prof.dr.ir. I.M. Vellekoop (Ivo)

Microscopes are great tools to investigate living cells. However, when the cell is embedded deep inside biological material (such as tumor tissue, or brain tissue), high-resolution imaging is not possible: the surrounding material is simply not transparent enough.

Is is my mission to develop a new approach to microscopy that allows researchers to look right through non-transparent layers of tissue. In order to achieve this, we use wavefront shaping, a technique developed in 2007 at the University of Twente by Allard Mosk and me. This technique allows one to focus light right through non-transparent materials.

From our first proof-of-concept experiment to a usable microscope is a long way to go. We have found that reaching our goal requires more than good physics and optics; we are integrating elements from information theory, quantum mechanics, mathematics and electrical engineering in our research to keep pushing forward. We work together closely with neuroscientists and other end users of microscopes to make sure our microscopes are optimally geared towards solving fundamental questions in the life sciences.

More information about my research can be found here.

Engineering & Materials Science

# Multimode Fibers
# Quantum Communication
# Scattering
# Secure Communication
# Wavefronts

Physics & Astronomy

# Phase Conjugation
# Scattering
# Visual Perception

Faculty of Science and Technology (TNW), Biomedical Photonic Imaging (BMPI)

Priwitaningrum, D. L., Pednekar, K., Gabriël, A. V., Varela-Moreira, A. A. , Gac, S. L. , Vellekoop, I. , Storm, G., Hennink, W. E. , & Prakash, J. (2023). Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy. Drug delivery and translational research, 13(5), 1470-1483. https://doi.org/10.1007/s13346-023-01310-1

Mastiani, B. (2023). Optimal wavefront shaping. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036555050

Mastiani, B. , Osnabrugge, G. , & Vellekoop, I. M. (2022). Wavefront shaping for forward scattering. Optics express, 30(21), 37436-37445. https://doi.org/10.1364/OE.470194

Mastiani, B. , & Vellekoop, I. M. (2021). Noise-tolerant wavefront shaping in a Hadamard basis. In European Conferences on Biomedical Optics, ECBO 2021 [ETh3C.5] (Optics InfoBase Conference Papers). The Optical Society. https://doi.org/10.1117/12.2616116

Cao, Z., Zhang, X. , Osnabrugge, G., Li, J. , Vellekoop, I. M. , & Koonen, A. M. J. (2021). Author Correction: Reconfigurable beam system for non-line-of-sight free-space optical communication (Light: Science & Applications, (2019), 8, 1, (69), 10.1038/s41377-019-0177-3). Light: Science and Applications, 10(1), [136]. https://doi.org/10.1038/s41377-021-00573-y

Mastiani, B. , & Vellekoop, I. M. (2021). Noise-tolerant wavefront shaping in a Hadamard basis. Optics express, 29(11), 17534-17541. https://doi.org/10.1364/OE.424147

Osnabrugge, G. , Benedictus, M. , & Vellekoop, I. M. (2021). Ultra-thin boundary layer for high-accuracy simulations of light propagation. Optics express, 29(2), 1649-1658. https://doi.org/10.1364/OE.412833

Thendiyammal, A. , Osnabrugge, G. , Knop, T. , & Vellekoop, I. M. (2020). Model-based wavefront shaping microscopy. Optics letters, 45(18), 5101-5104. https://doi.org/10.1364/OL.400985

Zhang, X., Cao, Z., Li, J., Ge, D., Chen, Z. , Vellekoop, I. M. , & Koonen, A. M. J. (2020). Wide-Coverage Beam-Steered 40-Gbit/s Non-Line-of-Sight Optical Wireless Connectivity for Industry 4.0. Journal of lightwave technology, 38(24), 6801-6806. [9187535]. https://doi.org/10.1109/JLT.2020.3022329

Osnabrugge, G. (2020). Wavefront shaping microscopy: Controlling scattered light for deep tissue imaging. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036550178

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