dr. G.P.R. Lajoinie (Guillaume)

postdoctoral researcher

About Me

After performing a master thesis in the Biomedical Photonic Imaging Group (BMPI) of the University of Twente, I graduated from Ecole Centrale de Lyon in 2011. I then came back to the university of Twente to fulfill a PhD in the Physics Of Fluids Group, under the supervision of prof. Michel Versluis, on ultrasound contrast agents and graduated in 2015. I am now a postdoctoral researcher in the Physics Of Fluids Group, working on ultrasound, microscale heat and mass transfer, phase change and contrast agents. 


In Vitro Techniques


My research interests include a broad array of microscale phenomena, in particular these that can lead to the generation of contrast for ultrasound and photoacoustics. Such phenomena often involve cavitation, phase change and heat and mass transfer. I also have a keen interest in therapeutic applications of microbubbles for sonoporation, sonoprinting and gene therapy. Studying microscale physics also requires a precise control of the particles properties, and in particular their size. Part of my research activities therefore focuses on production methods and precise control of agents created using microfluidics. High-speed imaging is a critical tool in such studies and allows for the direct visualization of the response of the contrast agents. The recent arrival of ultrafast plane-wave ultrasound technology combined with monodisperse microbubbles opens new possibilities for highly controlled and localized drug delivery and greatly improved diagnostics for personalized medicine.



Pereno, V., Aron, M., Vince, O., Mannaris, C., Seth, A., De Saint Victor, M., ... Stride, E. (2018). Layered acoustofluidic resonators for the simultaneous optical and acoustic characterisation of cavitation dynamics, microstreaming, and biological effects. Biomicrofluidics, 12(3), [034109]. DOI: 10.1063/1.5023729
Lajoinie, G., de Jong, N., & Versluis, M. (2017). Brandaris ultra high-speed imaging facility. In K. Tsuji (Ed.), The Micro-World Observed by Ultra High-Speed Cameras: We See What You Don't See (pp. 49-77). Springer International Publishing Switzerland. DOI: 10.1007/978-3-319-61491-5_3
Lajoinie, G., Linnartz, E., Kruizinga, P., de Jong, N., Stride, E., van Soest, G., & Versluis, M. (2017). Laser-driven resonance of dye-doped oil-coated microbubbles: A theoretical and numerical study. Journal of the Acoustical Society of America, 141(4), 2727-2745. DOI: 10.1121/1.4979257
Lajoinie, G., van Rooij, T., Skachkov, I., Blazejewski, E., Veldhuis, G., de Jong, N., ... Versluis, M. (2017). Laser-Activated Polymeric Microcapsules for Ultrasound Imaging and Therapy: In Vitro Feasibility. Biophysical journal, 112(9), 1894-1907. DOI: 10.1016/j.bpj.2017.03.033
Lajoinie, G., Lee, J-Y., Owen, J., Kruizinga, P., de Jong, N., van Soest, G., ... Versluis, M. (2017). Laser-driven resonance of dye-doped oil-coated microbubbles: Experimental study. Journal of the Acoustical Society of America, 141(6), 4832-4846. DOI: 10.1121/1.4985560
Luan, Y., Renaud, G., Raymond, J. L., Segers, T. J., Lajoinie, G. P. R., Beurskens, R., ... de Jong, N. (2016). Combined optical sizing and acoustical characterization of single freely-floating microbubbles. Applied physics letters, 109(23), 234104-. DOI: 10.1063/1.4971391
Lajoinie, G. P. R., De Cock, I., Coussios, C. C., Lentacker, I., le Gac, S., Stride, E., & Versluis, M. (2016). In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications. Biomicrofluidics, 10(1), -. [011501]. DOI: 10.1063/1.4940429
Luan, Y., Renaud, G., Raymond, J. L., Beurskens, R., Mastik, F., Kokhuis, T. J. A., ... Versluis, M. (2014). Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. In IEEE International Ultrasonics Symposium, IUS (pp. 1786-1789). [6932224] IEEE Computer Society. DOI: 10.1109/ULTSYM.2014.0443
Luan, Y., Lajoinie, G. P. R., Gelderblom, E. C., Skachkov, I., van der Steen, A. F. W., Vos, H. J., ... de Jong, N. (2014). Lipid shedding from single oscillating microbubbles. Ultrasound in medicine and biology, 40(8), 1834-1846. DOI: 10.1016/j.ultrasmedbio.2014.02.031

UT Research Information System

Google Scholar Link


For the past 6 years, I am involved in teaching medical acoustics to master students with Prof. Michel Versluis. I have also supervised several bachelor thesis students and 9 master thesis students.

Affiliated Study Programmes



The research projects in which I am involved revolve around the idea of using microscale physics in order to generate contrast or induce therapy on a single cell level. These mechanisms involve in particular phase change, microbubbles resonance and controlled production of complex particles.

Current Projects

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst - Meander (building no. 27), room 214
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst - Meander  214
P.O. Box 217
7500 AE Enschede
The Netherlands