prof.dr.ir. I.M. Vellekoop (Ivo)

Professor
TNW-BIS-BMPI
Horst Complex ZH265
i.m.vellekoop@utwente.nl
+31534893112
Business card

Microscopes are great tools to investigate living cells. However, when the cell is embedded deep inside biological material (such as tumor tissue, or brain tissue), high-resolution imaging is not possible: the surrounding material is simply not transparent enough. 

Is is my mission to develop a new approach to microscopy that allows researchers to look right through non-transparent layers of tissue. In order to achieve this, we use wavefront shaping, a technique developed in 2007 at the University of Twente by Allard Mosk and me. This technique allows one to focus light right through non-transparent materials.

From our first proof-of-concept experiment to a usable microscope is a long way to go. We have found that reaching our goal requires more than good physics and optics; we are integrating elements from information theory, quantum mechanics, mathematics and electrical engineering in our research to keep pushing forward. We work together closely with end users of microscopes to make sure our microscopes are optimally geared towards solving fundamental questions in the life sciences.

As part of understanding light propagation in biological tissue, we developed the open source tool WAVESIM for simulating light propagation in very large structures. WAVESIM is currently worlds fastest and most accurate grid-based Maxwell solver available, outperforming common methods like FDTD by orders of magnitude in speed and accuracy. 

More information about my research can be found here.

Expertise

  • Physics

    • Light
    • Media
    • Focusing
    • Foci
    • Line of Sight
    • Communications
    • Feedback
    • Utilization

Organisations

Publications

2024
Practical considerations for high-fidelity wavefront shaping experiments, Article 033003. Mastiani, B., Cox, D. W. S. & Vellekoop, I. M.https://doi.org/10.1088/2515-7647/ad5775
2023
Mirror Symmetry in three-dimensional Multiple-Scattering Media. ArXiv.org. Saini, S. K., Marakis, E., Start, K., Osnabrugge, G., Vellekoop, I. M. & Pinkse, P. W. H.https://arxiv.org/abs/2310.04862Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy, 1470-1483. Priwitaningrum, D. L., Pednekar, K., Gabriël, A. V., Varela-Moreira, A. A., Gac, S. L., Vellekoop, I., Storm, G., Hennink, W. E. & Prakash, J.https://doi.org/10.1007/s13346-023-01310-1Optimal wavefront shaping. University of Twente. Mastiani, B.https://doi.org/10.3990/1.9789036555050
2022
Wavefront shaping for forward scattering, 37436-37445. Mastiani, B., Osnabrugge, G. & Vellekoop, I. M.https://doi.org/10.1364/OE.470194
2021
Noise-tolerant wavefront shaping in a Hadamard basisIn European Conferences on Biomedical Optics, ECBO 2021, Article ETh3C.5. The Optical Society. Mastiani, B. & Vellekoop, I. M.https://doi.org/10.1117/12.2616116Author Correction: Reconfigurable beam system for non-line-of-sight free-space optical communication (Light: Science & Applications, (2019), 8, 1, (69), 10.1038/s41377-019-0177-3), Article 136. Cao, Z., Zhang, X., Osnabrugge, G., Li, J., Vellekoop, I. M. & Koonen, A. M. J.https://doi.org/10.1038/s41377-021-00573-yNoise-tolerant wavefront shaping in a Hadamard basis, 17534-17541. Mastiani, B. & Vellekoop, I. M.https://doi.org/10.1364/OE.424147Ultra-thin boundary layer for high-accuracy simulations of light propagation, 1649-1658. Osnabrugge, G., Benedictus, M. & Vellekoop, I. M.https://doi.org/10.1364/OE.412833
2020
Wide-Coverage Beam-Steered 40-Gbit/s Non-Line-of-Sight Optical Wireless Connectivity for Industry 4.0, Article 9187535, 6801-6806. Zhang, X., Cao, Z., Li, J., Ge, D., Chen, Z., Vellekoop, I. M. & Koonen, A. M. J.https://doi.org/10.1109/JLT.2020.3022329

Research profiles

Courses academic year 2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2022/2023

Address

University of Twente

Horst Complex (building no. 20), room ZH265
De Horst 2
7522 LW Enschede
Netherlands

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