Horst Complex

prof.dr. D.W. Grijpma (Dirk)

Full Professor
TNW-BET-AOT
Horst Complex ZH235
d.w.grijpma@utwente.nl
Business card

Dirk Grijpma's research interests are: resorbable polymers and composites for medical applications, structure-properties relationships in polymers, tissue engineering, drug delivery, ring-opening polymerization, photo-polymerization, combinatorial chemistry, hybrid networks, 3D printing and stereolithography.

Current research includes the development of advanced microstructures by additive manufacturing (3D printing and stereolithography), the synthesis of novel polymeric materials for use in these additive manufacturing technologies and research programs on composite membranes for the treatment of pelvic organ prolapse.

His research is characterized by a very high applicability of the developed polymeric biomaterials and implants in the clinic. Much of this work is done in cooperation with clinicians, and in collaboration with industry. Valorization occurs by actively patenting relevant research findings and investigating possibilities for the creation of spin-off companies.

Expertise

  • Medicine and Dentistry

    • Carbonic Acid
    • Cyclopropane

  • Material Science

    • Stereolithography
    • Composite Material
    • Mechanical Property
    • Three Dimensional Printing
    • Material
    • Surface

Organisations

Ancillary activities

  • Ardent VentureDGA

Publications

Jump to: 2025 | 2024 | 2023 | 2022 | 2021

2025

Rubber-like and Antifouling Poly(trimethylene carbonate-ethylphosphonate) Copolymers with Tunable Hydrolysis (2025)ACS applied materials & interfaces, 17(16), 23513-23521. Rheinberger, T., Ankone, M. J. K., Grijpma, D. W. & Wurm, F. R.https://doi.org/10.1021/acsami.4c21079Porous photo-crosslinked hybrid networks based on poly(trimethylene carbonate-co-ε-caprolactone) and recombinant human-like collagen (2025)Biomaterials Advances, 167. Article 214106. van Bochove, B., Warmink, L., Ankoné, M. J. K., Grijpma, D. W. & Poot, A. A.https://doi.org/10.1016/j.bioadv.2024.214106Porous polytrimethylenecarbonate scaffolds: Design considerations and porosity modulation techniques (2025)Materials & Design, 250. Article 113588. Jurczak, K. M., Zhang, R., Hinrichs, W. L. J., Grijpma, D. W., Schuurmann, R. C. L., de Vries, J.-P. P. M. & van Rijn, P.https://doi.org/10.1016/j.matdes.2025.113588

2024

Biomaterial approaches for improved bone regeneration: Bacterial exopolysaccharides, immunomodulation and coaxial printing (2024)[Thesis › PhD Thesis - Research external, graduation UT]. University of Twente. Bagnol, R. A.https://doi.org/10.3990/1.97890365604673D printing of porous poly(ε-caprolactone)-poly(trimethylene carbonate)-poly(ε-caprolactone) triblock copolymers and nano-apatite composite structures (2024)Express polymer letters, 18(4), 349-358. Güney, A., Kernebeck, L. & Grijpma, D. W.https://doi.org/10.3144/expresspolymlett.2024.26In Vitro and In Vivo Degradation of Photo‐Crosslinked Poly(Trimethylene Carbonate‐co‐ε‐Caprolactone) Networks (2024)Macromolecular bioscience, 24(3). Article 2300364. van Bochove, B., Rongen, J. J., Hannink, G., Seppälä, J. V., Poot, A. A. & Grijpma, D. W.https://doi.org/10.1002/mabi.202300364

2023

Physicochemical Characterization and Immunomodulatory Activity of Polyelectrolyte Multilayer Coatings Incorporating an Exopolysaccharide from Bifidobacterium longum (2023)Biomacromolecules, 24(12), 5589-5604. Bagnol, R., Siverino, C., Barnier, V., O’Mahony, L., Grijpma, D. W., Eglin, D. & Moriarty, T. F.https://doi.org/10.1021/acs.biomac.3c00516Development of a Biodegradable Porous Hybrid Material to Be Used As Patch for Diaphragmatic Hernia Closure (2023)Wound repair and regeneration, 31(S1), S30-S30. van Dommelen, L. H. A., van Bochove, B., Vossen, L., Versteeg, E. M. M., Ankoné, M. J. K., Grijpma, D. W., van Kuppevelt, T. H., Poot, A. A. & Daamen, W. F.https://doi.org/10.1111/wrr.13132Alginate chitosan microbeads and thermos-responsive hyaluronic acid hydrogel for phage delivery (2023)Journal of drug delivery science and technology, 79. Article 103991. Rotman, S. G., Post, V., Foster, A. L., Lavigne, R., Wagemans, J., Trampuz, A., Moreno, M. G., Metsemakers, W. J., Grijpma, D. W., Richards, R. G., Eglin, D. & Moriarty, T. F.https://doi.org/10.1016/j.jddst.2022.103991Enzymatic post-crosslinking of printed hydrogels of methacrylated gelatin and tyramine-conjugated 8-arm poly(ethylene glycol) to prepare interpenetrating 3D network structures (2023)International Journal of Bioprinting, 9(5). Liang, J., Wang, Z., Poot, A. A., Grijpma, D. W., Dijkstra, P. J. & Wang, R.https://doi.org/10.18063/ijb.750Optimizing the Formation of Hybrid Networks Based on Poly(trimethylene carbonate) and Collagen (2023)[Contribution to conference › Poster] Advanced Functional Polymers for Medicine 2023. Macarez, A.-C., van Bochove, B., Ankoné, M. J. K., Poot, A. A. & Grijpma, D. W.Porous Hybrid Networks based on Poly(trimethylene carbonate) and Collagen (2023)[Contribution to conference › Abstract] Advanced Functional Polymers for Medicine 2023. van Bochove, B., Kristen, M., Ankoné, M. J. K., Bayon, Y., Grijpma, D. W. & Poot, A. A.

2022

Hybrid Networks of Hyaluronic Acid and Poly(trimethylene carbonate) for Tissue Regeneration (2022)Biomacromolecules, 24(10), 4366–4374. Gielen, A. M. C., Ankone, M., Grijpma, D. W. & Poot, A. A.https://doi.org/10.1021/acs.biomac.2c00861Real-Time 1H and 31P NMR spectroscopy of the copolymerization of cyclic phosphoesters and trimethylene carbonate reveals transesterification from gradient to random copolymers (2022)European polymer journal, 180. Article 111607. Rheinberger, T., Ankone, M., Grijpma, D. & Wurm, F. R.https://doi.org/10.1016/j.eurpolymj.2022.111607Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up (2022)Bioactive Materials, 17, 439-456. Gareb, B., van Bakelen, N. B., Driessen, L., Buma, P., Kuipers, J., Grijpma, D. W., Vissink, A., Bos, R. R. M. & van Minnen, B.https://doi.org/10.1016/j.bioactmat.2022.01.015Structure–property relations in semi-crystalline combinatorial poly(urethane-isocyanurate)-type hydrogels (2022)Polymer international, 71(9), 1055-1061. Driest, P. J., Dijkstra, D. J., Stamatialis, D. & Grijpma, D. W.https://doi.org/10.1002/pi.6427The production and application of bacterial exopolysaccharides as biomaterials for bone regeneration (2022)Carbohydrate polymers, 291. Article 119550. Bagnol, R., Grijpma, D., Eglin, D. & Moriarty, T. F.https://doi.org/10.1016/j.carbpol.2022.119550Hybrid Hydrogels Based on Methacrylate-Functionalized Gelatin (GelMA) and Synthetic Polymers (2022)Biomedical Materials & Devices. Liang, J., Dijkstra, P. J., Poot, A. A. & Grijpma, D. W.https://doi.org/10.1007/s44174-022-00023-2In vitro and in vivo degradation of photo-crosslinked poly(trimethylene carbonate-co-ɛ-caprolactone) networks (2022)[Contribution to conference › Poster] Advanced Functional Polymers for Medicine, AFPM 2022. van Bochove, B., Rongen, J. J., Hannink, G. J., Buma, P., Poot, A. A. & Grijpma, D. W.

2021

Poly(trimethylene carbonate)-based membranes for biomimetic lung epithelial-endothelial models (2021)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Pasman, T.https://doi.org/10.3990/1.9789036552288Hybrid hydrogels based on gelatin methacrylate (2021)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Liang, J.https://doi.org/10.3990/1.9789036552004Designing advanced functional polymers for medicine (2021)European polymer journal, 155. Article 110573. van Bochove, B., Grijpma, D. W., Lendlein, A. & Seppälä, J. V.https://doi.org/10.1016/j.eurpolymj.2021.110573Tough fibrous mats prepared by electrospinning mixtures of methacrylated poly(trimethylene carbonate) and methacrylated gelatin (2021)European polymer journal, 152. Article 110471. Liang, J., Chen, H., Guo, Z., Dijkstra, P., Grijpma, D. & Poot, A.https://doi.org/10.1016/j.eurpolymj.2021.110471Advanced polymer-based composites and structures for biomedical applications (2021)European polymer journal, 149. Article 110388. Guo, Z., Poot, A. A. & Grijpma, D. W.https://doi.org/10.1016/j.eurpolymj.2021.110388Osteogenic differentiation of hBMSCs on porous photo-crosslinked poly(trimethylene carbonate) and nano-hydroxyapatite composites (2021)European polymer journal, 147. Article 110335. Geven, M. A., Lapomarda, A., Guillaume, O., Sprecher, C. M., Eglin, D., Vozzi, G. & Grijpma, D. W.https://doi.org/10.1016/j.eurpolymj.2021.110335

Research profiles

Courses academic year 2025/2026

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2024/2025

Address

University of Twente

Horst Complex (building no. 20), room ZH235
De Horst 2
7522 LW Enschede
Netherlands

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