dr. G.P.R. Lajoinie (Guillaume)

After performing a master thesis in the Biomedical Photonic Imaging Group (BMPI) of the University of Twente, I graduated from Ecole Centrale de Lyon in 2011. I then came back to the university of Twente to fulfill a PhD in the Physics Of Fluids Group, under the supervision of prof. Michel Versluis, on ultrasound contrast agents and graduated in 2015. I am now a assistant professor in the Physics Of Fluids Group, working on ultrasound, microscale fluid dynamics, bubble physics, and deep learning for ultrasound super-resolution contrast agents.

Medicine & Life Sciences

# Acoustics
# Microbubbles

Physics & Astronomy

# Acoustics
# Bubbles
# High Speed

Engineering & Materials Science

# Nanoparticles
# Plasmonics
# Ultrasonics

Faculty of Science and Technology (TNW), Physics of Fluids (POF)

My research interests include a broad array of microscale phenomena, in particular these that can lead to the generation of contrast for ultrasound and photoacoustics. Such phenomena often involve cavitation, phase change and heat and mass transfer. I also have a keen interest in therapeutic applications of microbubbles for sonoporation, sonoprinting and gene therapy. Studying microscale physics also requires a precise control of the particles properties, and in particular their size. Part of my research activities therefore focuses on production methods and precise control of agents created using microfluidics. High-speed imaging is a critical tool in such studies and allows for the direct visualization of the response of the contrast agents. The recent arrival of ultrafast plane-wave ultrasound technology combined with monodisperse microbubbles opens new possibilities for highly controlled and localized drug delivery and greatly improved diagnostics for personalized medicine.

Spiekhout, S., Voorneveld, J. , Elburg, B. V., Renaud, G. , Segers, T. , Lajoinie, G. P. R. , Versluis, M., Verweij, M. D., Jong, N. D., & Bosch, J. G. (2022). Time-resolved absolute radius estimation of vibrating contrast microbubbles using an acoustical camera. The Journal of the Acoustical Society of America, 151(6), 3993-4003. [3993]. https://doi.org/10.1121/10.0011619

Engelhard, S. , van Helvert, M., Voorneveld, J., Bosch, J. G. , Lajoinie, G. , Jebbink, E. G. , Reijnen, M. M. P. J. , & Versluis, M. (2022). Blood Flow Quantification with High-Frame-Rate, Contrast-Enhanced Ultrasound Velocimetry in Stented Aortoiliac Arteries: In Vivo Feasibility. Ultrasound in medicine and biology, 48(8), 1518-1527. https://doi.org/10.1016/j.ultrasmedbio.2022.03.016

Michels, S. E. , Lajoinie, G., Hedayatrasa, S. , Versluis, M., Kersemans, M., & Smet, P. F. (2022). A theoretical framework for acoustically produced luminescence: From thermometry to ultrasound pressure field mapping. Journal of luminescence, 248, [118940]. https://doi.org/10.1016/j.jlumin.2022.118940

Blanken, N. , Wolterink, J. M., Delingette, H. , Brune, C. , Versluis, M. , & Lajoinie, G. (2022). Super-Resolved Microbubble Localization in Single-Channel Ultrasound RF Signals Using Deep Learning. IEEE transactions on medical imaging, 41(9), 2532-2542. https://doi.org/10.1109/TMI.2022.3166443

Deprez, J., Roovers, S. , Lajoinie, G., Dewitte, H., Decruy, T., Coudenys, J., Descamps, B., Vanhove, C. , Versluis, M., Elewaut, D., Jacques, P., Smedt, S. C. D., & Lentacker, I. (2022). Evaluation of Liposome-Loaded Microbubbles as a Theranostic Tool in a Murine Collagen-Induced Arthritis Model. Scientia Pharmaceutica, 90(1), 17-23. [17]. https://doi.org/10.3390/scipharm90010017

de Maar, J. S., Rousou, C. , van Elburg, B., Vos, H. J. , Lajoinie, G. P. R., Bos, C., Moonen, C. T. W., & Deckers, R. (2021). Ultrasound-Mediated Drug Delivery With a Clinical Ultrasound System: In Vitro Evaluation. Frontiers in pharmacology, 12, [768436]. https://doi.org/10.3389/fphar.2021.768436

Cleve, S. , Diddens, C. , Segers, T. , Lajoinie, G. , & Versluis, M. (2021). Time-resolved velocity and pressure field quantification in a flow-focusing device for ultrafast microbubble production. Physical review fluids, 6(11), [114202]. https://doi.org/10.1103/PhysRevFluids.6.114202

Engelhard, S. , Helvert, M. V., Voorneveld, J., Bosch, J. G. , Lajoinie, G. P. R. , Versluis, M. , Jebbink, E. G. , & Reijnen, M. M. P. J. (2021). US Velocimetry in Participants with Aortoiliac Occlusive Disease. Radiology, 301(2), 332-338. https://doi.org/10.1148/radiol.2021210454

Nawijn, C. , Segers, T. , Lajoinie, G., Mørch, Ý., Berg, S., Snipstad, S., de Lange Davies, C. , & Versluis, M. (2021). Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release. Journal of visualized experiments : JoVE, 172, [e62251]. https://doi.org/10.3791/62251

Blanken, N. , Wolterink, J. M., Delingette, H. , Brune, C. , Versluis, M. , & Lajoinie, G. P. R. (2021). Contrast-enhanced single-RF-line simulations and super-resolution microbubble detection using deep learning. Abstract from 26th European Symposium on Ultrasound Contrast Imaging 2021, Online.

Peñas, P. , Moreno Soto, Á. , Lohse, D. , Lajoinie, G. , & van der Meer, D. (2021). Ultrasound-enhanced mass transfer during the growth and dissolution of surface gas bubbles. International journal of heat and mass transfer, 174, [121069]. https://doi.org/10.1016/j.ijheatmasstransfer.2021.121069

Michels, S. E., Kersemans, M. , Versluis, M. , Lajoinie, G., & Smet, P. F. (2021). Fast and High-Resolution Ultrasound Pressure Field Mapping Using Luminescent Membranes. Advanced Optical Materials, 9(12), [2100085]. https://doi.org/10.1002/adom.202100085

Deprez, J. , Lajoinie, G., Engelen, Y., De Smedt, S. C., & Lentacker, I. (2021). Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery. Advanced drug delivery reviews, 172, 9-36. https://doi.org/10.1016/j.addr.2021.02.015

van Elburg, B., Collado-Lara, G., Bruggert, G-W. , Segers, T. , Versluis, M. , & Lajoinie, G. (2021). Feedback-controlled microbubble generator producing one million monodisperse bubbles per second. Review of scientific instruments, 92(3), [035110]. https://doi.org/10.1063/5.0032140

Lajoinie, G. , Segers, T. , & Versluis, M. (2021). High-Frequency Acoustic Droplet Vaporization is Initiated by Resonance. Physical review letters, 126(3), [034501]. https://doi.org/10.1103/PhysRevLett.126.034501

Lajoinie, G., Visscher, M., Blazejewski, E., Veldhuis, G. , & Versluis, M. (2020). Three-phase vaporization theory for laser-activated microcapsules. Photoacoustics, 19, [100185]. https://doi.org/10.1016/j.pacs.2020.100185

Soto, A. M. , Penas, P. , Lajoinie, G. , Lohse, D. , & van der Meer, D. (2020). Ultrasound-enhanced mass transfer during single-bubble diffusive growth. Physical review fluids, 5(6), [063605]. https://doi.org/10.1103/PhysRevFluids.5.063605

Versluis, M., Stride, E. , Lajoinie, G., Dollet, B. , & Segers, T. (2020). Ultrasound Contrast Agent Modeling: A Review. Ultrasound in medicine and biology, 46(9), 2117-2144. https://doi.org/10.1016/j.ultrasmedbio.2020.04.014

Gauthier, A. , Lajoinie, G. , Snoeijer, J. H. , & van der Meer, D. (2020). Inverse leidenfrost drop manipulation using menisci. Soft matter, 16(16), 4043-4048. https://doi.org/10.1039/c9sm02363a

Zaytsev, M. E. , Wang, Y., Zhang, Y. , Lajoinie, G. , Zhang, X. , Prosperetti, A. , Zandvliet, H. J. W. , & Lohse, D. (2020). Gas-Vapor Interplay in Plasmonic Bubble Shrinkage. Journal of physical chemistry C, 124(10), 5861-5869. https://doi.org/10.1021/acs.jpcc.9b10675

Stride, E. , Segers, T. , Lajoinie, G., Cherkaoui, S., Bettinger, T. , Versluis, M., & Borden, M. (2020). Microbubble Agents: New Directions. Ultrasound in medicine and biology, 46(6), 1326-1343. https://doi.org/10.1016/j.ultrasmedbio.2020.01.027

Dewitte, H., Engelen, Y. , Lajoinie, G., Gomes-da-Silva, L. , Versluis, M., De Smedt, S. C., Kroemer, G., Breckpot, K., & Lentacker, I. (2019). Exploring the induction of immunogenic cell death (ICD) by high-intensity focused ultrasound (HIFU). Cancer immunology research, 7(2), [B151]. https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B151

de Matos, M. B. C., Deckers, R. , van Elburg, B. , Lajoinie, G., de Miranda, B. S. , Versluis, M., Schiffelers, R., & Kok, R. J. (2019). Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization. Frontiers in pharmacology, 10, [1463]. https://doi.org/10.3389/fphar.2019.01463

Roovers, S., Deprez, J. , Priwitaningrum, D. , Lajoinie, G. , Rivron, N., Declercq, H., De Wever, O., Stride, E. , Le Gac, S. , Versluis, M. , Prakash, J., De Smedt, S. C., & Lentacker, I. (2019). Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound. Journal of controlled release, 316, 79-92. https://doi.org/10.1016/j.jconrel.2019.10.051

Li, X. , Wang, Y. , Zaytsev, M. E. , Lajoinie, G. , Le The, H. , Bomer, J. G. , Eijkel, J. C. T. , Zandvliet, H. J. W. , Zhang, X. , & Lohse, D. (2019). Plasmonic Bubble Nucleation and Growth in Water: Effect of Dissolved Air. Journal of physical chemistry C, 123(38), 23586-23593. https://doi.org/10.1021/acs.jpcc.9b05374

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For the past 6 years, I am involved in teaching medical acoustics to master students with Prof. Michel Versluis. I have also supervised several bachelor thesis students and 9 master thesis students.

Master

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

The research projects in which I am involved revolve around the idea of using microscale physics in order to generate contrast or induce therapy down to the single cell level. These mechanisms involve in particular phase change, microbubbles resonance and controlled production of complex particles.

Recently, I have focused on the use of these physical mechanisms combined with deep-learning for super-resolution ultrasound imaging.