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H.H.T. Goosen - Middelkamp MSc (Heleen)

Researcher

About Me

Heleen Middelkamp PhD, is the support coordinator for EUROoCS. Furthermore, she works at the University of Twente in Enschede as a research assistant for the Dutch hDMT consortium.

Heleen obtained her BSc. Biomedical laboratory research at Saxion University of Applied Sciences in Enschede. Her BSc. thesis was performed at the University of Iowa (US) and was focused on measuring the in vivo effects of a new anti-cancer compound. Her MSc. in Health Sciences was obtained at the University of Twente, where her Master thesis was focused on the possibility of improving the drug development process using Organs-on-Chips. After graduating, she started at the group of prof. dr. Andries van der Meer as a researcher where she combined both her research programs and incorporated MCDA models in the development of a thrombosis-on-a-chip model. She then proceeded in the collaborative TURBO project together with the Radboud University Medical Center and which involved differentiating cells in a microfluidic platform with the intention to develop a blood-brain-barrier-on-a-chip model. Afterwards Heleen has worked for the Netherlands organ on chip initiative (NOCI) on her Ph.D. thesis titled: ‘Microfluidic vessels-on-chips for vascular disease modelling’ which she defended in September 2023.

Expertise

Medicine & Life Sciences
Endothelial Cells
Induced Pluripotent Stem Cells
Microfluidics
Technology
Thrombosis
Engineering & Materials Science
Angiography
Blood Vessels
Microfluidics

Publications

Recent
Middelkamp, H. H. T., Weener, H. J., Gensheimer, T., Vermeul, K. , de Heus, L. E. , Albers, H. J. , van den Berg, A. , & van der Meer, A. (2023). The effect of embedded macrophages on intravascular coagulation in 3D vessels-on-chips. In Abstracts of the 2nd Microphysiological Systems World Summit, Berlin, 2023
Middelkamp, H. H. T. (2023). Microfluidic vessels-on-chips for vascular disease modelling. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036557245
Le, K. , Goosen - Middelkamp, H. H. T., Do, L., Netea, M., Jonkers, I., Orlova, V., Withoff, S. , van der Meer, A., & Kumar, V. (2022). A Blood-vessel-on-chip to characterize trained immunity in endothelial cells. Poster session presented at EUROoCS Annual Meeting 2022, Grenoble, France.
Middelkamp, H. H. T. , van den Berg, A. , & van der Meer, A. D. (2021). 3D Blood Vessels-on-Chip for atherosclerosis modelling. In 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10-14 October 2021, Palm Springs, CA, USA (pp. 16931694). (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
Paloschi, V., Sabater-Lleal, M. , Middelkamp, H. , Vivas, A., Johansson, S. , van der Meer, A., Tenje, M., & Maegdefessel, L. (2021). Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular Research, 117(14), 2742-2754. https://doi.org/10.1093/cvr/cvab088
Albers, H. J., Linssen, J. E. A., Costa, P. F. , Middelkamp, H. H. T., van der Hout, L., Malda, J. , Passier, R. , van den Berg, A. , & van der Meer, A. D. (2020). Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1070-1071). The Chemical and Biological Microsystems Society.

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Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst Complex (building no. 20), room ZH113
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst Complex  ZH113
P.O. Box 217
7500 AE Enschede
The Netherlands

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