Horst Complex

prof.dr.ir. I.M. Vellekoop (Ivo)

Professor
TNW-BIS-BMPI
Horst Complex ZH265
i.m.vellekoop@utwente.nl
+31534893112
Business card

Microscopes are great tools to investigate living cells. However, when the cell is embedded deep inside biological material (such as tumor tissue, or brain tissue), high-resolution imaging is not possible: the surrounding material is simply not transparent enough. 

Is is my mission to develop a new approach to microscopy that allows researchers to look right through non-transparent layers of tissue. In order to achieve this, we use wavefront shaping, a technique developed in 2007 at the University of Twente by Allard Mosk and me. This technique allows one to focus light right through non-transparent materials.

From our first proof-of-concept experiment to a usable microscope is a long way to go. We have found that reaching our goal requires more than good physics and optics; we are integrating elements from information theory, quantum mechanics, mathematics and electrical engineering in our research to keep pushing forward. We work together closely with end users of microscopes to make sure our microscopes are optimally geared towards solving fundamental questions in the life sciences.

As part of understanding light propagation in biological tissue, we developed the open source tool WAVESIM for simulating light propagation in very large structures. WAVESIM is currently worlds fastest and most accurate grid-based Maxwell solver available, outperforming common methods like FDTD by orders of magnitude in speed and accuracy. 

More information about my research can be found here.

Expertise

  • Physics

    • Light
    • Media
    • Focusing
    • Foci
    • Line of Sight
    • Communications
    • Feedback
    • Utilization

Organisations

Publications

2024

Raw measurement data of wavefront shaping basis comparison, underlying the publication: Orthonormalization of phase-only basis functions (2024)[Dataset Types › Dataset]. 4TU.Centre for Research Data. Cox, D. & Vellekoop, I.https://doi.org/10.4121/3dca7548-66cc-4e64-b59f-765aaf830afbPractical considerations for high-fidelity wavefront shaping experiments (2024)Journal of physics. Photonics, 6(3). Article 033003. Mastiani, B., Cox, D. W. S. & Vellekoop, I. M.https://doi.org/10.1088/2515-7647/ad5775

2023

Data underlying the publication: Model-based aberration corrected microscopy inside a glass tube (2023)[Dataset Types › Dataset]. 4TU.Centre for Research Data. Cox, D. & Vellekoop, I.https://doi.org/10.4121/118c6472-dfc4-419b-ba0f-5d2baba77748Mirror Symmetry in three-dimensional Multiple-Scattering Media (2023)[Working paper › Preprint]. ArXiv.org. Saini, S. K., Marakis, E., Start, K., Osnabrugge, G., Vellekoop, I. M. & Pinkse, P. W. H.https://arxiv.org/abs/2310.04862Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy (2023)Drug delivery and translational research, 13(5), 1470-1483. Priwitaningrum, D. L., Pednekar, K., Gabriël, A. V., Varela-Moreira, A. A., Gac, S. L., Vellekoop, I., Storm, G., Hennink, W. E. & Prakash, J.https://doi.org/10.1007/s13346-023-01310-1Optimal wavefront shaping (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Mastiani, B.https://doi.org/10.3990/1.9789036555050

2022

Wavefront shaping for forward scattering (2022)Optics express, 30(21), 37436-37445. Mastiani, B., Osnabrugge, G. & Vellekoop, I. M.https://doi.org/10.1364/OE.470194

2021

Noise-tolerant wavefront shaping in a Hadamard basis (2021)In European Conferences on Biomedical Optics, ECBO 2021. Article ETh3C.5 (Optics InfoBase Conference Papers). The Optical Society. Mastiani, B. & Vellekoop, I. M.https://doi.org/10.1117/12.2616116Author Correction: Reconfigurable beam system for non-line-of-sight free-space optical communication (Light: Science & Applications, (2019), 8, 1, (69), 10.1038/s41377-019-0177-3) (2021)Light: Science and Applications, 10(1). Article 136. Cao, Z., Zhang, X., Osnabrugge, G., Li, J., Vellekoop, I. M. & Koonen, A. M. J.https://doi.org/10.1038/s41377-021-00573-yNoise-tolerant wavefront shaping in a Hadamard basis (2021)Optics express, 29(11), 17534-17541. Mastiani, B. & Vellekoop, I. M.https://doi.org/10.1364/OE.424147

Research profiles

Courses academic year 2024/2025

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2023/2024

Address

University of Twente

Horst Complex (building no. 20), room ZH265
De Horst 2
7522 LW Enschede
Netherlands

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