prof.dr. D.W. Grijpma (Dirk)

Dirk Grijpma's research interests are: resorbable polymers and composites for medical applications, structure-properties relationships in polymers, tissue engineering, drug delivery, ring-opening polymerization, photo-polymerization, combinatorial chemistry, hybrid networks, 3D printing and stereolithography.

Current research includes the development of advanced microstructures by additive manufacturing (3D printing and stereolithography), the synthesis of novel polymeric materials for use in these additive manufacturing technologies and research programs on composite membranes for the treatment of pelvic organ prolapse.

His research is characterized by a very high applicability of the developed polymeric biomaterials and implants in the clinic. Much of this work is done in cooperation with clinicians, and in collaboration with industry. Valorization occurs by actively patenting relevant research findings and investigating possibilities for the creation of spin-off companies.

Engineering & Materials Science

# Carbonates
# Scaffolds
# Stereolithography
# Tissue Engineering

Medicine & Life Sciences

# Polytrimethylene Carbonate
# Stereolithography
# Tissue Engineering

Chemistry

# Carbonate

Faculty of Science and Technology (TNW), Advanced Organ bioengineering and Therapeutics (AOT)

Ardent Venture
DGA
PUM
Voluntary expert advice

Liang, J., Wang, Z. , Poot, A. A. , Grijpma, D. W. , Dijkstra, P. J. , & Wang, R. (2023). Enzymatic post-crosslinking of printed hydrogels of methacrylated gelatin and tyramine-conjugated 8-arm poly(ethylene glycol) to prepare interpenetrating 3D network structures. International Journal of Bioprinting, 9(5). https://doi.org/10.18063/ijb.750

van Bochove, B., Kristen, M. , Ankoné, M. J. K., Bayon, Y. , Grijpma, D. W. , & Poot, A. A. (2023). Porous Hybrid Networks based on Poly(trimethylene carbonate) and Collagen. Abstract from Advanced Functional Polymers for Medicine 2023, Barcelona, Spain.

Macarez, A.-C. , van Bochove, B. , Ankoné, M. J. K. , Poot, A. A. , & Grijpma, D. W. (2023). Optimizing the Formation of Hybrid Networks Based on Poly(trimethylene carbonate) and Collagen. Poster session presented at Advanced Functional Polymers for Medicine 2023, Barcelona, Spain.

van Bochove, B., Rongen, J. J., Hannink, G., Seppälä, J. V. , Poot, A. A. , & Grijpma, D. W. (2023). In Vitro and In Vivo Degradation of Photo‐Crosslinked Poly(Trimethylene Carbonate‐co‐ε‐Caprolactone) Networks. Macromolecular bioscience. Advance online publication. https://doi.org/10.1002/mabi.202300364

Rotman, S. G., Post, V., Foster, A. L., Lavigne, R., Wagemans, J., Trampuz, A., Moreno, M. G., Metsemakers, W. J. , Grijpma, D. W., Richards, R. G., Eglin, D., & Moriarty, T. F. (2023). Alginate chitosan microbeads and thermos-responsive hyaluronic acid hydrogel for phage delivery. Journal of drug delivery science and technology, 79, Article 103991. https://doi.org/10.1016/j.jddst.2022.103991

van Bochove, B., Rongen, J. J., Hannink, G. J., Buma, P. , Poot, A. A. , & Grijpma, D. W. (2022). In vitro and in vivo degradation of photo-crosslinked poly(trimethylene carbonate-co-ɛ-caprolactone) networks. Poster session presented at Advanced Functional Polymers for Medicine, AFPM 2022, NIce, France.

Liang, J. , Dijkstra, P. J. , Poot, A. A. , & Grijpma, D. W. (2022). Hybrid Hydrogels Based on Methacrylate-Functionalized Gelatin (GelMA) and Synthetic Polymers. Biomedical Materials & Devices. https://doi.org/10.1007/s44174-022-00023-2

Gielen, A. M. C. , Ankone, M. , Grijpma, D. W. , & Poot, A. A. (2022). Hybrid Networks of Hyaluronic Acid and Poly(trimethylene carbonate) for Tissue Regeneration. Biomacromolecules. Advance online publication. https://doi.org/10.1021/acs.biomac.2c00861

Bagnol, R. , Grijpma, D., Eglin, D., & Moriarty, T. F. (2022). The production and application of bacterial exopolysaccharides as biomaterials for bone regeneration. Carbohydrate polymers, 291, Article 119550. https://doi.org/10.1016/j.carbpol.2022.119550

Driest, P. J., Dijkstra, D. J. , Stamatialis, D. , & Grijpma, D. W. (2022). Structure–property relations in semi-crystalline combinatorial poly(urethane-isocyanurate)-type hydrogels. Polymer international, 71(9), 1055-1061. https://doi.org/10.1002/pi.6427

Rheinberger, T. , Ankone, M. , Grijpma, D. , & Wurm, F. R. (2022). Real-Time ¹H and ³¹P NMR spectroscopy of the copolymerization of cyclic phosphoesters and trimethylene carbonate reveals transesterification from gradient to random copolymers. European polymer journal, 180, Article 111607. https://doi.org/10.1016/j.eurpolymj.2022.111607

Gareb, B., van Bakelen, N. B., Driessen, L., Buma, P., Kuipers, J. , Grijpma, D. W., Vissink, A., Bos, R. R. M., & van Minnen, B. (2022). Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up. Bioactive Materials, 17, 439-456. https://doi.org/10.1016/j.bioactmat.2022.01.015

Liang, J. , Chen, H. , Guo, Z. , Dijkstra, P. , Grijpma, D. , & Poot, A. (2021). Tough fibrous mats prepared by electrospinning mixtures of methacrylated poly(trimethylene carbonate) and methacrylated gelatin. European polymer journal, 152, Article 110471. https://doi.org/10.1016/j.eurpolymj.2021.110471

van Bochove, B. , Grijpma, D. W., Lendlein, A., & Seppälä, J. V. (2021). Designing advanced functional polymers for medicine. European polymer journal, 155, Article 110573. https://doi.org/10.1016/j.eurpolymj.2021.110573

Pasman, T. (2021). Poly(trimethylene carbonate)-based membranes for biomimetic lung epithelial-endothelial models. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036552288

Liang, J. (2021). Hybrid hydrogels based on gelatin methacrylate. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036552004

Guo, Z. , Poot, A. A. , & Grijpma, D. W. (2021). Advanced polymer-based composites and structures for biomedical applications. European polymer journal, 149, Article 110388. https://doi.org/10.1016/j.eurpolymj.2021.110388

Geven, M. A., Lapomarda, A., Guillaume, O., Sprecher, C. M., Eglin, D., Vozzi, G. , & Grijpma, D. W. (2021). Osteogenic differentiation of hBMSCs on porous photo-crosslinked poly(trimethylene carbonate) and nano-hydroxyapatite composites. European polymer journal, 147, Article 110335. https://doi.org/10.1016/j.eurpolymj.2021.110335

Blanquer, S. B. G. , & Grijpma, D. W. (2021). Triply Periodic Minimal Surfaces (TPMS) for the Generation of Porous Architectures Using Stereolithography. In Computer-Aided Tissue Engineering (pp. 19-30). (Methods in Molecular Biology; Vol. 2147). Humana Press. https://doi.org/10.1007/978-1-0716-0611-7_2

van Bochove, B. , & Grijpma, D. W. (2021). Mechanical properties of porous photo-crosslinked poly(trimethylene carbonate) network films. European polymer journal, 143, Article 110223. https://doi.org/10.1016/j.eurpolymj.2020.110223

Long, R. G., Ferguson, S. J., Benneker, L. M., Sakai, D., Li, Z., Pandit, A. , Grijpma, D. W., Eglin, D., Zeiter, S., Schmid, T., Eberli, U., Nehrbass, D., von Treuheim, T. D. P., Alini, M., Iatridis, J. C., & Grad, S. (2020). Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model. JOR Spine, 3(1), Article e1074. https://doi.org/10.1002/jsp2.1074

Liang, J. , Grijpma, D. W. , & Poot, A. A. (2020). Tough and biocompatible hybrid networks prepared from methacrylated poly(trimethylene carbonate) (PTMC) and methacrylated gelatin. European polymer journal, 123, Article 109420. https://doi.org/10.1016/j.eurpolymj.2019.109420

Guo, Z. , Grijpma, D. , & Poot, A. (2020). Leachable poly(trimethylene carbonate)/CaCO₃ composites for additive manufacturing of microporous vascular structures. Materials, 13(15), 1-13. Article 3435. https://doi.org/10.3390/ma13153435

Weisgrab, G., Guillaume, O. , Guo, Z., Heimel, P., Slezak, P. , Poot, A. , Grijpma, D., & Ovsianikov, A. (2020). 3D printing of large-scale and highly porous biodegradable tissue engineering scaffolds from poly(trimethylene-carbonate) using two-photon-polymerization. Biofabrication, 12(4), Article 045036. https://doi.org/10.1088/1758-5090/abb539

Driest, P. J., Dijkstra, D. J. , Stamatialis, D. , & Grijpma, D. W. (2020). Tough combinatorial poly(urethane-isocyanurate) polymer networks and hydrogels synthesized by the trimerization of mixtures of NCO-prepolymers. Acta biomaterialia, 105, 87-96. https://doi.org/10.1016/j.actbio.2020.01.025

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d.w.grijpma@utwente.nl

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University of Twente
Faculty of Science and Technology
Horst Complex (building no. 20), room ZH235
De Horst 2
7522LW Enschede
The Netherlands

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University of Twente
Faculty of Science and Technology
Horst Complex ZH235
P.O. Box 217
7500 AE Enschede
The Netherlands

Faculty of Science and Technology (TNW), Advanced Organ bioengineering and Therapeutics (AOT)

University of Twente Drienerlolaan 5
7522 NB Enschede

+31 (0)53 489 9111
info@utwente.nl
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