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J.E. van Dongen MSc (Nienke)

PhD Candidate

About Me

I obtained my BSc and MSc in Molecular Life Sciences both at Wageningen University. In my master, I specialized in physical chemistry, as well as analytical chemistry. During my MSc thesis project, I worked at RIKILT (Wageningen research) on the coupling of gut-on-a-chip to mass spectrometry. During my MSc internship, I joined the analytical chemistry group of the University of Amsterdam, to set up a microfluidic chip that allows online lignin degradation by immobilized enzymes. Developing suitable chromatographic techniques to follow this degradation was also part of this internship. 

 

In my PhD project, I will focus on biomarker detection on chip. For this, we will use the technique local surface plasmon resonance, whereby a local color change will indicate the presence of the biomarker. Normally a randomly patterned surface of gold particles is used. Challenges in this project are the fabrication of the array in combination with a microfluidic chamber and the detection of biomarkers in the fluid using a gold array.

Expertise

Physics & Astronomy
Methylation
Nuclease
Nucleic Acids
Engineering & Materials Science
Dna
Fractionation
Methylation
Nucleic Acids
Plasmonics

Publications

Recent
van Dongen, J. E. , Berendsen, J. T. W. , Eijkel, J. C. T. , & Segerink, L. (2021). Towards a multiplexed barcode CRISPR/Cas12a-Assisted platform for the identification and quantification of singele CpG Methylation Sites. In 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10 - 14 October 2021, Palm Springs, CA, USA (pp. 741-742)
van Dongen, J. E. , Berendsen, J. T. W. , Eijkel, J. C. T. , & Segerink, L. (2021). Towards a Multiplexed Barcode CRISPR/Cas12a-Assisted Platform for the Identification and Quantification of Single CpG Methylation Sites. Poster session presented at 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021, Palm Springs, California, United States.
van Dongen, J. E. , Le The, H. , Kolkman, R. W. , Wasserberg, D. , Huskens, J. , Eijkel, J. C. T. , & Segerink, L. (2019). Gold Nanoparticle Assays: A New Golden Standard for Optical DNA Detection. Poster session presented at 7th CHemistry As INnovating Science Conference, CHAINS 2019, Veldhoven, Netherlands.

UT Research Information System

Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré (building no. 15), room C2405
Hallenweg 23
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré  C2405
P.O. Box 217
7500 AE Enschede
The Netherlands