dr. G.C. Hassink (Gerco) | University of Twente

My name is Gerco Hassink. I’m a cell biologist with a background in ER membrane protein quality control, protein degradation, the ubiquitin system, and in the endolysosomal system. I performed my PhD at Leiden University Medical Center and continued my research at the Karolinska Institute in Stockholm, after which I did a second post-doc at Utrecht Medical Center. Currently I’m doing research and provide technical assistance to the research theme "Neurotechnology and cellular engineering" at both the clinical neurophysiology.

Medicine & Life Sciences

# Hypoxia
# Lewy Bodies
# Neurons
# Synucleins

Engineering & Materials Science

# Astrocytes
# Brain
# Cell Death
# Neurons

Faculty of Science and Technology (TNW), Clinical Neurophysiology (CNPH)

Biography

My name is Gerco Hassink. I’m a cell biologist with a background in ER membrane protein quality control, protein degradation, the ubiquitin system, and in the endolysosomal system. I performed my PhD at Leiden University Medical Center and continued my research at the Karolinska Institute in Stockholm, after which I did a second post-doc at Utrecht Medical Center. Currently I’m doing research and provide technical assistance to the research theme "Neurotechnology and cellular engineering" at both the clinical neurophysiology group.

Research interests

Beside assistance in the project “Effects of ischemia and hypoxemia on neuronal connectivity and synaptic neurotransmission” my research is focused around Parkinson’s disease. Together with the Nanobiophysics Group we try to elucidate the role of aggregate prone alpha-synuclein protein in cell death and disturbance of synaptic communication using cultured neurons on multi electrode arrays. Together with Biological Signals and Systems group and Applied Mathematics group we investigate altered GAP junctional coupling in the Globus Pallidus after ceased input of Substantia Nigra. This research we perform directly on brain slices.

Taxis Di Bordonia E Valnigra, D. , Hassink, G. C. , Levers, M. R. , Frega, M. , Hofmeijer, J. , van Putten, M. J. A. M. , & Le Feber, J. (2022). The Association between Hypoxia-Induced Low Activity and Apoptosis Strongly Resembles That between TTX-Induced Silencing and Apoptosis. International journal of molecular sciences, 23(5), Article 2754. Advance online publication. https://doi.org/10.3390/ijms23052754

Dias, I. , Levers, M. R. , Lamberti, M. , Hassink, G. C. , Van Wezel, R. , & Le Feber, J. (2021). Consolidation of memory traces in cultured cortical networks requires low cholinergic tone, synchronized activity and high network excitability. Journal of neural engineering, 18(4), Article 046051. https://doi.org/10.1088/1741-2552/abfb3f

Pires Monteiro, S. , Voogd, E. , Muzzi, L., De Vecchis, G., Mossink, B. , Levers, M. , Hassink, G. , van Putten, M. , Le Feber, J. , Hofmeijer, J. , & Frega, M. (2021). Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra. Journal of neural engineering, 18(3), Article 036016. https://doi.org/10.1088/1741-2552/abe68a

Strous, G., Da Silva Almeida, A., Putters, J., Schantl, J., Sedek, M., slotman, J., Nespital, T. , Hassink, G. C., & Mol, J. (2020). Growth Hormone Receptor Regulation in Cancer and Chronic Diseases: GHR Regulation in Cancer and Chronic Diseases. Frontiers in Endocrinology, 11, Article 597573. https://doi.org/10.3389/fendo.2020.597573

Pires Monteiro, S., Covelo, J. , Levers, M. , Hassink, G. , le Feber, J. , & Frega, M. (2019). Ischemic Stroke: Treatments to Improve Neuronal Functional Recovery in vitro. In B. Blobel, & M. Giacomini (Eds.), pHealth 2019 (Vol. 261, pp. 313-316). (Studies in health technology and informatics; Vol. 261). https://doi.org/10.3233/978-1-61499-975-1-313

le Feber, J. , Dummer, A. , Hassink, G. C. , van Putten, M. J. A. M. , & Hofmeijer, J. (2018). Evolution of excitation–Inhibition ratio in cortical cultures exposed to hypoxia. Frontiers in cellular neuroscience, 12, Article 183. https://doi.org/10.3389/fncel.2018.00183

Hassink, G. C. , Raiss, C. C. , Segers-Nolten, I. M. J. , van Wezel, R. J. A. , Subramaniam, V. , le Feber, J. , & Claessens, M. M. A. E. (2018). Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons. PLoS ONE, 13(3), Article e0193763. https://doi.org/10.1371/journal.pone.0193763

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+31534894051 (secretary)

+31534892760 (if no answer)

g.c.hassink@utwente.nl

Visiting Address

University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3384
Hallenweg 5
7522NH Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Technohal 3384
P.O. Box 217
7500 AE Enschede
The Netherlands

Faculty of Science and Technology (TNW), Clinical Neurophysiology (CNPH)

University of Twente Drienerlolaan 5
7522 NB Enschede

+31 (0)53 489 9111
info@utwente.nl
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