dr. G.C. Hassink (Gerco)

Researcher
TNW-BIS-CNPH
Technohal 3384
g.c.hassink@utwente.nl
+31534892762
Business card

My name is Gerco Hassink. Iā€™m a cell biologist with a background in ER membrane protein quality control, protein degradation, the ubiquitin system, and in the endolysosomal system. I performed my PhD at Leiden University Medical Center and continued my research at the Karolinska Institute in Stockholm, after which I did a second post-doc at Utrecht Medical Center. Currently Iā€™m doing research and provide technical assistance to the research theme "Neurotechnology and cellular engineering" at both the clinical neurophysiology.

Expertise

  • Neuroscience

    • Neuron
    • Excitability
    • In Vitro
    • Brain

  • Biochemistry, Genetics and Molecular Biology

    • Ubiquitin
    • Protease
    • Ubiquitin Ligase
    • Growth Hormone Receptor

Organisations

Biography

My name is Gerco Hassink. Iā€™m a cell biologist with a background in ER membrane protein quality control, protein degradation, the ubiquitin system, and in the endolysosomal system. I performed my PhD at Leiden University Medical Center and continued my research at the Karolinska Institute in Stockholm, after which I did a second post-doc at Utrecht Medical Center. Currently Iā€™m doing research and provide technical assistance to the research theme "Neurotechnology and cellular engineering" at both the clinical neurophysiology group.

Research interests



Beside assistance in the project ā€œEffects of ischemia and hypoxemia on neuronal connectivity and synaptic neurotransmissionā€ my research is focused around Parkinsonā€™s disease. Together with the Nanobiophysics Group we try to elucidate the role of aggregate prone alpha-synuclein protein in cell death and disturbance of synaptic communication using cultured neurons on multi electrode arrays. Together with Biological Signals and Systems group and Applied Mathematics group we investigate altered GAP junctional coupling in the Globus Pallidus after ceased input of Substantia Nigra. This research we perform directly on brain slices.

Publications

2022
The Association between Hypoxia-Induced Low Activity and Apoptosis Strongly Resembles That between TTX-Induced Silencing and Apoptosis, Article 2754. Taxis Di Bordonia E Valnigra, D., Hassink, G. C., Levers, M. R., Frega, M., Hofmeijer, J., van Putten, M. J. A. M. & Le Feber, J.https://doi.org/10.3390/ijms23052754
2021
Consolidation of memory traces in cultured cortical networks requires low cholinergic tone, synchronized activity and high network excitability, Article 046051. Dias, I., Levers, M. R., Lamberti, M., Hassink, G. C., Van Wezel, R. & Le Feber, J.https://doi.org/10.1088/1741-2552/abfb3fNeuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra, Article 036016. Pires Monteiro, S., Voogd, E., Muzzi, L., De Vecchis, G., Mossink, B., Levers, M., Hassink, G., van Putten, M., Le Feber, J., Hofmeijer, J. & Frega, M.https://doi.org/10.1088/1741-2552/abe68a
2020
Growth Hormone Receptor Regulation in Cancer and Chronic Diseases: GHR Regulation in Cancer and Chronic Diseases, Article 597573. Strous, G., Da Silva Almeida, A., Putters, J., Schantl, J., Sedek, M., slotman, J., Nespital, T., Hassink, G. C. & Mol, J.https://doi.org/10.3389/fendo.2020.597573

Research profiles

Address

University of Twente

Technohal (building no. 18), room 3384
Hallenweg 5
7522 NH Enschede
Netherlands

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Organisations

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