Research Theme
Eline is part of the 'Targeted (nano)therapeutics/(nano)theranostics for diagnosis and treatment of liver diseases' research topic within the Translational Liver Research group. Her research is focused on specific targeting of inflammatory macrophages that will open up highly promising therapeutic opportunities for the treatment of liver diseases (NASH and hepatocellular carcinoma), and, other metabolic and inflammatory diseases. This project is supported by TURBO grant and EASL fellowship.
Biography
Eline Geervliet started her Bachelor Technical Medicine in September 2014 at the University of Twente. She finished het Bachelor in 2017 with her thesis named: “The use of a shape memory material in the treatment of heart failure with a reduced ejection fraction” During her bachelor she discovered her interest in biomaterials and therefore decided to start the master Biomedical Engineering, Bionanotechnology and advanced biomanufacturing track, in September 2017, also at the University of Twente. Her internship she performed in Dresden at Leibniz-Institute for Polymer Research titled: “Decoration of extra cellular matrix degrading enzymes on a pH-responsive polymersome as treatment of liver cirrhosis”. Here she successfully decorated the collagen-I degrading enzyme matrix metalloproteinase 1 (MMP-1), for direct availability. Therefore, it was possible to continue this project for here thesis, where she tested the decorated smart polymersome in vitro and in vivo. She finished her master thesis titled “pH-responsive polymersomes for matrix metalloproteinase-1 delivery as a promising therapeutic strategy for the treatment of liver fibrosis” in December 2019. Since May 2020, she is a PhD student at the University of Twente working on a project in collaboration with RWTH Aachen, Germany.
Publication:
Geervliet, E. and R. Bansal, Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases. Cells, 2020. 9(5). Cells_article
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