Technohal

dr. E. Groot Jebbink (Erik)

Technical Physician | Assistant Professor
TNW-BIS-M3I
Technohal 2381
e.grootjebbink@utwente.nl
+31534895305
Business card

I studied Technical medicine between 2006 and 2013 at the University of Twente. My graduation project focused on the interaction between stents and blood flow in case of stenotic vascular pathologies. This topic has interested me ever since and I obtained my PhD on this topic within the Physics of Fluids group (University of Twente) in 2017, under the supervision of prof. dr. Michel Reijnen and prof. dr. Michel Versluis1. My PhD work incorporated both in vitro and in vivo flow visualization, for which I spent time in the Labs of PoF and at the department of Vascular Surgery, Rijnstate Hospital Arnhem. My PhD was setup as a six year project with a 50/50 balance between research and education, I’m involved in several courses within the Technical Medicine program.

During my Postdoc period I expanded my PhD work into a new research line, within the multi-modality medical imaging (M3i) group. In 2019 I was appointed as an Assistant Professor at the M3i group. In this role I’m continuing my work on investigating the interaction of blood flow and stents in relation to the durability of stents to maximize the outcome for patients. My work has a clear translational and applied focus, therefore I have an active secondment at the department of vascular surgery at the Rijnstate hospital.

To visualize and quantify blood flow I apply (and develop) several tools. In vitro we make use of laser particle image velocimetry techniques, realistic flow phantoms and flow circuits to simulate parts of human circulatory system2. In vivo we focus on the application of high frame-rate contrast enhanced ultrasound techniques3. Based on these techniques there are several project in which I’m involved:

  • Stichting Lijf en Leven project, focusing on the relation between blood flow and disease progression in case of aortoiliac peripheral arterial disease. Funded by the stichting Lijf en Leven.
  • ADEAR project, focusing on quantifying the in vivo deformation of endografts and in vitro interaction with blood flow at the timescale of a single heartbeat or breath cycle. Funded by the Connecting Industries Call and Terumo Aortic
  • 2ACP project, focusing on optimizing the visualization of polymers used for injection in case of active sac filling. The second goal of the project is to investigate the mechanical interaction between the stent graft and polymer. Funded by the TKI-LSH PPP call from Health Holland and TripleMed Bv.
  • Ultra-x-treme project, focusing on the development and application of 3D ultrasound based blood flow quantification aligned with biomechanical models for patient-specific characterization of cardiovascular status. Funded by NWO through the Perspectief program and several companies
  • Vortecs project, focusing at obtaining 2D in vivo blood flow quantification, both with and without the use of contrast agents. Funded by NWO through the OTP program, next to Philips and Medtronic.

1. Groot Jebbink, E. (2017). Aortoiliac stenting, how blood flow and stents interact. University of Twente. https://ris.utwente.nl/ws/portalfiles/portal/129917651/thesis_E_Groot_Jebbink.pdf

2.Groot Jebbink, E., Mathai, V., Boersen, J. T., Sun, C., Slump, C. H., Goverde, P. C., ... & Reijnen, M. M. (2017). Hemodynamic comparison of stent configurations used for aortoiliac occlusive disease. Journal of vascular surgery, 66(1), 251-260.

3. Engelhard, S., Voorneveld, J., Vos, H. J., Westenberg, J. J., Gijsen, F. J., Taimr, P., ... & Groot Jebbink, E. (2018). High-frame-rate contrast-enhanced US particle image velocimetry in the abdominal aorta: first human results. Radiology, 289(1), 119-125.

Expertise

  • Medicine and Dentistry

    • Stent
    • In Vitro
    • Particle Image Velocimetry
    • Patient
    • Endovascular Aneurysm Repair
    • Aortoiliac Occlusive Disease
    • Aneurysm
    • Therapeutic Procedure

Organisations

Publications

2024

Endovascular Repair of the Aorta: Flow Quantification of Limb Hemodynamic Parameters (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Mirgolbabaee, H.https://doi.org/10.3990/1.9789036563659High-Frame-Rate Ultrasound Velocimetry in the Healthy Femoral Bifurcation: A Comparative Study Against 4-D Flow Magnetic Resonance Imaging (2024)Ultrasound in medicine and biology, 50(12), 1755-1763. van Helvert, M., Ruisch, J., de Bakker, J. M. K., Saris, A. E. C. M., de Korte, C. L., Versluis, M., Groot Jebbink, E. & Reijnen, M. M. P. J.https://doi.org/10.1016/j.ultrasmedbio.2024.05.013Second order and transverse flow visualization through three-dimensional particle image velocimetry in millimetric ducts (2024)Experimental thermal and fluid science, 159. Article 111296. Harte, N. C., Obrist, D., Versluis, M., Jebbink, E. G., Caversaccio, M., Wimmer, W. & Lajoinie, G.https://doi.org/10.1016/j.expthermflusci.2024.111296Human hemodynamics further unraveled: Ultrafast ultrasound velocimetry for vascular flow imaging (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Helvert, M.https://doi.org/10.3990/1.9789036562737Swirling Flow Quantification in Helical Stents Using Ultrasound Velocimetry (2024)Journal of Endovascular Therapy (E-pub ahead of print/First online). Ghanbarzadeh-Dagheyan, A., van Helvert, M., van de Velde, L., Reijnen, M. M. P. J., Versluis, M. & Jebbink, E. G.https://doi.org/10.1177/15266028241283326Ex-Vivo Human-Sized Organ Machine Perfusion: A Systematic Review on the Added Value of Medical Imaging for Organ Condition Assessment (2024)Transplant international, 37. Article 12827. van der Hoek, J. L., Krommendijk, M. E., Manohar, S., Arens, J. & Groot Jebbink, E.https://doi.org/10.3389/ti.2024.12827Ex-Vivo Human-Sized Organ Machine Perfusion: A Systematic Review on the Added Value of Medical Imaging for Organ Condition Assessment (2024)Transplant international, 37. Article 12827. Van Der Hoek, J. L., Krommendijk, M. E., Manohar, S., Arens, J. & Groot Jebbink, E.https://doi.org/10.3389/ti.2024.12827Validation of ultrasound velocimetry and computational fluid dynamics for flow assessment in femoral artery stenotic disease (2024)Journal of medical imaging, 11(3). Article 2450001. van de Velde, L., van Helvert, M., Engelhard, S., Ghanbarzadeh-Dagheyan, A., Mirgolbabaee, H., Voorneveld, J., Lajoinie, G., Versluis, M., Reijnen, M. M. P. J. & Jebbink, E. G.https://doi.org/10.1117/1.JMI.11.3.037001Lesion Eccentricity Plays a Key Role in Determining the Pressure Gradient of Serial Stenotic Lesions: Results from a Computational Hemodynamics Study (2024)CardioVascular and Interventional Radiology, 47, 533-542. van de Velde, L., Groot Jebbink, E., Jain, K., Versluis, M. & Reijnen, M. M. P. J.https://doi.org/10.1007/s00270-024-03708-xCFD for peripheral artery disease: from Color For Doctors to Clinical Flow Disruption (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van de Velde, L.https://doi.org/10.3990/1.9789036559645

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University of Twente

Technohal (building no. 18), room 2381
Hallenweg 5
7522 NH Enschede
Netherlands

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