My name is Gerco Hassink. I’m a cell biologist with a background in ER membrane protein quality control, protein degradation, the ubiquitin system, and in the endolysosomal system. I performed my PhD at Leiden University Medical Center and continued my research on this subject at the Karolinska Institute in Stockholm, after which I did a second post-doc at Utrecht Medical Center focussing more on ubuquitin in the endolysosomal sytem. Currently I’m doing research and provide technical assistance here at the department of clinical neurophysiology. The research is in the field of neurophysiology which has both electrophysiological and celbiological aspects.

Expertise

  • Neuroscience

    • Neuron
    • Excitability
    • In Vitro
    • Brain
  • Biochemistry, Genetics and Molecular Biology

    • Ubiquitin
    • Protease
    • Ubiquitin Ligase
    • Growth Hormone Receptor

Organisations

Research interests

In our lab we do electrophysiological measurements and cell biologcical measurements on cultured neuronal networks derived from human stemcells and of rat origin. We use these in vitro neuronal cultures as a model system for the brain to studie e.g. the effects and possible treatment of temporay hypoxia due to brain infarcts or cardial arrests.

Publications

2022

The Association between Hypoxia-Induced Low Activity and Apoptosis Strongly Resembles That between TTX-Induced Silencing and Apoptosis (2022)International journal of molecular sciences, 23(5). Article 2754. Taxis Di Bordonia E Valnigra, D., Hassink, G. C., Levers, M. R., Frega, M., Hofmeijer, J., van Putten, M. J. A. M. & Le Feber, J.https://doi.org/10.3390/ijms23052754

2021

Consolidation of memory traces in cultured cortical networks requires low cholinergic tone, synchronized activity and high network excitability (2021)Journal of neural engineering, 18(4). Article 046051. Dias, I., Levers, M. R., Lamberti, M., Hassink, G. C., Van Wezel, R. & Le Feber, J.https://doi.org/10.1088/1741-2552/abfb3fNeuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra (2021)Journal of neural engineering, 18(3). Article 036016. Pires Monteiro, S., Voogd, E., Muzzi, L., De Vecchis, G., Mossink, B., Levers, M., Hassink, G., van Putten, M., Le Feber, J., Hofmeijer, J. & Frega, M.https://doi.org/10.1088/1741-2552/abe68a

2020

Growth Hormone Receptor Regulation in Cancer and Chronic Diseases: GHR Regulation in Cancer and Chronic Diseases (2020)Frontiers in Endocrinology, 11. Article 597573. Strous, G., Da Silva Almeida, A., Putters, J., Schantl, J., Sedek, M., slotman, J., Nespital, T., Hassink, G. C. & Mol, J.https://doi.org/10.3389/fendo.2020.597573

Research profiles

Address

University of Twente

Technohal (building no. 18), room 3384
Hallenweg 5
7522 NH Enschede
Netherlands

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