dr. G.P.R. Lajoinie (Guillaume)

Assistant Professor

About Me

After performing a master thesis in the Biomedical Photonic Imaging Group (BMPI) of the University of Twente, I graduated from Ecole Centrale de Lyon in 2011. I then came back to the university of Twente to fulfill a PhD in the Physics Of Fluids Group, under the supervision of prof. Michel Versluis, on ultrasound contrast agents and graduated in 2015. I am now a assistant professor in the Physics Of Fluids Group, working on ultrasound, microscale fluid dynamics, bubble physics, and deep learning for ultrasound super-resolution contrast agents. 


Medicine & Life Sciences
Physics & Astronomy
High Speed
Engineering & Materials Science


My research interests include a broad array of microscale phenomena, in particular these that can lead to the generation of contrast for ultrasound and photoacoustics. Such phenomena often involve cavitation, phase change and heat and mass transfer. I also have a keen interest in therapeutic applications of microbubbles for sonoporation, sonoprinting and gene therapy. Studying microscale physics also requires a precise control of the particles properties, and in particular their size. Part of my research activities therefore focuses on production methods and precise control of agents created using microfluidics. High-speed imaging is a critical tool in such studies and allows for the direct visualization of the response of the contrast agents. The recent arrival of ultrafast plane-wave ultrasound technology combined with monodisperse microbubbles opens new possibilities for highly controlled and localized drug delivery and greatly improved diagnostics for personalized medicine.



Oratis, A. T., Dijs, K. , Lajoinie, G. , Versluis, M. , & Snoeijer, J. H. (2024). A unifying Rayleigh-Plesset-type equation for bubbles in viscoelastic media. Journal of the Acoustical Society of America, 155(2), 1593-1605. https://doi.org/10.1121/10.0024984
van Elburg, B. (2024). Control of monodisperse microbubble properties for high-precision medical applications. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036559683
Harte, N. C., Obrist, D., Caversaccio, M. D. , Lajoinie, G. P. R., & Wimmer, W. (2023). Wall Shear Stress and Pressure Fluctuations under Oscillating Stimulation in Helical Square Ducts with Cochlea-like Geometrical Curvature and Torsion. In 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 1-7). IEEE. https://doi.org/10.1109/EMBC40787.2023.10340844
Spiekhout, S., Voorneveld, J. , Elburg, B. V., Renaud, G. , Segers, T. , Lajoinie, G. P. R. , Versluis, M., Verweij, M. D. , de Jong, N., & Bosch, J. G. (2022). Time-resolved absolute radius estimation of vibrating contrast microbubbles using an acoustical camera. The Journal of the Acoustical Society of America, 151(6), 3993-4003. Article 3993. https://doi.org/10.1121/10.0011619
Deprez, J., Roovers, S. , Lajoinie, G., Dewitte, H., Decruy, T., Coudenys, J., Descamps, B., Vanhove, C. , Versluis, M., Elewaut, D., Jacques, P., Smedt, S. C. D., & Lentacker, I. (2022). Evaluation of Liposome-Loaded Microbubbles as a Theranostic Tool in a Murine Collagen-Induced Arthritis Model. Scientia Pharmaceutica, 90(1), 17-23. Article 17. https://doi.org/10.3390/scipharm90010017
de Maar, J. S., Rousou, C. , van Elburg, B., Vos, H. J. , Lajoinie, G. P. R., Bos, C., Moonen, C. T. W., & Deckers, R. (2021). Ultrasound-Mediated Drug Delivery With a Clinical Ultrasound System: In Vitro Evaluation. Frontiers in pharmacology, 12, Article 768436. https://doi.org/10.3389/fphar.2021.768436
Michels, S. E., Kersemans, M. , Versluis, M. , Lajoinie, G., & Smet, P. F. (2021). Fast and High-Resolution Ultrasound Pressure Field Mapping Using Luminescent Membranes. Advanced Optical Materials, 9(12), Article 2100085. https://doi.org/10.1002/adom.202100085
Deprez, J. , Lajoinie, G., Engelen, Y., De Smedt, S. C., & Lentacker, I. (2021). Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery. Advanced drug delivery reviews, 172, 9-36. https://doi.org/10.1016/j.addr.2021.02.015
Lajoinie, G., Visscher, M., Blazejewski, E., Veldhuis, G. , & Versluis, M. (2020). Three-phase vaporization theory for laser-activated microcapsules. Photoacoustics, 19, Article 100185. https://doi.org/10.1016/j.pacs.2020.100185

UT Research Information System

Google Scholar Link


For the past 6 years, I am involved in teaching medical acoustics to master students with Prof. Michel Versluis. I have also supervised several bachelor thesis students and 9 master thesis students.

Affiliated Study Programmes


Courses Academic Year  2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2022/2023


The research projects in which I am involved revolve around the idea of using microscale physics in order to generate contrast or induce therapy down to the single cell level. These mechanisms involve in particular phase change, microbubbles resonance and controlled production of complex particles.

Recently, I have focused on the use of these physical mechanisms combined with deep-learning for super-resolution ultrasound imaging.

Current Projects

Finished Projects

  • Phase-change agents for ultrasound.

  • Multimodal agents: ultrasound and photoacoustics

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst Complex (building no. 20), room ME214A
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst Complex  ME214A
P.O. Box 217
7500 AE Enschede
The Netherlands