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dr. G.P.R. Lajoinie (Guillaume)

Assistant Professor

About Me

After performing a master thesis in the Biomedical Photonic Imaging Group (BMPI) of the University of Twente, I graduated from Ecole Centrale de Lyon in 2011. I then came back to the university of Twente to fulfill a PhD in the Physics Of Fluids Group, under the supervision of prof. Michel Versluis, on ultrasound contrast agents and graduated in 2015. I am now a assistant professor in the Physics Of Fluids Group, working on ultrasound, microscale fluid dynamics, bubble physics, and deep learning for ultrasound super-resolution contrast agents. 

Expertise

Bubbles
Ultrasonics
Microbubbles
Bubble
Acoustics
Drug
Nanoparticle
Pharmaceutical Preparations

Research

My research interests include a broad array of microscale phenomena, in particular these that can lead to the generation of contrast for ultrasound and photoacoustics. Such phenomena often involve cavitation, phase change and heat and mass transfer. I also have a keen interest in therapeutic applications of microbubbles for sonoporation, sonoprinting and gene therapy. Studying microscale physics also requires a precise control of the particles properties, and in particular their size. Part of my research activities therefore focuses on production methods and precise control of agents created using microfluidics. High-speed imaging is a critical tool in such studies and allows for the direct visualization of the response of the contrast agents. The recent arrival of ultrafast plane-wave ultrasound technology combined with monodisperse microbubbles opens new possibilities for highly controlled and localized drug delivery and greatly improved diagnostics for personalized medicine.

 

Publications

Recent
de Maar, J. S., Rousou, C. , van Elburg, B., Vos, H. J. , Lajoinie, G. P. R., Bos, C., Moonen, C. T. W., & Deckers, R. (2021). Ultrasound-Mediated Drug Delivery With a Clinical Ultrasound System: In Vitro Evaluation. Frontiers in pharmacology, 12, [768436]. https://doi.org/10.3389/fphar.2021.768436
Michels, S. E., Kersemans, M. , Versluis, M. , Lajoinie, G., & Smet, P. F. (2021). Fast and High-Resolution Ultrasound Pressure Field Mapping Using Luminescent Membranes. Advanced Optical Materials, 9(12), [2100085]. https://doi.org/10.1002/adom.202100085
Deprez, J. , Lajoinie, G., Engelen, Y., De Smedt, S. C., & Lentacker, I. (2021). Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery. Advanced drug delivery reviews, 172, 9-36. https://doi.org/10.1016/j.addr.2021.02.015
Versluis, M., Stride, E. , Lajoinie, G., Dollet, B. , & Segers, T. (2020). Ultrasound Contrast Agent Modeling: A Review. Ultrasound in medicine and biology, 46(9), 2117-2144. https://doi.org/10.1016/j.ultrasmedbio.2020.04.014
Stride, E. , Segers, T. , Lajoinie, G., Cherkaoui, S., Bettinger, T. , Versluis, M., & Borden, M. (2020). Microbubble Agents: New Directions. Ultrasound in medicine and biology, 46(6), 1326-1343. https://doi.org/10.1016/j.ultrasmedbio.2020.01.027
Dewitte, H., Engelen, Y. , Lajoinie, G., Gomes-da-Silva, L. , Versluis, M., De Smedt, S. C., Kroemer, G., Breckpot, K., & Lentacker, I. (2019). Exploring the induction of immunogenic cell death (ICD) by high-intensity focused ultrasound (HIFU). Cancer immunology research, 7(2), [B151]. https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B151
de Matos, M. B. C., Deckers, R. , van Elburg, B. , Lajoinie, G., de Miranda, B. S. , Versluis, M., Schiffelers, R., & Kok, R. J. (2019). Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization. Frontiers in pharmacology, 10, [1463]. https://doi.org/10.3389/fphar.2019.01463
Roovers, S., Deprez, J. , Priwitaningrum, D. , Lajoinie, G. , Rivron, N., Declercq, H., De Wever, O., Stride, E. , Le Gac, S. , Versluis, M. , Prakash, J., De Smedt, S. C., & Lentacker, I. (2019). Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound. Journal of controlled release, 316, 79-92. https://doi.org/10.1016/j.jconrel.2019.10.051
Roovers, S. , Lajoinie, G., De Cock, I., Brans, T., Dewitte, H., Braeckmans, K. , Versuis, M., De Smedt, S. C., & Lentacker, I. (2019). Sonoprinting of nanoparticle-loaded microbubbles: Unraveling the multi-timescale mechanism. Biomaterials, 217, [119250]. https://doi.org/10.1016/j.biomaterials.2019.119250
Koshkina, O. , Lajoinie, G., Baldelli Bombelli, F., Swider, E., Cruz, L. J., White, P. B., Schweins, R., Dolen, Y., van Dinther, E. A. W., van Riessen, N. K., Rogers, S. E., Fokkink, R., Voets, I. K., van Eck, E. R. H., Heerschap, A. , Versluis, M. , de Korte, C. L. , Figdor, C. G., de Vries, I. J. M., & Srinivas, M. (2019). Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and 19 F MRI Applied to In Vivo Cell Tracking. Advanced functional materials, 29(19), [1806485]. https://doi.org/10.1002/adfm.201806485
Visscher, M. , Lajoinie, G., Blazejewski, E., Veldhuis, G. , & Versluis, M. (2019). Laser-activated microparticles for multimodal imaging: ultrasound and photoacoustics. Physics in medicine and biology, 64(3), [034001]. https://doi.org/10.1088/1361-6560/aaf4a2

UT Research Information System

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Education

For the past 6 years, I am involved in teaching medical acoustics to master students with Prof. Michel Versluis. I have also supervised several bachelor thesis students and 9 master thesis students.

Affiliated Study Programmes

Master

Courses

Projects

The research projects in which I am involved revolve around the idea of using microscale physics in order to generate contrast or induce therapy down to the single cell level. These mechanisms involve in particular phase change, microbubbles resonance and controlled production of complex particles.

Recently, I have focused on the use of these physical mechanisms combined with deep-learning for super-resolution ultrasound imaging.

Current Projects

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst - Meander (building no. 27), room 214-A
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst - Meander  214-A
P.O. Box 217
7500 AE Enschede
The Netherlands