi.org/10.4244/EIJ-D-22-00306

Pinxterhuis, T. H. , Ploumen, E. H. , Zocca, P. , Doggen, C. J. M., Schotborgh, C. E., Anthonio, R. L., Roguin, A., Danse, P. W., Benit, E., Aminian, A., Stoel, M. G., Linssen, G. C. M. , Geelkerken, R. H. , & von Birgelen, C. (2023). Risk of bleeding after percutaneous coronary intervention and its impact on further adverse events in clinical trial participants with comorbid peripheral arterial disease. International journal of cardiology, 374, 27-32. Advance online publication. https://doi.org/10.1016/j.ijcard.2022.12.009

Sanz-Sánchez, J., Chiarito, M., Gill, G. S. , van der Heijden, L. C., Piña, Y., Cortese, B., Alfonso, F. , von Birgelen, C., Diez Gil, J. L., Waksman, R., & Garcia-Garcia, H. M. (2022). Small Vessel Coronary Artery Disease: Rationale for Standardized Definition and Critical Appraisal of the Literature. Journal of the Society for Cardiovascular Angiography and Interventions, 1(5), Article 100403. https://doi.org/10.1016/j.jscai.2022.100403

Ploumen, E. H., Pinxterhuis, T. H., Buiten, R. A. , Zocca, P., Danse, P. W., Schotborgh, C. E., Scholte, M., Tjon Joe Gin, R. M., Somi, S., van Houwelingen, K. G., Stoel, M. G., de Man, H. A. F. , Hartmann, M., Linssen, G. C. M. , van der Heijden, L. C. , Kok, M. M. , Doggen, C. J. M. , & von Birgelen, C. (2022). Final 5-Year Report of the Randomized BIO-RESORT Trial Comparing 3 Contemporary Drug-Eluting Stents in All-Comers. Journal of the American Heart Association, 11(22), Article e026041. https://doi.org/10.1161/JAHA.122.026041

De Luca, G., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Zimbakov, Z., Cercek, M., Jensen, L. O., Loh, P. H., Calmac, L., Ferrer, G. R. I., Quadros, A., Milewski, M., Scotto D’Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., Wong Sung Lung, A., ... Verdoia, M. (2022). Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS–STEMI COVID-19 Registry. Journal of Clinical Medicine, 11(22), Article 6722. https://doi.org/10.3390/jcm11226722

De Luca, G., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Zimbakov, Z., Cercek, M., Okkels Jensen, L., Loh, P. H., Calmac, L., Roura i Ferrer, G., Quadros, A., Milewski, M., Scotto Di Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., Wong Sung Lung, A., ... Verdoia, M. (2022). SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion. Angiology. Advance online publication. https://doi.org/10.1177/00033197221129351

Konigstein, M., Redfors, B., Zhang, Z., Kotinkaduwa, L. N., Mintz, G. S., Smits, P. C., Serruys, P. W. , von Birgelen, C., Madhavan, M. V., Golomb, M., Ben-Yehuda, O., Mehran, R., Leon, M. B., & Stone, G. W. (2022). Utility of the ACC/AHA Lesion Classification to Predict Outcomes After Contemporary DES Treatment: Individual Patient Data Pooled Analysis From 7 Randomized Trials. Journal of the American Heart Association, 11(24), Article e025275. https://doi.org/10.1161/JAHA.121.025275

Roleder-Dylewska, M., Gasior, P., Hommels, T. M., Roleder, T., Berta, B., Ang, H. Y., Ng, J. C. K., Hermanides, R. S., Fabris, E., IJsselmuiden, A., Kauer, F., Alfonso, F. , von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., ... Kedhi, E. (2022). Morphological characteristics of lesions with thin cap fibroatheroma: A substudy from the COMBINE (OCT-FFR) trial . European Heart Journal Cardiovascular Imaging. Advance online publication. https://doi.org/10.1093/ehjci/jeac218

Haude, M., Toelg, R., Lemos, P. A., Christiansen, E. H., Abizaid, A. , von Birgelen, C., Neumann, F. J., Wijns, W., Ince, H., Kaiser, C., Lim, S. T., Escaned, J., Eeckhout, E., Garcia-Garcia, H. M., & Waksman, R. (2022). Sustained Safety and Performance of a Second-Generation Sirolimus-Eluting Absorbable Metal Scaffold: Long-Term Data of the BIOSOLVE-II First-in-Man Trial at 5 Years. Cardiovascular Revascularization Medicine, 38, 106-110. https://doi.org/10.1016/j.carrev.2021.07.017

Fabris, E., Berta, B., Roleder, T., Hermanides, R. S., Ijsselmuiden, A. J. J., Kauer, F., Alfonso, F. , Von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., Reith, S., Roleder-Dylewska, M., Gasior, P., Malinowski, K., De Luca, G., ... Kedhi, E. (2022). Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights from the COMBINE OCT-FFR Trial. Circulation: Cardiovascular Interventions, 15(5), 430-438. https://doi.org/10.1161/CIRCINTERVENTIONS.121.011728

Ploumen, E. H. , & von Birgelen, C. (2022). Search for Holy Grail of Stent Coating Will Go On. Cardiovascular Revascularization Medicine, 42, 100-101. Advance online publication. https://doi.org/10.1016/j.carrev.2022.06.019

Burrello, J., Gallone, G., Burrello, A., Pagliari, D. J. , Ploumen, E. H., Iannaccone, M., De Luca, L. , Zocca, P., Patti, G., Cerrato, E., Wojakowski, W., Venuti, G., De Filippo, O., Mattesini, A., Ryan, N., Helft, G., Muscoli, S., Kan, J., Sheiban, I., ... D’ascenzo, F. (2022). Prediction of All-Cause Mortality Following Percutaneous Coronary Intervention in Bifurcation Lesions Using Machine Learning Algorithms. Journal of Personalized Medicine, 12(6), Article 990. https://doi.org/10.3390/jpm12060990

De Luca, G., Nardin, M., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Zimbakov, Z., Cercek, M., Okkels Jensen, L., Loh, P. H., Calmac, L., Roura Ferrer, G., Quadros, A., Milewski, M., Scotto di Uccio, F. , von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., ... Verdoia, M. (2022). Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry. Respiratory research, 23(1), Article 207. Advance online publication. https://doi.org/10.1186/s12931-022-02128-0

Pinxterhuis, T. H. , Ploumen, E. H. , Zocca, P. , Doggen, C. J. M., Schotborgh, C. E., Anthonio, R. L., Roguin, A., Danse, P. W., Benit, E., Aminian, A., Stoel, M. G., Linssen, G. C. M. , Geelkerken, R. H. , & von Birgelen, C. (2022). Outcome after percutaneous coronary intervention with contemporary stents in patients with concomitant peripheral arterial disease: A patient-level pooled analysis of four randomized trials. Atherosclerosis, 355, 52-59. Advance online publication. https://doi.org/10.1016/j.atherosclerosis.2022.05.002

PIONEER IV trial investigator (2022). Angiography-derived physiology guidance vs usual care in an All-comers PCI population treated with the healing-targeted supreme stent and Ticagrelor monotherapy: PIONEER IV trial design. American heart journal, 246, 32-43. Advance online publication. https://doi.org/10.1016/j.ahj.2021.12.018

ISACS-STEMI COVID-19, & Collaborators (2022). COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction. Heart (British Cardiac Society), 108(6), 458-466. Advance online publication. https://doi.org/10.1136/heartjnl-2021-319750

Publications in scientific journals

A complete list of all manuscripts published in scientific journals is provided on the homepage of PubMed.gov (https://www.ncbi.nlm.nih.gov/pubmed/). Please use the search term: von Birgelen C[AU] .

Alternatively, you may copy and paste this direct link into your Internet browser: https://www.ncbi.nlm.nih.gov/pubmed/?term=von+Birgelen+C%5BAU%5D .

Ph.D. supervised at the University of Twente

M.M. Kok. Percutaneous coronary interventions from various perspectives. Ph.D. (cum laude), 13-12-2018. Supervisor: von Birgelen C.

L.C. van der Heijden. Second-generation drug-eluting stents and beyond. Ph.D., 06-12-2017. Supervisor: von Birgelen C.

J.J. Kandhai-Ragunath. Peripheral endothelial function after ST-segment elevation myocardial infarction. Ph.D., 06-12-2017. Supervisor: von Birgelen C.

M.K. Lam. Lesion morphology, vessel anatomy and the outcome of coronary stenting: Insight from the TWENTE trials. Ph.D., 17-06-2015. Supervisors: von Birgelen C. and IJzerman M.J.

H. Sen. Drug-eluting stent use in patients with increased risk. Ph.D., 19-12-2014. Supervisor: von Birgelen C.

K. Tandjung. Clinical assessment of drug-eluting stents: TWENTE trial and beyond. Ph.D. (cum laude), 25-06-2014. Supervisor: von Birgelen C.

M.A.G.M. Olimulder. Utility of cardiovascular magnetic resonance imaging with contrast- enhancement beyond the scope of viability. Ph.D., 25-06-2014. Supervisor: von Birgelen C.

M.G. Stoel. Angiography and coronary function – a clinical approach. Ph.D., 11-10-2013. Supervisors: von Birgelen C. and Zijlstra F.

M.W.Z. Basalus. Drug-eluting stents: from bench-top to clinical research. Ph.D., 11-10-2013. Supervisor: von Birgelen C.

M. Hartmann. Serial intravascular ultrasound assessment of coronary atherosclerosis progression and remodeling. Ph.D., 27-11-2008. Supervisor: von Birgelen C.