Horst Complex

H.H.T. Goosen - Middelkamp MSc (Heleen)

Researcher
TNW-BET-AST
Horst Complex ZH113
h.h.t.middelkamp@utwente.nl
+31534897893
Business card

Heleen Middelkamp PhD, is the support coordinator for EUROoCS. Furthermore, she works at the University of Twente in Enschede as a research assistant for the Dutch hDMT consortium.

Heleen obtained her BSc. Biomedical laboratory research at Saxion University of Applied Sciences in Enschede. Her BSc. thesis was performed at the University of Iowa (US) and was focused on measuring the in vivo effects of a new anti-cancer compound. Her MSc. in Health Sciences was obtained at the University of Twente, where her Master thesis was focused on the possibility of improving the drug development process using Organs-on-Chips. After graduating, she started at the group of prof. dr. Andries van der Meer as a researcher where she combined both her research programs and incorporated MCDA models in the development of a thrombosis-on-a-chip model. She then proceeded in the collaborative TURBO project together with the Radboud University Medical Center and which involved differentiating cells in a microfluidic platform with the intention to develop a blood-brain-barrier-on-a-chip model. Afterwards Heleen has worked for the Netherlands organ on chip initiative (NOCI) on her Ph.D. thesis titled: ‘Microfluidic vessels-on-chips for vascular disease modelling’ which she defended in September 2023.

Expertise

  • Medicine and Dentistry

    • Vascular Bundle
    • Endothelial Cell
    • Induced Pluripotent Stem Cell
    • Macrophage
    • Thrombosis
    • Vascular Disease

  • Engineering

    • Models

  • Biochemistry, Genetics and Molecular Biology

    • Vascularization

Organisations

Publications

2024

Standardizing designed and emergent quantitative features in microphysiological systems (2024)Nature Biomedical Engineering, 8, 941-962. Nahon, D., Moerkens, R., Aydogmus, H., Lendemeijer, B., Martínez-Silgado, A., Stein, J., Dostanić, M., Frimat, J.-P., Gontan, C., de Graaf, M. N. S., Hu, M., Kasi, D., Koch, L. S., Le, K., Lim, S., Middelkamp, H. H. T., Mooiweer, J., Montreux-Ragot, P., Niggl, E., … Mummery, C. L.https://doi.org/10.1038/s41551-024-01236-0Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip (2024)Biomedical microdevices, 26(1). Article 2. Middelkamp, H. H. T., Weener, H. J., Gensheimer, T., Vermeul, K., Heus, L. E. d., Albers, H. J., Berg, A. v. d. & Meer, A. D. v. d.https://doi.org/10.1007/s10544-023-00684-w

2023

Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography (2023)Biomedical optics express, 14(11), 5642-5655. Cuartas Velez, C. A., Middelkamp, H. H. T., van den Berg, A., van der Meer, A. & Bosschaart, N.https://doi.org/10.1364/BOE.500434Microfluidic vessels-on-chips for vascular disease modelling (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Middelkamp, H. H. T.https://doi.org/10.3990/1.9789036557245The effect of embedded macrophages on intravascular coagulation in 3D vessels-on-chips (2023)In Abstracts of the 2nd Microphysiological Systems World Summit, Berlin, 2023. Middelkamp, H. H. T., Weener, H. J., Gensheimer, T., Vermeul, K., de Heus, L. E., Albers, H. J., van den Berg, A. & van der Meer, A.

2022

A Blood-vessel-on-chip to characterize trained immunity in endothelial cells (2022)[Contribution to conference › Poster] EUROoCS Annual Meeting 2022. Le, K., Goosen - Middelkamp, H. H. T., Do, L., Netea, M., Jonkers, I., Orlova, V., Withoff, S., van der Meer, A. & Kumar, V.

2021

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases (2021)Cardiovascular Research, 117(14), 2742-2754. Paloschi, V., Sabater-Lleal, M., Middelkamp, H., Vivas, A., Johansson, S., van der Meer, A., Tenje, M. & Maegdefessel, L.https://doi.org/10.1093/cvr/cvab0883D Blood Vessels-on-Chip for atherosclerosis modelling (2021)In 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10-14 October 2021, Palm Springs, CA, USA (pp. 16931694) (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Middelkamp, H. H. T., van den Berg, A. & van der Meer, A. D.Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips (2021)Scientific reports, 11(1). Article 2281. Middelkamp, H. H. T., Verboven, A. H. A., de Sá Vivas, A. G., Schoenmaker, C., Klein Gunnewiek, T. M., Passier, R., Albers, C. A., 't Hoen, P. A. C., Nadif Kasri, N. & van der Meer, A. D.https://doi.org/10.1038/s41598-021-81933-x

2020

Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis (2020)In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1070-1071). The Chemical and Biological Microsystems Society. Albers, H. J., Linssen, J. E. A., Costa, P. F., Middelkamp, H. H. T., van der Hout, L., Malda, J., Passier, R., van den Berg, A. & van der Meer, A. D.

Research profiles

Address

University of Twente

Horst Complex (building no. 20), room ZH113
De Horst 2
7522 LW Enschede
Netherlands

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