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Consciously breathe in and out one time. This is exactly what you unconsciously do about 20,000 times a day to supply your body with oxygen. In some cases, however, various illnesses and diseases can interfere with the pulmonary gas exchange in the lungs and thus become a life-threatening problem. If medical treatment, drug therapy, and artificial respiration cannot help, artificial lungs can be used as an intensive care treatment.

The development of such artificial lungs into a realistic organ replacement is a dedicated research focus of Dr.-Ing. Jutta Arens, Professor and Chair of Engineering Organ Support Technologies at UTwente. Jutta works together with partners from the medical, natural, and engineering sciences inter alia as part of the German Research Foundation’s “Towards an Implantable Lung” priority program to address the diverse issues that arise from artificial lung systems in contact with blood. She combines engineering and medicine to the benefit of patients and contributes her knowledge on a national and international level to develop standards for testing and approving artificial organs in order to ensure patient safety. In her free time, she likes to take deep breaths while enjoying long-distance hikes.

Expertise

  • Medicine and Dentistry

    • Lung
    • Oxygenator
    • Extracorporeal Membrane Oxygenation
    • Patient
    • Pump
    • Gas Exchange
    • In Vitro
    • Heart

Organisations

Ancillary activities

  • German Federal Institute of Drugs and Medical Devices (BfArM)Member of the Scientific Advisory Board
  • PerfusionMember of the Editorial Board of “Perfusion"
  • ASAIOMember of Board of Trustees of ASAIO
  • ISOMember of ISO/TC 150/SC 2/WG 4 – Extracorporeal Circuits
  • NENMember of NEN Standards Committee (NC) 301060 ‘Implants for surgery’
  • Transplant InternationalMember of the Editorial Board of "Transplant International"

Jutta holds the Chair of Engineering Organ Support Systems within the Department of Biomechanical Engineering, Faculty of Engineering Technologies. Her research at UTwente will mainly focus on artificial organs such as Artificial Lungs (oxygenators), Heart Assist, and Kidney Replacement with strong emphasis on combining these therapies in highly integrated devices for safer use and easier mobilization of patients and increasing their long-term stability and blood compatibility. An additional focus is on the development of miniaturized artificial organs for our youngest patients such as an artificial placenta system for preterm born babies with immature lungs.

The last two years, before coming to University of Twente in November 2019, Jutta was the acting head of the Department of Cardiovascular Engineering, CVE, Institute of Applied Medical Engineering, RWTH Aachen University with the core competencies of the department being in the development of heart assist and lung assist devices and their preclinical testing including computer simulations and the development and design of special purpose in-vitro test setups. Within the CVE over the past decade Jutta build up the Group `Artificial Lung Technologies´, at the beginning mainly focusing on miniaturization concepts for oxygenators used for newborns and preterm infants. This resulted in research on a Heart-Lung Machine for neonates with congenital heart defects (her PhD project) and the artificial placenta system NeonatOx. Miniaturization and modularization concepts were investigated for ECMO systems for personalized treatment and to allow for the mobilization of ICU patients including the development of new production methods. An overarching goal has been the improvement of hemocompatibility of the assist devices in order to make them long-term stable. Therefore, the group worked on reliable CFD simulation concepts and flow visualization inside the oxygenators´ fiber bundle by PIV to be able to validate the flow simulations in detail and to better understand the flow distribution between the hollow fibers. Active mixing in the oxygenators´ fiber bundle, the simulation of the gas exchange, evaluate the modeling of thrombus growth in vitro, and the influence of pulsatile blood flow on the gas exchange capacity of oxygenators were research topics as well as the work on an alternative method for the connection of ECMO systems to patients. 

Jutta studied Mechanical Engineering at RWTH Aachen University with specialization in Plastics Technologie and Medical Engineering and performed her PhD at the above-mentioned Institute in Aachen.

Publications

2024
Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical settingCommunications Engineering, 3, Article 68. Ligtenberg, L.-J., Rabou, N. C. A., Goulas, C., Duinmeijer, W., Halfwerk, F. R., Arens, J., Lomme, R., Magdanz, V., Klingner, A., Rot, E. A. M. K., Nijland, C. H. E., Wasserberg, D., Liefers, H. R., Jonkheijm, P., Susarrey-Arce, A., Warlé, M. & Khalil, I. S. M.https://doi.org/10.1038/s44172-024-00215-2ECMOve: A Mobilization Device for Extracorporeal Membrane Oxygenation PatientsASAIO Journal, 70(5), 377-386 (E-pub ahead of print/First online). van Galen, D. J. M., Meinders, Q., Halfwerk, F. R. & Arens, J.https://doi.org/10.1097/mat.0000000000002153TRACKing or TRUSTing transfusion prediction: Validation of Red blood cell transfusion prediction models for low transfusion rate cardiac surgery and high transfusion rate post-cardiotomy veno-arterial extracorporeal life support (Submitted). Haumann, R. G., Alp, R., Płonek, T. P., Niesten, E. D., Maaskant, J. M., Mariani, S., Wiegmann, B., Arens, J., van der Palen, J. & Halfwerk, F. R.Influence of utilizing hemodialysis membranes outside-in on solute clearance and filtration efficiency – One step towards a novel combined lung and kidney support deviceJournal of membrane science, 698, Article 122575. Martins Costa, A., Halfwerk, F. R., Thiel, J.-N., Wiegmann, B., Neidlin, M. & Arens, J.https://doi.org/10.1016/j.memsci.2024.122575Designing a Patient-Centred Educational Extracorporeal Membrane Oxygenation Simulator (EduECMO) – A training needs analysis with international experts. Halfwerk, F. R., Duinmeijer, W., Arens, J. & Groenier, M.
2023
Helical Propulsion in Low-Re Numbers with Near-Zero Angle of AttackIn 2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) (pp. 2647-2652). IEEE. Ligtenberg, L.-J. W., Ekkelkamp, I. A. A., Halfwerk, F. R., Goulas, C., Arens, J., Warlé, M. & Khalil, I. S. M.https://doi.org/10.1109/iros55552.2023.10341627Patient Centred Educational ECMO Simulator (EduECMO) – An international training needs analysis, 7-8. Halfwerk, F. R., Duinmeijer, W., Groenier, M. & Arens, J.Refurbishment of Extracorporeal Life Support Oxygenators in the Context of In Vitro TestingASAIO Journal, 69(10), 924-931. Strudthoff, L. J., Hesselmann, F., Clauser, J. C. & Arens, J.https://doi.org/10.1097/mat.0000000000001999Effect of hollow fiber configuration and replacement on the gas exchange performance of artificial membrane lungsJournal of membrane science, 680, Article 121742. Costa, A. M., Halfwerk, F. R., Thiel, J.-N., Wiegmann, B., Neidlin, M. & Arens, J.https://doi.org/10.1016/j.memsci.2023.121742Inflow from a Cardiopulmonary Assist System to the Pulmonary Artery and Its Implications for Local Hemodynamics—a Computational Fluid Dynamics StudyJournal of cardiovascular translational research, 16(4), 842-851. Hugenroth, K., Krooß, F., Hima, F., Strudthoff, L., Kopp, R., Arens, J., Kalverkamp, S., Steinseifer, U., Neidlin, M. & Spillner, J.https://doi.org/10.1007/s12265-022-10349-3In situ patient-specific simulation of complex cardiac surgery: A simulation-based observational study with 3D heart models. Halfwerk, F. R., Smits, K., Hekman, E. E. G., van Es, J., Koenrades, M. A., Arens, J. & Speekenbrink, R.Defining low- and high-fidelity simulation in systematic reviews: the case of heart auscultation simulatorsInternational Journal of Healthcare Simulation, Article PKB4904. Halfwerk, F. R., Duinmeijer, W. C., Haumann, R. & Arens, J.https://doi.org/10.54531/fpkb4904ECMO Mobilizing DeviceASAIO Journal, 69(Supplement 2), 148-148. van Galen, D. J. M., Meinders, Q., Halfwerk, F. & Arens, J.https://doi.org/10.1097/01.mat.0000944096.36171.f5CARD8: A Gas-Exchange-Area-Adjustable Oxygenator for Extremely Preterm InfantsASAIO Journal, 69(Suppl. 2), 59-59. Heyer, J., Schubert, F., Lunemann, M., Arens, J., Steinseifer, U., Schoberer, M. & Jansen, S. V.https://doi.org/10.1097/01.mat.0000943556.30315.34Development of a combined, highly integrated extracorporeal lung and kidney support device (RenOx): Evaluation of fibre configurations on gas exchange preservationPerfusion, 38(1 suppl), 140-141. Martins Costa, A., Wiegmann, B., Thiel, J.-N., Neidlin, M., Halfwerk, F. R. & Arens, J.https://doi.org/10.1177/02676591231162023Development and evaluation of a variable, miniaturized oxygenator for various test methodsArtificial organs, 47(4), 695-704. Arens, J., Schraven, L., Kaesler, A., Flege, C., Schmitz-Rode, T., Rossaint, R., Steinseifer, U. & Kopp, R.https://doi.org/10.1111/aor.14465Novel Size-Variable Dedicated Rodent Oxygenator for ECLS Animal Models: Introduction of the “Ratox” Oxygenator and Preliminary In-Vitro ResultsMicromachines, 14(4), Article 800. Strudthoff, L., Focke, J. M., Hesselmann, F., Kaesler, A., Martins Costa, A., Schlanstein, P. C., Schmitz-Rode, T., Steinseifer, U., Steuer, N. B., Wiegmann, B., Arens, J. & Jansen, S. V.https://doi.org/10.3390/mi14040800Simulators and Simulations for Extracorporeal Membrane Oxygenation: An ECMO Scoping ReviewJournal of Clinical Medicine, 12(5), Article 1765. Duinmeijer, W. C., Fresiello, L., Swol, J., Torrella, P., Riera, J., Obreja, V., Puślecki, M., Dąbrowski, M., Arens, J. & Halfwerk, F. R.https://doi.org/10.3390/jcm12051765Classifying fidelity for ECMO simulators and simulations: An overview of existing physical and computational ECMO simulators. Duinmeijer, W., Halfwerk, F. R. & Arens, J.Classifying fidelity for ECMO simulators and simulations: an overview of existing physical and computational ECMO simulators. Duinmeijer, W., Halfwerk, F. R. & Arens, J.Combining Extracorporeal Lung and Kidney Support: Evaluation of Fibre Configurations on Gas Exchange Preservation for the Development of a Novel Highly Integrated Device (RenOx)In ASAIO 2023 Annual Meeting Abstracts (pp. 87). Martins Costa, A., Halfwerk, F. R., Wiegmann, B., Thiel, J.-N., Neidlin, M. & Arens, J.https://doi.org/10.1097/01.mat.0000943716.11119.d8
2022
TPMS-based membrane lung with locally-modified permeabilities for optimal flow distributionScientific reports, 12(1), Article 7160. Hesselmann, F., Halwes, M., Bongartz, P., Wessling, M., Cornelissen, C., Schmitz-Rode, T., Steinseifer, U., Jansen, S. V. & Arens, J.https://doi.org/10.1038/s41598-022-11175-yIn vitro thrombogenicity evaluation of rotary blood pumps by thromboelastometryBiomedizinische Technik, 67(6), 471-480. Klein, M., Tack, J. C., Mager, I., Maas, J., Schmitz-Rode, T., Arens, J., Steinseifer, U. & Clauser, J. C.https://doi.org/10.1515/bmt-2022-0078The CircuitIn Extracorporeal Life Support: The ELSO Red Book (pp. 29-46). Extracorporeal Life Support Organization. Vercaemst, L., Arens, J., Maul, T. & Toomasian, J.Controlled Helical Propulsion Against the Flow of a Physiological Fluid. Li, C., Halfwerk, F. R., Arens, J., Misra, S., Warlé, M. C. & S. M. Khalil, I.https://doi.org/10.1109/marss55884.2022.9870248

Research profiles

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Visiting address

University of Twente

Horst Complex (building no. 20), room W116
De Horst 2
7522 LW Enschede
Netherlands

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