prof.dr. D.W. Donker MD (Dirk)

In March 2021, I was appointed on the chair of Cardiovascular and Respiratory Physiology (CRPH) at the faculty of Science and Technology of the University of Twente.

The chair is specifically intended to stimulate translational research and education. This, in order to allow patients and health care professionals to maximally benefit from the latest ingenious technologies integrated into modern clinical practice. In this sense, I consider my academic-clinical ambitions equally important as my dedication to professional education in technical medicine, biomedical technology and medicine.

I am indebted for the opportunity to combine my professorship with a position as a senior staff member and intensivist-cardiologist in the Intensive Care Centre at the University Medical Centre Utrecht.

The care for patients with acute and life-threatening disease remains complex and challenging. My experience from daily critical care underlines my enduring personal aspiration to advance technological innovation and improve clinical practice.

After attending medical school in Essen, Germany, I received my PhD thesis entitled ‘Cardiac mechanomyopathy - integrating the picture from cell to beating heart’ from Maastricht University in 2008. Meanwhile, I completed my medical specialization in Cardiology followed by Intensive Care training at the Maastricht University Medical Center. In 2013, I joined the staff of the Intensive Care Centre at the University Medical Centre Utrecht and in 2019, I expanded my academic-clinical experience in Cardiological Critical Care at the La Pitié-Salpêtrière hospital in Paris.

My clinical, educational and research interests center around complex cardiovascular and respiratory care. In recent years, I focused on cardiac and pulmonary extracorporeal life support to optimize its clinical use and expand practice-relevant mechanistic insights. My affinity with echocardiography and an inspiring collaboration on patient-specific computer simulation through the years has greatly enlarged my comprehensive physiological understanding and contributes importantly to my work as a physician.

I am actively involved in national and international scientific organizations in the field, collaborate with many dedicated clinicians, researchers and companies, authored many scientific publications and provided numerous presentations. All this, to foster professionals’ enthusiasm and strive to realize a continuing translation of technology, where it is most urgently needed: at the bedside of the individual patient.

Medicine & Life Sciences

# Cardiogenic Shock
# Computer Simulation
# Critical Illness
# Extracorporeal Membrane Oxygenation
# Heart Failure
# Heart-Assist Devices
# Hemodynamics
# Weaning

Faculty of Science and Technology (TNW), Cardiovascular and Respiratory Physiology (CRPH)

University Medical Center Utrecht
Intensivist-Cardiologist
Getinge Maquet Critical Care AB
Consultancy research
Sonion BV
Contract research

Mulder, M. P. , Fresiello, L., Rumindo, K., Jalde, F., Hallbäck, M., Maksuti, E. , & Donker, D. W. (Accepted/In press). A computational platform for virtual patient trials of fluid responsiveness prediction in septic shock phenotypes. Abstract from ESICM LIVES Forum Conference 2023, Utrecht, Netherlands.

Mulder, M. P., Harmannij-Markusse, M. , Donker, D. W. , Fresiello, L., & Potters, J-W. (2023). Is Continuous Intraoperative Monitoring of Mean Arterial Pressure as Good as the Hypotension Prediction Index Algorithm? Research Letter. Anesthesiology, 138(6), 657-658. https://doi.org/10.1097/ALN.0000000000004541

van der Zande, J., Strik, M., Dubois, R., Ploux, S., Abu Alrub, S., Caillol, T., Nasarre, M. , Donker, D. W. , Oppersma, E., & Bordachar, P. (2023). Using a Smartwatch to Record Precordial Electrocardiograms: A Validation Study. Sensors (Basel, Switzerland), 23(5), [2555]. https://doi.org/10.3390/s23052555

Adriaansen, E. J. M., Hermens, J. A. J., Broome, M., Pladet, L., Dubois, E. , Donker, D. W., & Meuwese, C. L. (2023). Cardiac tamponade during venoarterial extracorporeal membrane oxygenation: a case report. Journal of Medical Case Reports, 17(1), [50]. https://doi.org/10.1186/s13256-022-03741-9

Saeed, D., Loforte, A., Morshuis, M., Schibilsky, D., Zimpfer, D., Riebandt, J., Pappalardo, F., Attisani, M., Rinaldi, M., Haneya, A., Ramjankhan, F. , Donker, D. W., Jorde, U. P., Pacini, D., Otto, W., Stein, J., Lewin, D., Jawad, K., Wieloch, R., ... Potapov, E. (2023). Stroke Complications in Patients Requiring Durable Mechanical Circulatory Support Systems after Extracorporeal Life Support. ASAIO Journal, 69(2), 145-150. https://doi.org/10.1097/MAT.0000000000001732

Suverein, M. M., Delnoij, T. S. R., Lorusso, R., Brandon Bravo Bruinsma, G. J., Otterspoor, L., Elzo Kraemer, C. V., Vlaar, A. P. J., van der Heijden, J. J., Scholten, E., den Uil, C., Jansen, T., van den Bogaard, B., Kuijpers, M., Lam, K. Y., Montero Cabezas, J. M., Driessen, A. H. G., Rittersma, S. Z. H., Heijnen, B. G., Dos Reis Miranda, D., ... van de Poll, M. C. G. (2023). Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 388(4), 299-309. https://doi.org/10.1056/NEJMoa2204511

Pladet, L. C. A., Barten, J. M. M., Vernooij, L. M., Kraemer, C. V. E., Bunge, J. J. H., Scholten, E., Montenij, L. J., Kuijpers, M. , Donker, D. W., Cremer, O. L., & Meuwese, C. L. (2023). Prognostic models for mortality risk in patients requiring ECMO. Intensive care medicine, 49, 131-141. https://doi.org/10.1007/s00134-022-06947-z

On behalf of the Dutch ECLS Study group (2023). Health-related quality of life, one-year costs and economic evaluation in extracorporeal membrane oxygenation in critically ill adults. Journal of critical care, 73, [154215]. https://doi.org/10.1016/j.jcrc.2022.154215

Cvetkovic, M., Chiarini, G., Belliato, M., Delnoij, T., Zanatta, P., Taccone, F. S., dos Reis Miranda, D., Davidson, M., Matta, N., Davis, C., IJsselstijn, H., Schmidt, M., Broman, L. M. , Donker, D. W., Vlasselaers, D., David, P., Di Nardo, M., Muellenbach, R. M., Mueller, T., ... Hoskote, A. (2023). International survey of neuromonitoring and neurodevelopmental outcome in children and adults supported on extracorporeal membrane oxygenation in Europe. Perfusion, 38(2), 245-260. https://doi.org/10.1177/02676591211042563

Broomé, M., Carlsson, M., Frieberg, P., Hakacova, N. , & Donker, D. W. (2022). Cardiovascular Simulation as a Decision Support Tool. In Modelling Congenital Heart Disease (pp. 261- 271) https://doi.org/10.1007/978-3-030-88892-3_26

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