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Islam S. M. Khalil received his master’s and doctoral degrees in Mechatronics Engineering. He is currently an Assistant Professor in the  Department of Biomechanical Engineering  at the University of Twente. For two years he was a post-doctoral fellow in the Robotics and Mechatronics research group and MIRA–Institute for Biomedical Technology and Technical Medicine, University of Twente. He was also the Director of the Medical Micro and Nanorobotics Laboratory at the German University in Cairo, Egypt. His research interests include modeling and design of motion control systems for soft microrobots, biologically-inspired microrobots, mechatrnoic system design, and untethered magnetic micro/nanorobotics with applications to micro/nanomanipulation, microassembly, and targeted drug delivery.

Expertise

  • Physics

    • Propulsion
    • Magnetic Fields
    • Speed
    • Frequencies
    • Model
  • Engineering

    • Robot
    • Microrobots
    • Actuation

Organisations

Publications

2024
Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting, Article 68. Ligtenberg, L.-J., Rabou, N. C. A., Goulas, C., Duinmeijer, W., Halfwerk, F. R., Arens, J., Lomme, R., Magdanz, V., Klingner, A., Rot, E. A. M. K., Nijland, C. H. E., Wasserberg, D., Liefers, H. R., Jonkheijm, P., Susarrey-Arce, A., Warlé, M. & Khalil, I. S. M.https://doi.org/10.1038/s44172-024-00215-2Remote Control of Untethered Magnetic Robots within a Lumen using X-Ray-Guided Robotic Platform: Remote Control of Untethered Magnetic Robots within a Lumen using X-Ray-Guided Robotic PlatformIn 2024 IEEE International Conference on Robotics and Automation (ICRA 2024) (pp. 17763-17769). Ligtenberg, L.-J. W., Rabou, N. C. A., Peters, S., Vengetela, T., Schut, V., Liefers, H. R., Warlé, M. C. & S.M. Khalil, I.Soft Bio-Microrobots: Toward Biomedical Applications, Article 2300093. Wang, Z., Klingner, A., Magdanz, V., Misra, S. & S.M. Khalil, I.https://doi.org/10.1002/aisy.202300093Magnetic polycaprolactone microspheres: drug encapsulation and control, 143-153. El Gohary, N. A., Mahmoud, A., Ashraf Nazmy, M., Zaabalawi, R., El Zahar, L., Khalil, I. S. M. & Mitwally, M. E.https://doi.org/10.1080/00914037.2022.2132248
2023
Helical Propulsion in Low-Re Numbers with Near-Zero Angle of AttackIn 2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) (pp. 2647-2652). IEEE. Ligtenberg, L.-J. W., Ekkelkamp, I. A. A., Halfwerk, F. R., Goulas, C., Arens, J., Warlé, M. & Khalil, I. S. M.https://doi.org/10.1109/iros55552.2023.10341627Influence of Nanoparticle Coating on the Differential Magnetometry and Wireless Actuation of Biohybrid MicrorobotsIn 2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) (pp. 2653-2658). IEEE. Magdanz, V., Cumming, J. R., Salamzadeh, S., Tesselaar, S., Alic, L., Abelmann, L. & S.M. Khalil, I.https://doi.org/10.1109/IROS55552.2023.10341258Navigation of Untethered Small-Scale Helical Devices Using Magnetic System under Ultrasound Guidance, 1093-1104. Li, C., Misra, S. & Khalil, I. S. M.https://doi.org/10.1109/TMRB.2023.3318642IRONSperm swimming by rigid-body rotation versus transverse bending waves influenced by cell membrane charge, 49-60. Magdanz, V., Klingnert, A., Abelmann, L. & S.M. Khalil, I.https://doi.org/10.1007/s12213-023-00158-5Input-Output Boundedness of a Magnetically-Actuated Helical DeviceIn 2023 IEEE International Conference on Robotics and Automation (ICRA 2023) (pp. 5433-5438). IEEE. Ligtenberg, L.-J. W. & S.M. Khalil, I.https://doi.org/10.1109/ICRA48891.2023.10160556Closed-Loop Control Characterization of Untethered Small-Scale Helical Device in Physiological Fluid with Dynamic Flow Rates, Article 2200322. Li, C., Misra, S. & Khalil, I. S. M.https://doi.org/10.1002/aisy.202200322Locomotion of bovine spermatozoa during the transition from individual cells to bundles, Article e2211911120. Zhang , K., Klingner, A., Le Gars, Y., Misra, S., Magdanz, V. & S.M. Khalil, I.https://doi.org/10.1073/pnas.2211911120Flagellar Propulsion of Sperm Cells Against a Time-Periodic Interaction Force, Article 2200210. Wang, Z., Klingnert, A., Magdanz, V., Hoppenreijs, M., Misra, S. & S.M. Khalil, I.https://doi.org/10.1002/adbi.202200210Embedded 3D printing of dilute particle suspensions into dense complex tissue fibers using shear thinning xanthan baths, Article 015014. Trikalitis, V. D., Kroese, N. J. J., Kaya, M., Cofino Fabres, C., ten Den, S. A., S.M. Khalil, I., Misra, S., Koopman, B. F. J. M., Passier, R., Schwach, V. & Rouwkema, J.https://doi.org/10.1088/1758-5090/aca124
2022
Visualization of micro-agents and surroundings by real-time multicolor fluorescence microscopy, Article 13375. Kaya, M., Stein, F., Padmanaban, P., Zhang, Z., Rouwkema, J., Khalil, I. S. M. & Misra, S.https://doi.org/10.1038/s41598-022-17297-7Drug-Loaded IRONSperm clusters: modeling, wireless actuation, and ultrasound imaging, Article 065001. Middelhoek, K., Magdanz, V., Abelmann, L. & S. M. Khalil, I.https://doi.org/10.1088/1748-605X/ac8b4bMulticolor fluorescence microscopy for tracking magnetic micro-agents. University of Twente. Kaya, M.https://doi.org/10.3990/1.9789036554343Bundle formation of sperm: Influence of environmental factors, Article 957684, 1. Morcillo i Soler1, P., Hidalgo, C., Fekete, Z., Zalanyi, L., S.M. Khalil, I., Yeste , M. & Magdanz, V.https://doi.org/10.3389/fendo.2022.957684Rigid-Body rotation versus transverse bending wave swimming of magnetically-functionalized sperm cellsIn 2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS). IEEE. Magdanz, V., Klingner, A., Abelmann, L. & S. M. Khalil, I.https://doi.org/10.1109/MARSS55884.2022.9870506An open-source automated magnetic optical density meter for analysis of suspensions of magnetic cells and particles, Article 094101. Welleweerd, M. K., Hageman, T., Pichel, M., Van As, D., Keizer, H., Hendrix, J., Micheal, M. M., Khalil, I. S. M., Mir, A., Korkmaz, N., Kräwinkel, R., Chevrier, D. M., Faivre, D., Fernandez-Castane, A., Pfeiffer, D. & Abelmann, L.https://doi.org/10.1063/5.0098008Scaling Rules for Microrobots with Full Energetic AutonomyIn Proceedings of MARSS, International Conference on Manipulation, Automation and Robotics at Small Scales. IEEE. van Renselaar, E., Keitel, B., Dinc, M., Mizaikoff, B., Susarrey Arce, A., Gardeniers, H., Abelmann, L. & S. M. Khalil, I.https://doi.org/10.1109/MARSS55884.2022.9870509Controlled Helical Propulsion Against the Flow of a Physiological Fluid. Li, C., Halfwerk, F. R., Arens, J., Misra, S., Warlé, M. C. & S. M. Khalil, I.https://doi.org/10.1109/marss55884.2022.9870248Understanding Robustness of Magnetically Driven Helical Propulsion in Viscous Fluids Using Sensitivity Analysis, Article 2100519, 1-14. S. M. Khalil, I. & Venezian, R.https://doi.org/10.1002/adts.2021005192D Magnetic Actuation and Localization of a Surface Milli-Roller in Low Reynolds Numbers, 3874-3881. Farag, M. M. M., Sadek, A. A. M. M., Kim, C.-S., Park, J.-O., Misra, S. & S. M. Khalil, I.https://doi.org/10.1109/LRA.2022.3148787Modeling and Characterization of the Passive Bending Stiffness of Nanoparticle-Coated Sperm Cells using Magnetic Excitation, Article 2100438. Dias, J. M. S., Estima, D., Punte, H., Klingner, A., Marques, L., Magdanz, V. & S. M. Khalil, I.https://doi.org/10.1002/adts.202100438
2021
Open-Loop magnetic actuation of helical robots using position-constrained rotating dipole fieldIn Proceedings of the IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) (pp. 8522-8527). Avaneesh, R., Venezian, R., Kim, C.-S., Park, J.-O., Misra, S. & S. M. Khalil, I.https://doi.org/10.1109/IROS51168.2021.9636564

Research profiles

In the press

  • FOX NEWS: How tiny corkscrew robots could save lives by breaking up blood clots

https://www.foxnews.com/tech/how-tiny-corkscrew-robots-could-save-lives-by-breaking-up-blood-clots

Robot through your bloodsteam: 

https://www.rtlnieuws.nl/video/uitzendingen/video/5424005/aflevering-346

  • Dutch researchers let robot swim through blood vessel

https://www.rd.nl/artikel/1045295-nederlandse-onderzoekers-laten-robot-door-bloedvat-zwemmen

  • Robot for clearing blood clots 

https://www.rtvoost.nl/radio/aflevering/marcel-en-bastiaan/1520942_20231212080000

  • Suit of iron turns sperm cells into spermbots

https://www.chemistryworld.com/news/suit-of-iron-turns-sperm-cells-into-spermbots/4012128.article

  • Wireless millirobots successfully navigate blood vessels, piercing blood clots along the way

https://innovationorigins.com/nl/millirobots-op-avontuur-draadloze-millirobots-navigeren-succesvol-door-slagaders/

  • Millirobots on an adventure: wireless robots navigate arteries

https://innovationorigins.com/nl/millirobots-op-avontuur-draadloze-robots-navigeren-door-slagaders/

  • Millirobots on an adventure: wireless millirobots successfully navigate arteries

https://kennispark.nl/nl/millirobots-op-avontuur-draadloze-millirobots-navigeren-succesvol-door-slagaders/

  • Clot-busting "millirobots" corkscrew their way through blood vessels

https://newatlas.com/medical/millirobots-blood-clots/

News on utwente.nl

MINIATURE MARVELS: WIRELESS MILLIROBOTS SUCCESSFULLY NAVIGATE ARTERIESUT-RESEARCHERS NAVIGATE MILLIROBOTS THROUGH EX VIVO AORTA MODEL

https://www.utwente.nl/en/news/2023/12/1276043/miniature-marvels-wireless-millirobots-successfully-navigate-arteries

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University of Twente

Horst Complex (building no. 20), room W115
De Horst 2
7522 LW Enschede
Netherlands

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