prof.dr. F.R. Wurm (Frederik)

Full Professor

About Me

Frederik R. Wurm (Prof. Dr.) is currently leading the group “Sustainable Polymer Chemistry” (SPC) at the Universiteit Twente (UT, Enschede, NL). The group designs materials with molecular defined functions for degradable polymers and nanocarriers for agricultural or biomedical applications and especially phosphorus-based polymers. He received his Ph.D. in 2009 (Johannes Gutenberg-University, Mainz, D). After a two-year stay at EPFL (CH) as a Humboldt fellow, he joined the Max Planck Institute for Polymer Research (Mainz, D) and finished his habilitation in Macromolecular Chemistry in 2016. In August 2020, he was appointed as a full professor at UT. He has published more than 200 papers and his research was awarded several times, e.g. with the Reimund Stadler Award of the German Chemical Society (2016), the “Dozentenpreis des Fonds der deutschen chemischen Industrie” (2017) and Polymer Chemistry Lectureship (2019). Since 2019 Frederik works as an Editor for the European Polymer Journal.


Engineering & Materials Science
Anionic Polymerization
Block Copolymers
Polyethylene Glycols
Ring Opening Polymerization


The “Sustainble Polymer Chemistry“ (SPC) group focusses on the development of novel synthesis strategies and polymeric materials to tackle different fundamental questions. The development of novel (bio)degradable materials, primarily based on phosphorus-containing polymers or biopolymers, such as starch or lignin, is a major research focus of the group. We combine modern organic and inorganic chemistry with precision polymer synthesis and colloidal formulations (miniemulsions, reactions at the interface, etc.) in order to produce smart materials for drug delivery, agriculture, adhesive technologies, flame retardants, and optics.


DNA as a blueprint for synthetic polyphosphoesters

Inspired by DNA, a natural polyphosphodiester, my group has especially driven the development of phosphorus-containing polymers, i.e. polyphosphoesters (PPEs). With the natural phosphate building block, biodegradable and biomimetic PPEs can be synthesized by different strategies. We take the bridging element from DNA to materials science as the installation of the phosphate group into the polymer main chain allows installing diverse chemical functionalities, which eventually control the materials properties such as chemical reactivity, folding, self-assembly, or interactions (functionality, responsibility, degradation, blood interactions). Such PPEs can be used in diverse applications and have an industrial interest (e.g. as surfactants or flame retardants). By a living ring-opening polymerization of cyclic phosphoesters, we were able to prepare libraries of functional PPEs, which degrade on demand and carry functional groups to allow drug attachment, surface-immobilization (Polym. Chem. 2018), adhesive (Biomacromolecules 2017) or anti-fouling properties (Nat. Nano. 2016), or flame-retardant properties (Polym. Chem. 2014). The class of PPEs has emerged in the last decade to a powerful polymer class for various applications and due to the versatility of its chemistry, it certainly will find applications in diverse areas of research and industry. We further developed a reliable protocol for the preparation of hydrophobic polyphosphoesters allowing the large-scale preparation of phosphate-based flame-retardants by engineering the chemical structure, we control the degradation during a fire event (collaboration project with BAM (Prof. Schartel)) (Polym. Chem. 2014, Angew. Chem. 2018).

In addition, smart polymers (with LCST and UCST) are accessible from PPEs (Polym. Chem. 2017). For example, amphiphilic polyphosphonate block copolymers carrying hydrogen-bonding motifs allowed us to assemble stimuli-responsive polymersomes, which can be reversibly opened and closed by a temperature trigger (J. Am. Chem. Soc. 2017). Such vesicles are a first step towards the development of compartmentalized reactors on the nano- or microscale that can release reagents. The overall hydrophilicity controls the interactions with blood proteins (Angew. Chem. 2018). Such materials have led to the unraveling of the “stealth effect” of nanocarriers that is an underlying principle for drug delivery (in collaboration with Universitätsmedizin Mainz) (Nat. Nano. 2016, Biomaterials 2015 & 2017). Nanocarriers, coated with hydrophilic PPEs exhibit a “stealth” effect, similar to the well-known poly(ethylene glycol), rendering them as perfect biodegradable alternatives, especially for chronical diseases.

Plastics and Biodegradable Polymers

We live in a polymer age – our modern life is shaped by polymers every day. From food packaging to high-tech polymers in our laptops or cars, synthetic macromolecules surround us.

Research in the “SPC” Group is driven by the molecular design of (bio)degradable polymers – both fully synthetic or based on modified biopolymers.

We design biodegradable nanocarriers, i.e. nanoscopic packaging, of drugs, which we use together with the Uniclinics or the Biology department in Mainz for drug delivery – into cells for the treatment of human diseases, but also as targeted drug delivery inside of plants. The latter project especially targets the treatment of the grapevine trunk disease “Esca” – a deadly fungal disease that does not have a cure to date. We have developed a reliable protocol, based on modified wood-components, that entrap a fungicide and allow a direct transport inside of a living plant and to treat the disease at the place of action – such a nanocarrier-mediated drug delivery for plants will reduce the amounts of pesticides which are sprayed on the fields in the agriculture in general.

Fully synthetic polyethylene-mimics are another major topic in this research area. We design monomers with breaking points, e.g. phosphoesters or orthoesters, that undergo hydrolysis or enzymatic cleavage under certain conditions. These very hydrophobic polymers might be able to replace the non-biodegradable polyethylene is certain applications as they ensure complete degradation. Further information can be found via the link of the interdisciplinary project “PlastX”.

Besides research on novel biodegradable polymers, we also conduct studies about commodity plastics and packaging. The results are published together with the PlastX workgroup (see external link). Shorter stories about plastics and packaging are currently published online via the institute’s Twitter account and cover for example explanations about “To Go”-products or biodegradable waste bags for organic waste. In a recent article (Haider et al. Angew. Chem 2019), we discuss the term “biodegradability” – and compare test methods from the lab to real-life applications that concern biodegradability of plastics and polymers.

Sequence-controlled copolymers

Even 60 years after its discovery, the living anionic polymerization is still the method of choice, when it comes to well-defined polymers of high molar mass, end group functionality, block copolymers. The anionic polymerization is also very important in the industry to prepare block copolymers from vinyl monomers or epoxides, for example. The high control of the anionic polymerization allows also controlling comonomer sequences, either by sequential polymerization or a competing copolymerization of several monomers.

SPC develops comonomer systems, which undergo a selective sequenced copolymerization. By monomer design, we control the polymerization kinetics in order to prepare block copolymers (Gleede et al. J. Am. Chem. Soc. 2018) or (multi) gradient copolymers (Rieger et al. Angew. Chem. 2018 & Macromol. Rapid Comm. 2016).

In contrast to solid-supported synthetic strategies, our approach allows us to prepare sophisticated macromolecules on a large scale with high structural precision. The monomer design controls the reactivity.

A synthetic platform to realize such sequenced copolymers was established in the SPC in recent years: the living anionic polymerization of aziridines. Aziridines were missing in the monomer family for anionic polymerization and access to well-defined polyamine structures or copolymers with styrenes or epoxides are challenging or even impossible to prepare. Aziridine, or ethylene imine, is produced industrially and polymerized only by uncontrolled cationic polymerization. It has a plethora of applications, ranging from chelator, wastewater treatment to gene transfection. The combination of such building blocks with other industrially relevant materials would be desirable to prepare novel materials with unprecedented properties. However, controlled synthesis of linear or branched poly(ethylene imine) (PEI) from aziridine had been missing. The only way for preparing linear PEI is the detour via oxazoline chemistry and subsequent hydrolysis. We established a novel monomer family for the living anionic polymerization, namely activated aziridines. By activation of the aziridine-ring with sulfonamides to allow nucleophilic ring opening, a variety of novel monomers and polymers becomes available. More importantly, base-initiated polymerization proceeds via a “living” mechanism, allowing the formation of polymer architectures or combination with other monomer types. We were able to introduce several chemical functions into the polyaziridines, either in the activating group or as a pendant chain. Removal of the activating group, if desired, is possible by several methods to prepare polyamines which were not accessible so far.

The activating group can do more: by adjustment of the electron-withdrawing effect, the sulfonamide finely tunes the monomer reactivity and controls the synthetic primary structure. This allowed us to prepare sequence-controlled copolymers by a competing anionic polymerization of up to 5 different monomers in a one-pot and one-shot reaction (Macromol. Rapid Comm. 2016). This will allow us to prepare functional materials mimicking the primary structure of proteins and allow folding into hierarchical assemblies. In addition, chirality is currently installed into such synthetic primary structures to further control the chirality of the folding. The combination of aziridine chemistry with epoxides allowed us to prepare amphiphilic multi-block copolymers.

Compartmentalization is another handle to control the synthetic primary structure: By confining a copolymerization to nanodroplets in an emulsion, an ideal (random) copolymerization is forced into gradient copolymers. Polymerization began only inside the droplets. As that compound was gradually consumed, the change in concentration pulled ever-greater amounts of the other ingredient into the chains, creating a gradient effect.


Pelosi, C., Constantinescu, I., Son, H. H., Tinè, M. R., Kizhakkedathu, J. N. , & Wurm, F. R. (2022). Blood Compatibility of Hydrophilic Polyphosphoesters. ACS Applied Bio Materials, 5(3), 1151-1158. https://doi.org/10.1021/acsabm.1c01210
Jo, S. M., Kim, H. S., Won, M., Champanhac, C., Kim, J. S. , Wurm, F. R., & Landfester, K. (2022). Dual-Targeted Nanoreactors and Prodrugs: Hydrogen Peroxide Triggers Oxidative Damage and Prodrug Activation for Synergistic Elimination of Cancer Cells. Advanced functional materials, 32(26), [2200791]. https://doi.org/10.1002/adfm.202200791
Jo, S. M., Kim, J., Lee, J. E. , Wurm, F. R., Landfester, K., & Wooh, S. (2022). Multimodal Enzyme-Carrying Suprastructures for Rapid and Sensitive Biocatalytic Cascade Reactions. Advanced science, 9(10), [2104884]. https://doi.org/10.1002/advs.202104884
Ragauskas, A. J., Huber, G. W., Wang, J., Guss, A., O'Neill, H. M., Lin, C. S. K., Wang, Y. , Wurm, F. R., & Meng, X. (2021). New Technologies are Needed to Improve the Recycling and Upcycling of Waste Plastics. ChemSusChem, 14(19), 3982-3984. https://doi.org/10.1002/cssc.202101872
Guazzelli, E., Lusiani, N., Monni, G., Oliva, M., Pelosi, C. , Wurm, F. R., Pretti, C., & Martinelli, E. (2021). Amphiphilic polyphosphonate copolymers as new additives for pdms‐based antifouling coatings. Polymers, 13(19), [3414]. https://doi.org/10.3390/polym13193414
Eckrich, J., Hoormann, N., Kersten, E., Piradashvili, K. , Wurm, F. R., Heller, M., Becker, S., Anusic, T., Brieger, J., & Strieth, S. (2021). Surface modification of porous polyethylene implants with an albumin-based nanocarrier-release system. Biomedicines, 9(10), [1485]. https://doi.org/10.3390/biomedicines9101485
Golbaten-Mofrad, H., Seyfi Sahzabi, A., Seyfikar, S., Salehi, M. H., Goodarzi, V. , Wurm, F. R., & Jafari, S. H. (2021). Facile template preparation of novel electroactive scaffold composed of polypyrrole-coated poly(glycerol-sebacate-urethane) for tissue engineering applications. European polymer journal, 159, [110749]. https://doi.org/10.1016/j.eurpolymj.2021.110749
Fakhri, V., Jafari, A., Shafiei, M. A., Ehteshamfar, M. V., Khalighiyan, S., Hosseini, H., Goodarzi, V. , Wurm, F. R., Moosazadeh Moghaddam, M., & Khonakdar, H. A. (2021). Development of physical, mechanical, antibacterial and cell growth properties of poly(glycerol sebacate urethane) (PGSU) with helping of curcumin and hydroxyapatite nanoparticles. Polymer chemistry, 12(43), 6263-6282. https://doi.org/10.1039/d1py01040a
Haider, T. P., Suraeva, O., Lieberwirth, I., Paneth, P. , & Wurm, F. R. (2021). RNA-inspired intramolecular transesterification accelerates the hydrolysis of polyethylene-like polyphosphoesters. Chemical science, 12(48), 16054-16064. https://doi.org/10.1039/d1sc05509g
Rheinberger, T., Wolfs, J., Paneth, A. , Gojzewski, H., Paneth, P. , & Wurm, F. R. (2021). RNA-Inspired and Accelerated Degradation of Polylactide in Seawater. Journal of the American Chemical Society, 143(40), 16673-16681. https://doi.org/10.1021/jacs.1c07508
Beckers, S. J., Fischer, J. , & Wurm, F. R. (2021). Synthetic lignin-like and degradable nanocarriers. Polymer chemistry, 12(32), 4661-4667. https://doi.org/10.1039/d1py00818h
Wurm, F. R., Boyer, C., & Sumerlin, B. S. (2021). Progress on Stimuli-Responsive Polymers. Macromolecular rapid communications, 42(18), [2100512]. https://doi.org/10.1002/marc.202100512
Machado, T. O., Beckers, S. J., Fischer, J., Sayer, C., Araújo, P. H. H. D., Landfester, K. , & Wurm, F. R. (2021). Cellulose nanocarriers via miniemulsion allow Pathogen-Specific agrochemical delivery. Journal of colloid and interface science, 601, 678-688. https://doi.org/10.1016/j.jcis.2021.05.030
Chenani, F. H., Rezaei, V. F., Fakhri, V. , Wurm, F. R., Uzun, L., & Goodarzi, V. (2021). Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine. Journal of applied polymer science, 138(24), [50563]. https://doi.org/10.1002/app.50563
Beckers, S. J., Staal, A. H. J., Rosenauer, C., Srinivas, M., Landfester, K. , & Wurm, F. R. (2021). Targeted Drug Delivery for Sustainable Crop Protection: Transport and Stability of Polymeric Nanocarriers in Plants. Advanced science, 8(11), [2100067]. https://doi.org/10.1002/advs.202100067
Suraeva, O., Jeong, B., Asadi, K., Landfester, K. , Wurm, F. R., & Lieberwirth, I. (2021). Polymer defect engineering - conductive 2D organic platelets from precise thiophene-doped polyethylene. Polymer chemistry, 12(14), 2045-2053. https://doi.org/10.1039/d1py00117e

UT Research Information System

Google Scholar Link


get in contact for more projects and descriptions or check out our Twitter account


follow SPC on Twitter: @FrederikWurm


Internet: https://www.utwente.nl/en/tnw/spc/

In the press

September 202 - Interview about plastic bags and alternatives in supermarkets.


September 202 - Interview in "Die Zeit" on recycled plastic toys.


February 2022 -  Interview for "Der Spiegel" - Plastic waste problem


October 2021 -  Interview for Spektrum on seawater-degradable polymers


October 2020 -  A chance for bioplastics - article in Spektrum.


June 2020 - Youtube video about plastic and sustainable alternatives


November 2019 – Youtube summary of Future award on drug delivery in plants:


July 2019 – TV broadcast (BR Alpha) Campus TV about reducing pesticides in agriculture and the use of biobased and biodegradable polymer carriers.


July 2019 – Interview of “The Guardian” about biodegradable polymers


June 2019 – Interview and TV broadcast for Sat.1 (regional TV news) about biobased and biodegradable nanocarriers in agriculture


May 2019 – Interview for Heise Verlag (Journal “Technology Review”) “Gutes Plastik – schlechtes Plastik“


May 2019 – Interview for Plastisphere Blog about biodegradable polymers


April 2019 – Interview with Dresdner Morgenpost on Sustainable Polymer Packaging


21. February 2019 TV Interview about polymer packaging and degradable polymers in 3sat


18. September 2018 Radio Broadcast in “Deutschlandfunk” about Drug Delivery in Agriculture.


21. September 2018 TV Beitrag in 3sat Nano about Biodegradable Polymer Packaging and composting.


28. August 2018 Interview in ZEIT online “Was, wenn nicht Plastik?” - about biodegradable polymers and packaging.


5 July 2018 Radio Broadcast in „SWR Aktuell“ (Frederik explains nanotechnology for treating grapevine plants)


30 June 2018 Radio Broadcast in „Deutschlandfunk“ (Frederik was interviewed about plastics and recycling).


29 June 2018 Public panel discussion about plastic packaging (“Leben im Plastikzeitalter: Wie ist ein nachhaltiger Umgang mit Plastik möglich?“, Frankfurt Institute for Social-Ecological Research).


18 June 2018 Journal Article in profil.at (Frederik was interviewed about degradable polyethylene alternatives)


18 June 2018 Radio broadcast at „Bayern 2” (Radioshow: IQ, Frederik was interviewed about nanotechnology for agricultural use)


10 May 2018 Journal Article “Plastik, gut verträglich." The research on biodegradable polymers of the "Functional Polymers" group was highlighted in the Max Planck Forschung Research Journal.


1 May 2018 Journal Interview for the journal EURO (Frederik interviewed about polymers in daily life)

20 April 2018 Article for schools: Techmax (Link: https://www.max-wissen.de/ ) about microplastics and degradable polymers. Our research about degradable polymers summarized (in German) for schools in Germany.


13 April 2018 Journal Article in “Gesunde Pflanzen (2018) 70:109–113“ – about treatment of plant diseases with biodegradable nanocarriers


16 February 2018 Youtube Video about BioRescue online (“BIOrescue - A novel biorefinery concept for mushroom compost”)


15 November 2017 Radio Interview; Frederik was interviewed about reusable plastic bags in supermarkets.


15 August 2017 Journal Article; The research about biodegradable polymers of the group was highlighted in “Chemie Extra” (ChemieXtra 7-8/2017)


25 April 2017 Public panel discussion at the Max-Planck-Forum (Berlin) – “Plastik – nicht nur Müll“


23 February 2016 Journal Article in “DocCheck” about our Research on the “Stealth” Effect of Nanocarriers


16 February 2016 Journal Article in “Krebs Nachrichten” on the “Stealth” Effect of Nanocarriers



Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Carré (building no. 15), room C4241
Hallenweg 23
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Carré  C4241
P.O. Box 217
7500 AE Enschede
The Netherlands

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