Hi! I’m Guido, a junior researcher at the CNPH group.
Organisations
I use computational modeling to understand neuronal disease mechanisms. By constructing biologically motivated models, I simulate the electrophysiological activity measured from diseased networks and healthy controls.
The models I work with are microscale models, in which we can study neurons both on an individual scale, but also how they interact in networks. The models consist of a hundred to thousands of neurons. The information of cellular, synaptic and network properties in these models is captured by parameters.
To find the parameters that produce simulations resembling the electrophysiological measurements, I apply Simulation-Based Inference. Studying how parameters differ in diseased and healthy networks, allows us to explore a wide range of biological mechanisms that might be disturbed due to the disease. In the end, this might provide us with novel insights into and hypotheses about the disease mechanisms.
Currently, my work focusses on burst suppression in the postanoxic brain, and on tuberous sclerosis. Please feel free to reach out if you want to know more!
Address
University of Twente
Technohal (building no. 18), room 3384
Hallenweg 5
7522 NH Enschede
Netherlands
University of Twente
Technohal 3384
P.O. Box 217
7500 AE Enschede
Netherlands
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