TNW-BET-AOT

Jan Feijen is ¬†Emeritus Professor of Polymer Chemistry and Biomaterials at the University of Twente (The Netherlands), Chair Professor at Soochow University Biomedical Polymers Laboratory and Adjunct Professor of Pharmaceutics at the University of Utah. From 1995 ‚Äď 2009 he has been the Scientific Director and Founder of the Institute for Biomedical Engineering, BMTI, at the University of Twente.His research interests are biomaterials, biodegradable polymers, bio-interfacial phenomena, ring-opening polymerization, hydrogels, drug delivery systems and nano-systems for cancer therapy. He trained 90 PhD students and has (co)-authored over 600 papers with more than 34.000 citations, H-index 94 (Web of Science), H-index 97 (Scopus) and H-index 115 (Google Scholar). He has served on many editorial boards, was the co-founding editor of the J. Controlled Release and has been guest editor for the Journal for many years. Since 1990 he has organized and was the chairman of the first 10 European Symposia on Controlled Drug Delivery Systems, The Netherlands and this series of biannual Symposia is still continuing. Since 2010 he has been the co-organizer of the biannual Symposia on Innovative Polymers for Controlled Delivery (SIPCD) in Suzhou, China. In 2005 he initiated and became a chairman of the Dutch program for Tissue Engineering (DPTE). He is a Fellow of the American Society for Biomaterials, since the start, and a Fellow of the Controlled Release Society. He was former governor of the Controlled Release Society, European Society for Biomaterials and International Society for Artificial Internal Organs. He was a chairman for five years of the Concerted Action on Heart and Replacement Technology, Medical Health Research Programme of the European Community. He has received numerous awards including the Best Paper Award of the J. Controlled Release, Controlled Release Society (1992), the Clemson Award, American Society for Biomaterials (1994), the Founders Award, Controlled Release Society, (1998), the George Winter Award, ESB, (2002) and the Award for Distinguished Service in Advancement of Biomaterials Science, Japanese Society for Biomaterials, (2008). He also received the Honorary Medal of the University of Twente (2008). In 2018 he became an Honorary Member of the European Society of Biomaterials. He was a highly cited author in the field of Pharmacology and Toxicology in 2018 and 2019 (Publon).

TRAINING

  • M.S. Organic Chemistry, University of Groningen, Groningen, Netherlands, 1967
  • Ph.D. Organic Chemistry, University of Groningen, Groningen, Netherlands, 1970

PROFESSIONAL EXPERIENCE

  • 1995-2008, Scientific director of the Institute for Biomedical Engineering, BMTI, University of Twente, Enschede, Netherlands.
  • 1989 ‚ÄĎ2003, Affiliate Professor in Bioenginee¬≠ring, University of Washington, Seattle, US
  • 1979 ‚ÄĎ present, Professor of Polymer Chemistry and Biomaterials, Twente University of Technology, Enschede, The Netherlands.
  • 1979-1985, Adjunct Professor of Pharmaceu¬≠tics, University of Utah, Salt lake City, US.
  • July ‚ÄĎ August 1978, Visiting Associate Professor Dept. of Applied Pharmaceutical Science, College of Pharmacy, University of Utah, Salt Lake City, US.
  • 1 Oct. 1978 ‚ÄĎ 1979, Adjunct Associate Professor Dept. of Applied Pharmaceutical Science, College of Pharmacy, University of Utah, Salt Lake City, US.
  • 1973 ‚ÄĎ 1978, Associate Professor of Materials Science and Engineering, Twente University of Technology, Enschede, Netherlands.
  • Juni 1972 ‚ÄĎ September 1977, Visiting Associate Professor, Dept. of Applied Pharmaceutical Scien¬≠ce, College of Pharmacy, University of Utah, Salt Lake City, US.
  • June 1973 ‚ÄĎ September 1973, Visiting Assistant Professor, Division of Materials Science and Engineering, University of Utah, Salt lake City, US.
  • 1970 ‚ÄĎ 1972, Assistant Professor, Materials Scien¬≠ce and Engineering, Twente University of Technolo¬≠gy, Enschede, Netherlands.

Expertise

  • Material Science

    • Polyethylene Glycol
    • Polymer
    • Hydrogel
    • Mechanical Property
    • Stereolithography
    • Block Copolymer
  • Pharmacology, Toxicology and Pharmaceutical Science

    • Copolymer
  • Chemistry

    • Poly(ethylene Glycol)

Organisations

MAJOR RESEARCH INTERESTS:

  • Biomedical Polymers
  • Biointerfacial Phenomena
  • Artificial Organ
  • Drug Delivery Systems
  • Tissue engineering
  • Ring-opening polymerization
  • Engineering polymers

RESEARCH EXPERIENCE

  • 1972 ‚Äď present: Biomaterials, Biodegradable Polymers, Biointer¬≠facial Phenomena, Polymeric Drug Delivery Sy¬≠stems, Membranes, Transport Phenomena, Artifi¬≠cial Organs (Hemoperfusion, Oxy¬≠genation, Heart Assist Devices), Tissue engineering, ring-opening polymerization, engineering polymers
  • 1970 ‚Äď 1972: Synthetic poly(a‚ÄĎamino acids), Synthe¬≠sis, Charac¬≠terization in solution, Conformational Studies
  • 1967 ‚Äď 1970: Synthetic Organic Chemistry, Isoannelated hetero¬≠aromatic systems

MEMBER OF SOCIETIES

  • European Society for Artificial Organs
  • Royal Dutch Chemical Society
  • Controlled Release Socie¬≠ty
  • European Society for Biomaterials
  • International Society for Artificial Organs
  • American Chemical Society
  • Dutch Biomaterials Society (NVB)

OTHER PROFESSIONAL ACTIVITIES

  • 1995- 2008, Graduate School ‚ÄėIntegrated BioMedical Engineering for restoration of human function‚Äô, University of Twente, scientific director
  • 1990- 2008, First/Second/Third/Fourth/Fifth/Sixth/ Seventh/Eight/Nineth, European Symposium on Controlled Drug Delivery Systems, The¬†Netherlands, chairman and organiser
  • Study section Biomaterials, NWO, former chairman and member
  • Study section Macromolecules, NWO-CW (Chemical Sciences), former chairman and member
  • Controlled Release Society, member, former governor
  • European Society for Biomaterials, member, former governor
  • International Society for Artificial Internal Organs, former governor
  • Foundation of Polymer Technology (PTN), member of the council
  • Graduate School Polymers, PTN, member board of governors
  • Polymer Center Twente (PCT), University of Twente, chairman
  • Concerted Action on Heart and Replacement Technologie, Medical Health Research Programme of the European Communities, chairman for five years
  • Dutch Polymer Institute (DPI), member management team
  • European Degradable Polymer Society, co-founder
  • 2005- present, Dutch Program for Tissue Engineering (DPTE), chairman

EDITOR

  • Journal of Controlled Release, co-founding editor
  • International Journal of Artificial Organs, Section Biomaterials, European editor

EDITORIAL BOARD

  • Biomaterials,
  • Journal of Biomaterials Science, Polymer Edition
  • Materials in Medicine
  • Macromolecular Bioscience
  • Biomacromolecules
  • The International Journal of Artificial Organs
  • Journal of Biomedical Materials Research
  • Journal of Material Science

FELLOWSHIPS

  • Fellow of the American Society for Biomaterials
  • Fellow of AIMBE
  • Fellow of the Dutch Forum for Technology and Science

AWARDS

  • Best Paper Award Journal of Controlled Release, Controlled Release Society, 1992.
  • Clemson Award, American Society for Biomaterials, 1994.
  • Founders Award, Controlled Release Society, 1998.
  • George Winter Award, ESB, 2002.
  • Royal decoration ‚ÄėRidder in de Orde van de Nederlandse Leeuw‚Äô, April 28, 2003.
  • The Award for Distinguished Service in Advancement of Biomaterials Science, Japanese Society for Biomaterials, 2008

Publications

2023
2021
Multi-functional polymeric micelles for chemotherapy-based combined cancer therapyJournal of materials chemistry. B: materials for biology and medicine, 9(42), 8718-8738. Bholakant, R., Dong, B., Zhou, X., Huang, X., Zhao, C., Huang, D., Zhong, Y., Qian, H., Chen, W. & Feijen, J.https://doi.org/10.1039/d1tb01771c
2020
The triangle, in memory of Prof. Sung Wan KimJournal of controlled release, 328, 962-969. Feijen, J.https://doi.org/10.1016/j.jconrel.2020.09.049Recent Advances of Polycationic siRNA Vectors for Cancer TherapyBiomacromolecules, 21(8), 2966-2982. Bholakant, R., Qian, H., Zhang, J., Huang, X., Huang, D., Feijen, J., Zhong, Y. & Chen, W.https://doi.org/10.1021/acs.biomac.0c00438
2019
Folated pH-degradable nanogels for the simultaneous delivery of docetaxel and an IDO1-inhibitor in enhancing cancer chemo-immunotherapyBiomaterials Science, 7(7), 2749-2758. Qiao, H., Chen, X., Chen, E., Zhang, J., Huang, D., Yang, D., Ding, Y., Qian, H., Feijen, J. & Chen, W.https://doi.org/10.1039/c9bm00324j

Other contributions

ARTICLES

2010

  • Arun, A., Baack, K.K.J. & Gaymans, R.J. (2010) Polyurethane Tri-block Copolymers-Synthesis, Mechanical, Elastic, and Rheological Properties.¬†Polymer Engineering and Science, 50(4), 747-755.¬†DOI
  • Arun, A., Dullaert, K. & Gaymans, R.J. (2010) The Melt Rheological Behavior of AB, ABA, BAB, and (AB)(n) Block Copolymers With Monodisperse Aramide Segments.¬†Polymer Engineering and Science, 50(4), 756-761.¬†DOI
  • Basalus, M.W. Z., van Houwelingen, K.G., Ankone, M.J. K., Feijen, J. & von Birgelen, C. (2010) Micro-computed tomographic assessment following extremely oversized partial postdilatation of drug-eluting stents.
    EuroIntervention, 6(1), 141-8.
  • Berg van den, J.H.; Oosterhuis, K., Hennink, W.E., Storm, G., van der Aa, L.J., Engbersen, J.F.J., Haanen, J.B.A.G., Beijnen, J.H., Schumacher, T.N. & Nuijen, B. (2010) Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity.¬†Journal of Controlled Release, 141(2), 234-240.¬†DOI
  • Biemond, G.J.E., & Gaymans, R.J. (2010) Elastic properties of thermoplastic elastomers based on poly(tetramethylene oxide) and monodisperse amide segments.¬†Journal of Materials Science, 45(1), 158-167.¬†DOI
  • Buwalda, S.J., Dijkstra, P.J., Calucci, L., Forte, C. & Feijen, J. (2010) Influence of Amide versus Ester Linkages on the Properties of Eight-Armed PEG-PLA Star Block Copolymer Hydrogels
    Biomacromolecules, 11(1), 224-232. DOI
  • Habraken, W.J.E.M., Liao, H.B., Zhang, Z., Wolke, J.G.C., Grijpma, D.W., Mikos, A.G., Feijen, J. & Jansen, J.A. (2010) In vivo degradation of calcium phosphate cement incorporated into biodegradable microspheres.
    Acta Biomaterialia, 6(6), 2200-2211. DOI
  • Jeong, J.H., Kim, S.H., Christensen, L.V., Feijen, J. & Kim, S.W. (2010) Reducible Poly(amido ethylenimine)-Based Gene Delivery System for Improved Nucleus Trafficking of Plasmid DNA.¬†Bioconjugate¬†Chemistry,¬†21(2), 296-301.¬†DOI
  • Jin, R., Teixeira, L.S.M., Krouwels, A., Dijkstra, P. J., van Blitterswijk, C. A., Karperien, M. & Feijen, J. (2010) Synthesis and characterization of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: An injectable biomaterial for cartilage repair.¬†ACTA BIOMATERIALIA,¬†6(6), 1968-1977.¬†DOI
  • Jin, R; Teixeira, L.S.M., Dijkstra, P.J., van Blitterswijk, C.A., Karperien, M., Feijen, J. (2010) Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran-hyaluronic acid conjugates for cartilage tissue engineering.¬†BIOMATERIALS,¬†¬†31(11), 3103-3113.¬†DOI
  • Jukes, J.M., van der Aa, L.J., Hiemstra, C., van Veen, T., Dijkstra, P.J., Zhong, Z., Feijen, J., van Blitterswijk, C.A. & de Boer, J. (2010) A Newly Developed Chemically Crosslinked Dextran-Poly(Ethylene Glycol) Hydrogel for Cartilage Tissue Engineering.¬†Tissue Engineering Part A, 16(2), 565-573.¬†DOI
  • Meer van der, A.D., Poot, A.A., Feijen, J. & Vermes, I. (2010) Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay.¬†BIOMICROFLUIDICS,¬†4(1).¬†DOI
  • Meer van der, A.D., Vermeul, K., Poot, A.A., Feijen, J. & Vermes, I. (2010) A microfluidic wound-healing assay for quantifying endothelial cell migration.¬†American Journal of Physiology-Heart and Circulatory Physiology, 298(2), H719-H725.¬†DOI
  • Melchels, F.P.W., Feijen, J. & Grijpma, D.W. (2010) A review on stereolithography and its applications in biomedical engineering.¬†Biomaterials, 31(24),¬†6121-30.
  • Namgung, R., Brumbach, J.H., Jeong, J.H., Yockman, J.W., Kim, S.W., Lin, C., Zhong, Z., Feijen, J., Engbersen, J.F.J. & Kim, W.J. (2010) Dual bio-responsive gene delivery via reducible poly(amido amine) and survivin-inducible plasmid DNA.¬†Biotechnology Letters, 32(6), 755-764.
  • Papenburg, B.J., Bolhuis-Versteeg, L.A.M., Grijpma, D.W, Feijen, J., Wessling, M. & Stamatialis, D. (2010) A facile method to fabricate poly(L-lactide) nano-fibrous morphologies by phase inversion.¬†Acta Biomater,¬†6(7), 2477-83.
  • Song, Y., Kamphuis, M.M.J., Zhang, Z., Sterk, L.M.Th., Vermes, I., Poot, A.A., Feijen, J. & Grijpma, D.W. (2010) Flexible and elastic porous poly(trimethylene carbonate) structures for use in vascular tissue engineering.¬†Acta Biomaterialia,¬†6(4), 1269-1277.¬†DOI
  • IJzer, A.C., Arun, A., Reijerkerk, S.R., Nijmeijer, K., Wessling, M. & Gaymans, R.J. (2010) Synthesis and Properties of Hydrophilic Segmented Block Copolymers Based on Poly(ethylene oxide)-ran-poly(propylene oxide).¬†Journal of Applied Polymer Science, 117(3), 1394-1404.¬†DOI

2009

  • Araichimani, A. & Gaymans, R.J. (2009). Hydrophilic poly(ethylene oxide)-aramide segmented block copolymers.¬†European polymer journal, 45(10), 2858-2866.¬†DOI
  • Araichimani, A. & Gaymans, R.J. (2009). Melt rheological behavior of a triblock copolymer based on aramide end-segments. Journal¬†of applied polymer science, 112(5), 2663-2668.¬†DOI
  • Araichimani, A., Dullaert, K. & Gaymans, R.J. (2009). Structure and properties of mono-, di-, tri-, and multiblock segmented copolymers with diamide hard segments.¬†Macromolecular chemistry and physics, 210(1), 48-59.¬†DOI
  • Araichimani, A. & Gaymans, R.J. (2009). Tensile and elastic properties of triblock copolymer based on aramide end-segments and polyether mid-segments.¬†Journal of applied polymer science, 111, 1780-1785.¬†DOI
  • Araichimani, A. & Gaymans, R.J. (2009). Thermoplastic polyurethanes with TDI-based monodisperse hard segments.¬†Macromolecular materials and engineering, 294(6-7), 405-413.¬†DOI
  • Basalus, M.Z., Ankone, M.J.K., Houwelingen, K.G. van , Man, F.H. de & Birgelen, C. von (2009). Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy.¬†EuroIntervention, 5(1), 157-165.
  • Basalus, M.Z., Houwelingen, K.G. van, Ankone, M.J.K. , Man, F.H. de & Birgelen, C. von (2009). Scanning electron microscopic assessment of the biodegradable coating on expanded biolimus-eluting stents.¬†EuroIntervention, 5(4), 505-510.
  • Bat, E., Kooten, T.G., Feijen, J. & Grijpma, D.W. (2009). Macrophage-mediated erosion of gamma irradiated poly(trimethylene carbonate films.¬†Biomaterials, 30(22), 3652-3661.¬†DOI
  • Biemond, G.J.E., Feijen, J. & Gaymans, R.J. (2009). Segmented block copolymers with monodisperse hard segments: the influence of H-bonding on various properties.¬†Macromolecular materials and engineering, 294(8), 492-501.¬†DOI
  • Bladergroen, B., Siebum, B., Siebers-Vermeulen, K.G.C., Kuppevelt, T.H. van, Poot, A.A., Feijen, J., Figdor, C.G. & Torensma, R. (2009). In vivo recruitment of hematopoietic cells using stromal cell-derived factor 1 alpha-loaded heparinized three dimensional collagen scaffolds.¬†Tissue Engineering Part A, 15(7), 1591-1599.¬†DOI
  • Du, H(ongzhi) , Velders, A.H. , Dijkstra, P.J. , Sun, J.R. , Zhong, Z. , Chen, X. & Feijen, J. (2009). Chiral salan aluminium ethyl complexes and their application in lactide polymerization.¬†Chemistry: a European journal, 15(38), 9836-9845.¬†DOI
  • Du, H(ongzhi), Velders, A.H., Dijkstra, P.J., Zhong, Z., Chen, X. & Feijen, J. (2009). Polymerization of lactide using achiral bis(pyrrolidene) schiff base aluminium complexes.¬†Macromolecules, 42(4), 1058-1066.¬†DOI
  • Feijen, J.(2009). In memory of Jorge Heller Obituary.¬†Journal of controlled release, 139(3), 173.¬†DOI
  • Hou, Q., Grijpma, D.W. & Feijen, J. (2009). Creep-resistant elastomeric networks prepared by photo-crosslinking fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers.¬†Acta biomaterialia, 5, 1543-1551.¬†DOI
  • Husken, D., Feijen, J. & Gaymans, R.J. (2009). Surface properties of poly(ethylene oxide)-based segmented block copolymers with monodisperse hard segments.¬†Journal of applied polymer science, 114(2), 1264-1269.¬†DOI
  • Husken, D. & Gaymans, R.J. (2009). The tensile properties of poly(ethylene oxide)-based segmented block copolymers in the dry and wet state.¬†Journal of materials science, 44, 2656-2664.¬†DOI
  • Husken, D. & Gaymans, R.J. (2009). Water vapor transmission of poly(ethylene oxide)-based segmented block copolymers.¬†Journal of applied polymer science, 112, 2143-2150.¬†DOI
  • Jansen, J., Melchels, F.P.W., Grijpma, D.W. & Feijen, J. (2009). Fumaric acid monoethyel ester-functionalized poly(D-Llactide/N-vinyl-2-pyrrolidone resins for the preparation of tissue engineering scaffolds by stereolithography.¬†Biomacromolecules, 10(2), 214-210.¬†DOI
  • Jin, R., Moreira Teixeira, L.S., Dijkstra, P.J., Karperien, H.B.J., Blitterswijk, C.A. van, Zhong, Z.Y. & Feijen, J. (2009). Injectable chitosan-based hydrogels for cartilage tissue engineering.¬†Biomaterials, 30(13), 2544-2551¬†DOI
  • Koenders, M.M.J.F., Yang, Lanti, Wismans, R.G., Werf, K.O. van der , Reinhardt, D.P., Daamen, W.F., Bennink, M.L., Dijkstra, P.J., Kuppevelt, T.H. van & Feijen, J. (2009). Microscale mechanical properties of single elastic fibers: the role of fibrillin-microfibrils.¬†Biomaterials, 30(13), 2425-2432.¬†DOI
  • Lin, C. & Engbersen, J.F.J. (2009). The role of the disulfide group in disulfide-based polymeric gene carriers.¬†Expert opinion on drug delivery, 6(4), 421-439.¬†DOI
  • Meer, A.D. van der, Poot, A.A., Duits, M.H.G., Feijen, J. & Vermes, I. Microfluidic technology in vascular research.¬†Journal of biomedicine and biotechnology, ID(823148).¬†DOI
  • Meer, A.D. van der, Kamphuis, M.M.J., Poot, A.A. , Feijen, J. & Vermes, I. (2009). Lowering caveolin-1 expression in human vascular cells inhibits signal transduction in response to shear stress.¬†International journal of cell biology
  • Meer, F.J. van der, Faber, D.J., Aalders, M.C., Poot, A.A., Vermes, I. & Leeuwen, A.G.J.M. van (2009). Apoptosis - and necrosis - induced changes in light attenuation measured by optical coherence tomography.¬†Lasers in medical science, 25(2), 259-267.¬†DOI
  • Melchels, F.P.W., Feijen, J. & Grijpma, D.W. (2009). A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography.¬†Biomaterials, 30, 3801-3809.¬†DOI
  • Meng, F., Zhong, Z. & Feijen, J. (2009). Stimuli-responsive polymersomes for programmed drug delivery.¬†Biomacromolecules, 10(2), 197-209.¬†DOI
  • Neut, D.D., Kluin, O.S., Crielaard, B.J., Mei, H.C. van der, Busscher, H.J. & Grijpma, D.W. (Polymer (2009). A biodegradable antibiotic delivery system on poly(trimethylene carbonate) for the treatment of osteomyelitis.¬†Acta Orthopaedica, 80(5), 514-519.¬†DOI
  • Papenburg, B.J., Sch√ľller-Ravoo, S., Bolhuis-Versteeg, L.A.M., Hartsuiker, L., Grijpma, D.W., Feijen, J., Wessling, M. & Stamatialis, D. (2009). Designing porosity and topography of poly(1,3-trimethylene carbonate) scaffolds.¬†Acta biomaterialia, 5, 3281-3294.¬†DOI
  • Papenburg, B.J., Boer, J. de, Grijpma, D.W., Feijen, J., Blitterswijk, C.A. van, Wessling, M. & Stamatialis, D. (2008). Novel membrane based scaffolds for tissue engineering.¬†International journal of artificial organs, 32, 409-410.
  • Russell-Lodrigue, K.E., Andoh, M. , Poels, M.W.J., Shive, H.R., Weeks, B.R. , Zhang, G.Q., Tersteeg, C., Masegi, T., Hotta, A., Yamaguchi, T., Fukushi, H., Hirai, K., McMurray, D.N. & Samuel, J.E. (2009). Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever.¬†Infection and immunity, 77(12), 5640-5650.¬†DOI
  • Stephen, R., Gibon, C.M., Weber, M. & Gaymans, R.J. (2009). Synthesis and properties of poly(sulfone-acrylate) copolymers.¬†Journal of polymer science, part A, 47, 3904-3913.¬†DOI
  • Subbiahdoss, G., Kuijer, R., Grijpma, D.W., Mei, H.C. van der & Busscher, H.J. (2009). Biofilm growth versus tissue integration: the race for the surface experimentally studied.¬†Acta biomaterialia, 5, 1399-1404.¬†DOI
  • Subbiahdoss, G., Kuijer, R., Grijpma, D.W., Mei, H.C. van der & Busscher, H.J. (2009). Microbial biofilm growth vs. tissue integration: "the race for the surface" experimentally studied.¬†Acta biomaterialia, 5(5), 1399-1404.¬†DOI
  • Tan, B.H., Nabuurs, T. , Feijen, J. & Grijpma, D.W. (2009). Redox-initiated PMMA emulsion polymerizations stabilized with block copolymers based on poly(ethylene oxide), e-caprolactone and linoleic acid.¬†Journal of Polymer Science, Part A: Polymer Chemistry, 47, 4234-4244.¬†DOI
  • Velthoen, I.W., Dijkstra, P.J. & Feijen, J. (2009). AB(2) functional polyesters via ring opening polymerization: synthesis and characterization.¬†Macromolecular chemistry and physics, 210(8), 689-697.¬†DOI

2008

  • Araichimani, A. & Gaymans, R.J. (2008). Tri-block copolymers with mono-disperse crystallizable diamide segments: synthesis, analysis and rheological properties.¬†Polymer,¬†49(10), 2461-2470.¬†DOI
  • Araichimani, A. & Gaymans, R.J. (2008). Segmented block copolymers with monodisperse aramide end-segments.¬†Macromolecular chemistry and physics,¬†209(8), 854-863.¬†DOI
  • Araichimani, A., Baack, K.K.J. & Gaymans, R.J. (2008). Polyurethaan triblock copolymers with mono-disperse hard segments. Influence of the hard segment length on thermal and thermomechanical properties.¬†Polymer engineering and science,¬†48(6), 1222-1230.¬†DOI
  • Bat, E., Zhang Zheng, Z.Z., Grijpma, D.W. & Feijen, J. (2008). Trimethylene carbonate and e-caprolactone based (co)polymer networks: mechanical properties and enzymatic degradation.¬†Biomacromolecules,¬†9(11), 3208-3215.¬†DOI
  • Bat, E., Grijpma, D.W. & Feijen, J. (2008). Thermoreversible gelation behaviour of PTMC-PEG-PTMC triblock copolymers.¬†Journal of controlled release, 132,¬†e37-e39.¬†DOI
  • Biemond, G.J.E., Feijen, J. & Gaymans, R.J. (2008). Tensile properties of segmented block copolymers with monodisperse hard segments.¬†Journal of materials science,¬†43(10), 3689-3696.¬†DOI
  • Biemond, G.J.E., Braspenning, K. & Gaymans, R.J. (2008). Polyurethanes with monodisperse rigid segments based on a diamine-diamine chain extender.¬†Journal of applied polymer science,¬†107(4), 2180-2189.¬†DOI
  • Biemond, G.J.E., Feijen, J. & Gaymans, R.J. (2008). Influence of polydispersity of crystallizable segments on the properties of segmented block copolymers.¬†Polymer engineering and science,¬†48(7), 1389-1400.¬†DOI
  • Cou√©, G.M.J.P.C., Feijen, J. & Engbersen, J.F.J. (2008). Development of biodegradable poly(amidoamine)s for protein delivery.¬†Journal of controlled release, 132,¬†e2-e3.¬†DOI
  • De, D. & Gaymans, R.J. (2008). Thermoplastic polyurethanes with poly(butylene terephthalate) as crystallizable hard phase.¬†Macromolecular materials and engineering,¬†293(3), 228-234.¬†DOI
  • De, D. & Gaymans, R.J. (2008). Polyurethanes with narrow- and polydisperse hard segment distributions.¬†Macromolecular materials and engineering,¬†293(11), 887-894.¬†DOI
  • Dijkink, R.J., Le Gac, S., Nijhuis, E.H.A., Berg, A. van den, Vermes, I., Poot, A.A. & Ohl, C.D. (2008). Controlled cavitation-cell interaction: trans-membrane transport and viability studies.¬†Physics in medicine and biology,¬†53, 375-390.¬†DOI
  • Habraken, W.J.E.M., Zhang Zheng, Z.Z., Wolke, J.G.C., Grijpma, D.W., Mikos, A.G., Jansen, J.A. & Feijen, J. (2008). Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement.¬†Biomaterials,¬†29, 2464-2476.¬†DOI
  • Husken, D. & Gaymans, R.J. (2008). The structure of water in PEO-based segmented block copolymers and its effect on transition temperatures.¬†Macromolecular chemistry and physics,¬†209(9), 967-979.¬†DOI
  • Husken, D., Feijen, J. & Gaymans, R.J. (2008). Sythesis and properties of segmented block copolymers based on mixtures of poly(ethylene oxide) and poly(tetramethylene oxide) segments.¬†European polymer journal,¬†44(1), 130-143.¬†DOI
  • Husken, D., Feijen, J. & Gaymans, R.J. (2008). Segmented block copolymers with terephthalic-extended poly(ethylene oxide) segments.¬†Macromolecular chemistry and physics,¬†209(5), 525-534.¬†DOI
  • Jansen, G.H., Franke, H.R., Wolbers, F., Brinkhuis, M. & Vermes, I. (2008). Effects of fulvestrant alone or combined with different steroids in human breast cancer cells.¬†Climacteric,¬†11(4), 315-321.¬†DOI
  • Jin, R., Moreira Teixeira, L.S., Dijkstra, P.J., Karperien, H.B.J., Zhong, Z. & Feijen, J. (2008). Fast in-situ formation of dextran-tyramine hydrogels for in vitro chondrocyte culturing.¬†Journal of controlled release, 132,¬†e24-e26.¬†DOI
  • Komen, J., Wolbers, F., Franke, H.R., Andersson, S.M.H., Vermes, I. & Berg, A. van den (2008). Viability analysis and apoptosis induction of breast cancer cells in a microfluidic device: effect of cytostatic drugs.¬†Biomedical microdevices,¬†10(5), 727-737.¬†DOI
  • Lee, J.S., Zhou, W., Zhang, D., Otto, C. & Feijen, J. (2008). Hydrosomes, novel thermosensitive gel-containing polymersomes.¬†Journal of controlled release, 132,¬†e28-e29.¬†DOI
  • Leeuwen, S.M. van, Tan, B.H., Grijpma, D.W., Feijen, J. & Karst, U. (2008). Characterization of synthetic block copolymers by LC-MS.¬†American laboratory,¬†40, 36.
  • Lin, C. & Engbersen, J.F.J. (2008). Effect of chemical functionalities in poly(amido amine)s for non-viral gene transfection.¬†Journal of controlled release, 132,¬†267-272.¬†DOI
  • Lin, C., Blaauboer, C., Mateos timoneda, M.A., Lok, M.C., Steenbergen, M. van, Hennink, W.E., Zhong, Z., Feijen, J. & Engbersen, J.F.J. (2008). Bioreducible poly(amido amine)s with oligoamine side chains: synthesis, characterization, and structural effects on gene delivery. Journal of controlled release,¬†126(2), 166-174.¬†DOI
  • Lin, C., Zhong, Z., Lok, M.C., Wolf, H.K. de, Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2008). Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells.¬†Journal of controlled release, 132,¬†e9-e10.¬†DOI
  • Martello, F., Engbersen, J.F.J. & Ferruti, P. (2008). Hyperbranched poly(amido amine)s for gene delivery to ovarian cancer cells.¬†Journal of controlled release, 132,¬†e10-e12.¬†DOI
  • Mateos timoneda, M.A., Lok, M.C., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2008). Poly(amido amine)s as gene delivery vectors: effects of quaternary nicotinamide moieties in the side chains.¬†ChemMedChem,¬†3(3), 478-486.¬†DOI
  • Meer, A.D. van der, Kamphuis, M.M.J., Poot, A.A., Feijen, J. & Vermes, I. (2008). A microfluidic device for monitoring siRNA delivery under fluid now.¬†Journal of controlled release, 132,¬†e42-e44.¬†DOI
  • Melchels, F.P.W., Grijpma, D.W., Kellomaki, M. & Peltola, S.M. (2008). A review of rapid prototyping techniques for tissue engineering purposes.¬†Annals of medicine,¬†40, 268-280.¬†DOI
  • Melchels, F.P.W., Grijpma, D.W. & Feijen, J. (2008). Properties of porous structures prepared by stereolithography using a polylactide resin.¬†Journal of controlled release, 132,¬†e71-e73.¬†DOI
  • Moreira Teixeira, L.S., Jin, R., Dijkstra, P.J., Feijen, J., Blitterswijk, C.A. van & Karperien, H.B.J. (2008). Chitosan-based hydrogels as extracellular matrix for cartilage tissue engineering: in vitro biological evaluation.¬†Tissue Engineering Part A, 14,¬†711.¬†DOI
  • Nalawade, S.P., Picchioni, F., Janssen, L.P.B.M., Grijpma, D.W. & Feijen, J. (2008). Investigation of the interaction of CO2 with poly(L-lactide), poly(D,L-lactide) and poly(e-caprolactone).¬†Journal of applied polymer science,¬†109, 3376-3381.¬†DOI
  • Nalawade, S.P., D. Westerman, G. Leeke, R.C.D. Santos, Grijpma, D.W. & Feijen, J. (2008). Preparation of porous poly(trimethylene carbonate) structures for controlled release applications using high pressure CO2¬†.¬†Journal of controlled release, 132,¬†e73-e75.¬†DOI
  • Nijhuis, E.H.A., Poot, A.A., Feijen, J. & Vermes, I. (2008). Hsp70- and p53-responses after heat treatment and/or X-radiation mediate the susceptibility of hematopoietic cells to undergo apoptosis.¬†International journal of radiation biology,¬†84, 99-105.¬†DOI
  • Nijhuis, E.H.A., Gac, S. le, Poot, A.A., Feijen, J. & Vermes, I. (2008). Bax-mediated mitochondrial membrane permeabilization after heat treatment in caspase-2 dependent.¬†International journal of hyperthermia,¬†24, 357-365.¬†DOI
  • Papenburg, B.J., Schuller, S., Stamatialis, D., Grijpma, D.W., Boer, J. de, Blitterswijk, C.A. van & Wessling, M. (2008). Flexible micropatterned porous scaffolds.¬†Tissue Engineering Part A,¬†14, 855.¬†DOI
  • Piest, M., Lin, C., Mateos timoneda, M.A., Lok, M.C., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2008). Novel poly(amido amine)s with bioreducible disulfide linkages in their diamino-units: structure effects and in vitro gene transfer properties.¬†Journal of controlled release, 132,¬†e12-e13.¬†DOI
  • Piest, M., Lin, C., Mateos timoneda, M.A., Lok, M.C., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2008). Novel poly(amido amine)s with bioreducible disulfide linkages in their diamino-units: structure effects and in vitro gene transfer properties.¬†Journal of controlled release,¬†130(1), 38-45.¬†DOI
  • Song, Y., Kamphuis, M.M.J., Zhang Zheng, Z.Z., Vermes, I., Poot, A.A., Grijpma, D.W. & Feijen, J. (2008). Poly(trimethylene carbonate)-based porous tubular structures for tissue engineering of small diameter blood vessels.¬†Tissue Engineering Part A, 14,¬†927.¬†DOI
  • Song, Y., Yang, L., Jansen, J., Kamphuis, M.M.J., Zhang Zheng, Z.Z., Poot, A.A., Vermes, I., Grijpma, D.W. & Feijen, J. (2008). Poly(trimethylene carbonate) porous tubular structures made by electro-spinning.¬†Journal of controlled release,132, e79-e80.¬†DOI
  • Valero, A., Post, J.N., Nieuwkasteele, J.W. van, Braak, P.M. ter, Kruijer, W. & Berg, A. van den (2008). Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device.¬†Lab on a chip,¬†8(1), 62-67.¬†DOI
  • Velthoen, I.W., Tijsma, E.J., Dijkstra, P.J. & Feijen, J. (2008). Thermo-responsive hydrogels based on branched poly(L-lactide)-poly(ethylene glycol) copolymers.¬†Macromolecular symposia, 272,¬†13-27.¬†DOI
  • Vos, S.V.N. de, Feijen, J. & Grijpma, D.W. (2008). Poly(1,3-trimethylene carbonate) networks as a resorbable scleral buckle.¬†Journal of controlled release, 132,¬†e51-e52.¬†DOI
  • Yang, Lanti, Fiti√©, C.F.C., Werf, K.O. van der, Bennink, M.L., Dijkstra, P.J. & Feijen, J. (2008). Mechanical properties of single electrospun collagen type I fibers.¬†Biomaterials,¬†29, 955-962.¬†DOI
  • Yang, Lanti, Werf, K.O. van der, Fitie, C.F.C., Bennink, M.L., Dijkstra, P.J. & Feijen, J. (2008). Mechanical properties of native and cross-linked type I collagen fibrils.¬†Biophysical journal,¬†94, 2204-2211.¬†DOI
  • Zhang Zheng, Z.Z., Buwalda, S.J., Dijkstra, P.J., Grijpma, D.W., Poot, A.A., Steenbergen, W. & Feijen, J. (2008). Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering.¬†Journal of controlled release,¬†132, e52-e53.¬†DOI
  • Zhou W., & Feijen, J. (2008).Biodegradable polymersomes for controlled drug release.¬†Journal of controlled release,¬†132, e35-e36.¬†DOI
  • Zuiderduin, W.C.J. & Gaymans, R.J. (2008). Polycarbonate modified with crystallisable bis-ester tetra-amide units in a reaction extrusion process.¬†Reactive and functional polymers,¬†68(2), 527-534.¬†DOI

2007

  • Araichimani, A., Baack, K.K.J. & Gaymans, R.J. (2007). Polyurethane triblock copolymers based on monodisperse amide segments synthesis, mechanical rheological properties.¬†Polymer preprints, 48(1), 483-484.
  • Araichimani, A. & Gaymans, R.J. (2007). Tri-block copolymers based on monodisperse aramide segments-synthesis, mechanical and rheological properties.¬†Polymer preprints, 48(1), 856-857.
  • Biemond, G.J.E., Feijen, J. & Gaymans, R.J. (2007). Poly(ether amide) segmented block copolymers with adipicacid based tetra amide segments.¬†Journal of applied polymer science, 105(2), 951-963.
  • Breteler, M.R. ten, Zhong, Z., Dijkstra, P.J., Palmans, A.R.A., Peeters, J. & Feijen, J. (2007). Ring-opening polymerization of substituted e-caprolactones with chiral (salen) AIOiPr complex.¬†Journal of polymer science, part A, 45(3), 429-436.
  • Christensen, L., Chang, C.W., Yockman, J.W., Conners, R., Jackson, H., Zhong, Z., Feijen, J., Bull, D.A. & Kim, S.W. (2007). Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery.¬†Journal of controlled release, 118, 254-261.
  • Claase, M.B., Bruijn, J.D. de, Grijpma, D.W. & Feijen, J. (2007). Ectopic bone formation in cell-seeded poly(ethylene oxide)/poly(butylene terephtalate) copolymer scaffolds of varying porosity.¬†Journal of materials science. Materials in medicine, 18, 1299-1307.
  • De, D. & Gaymans, R.J. (2007). Polyurethanes with diamine-diamine chain extender.¬†Polymer preprints, 48(1), 485-486.
  • Du, H(ongzhi), Pang, X., Chen, X., Wang, Xianhong & Jing, X. (2007). Enolic schiff-base aluminium complexes and their application in lactide polymerization.¬†Journal of organometallic chemistry, 692, 5605-5613.
  • Du, H(ongzhi), Pang, X., Yu, H., Zhuang, X., Chen, X., Cui, D., Wang, Xianhong & Jing, X. (2007). Polymerization of rac-lactide using schiff base aluminum catalysts: structure, activity and stereoselectivity.¬†Macromolecules, 692, 5605-5613.
  • Everaerts, F., Torriani, M., Hendriks, M. & Feijen, J. (2007). Quantification of carboxyl groups in carbodiimide cross-linked collagen sponges.¬†Journal of biomedical materials research. Part A, 83(4), 1176-1183.
  • Hiemstra, C., Zhong, Z., Tomme, S.R. van, Steenbergen, M. van, Jacobs, J.J.L., Otter, W. den, Hennink, W.E. & Feijen, J. (2007). In vitro in vivo protein delivery from in situ forming poly(ethylene glycol)-poly(lactide) hydrogels.¬†Journal of controlled release, 119, 320-327.
  • Hiemstra, C., Aa, L.J. van der, Zhong, Z., Dijkstra, P.J. & Feijen, J. (2007). Novel in situ forming, degradable dextran hydrogels by michael addition chemistry: synthesis, rheology, and degradation.¬†Macromolecules, 40, 1165-1173.
  • Hiemstra, C., Zhou, W., Zhong, Z., Wouters, M. & Feijen, J. (2007). Rapidly in situ forming biodegradable robust hydrogels by combining stereocomplexation and photopolymerization.¬†Journal of the American Chemical Society, 129, 9918-9926.
  • Hiemstra, C., Aa, L.J. van der, Zhong, Z., Dijkstra, P.J. & Feijen, J. (2007). Rapidly in situ-forming degradable hydrogels from dextran thiols through michael addition.¬†Biomacromolecules, 8, 1548-1556.
  • Hiemstra, C., Zhong, Z., Steenbergen, M.J. van, Hennink, W.E. & Feijen, J. (2007). Release of model proteins and basic fibroblast growth factor from in situ forming degradable dextran hydrogels.¬†Journal of controlled release, 122(1), 71-78.
  • Husken, D., Feijen, J. & Gaymans, R.J. (2007). Hydrophilic segmented block copolymers based on poly(ethylene oxide) and monodisperse amide segments.¬†Journal of polymer science, part A, 45(19), 4522-4535.
  • Husken, D., Feijen, J., Visser, T., Wessling, M. & Gaymans, R.J. (2007). Influence of hydrophilicity of segmented block copolymers on vapor transport behavior.¬†Polymer preprints, 48(1), 404-405.
  • Jeong, J.H., Christensen, L., Yockman, J.W., Zhong, Z., Engbersen, J.F.J., Kim, W.J., Feijen, J. & Kim, S.W. (2007). Reducible poly(amido ethylenimine) directed to enhance RNA interference.¬†Biomaterials, 28, 1912-1917.
  • Jin, R., Hiemstra, C., Zhong, Z. & Feijen, J. (2007). Enzyme-mediated in situ formation for hydrogels form dextran-tyramine conjugates.¬†Biomaterials, 18, 2791-2800.
  • Krijgsman, J., Biemond, G.J.E., Stephen, R. & Gaymans, R.J. (2007). High Tg segmented copolymers with monodisperse crystallisable segments.¬†Polymer preprints, 48(1), 418-419.
  • Krijgsman, J., Biemond, G.J.E. & Gaymans, R.J. (2007). Segmented copolymers of uniform tetra-amide units and poly(phenylene oxide) by direct coupling.¬†Journal of applied polymer science, 103, 512-518.
  • Leeuwen, S.M. van, Tan, B.H., Grijpma, D.W., Feijen, J. & Karst, U. (2007). Characterization of the chemical composition of a block copolymer by liquid chromotography/mass spectroscopy using atomspheric pressure chemical ionization and electrospray ionization.¬†Rapid communications in mass spectrometry, 21, 2629-2637.
  • Li, L., Meng, F., Zhong, Z., Byelov, B., Jeu, W. de & Feijen, J. (2007). Morphology of a highly asymmetric double crystallizable poly(e-caprolactone-b-ethylene oxide) block copolymer.¬†Journal of chemical physics, 126, 024904.
  • Lin, C., Zhong, Z., Lok, M.C., Jiang, X., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2007). Novel bioreducible poly(amido amine)s for highly efficient gene delivery.¬†Bioconjugate chemistry, 18, 138-145.
  • Lin, C., Zhong, Z., Lok, M.C., Jiang, X., Hennink, W.E., Feijen, J. & Engbersen, J.F.J. (2007). Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection.¬†Journal of controlled release, 123, 67-75.
  • Roerdink, M., Zanten, T.S. van, Hempenius, M.A., Zhong, Z., Feijen, J. & Vancso, G.J. (2007). Poly(ferrocenylsilane)-block-Polylactide Block Copolymers.¬†Macromolecular rapid communications, 28, 2125-2130.
  • Rusmini, F., Zhong, Z. & Feijen, J. (2007). Protein immobilization strategies for protein biochips.¬†Biomacromolecules, 8(16), 1775-1789.
  • Schuur, J.M. van der & Gaymans, R.J. (2007). Influence of liquid-liquid demixed vs crystalline morphology on the properties of segmented block copolymers.¬†Polymer preprints, 48(1), 829-830.
  • Schuur, J.M. van der & Gaymans, R.J. (2007). Influence of morphology on the properties of segmented block copolymers.¬†Polymer, 48(7), 1998-2006.
  • Song, Y., Weekamp, H.H., Kamphuis, M.M.J., Zhang, Z., Vermes, I., Poot, A.A., Grijpma, D.W. & Feijen, J. (2007). Porous tubular scaffolds based on flexible and elastic TMC (co)polymers.¬†Tissue engineering, 13(7), 1745-1745.
  • Verdijk, R., Franke, H.R., Wolbers, F. & Vermes, I. (2007). Differential effects of biphosphonates on breast cancer cell lines.¬†Cancer letters, 246, 308-312.
  • Vrouwe, E.X., L√ľttge, R., Vermes, I. & Berg, A. van den (2007). Microchip capillary electrophoresis for point-of-care analysis of lithium.¬†Clinical chemistry, 53(1), 117-123.
  • Yang, Lanti, Werf, K.O. van der, Koopman, H.F.J.M., Subramaniam, V., Bennink, M.L., Dijkstra, P.J. & Feijen, J. (2007). Micromechanical bending of single collagen firils using atomic force microscopy.¬†Journal of biomedical materials research. Part A, 82A, 160-168.
  • Yang, Lanti, Werf, K.O. van der, Bennink, M.L., Dijkstra, P.J. & Feijen, J. (2007). Viscoelastic behavior of individual collagen fibrils tested by AFM.¬†Tissue engineering, 13, 1777-1777.
  • Zuiderduin, W.C.J., Huetink, J. & Gaymans, R.J. (2007). Pre-yield tensile set of a semi-crystalline polymer, its blend and composite.¬†Journal of materials science, 42, 4131-4135.

2006

  • Buttafoco, L.; Kolkman, N.G.; Engbers-Buijtenhuijs, P.; Poot, A.A.; Dijkstra, P.J.; Vermes, I.; Feijen, J. (2006)Electrospinning of collagen and elastin for tissue engineering applications.
    Biomaterials; vol. 27, 724-734 
  • Christensen, L.V.; Chang, C.-W.; Kim, W.J.; Kim, S.W.; Zhong, Z.; Lin, C.; Engbersen, J.F.J.; Feijen, J. (2006) Reducible Poly(amido ethylenimine)s Designed for Triggered Intracellular Gene Delivery.¬†Bioconjugate chemistry; vol.¬†17 (2006, 1233-1240¬†
  • Dankers, P.Y.W.; Zhang, Z.; Wisse, E.; Grijpma, D.W.; Sijbesma, R.P.; Feijen, J.; Meijer, E.W. (2006) Oligo(trimethylene carbonate)-Based Supramolecular Biomaterials¬†Macromolecules; vol.¬†39, 8763-8771
  • Nijhuis, E.H.A.; Poot, A.A.; Feijen, J.; Vermes, I. (2006) Induction of apoptosis by heat and gamma;-radiation in a human lymphoid cell line; role of mitochondrial changes and caspase activation.¬†International journal of hyperthermia; vol.¬†22 , 687-698
  • Hiemstra, C.; Zhong, Z.Y.; Van Tomme, S.R.; Hennink, W.E.; Dijkstra, P.J.; Feijen, J. (2006) Protein release from injectable stereocomplexed hydrogels based on PEG‚ÄďPDLA and PEG‚ÄďPLLA star block copolymers.¬†Journal of controlled release; vol.¬†116,¬†e19¬†
  • Hiemstra, C.; Zhong, Z.Y.; Jiang, X.; Hennink, W.E.; Dijkstra, P.J.; Feijen, J. (2006) PEG‚ÄďPLLA and PEG‚ÄďPDLA multiblock copolymers : Synthesis and in situ hydrogel formation by stereocomplexation.¬†Journal of controlled release; vol.¬†116, e17
  • Lin, C.; Lammens, T.M.; Zhong, Z.Y.; Gu, H.; Lok, M.C.; Jiang, X.; Hennink, W.E.; Feijen, J.; Engbersen, J.F.J. (2006) Disulfide-containing poly(ő≤-amino ester)s for gene delivery.
    Journal of controlled release; vol. 116, pag. e79
  • Melchels, F.P.W.; Grijpma, D.W.; Feijen, J.; Photo-crosslinking of functionalised lactide oligomers for the fabrication of osteochondral tissue engineering scaffolds.¬†Journal of controlled release; vol.¬†116; e98
  • Nalawade, S.P.; Picchioni, F.; Marsman, J.H.; Grijpma, D.W.; Feijen, J.; Janssen, L.P.B.M. (2006) Intermolecular interactions between carbon dioxide and the carbonyl groups of polylactides and poly(őĶ-caprolactone).¬†Journal of controlled release; vol.¬†116, e38
  • Zhang, Z.; Grijpma, D.W.; Feijen, J. (2006) Thermoplastic elastomers based on poly(lactide)‚Äďpoly(trimethylene carbonate-co-caprolactone)‚Äďpoly(lactide) triblock copolymers and their stereocomplexes.¬†Journal of controlled release; vol.¬†116, ¬†e29¬†
  • Zhang, Z.; Grijpma, D.W.; Feijen, J. (2006) Trimethylene carbonate-based polymers for controlled drug delivery applications.¬†Journal of controlled release; vol.¬†116, ¬†e28¬†
  • Zhong, Z.Y.; Lin, C.; Ma, Y.; Hempenius, M.A.; Lok, M.C.; Fretz, M.M.; Engbersen, J.F.J.; Vancso, G.J.; Hennink, W.E. (2006) Water-soluble cationic poly(ferrocenylsilane): An efficient DNA condensation and transfection agent.¬†Journal of controlled release; vol.¬†116 e81¬†
  • Zhou, W.; Meng, F.; Engbers, G.H.M.; Feijen, J. (2006) Biodegradable polymersomes for targeted ultrasound imaging.¬†Journal of controlled release; vol.¬†116, ¬†e62
  • Leemhuis, M.; Nostrum, C.F. van; Kruijtzer, J.A.W.; Zhong, Z.Y.; Breteler, M.R. ten; Dijkstra, P.J.; Feijen, J.; Hennink, W.E. (2006) Functionalized Poly(őĪ-hydroxy acid)s via Ring-Opening Polymerization:¬† Toward Hydrophilic Polyesters with Pendant Hydroxyl Groups.¬†Macromolecules; vol.¬†39, 3500-3508

2005

  • Dijkstra, P.J., Engbers, G.H.M., Poot, A.A., Grijpma, D.W. and Zhong, Z. (2005).Bone tissue engineering on amorphous carbonated apatite and crystalline octacalcium phosphate-coated titanium discs.¬†Biomaterials, 26, 5231-5239.
  • Professor Jan Feijen - 30 years research in biomedical technology.Journal of controlled release, 109(1-3), 2-4.
  • Engbers-Buijtenhuijs, P., Kamphuis, M.M.J., Sluijs veer, G. van der, Haanen, C., Poot, A.A., Feijen, J. and Vermes, I. (2005). A novel time resolved fl uorometric assay of anoikis using Europium-labelled annexin V in cultured adherent cells.¬†Apoptosis, 10(2), 429-437.
  • Engbers-Buijtenhuijs, P., Buttafoco, L., Poot, A.A., Geelkerken, R.H., Feijen, J. and Vermes, I. (2005). Analysis of the balance between proliferation and apoptosis of cultured vascular smooth muscle cells for tissue-engineering applications.¬†Tissue engineering, 11(11/12), 1631-1639.
  • Feng, C., Zhang, Z., F√∂rch, R., Knoll, W., Vancso, G.J. and Sch√∂nherr, H. (2005).Reactive Thin Polymer Films as Platforms for the Immobilization of Biomolecules.¬†Biomacromolecules, 6, 3243-3251.
  • Gaymans, R.J. and Zuiderduin, W.C.J. (2005). Toughening with rigid particles.¬†Polymeric materials science and engineering, 93, 917-918.
  • Grijpma, D.W., Hou, Q. and Feijen, J. (2005). Preparation of biodegradable networks by photo-crosslinking lactide, e-caprolactone and trimethylene carbonate-based oligomers functionalized with fumaric acid monoethyl ester.¬†Biomaterials, 26(16), 2795-2802.
  • Husken, D., Feijen, J. and Gaymans, R.J. (2005). Microenvironment as essential element of osteoinduction by biomaterials.¬†Biomaterials, 26(17), 3565-3575.
  • Krijgsman, J. and Gaymans, R.J. (2005). Influence of hydrophilicity of segmented block copolymers on vapor transport behavior.¬†Polymeric materials science and engineering, 93, 334-335.
  • Segmented copolymers of poly(phenylene ether) and polyester. Polymer, 46(16), 6122-6127.
  • Krijgsman, J., Biemond, G.J.E. and Gaymans, R.J. (2005). Segmented copolymers of uniform tetra-amide units and poly(phenylene oxide). Part 4. Infl uence of the extender.¬†Polymer, 46(19), 8250-8257.
  • Lips, P.A.M., Velthoen, I.W., Dijkstra, P.J., Wessling, M. and Feijen, J. (2005). Erratum - Gas foaming of segmented poly(ester amide) films.¬†Polymer, 46, 12737-12737.
  • Lips, P.A.M., Velthoen, I.W., Dijkstra, P.J., Wessling, M. and Feijen, J. (2005).Gas foaming of segmented poly(ester amide) films.¬†Polymer, 46, 9396-9403.
  • Lips, P.A.M., Broos, R., Heeringen, M.J.M. van, Dijkstra, P.J. and Feijen, J. (2005).Incorporation of different crystallizable amide blocks in segmented poly(ester amide)s.¬†Polymer, 46, 7834-7842.
  • Lips, P.A.M., Broos, R., Heeringen, M.J.M. van, Dijkstra, P.J. and Feijen, J. (2005). Synthesis and characterization of poly(ester amide)s containing crystallizable amide segments.¬†Polymer, 46, 7823-7833.
  • Schuur, J.M. van der and Gaymans, R.J. (2005). Infl uence of chemical crosslinks on the elastic behavior of segmented block copolymers.¬†Polymer, 46(18), 6862-6868.
  • Schuur, J.M. van der), Boer, J. de and Gaymans, R.J. (2005). Structure-property relations of poly(propylene oxide) block copolymers with monodisperse and polydisperse crystallisable segments.¬†Polymer, 46(22), 9243-9256.
  • Schuur, J.M. van der, Heide, E. van der, Feijen, J. and Gaymans, R.J. (2005).Structure-property relations of segmented block copolymers with liquid liquid demixed morphologies.¬†Polymer, 46(11), 3616-3627.
  • Schuur, J.M. van der, Feijen, J. and Gaymans, R.J. (2005).Synthesis and characterization of bisester-amide segments of uniform and random length. Polymer, 46(13), 4584-4595.
  • Schuur, J.M. van der, Feijen, J. and Gaymans, R.J. (2005). Synthesis of polyether-based block copolymers based on poly(propylene oxide) and terephthalates.¬†Polymer, 46(2), 327-334.
  • Tan, B.H., Grijpma, D.W., Nabuurs, T. and Feijen, J. (2005). Crosslinkable surfactants based on linoleic acid-functionalized block copolymers of ethylene oxide and e-caprolactone for the preparation of stable PMMA latices.¬†Polymer, 46(4), 1347-1357.
  • Vleggeert-Lankamp, C.L.A.M., Ruiter, G.W.C. de, Wolfs, J.F.C., P√™go, A.P., Feirabend, H.K.P., Lakke, E.A.J.F. and Malessy, M.J.A. (2005). Type grouping in skeletal muscles after experimental reinnervation: another explanation.¬†European journal of neuroscience, 21, 1249-1256.
  • Zhang, Z., Zou, S., Vancso, G.J., Grijpma, D.W. and Feijen, J. (2005). Enzymatic Surface Erosion of Poly(trimethylene carbonate) Films Studied by Atomic Force Microscopy.¬†Biomacromolecules, 6, 3404-3409.
  • Zhong, Z., Song, Y., Engbersen, J.F.J., Lok, M.C., Hennink, W.E. and Feijen, J. (2005).A versatile family of degradable non-viral gene carriers based on hyperbranched oly(ester amine)s.¬†Journal of controlled release, 109(1-3), 317-329.
  • Zhong, Z., Feijen, J., Lok, M.C., Hennink, W.E., Christensen, L., Yockman, J.W., Kim, Y.-H and Kim, S.W. (2005). Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, haracterization, and in vitro gene transfer properties.¬†Biomacromolecules, 6(6), 3440-3448.
  • Zuiderduin, W.C.J., Homminga, D.S., Hu√©tink, J. and Gaymans, R.J. (2005). Infl uence of copolymerisation on fracture behaviour of aliphatic polyketones.¬†Polymer, 46(11), 1921-1934.
  • Zuiderduin, W.C.J., Hu√©tink, J., Vlasveld, D.P.N. and Gaymans, R.J. (2005).Infl uence of sample thickness on fracture behaviour of polyketone and a polyketone-rubber blend.¬†Polymer, 46(23), 10321-10330.

2004

  • Altpeter, H., Bevis, M.J., Grijpma, D.W. and Feijen, J. (2004). Non-conventional injection molding of poly(lactide) and poly(e-caprolactone) intended for orthopedic applications.¬†Journal of materials science. Materials in medicine 15, 175-184.
  • Becker, G., Niemeyer, M., Mundt, O., Schwarz, W., Westerhausen, M., Ossberger, M.W., Mayer, P., N√∂th, H., Zhong, Z., Dijkstra, P.J. and Feijen, J. (2004). Crystal structures and spectroscopic properties of 2 l3 phospha-1,3-dionates and 1,3-dionates of calcium - comparative studies on the 1,3-diphenyl- and 1,3-Di(tertbutyl)derivatives.¬†Zeitschrift f√ľr anorganische und allgemeine Chemie 630, 2605-2621.
  • Buijtenhuijs, P., Buttafoco, L., Poot, A.A., Dijkstra, P.J., Vos, R.A.I. de, Sterk, L.M.Th., Geelkerken, R.H., Feijen, J. and Vermes, I. (2004). Tissue engineering of blood vessels: characterisation of smooth muscle cells for culturing on collagen and elastin based scaffolds.¬†Biotechnology and applied biochemistry 39, 141-149.
  • Deschamps, A.A., Apeldoorn, A.A. van, Hayen, H., Bruijn, J.D. de, Karst, U., Grijpma, D.W. and Feijen, J. (2004). In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate.¬†Biomaterials 25, 247-258.
  • Dijkhuizen-Radersma, R., Roosma, J.R., Kaim, P., M√©tairie, S., P√©ters, F.L.A.M.A., Wijn, J. de, Zijlstra, P.G., Groot, K. de and Bezemer, J.M.(2004). Biodegradable poly(ether-ester) multiblock copolymers for controlled release applications.¬†Journal of biomedical materials research 71A (1), 118-127.
  • Dijkhuizen-Radersma, R., Wright, S.J., Taylor, R.M., John, B.A., Groot, K. de and Bezemer, J.M. (2004). In vitro/in vivo correlation for 14C-methylated lysozyme release from poly(ether-ester) microspheres.¬†Pharmaceutical research 21 (3), 484-491.
  • Hayen, H., Deschamps, A.A., Grijpma, D.W., Feijen, J. and Karst, U. (2004). Liquid chromatographic-mass spectrometric studies on the in vitro degradation of a poly(ether ester) block copolymer.¬†Journal of chromatography A 1029, 29-36.
  • Husken, D., Krijgsman, J. and Gaymans, R.J. (2004). Segmented blockcopolymers with uniform amide segments.¬†Polymer 45, 4837-4843.
  • Krijgsman, J. and Gaymans, R.J. (2003). Copolymers of poly(2,6-dimethyl-1,4-phenylene ether) and ester units.¬†Polymer 44, 7589-7599.
  • Krijgsman, J., Feijen, J. and Gaymans, R.J. (2004). Segmented copolymers of uniform tetra-amide units and poly(phenylene oxide): 2. Crystallisation behaviour.¬†Polymer 45, 4685-4691.
  • Krijgsman, J.,Feijen, J. and Gaymans, R.J. (2004). Segmented copolymers of uniform tetra-amide units and poly(phenyllene oxide): 1. Synthesis and thermal-mechanical properties.¬†Polymer 45, 4677-4684.
  • Li, L., Zhong, Z., Jeu, W. de, Dijkstra, P.J. and Feijen, J. (2004). Crystal structure and morphology of poly(L-lactide-b-D-lactide)diblock copolymers.¬†Macromolecules 37, 8641-8646.
  • Meng, F., Engbers, G.H.M., Gessner, A., M√ľller, R.H. and Feijen, J. (2004). Pegylated polystyrene particles as a model system for artificial cells.¬†Journal of biomedical materials research 70A (1), 97-106.
  • Meng, F., Engbers, G.H.M. and Feijen, J. (2004). Polyethylene glycol-grafted polystyrene particles.¬†Journal of biomedical materials research 70A (1), 49-58.
  • Signori, F., Lips, P.A.M., Dijkstra, P.J., Feijen, J. and Chiellini, E. (2004). Segmented multifunctional poly(ether ester) polymers containing H-bonding units. Preparation and charactization.¬†Macromolecular chemistry and physics 205, 1299-1308.

PROGRESS REPORT 2004

  • Zhang, Z., Grijpma, D.W. and Feijen, J. (2004). Creep-resitant porous stuctures based on stereo-complex forming triblock copolymers of 1,3-trimethylene carbonate and lactides.¬†Journal of materials science. Materials in medicine 15, 381-385.
  • Zhang, Z., Grijpma, D.W. and Feijen, J. (2004). Triblock copolymers based on 1,3-trimethylene carbonate and lactide as biodegradable thermoplastic elastomers.¬†Macromolecular chemistry and physics 205, 867-875.
  • Zhong, Z., Dijkstra, P.J. and Feijen, J. (2004). Controlled synthesis of biodegradable lactide polymers and copolymers using novel in situ generated or single-site stereoselective polymerisation initiators.¬†Journal of biomaterials science: polymer edition 15 (7), 929-946.
  • Zweers, M.L.T., Engbers, G.H.M., Grijpma, D.W. and Feijen, J. (2004). In vitro degradation of nanoparticles prepared from polymers based on DL-lactide, glycolide and poly(ethylene oxide).¬†Journal of controlled release 100 (3), 347-356.

2003

  • Azevedo, M.C., Reis, R.L., Claase, M.B., Grijpma, D.W. and Feijen, J. (2003). Development and properties of polycaprolactone/hydroxyapatite composite biomaterials.¬†Journal of materials science. Materials in medicine, 14, 103-107 .
  • Buttafoco, L., Dijkstra, P.J., Poot, A.A., Vermes, I. and Feijen, J. (2003). Collagenous porous structures for the development of an artificial small diameter blood vessel.¬†Proceedings of the Seventh European Symposium on Controlled Drug Delivery. Vol. 87. Journal of controlled release (pp. 295-297).
  • Claase, M.B., Olde riekerink, M.B., Bruijn, J.D. de, Grijpma, D.W., Engbers, G.H.M. and Feijen, J. (2003). Enhanced bone marrow stromal cell adhesion and growth on segmented poly(ether ester)s based on poly(ethylene oxide) and poly(butylene terephthalate).Biomacromolecules, 4(1), 57-63, issn. 1525-7797.
  • Claase, M.B., Grijpma, D.W., Mendes, S.C., Bruijn, J.D. de and Feijen, J. (2003). Porous PEOT/PBT scaffolds for bone tissue engineering: preparation, characterization, and in vitro bone marrow cell culturing.¬†Journal of biomedical materials research, 64a(2), 291-300.
  • Claase, M.B., Olde riekerink, M.B., Grijpma, D.W., Feijen, J., Mendes, S.C. and Bruijn, J.D. de (2003). Surface modification of PEOT/PBT copolymers for the improvement of bone marrow stromal cell attachment.¬†Proceedings of the Seventh European Symposium on Controlled Drug Delivery. Vol. 87. Journal of controlled release (pp. 298-301).
  • Daamen, F., Moerkerk, H. van, Hafmans, T., Buttafoco, L., Poot, A.A., Veerkamp, J.H. and Kuppevelt, T.H. van (2003). Preparation and evaluation of molecularly-defined collagen-elastinglycosaminoglycan scaffolds for tissue engineering.¬†Biomaterials, 24, 4001-4009.
  • Deschamps, A.A., Apeldoorn, A.A. van, Bruijn, J.D. de, Grijpma, D.W. and Feijen, J. (2003). Poly(ether ester amide)s for tissue engineering.¬†Biomaterials, 24, 2643-2652.
  • Deschamps, A.A., Grijpma, D.W. and Feijen, J. (2003). Segmented poly(ether ester amide) copolymers as scaffolds for tissue engineering.¬†Proceedings of the Seventh European Symposium on Controlled Drug Delivery. Vol. 87. Journal of controlled release (pp. 302-303).
  • Gottenbos, B., Mei, H.C. van der, Klatter, F., Grijpma, D.W., Feijen, J., Nieuwenhuis, P. and Busscher, H.J. (2003). Positively charged biomaterials exert antimicrobial effects of gram-negative bacilli in rats.¬†Biomaterials, 24, 2707-2710.
  • Groenewoud, L.M.H., Engbers, G.H.M. and Feijen, J. (2003). Plasma polymerization of thiophene derivatives.¬†Langmuir, 19, 1368-1374.
  • Hou, Q., Grijpma, D.W. and Feijen, J. (2003). Porous polymeric structures for tissue engineering prepared by a coagulation, compression moulding and salt leaching technique.Biomaterials, 24, 1937-1947.
  • Hou, Q., Grijpma, D.W. and Feijen, J. (2003). Preparation of interconnected highly porous polymeric structures by a replication and freeze-drying process. Journal of biomedical materials research, 67B(2), 732-740.
  • Hou, Q., Grijpma, D.W. and Feijen, J. (2003). Preparation of interconnected highly porous (D,L-lactide) structures by sugar templating and freezedrying.¬†Proceedings of the Seventh European Symposium on Controlled Drug Delivery. Vol. 87. Journal of controlled release (pp. 304-306).
  • Krijgsman, J., Husken, D. and Gaymans, R.J. (2003). Melt spinnable elastane (spandex) fibers from segmented copolyetheresteramides (part 2).¬†Chemical fibers international, 53, 176-178.
  • Krijgsman, J., Husken, D., Feijen, J. and Gaymans, R.J. (2003). Synthesis and characterisation of uniform bisester tetra-amide segments.¬†Polymer, 44, 7043-7053.
  • Krijgsman, J., Feijen, J. and Gaymans, R.J. (2003). Synthesis and properties of poly(2,6-dimethyl-1,4-phylene ether), dodecanediol and uniform tetra-amide units.¬†Macromolecular¬†symposia, 199, 135-146.
  • Krijgsman, J., Husken, D. and Gaymans, R.J. (2003). Synthesis and properties of thermoplastic elastomers based on PTMO and tetra-amide.¬†Polymer, 44, 7573-7588.
  • Mendes, S.C., Bezemer, J.M., Claase, M.B., Grijpma, D.W., Bellia, G., Degli-Innocenti, F., Reis, R.L., Groot, K. de, Blitterswijk, C.A. van and Bruijn, J.D. de (2003). Evaluation of two¬†biodegradable polymeric systems as substrates for bone tissue engineering.¬†Tissue engineering, 9(1), S91-S102.
  • Meng, F., Engbers, G.H.M. and Feijen, J. (2003). Preparation and in vitro evaluation of polyethylene glycol modified microspheres. Proceedings of the Seventh European Symposium on Controlled Drug Delivery. Vol. 87.¬†Journal of controlled release (pp. 243-245).
  • Meng, F., Hiemstra, C., Engbers, G.H.M. and Feijen, J. (2003). Biodegradable polymersomes.Macromolecules, 36, 3004-3006.
  • Olde riekerink, M.B., Claase, M.B., Engbers, G.H.M., Grijpma, D.W. and Feijen, J. (2003). Gas plasma etching of PEO/PBT segmented block copolymer films.¬†Journal of biomedical materials research, 65A(4), 417-428.
  • P√™go, A.P., Vleggeert-lankamp, C.L.A.M., Deenen, M., Lakke, E.A.J.F., Grijpma, D.W., Poot, A.A., Marani, E. and Feijen, J. (2003). Adhesion and growth of human schwann cells on trimethylene carbonate (co)polymers.¬†Journal of biomedical materials research, 67a, 876-885.
  • P√™go, A.P., Poot, A.A., Grijpma, D.W. and Feijen, J. (2003). Biodegradable elastomeric scaffolds for soft tissue engineering.¬†Journal of controlled release, 87, 69-79.
  • P√™go, A.P., Grijpma, D.W. and Feijen, J. (2003). Enhanced mechanical properties of 1,3-trimethylene carbonate polymers and networks.¬†Polymer, 44, 6495-6504.
  • P√™go, A.P., Luyn, M.J.A. van, Brouwer, L.A., Wachem, P.B. van, Poot, A.A. and Grijpma, D.W. (2003). In vivo behavior of poly(1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with D,L-lactide or e-caprolactone: degradation and tissue response. Journal of biomedical materials research, 67A(3), 1044-1054.
  • P√™go, A.P., Zhong, Z., Dijkstra, P.J., Grijpma, D.W. and Feijen, J. (2003). Influence of catalyst and polymerization conditions on the properties of 1,3-trimethylene carbonate and e-caprolactone copolymers.¬†Macromolecular chemistry and physics, 204(5-6), 747-754.
  • P√™go, A.P., Poot, A.A., Grijpma, D.W. and Feijen, J. (2003). Physical properties of high molecular weight 1,3-trimethylene carbonate and D,Llactide copolymers.¬†Journal of materials science. Materials in medicine, 14, 767-773.
  • P√™go, A.P., Siebum, B., Luyn, M.J.A. van, Gallego y Van Seijen, X.J., Poot, A.A., Grijpma, D.W. and Feijen, J. (2003). Preparation of degradable porous structures based on 1,3-trimethylene carbonate and D,Llactide (co)polymers for heart tissue engineering.¬†Tissue engineering, 9(5), 981-994.
  • Signori, F., Solaro, R., Chiellini, E., Lips, P.A.M., Dijkstra, P.J. and Feijen, J. (2003). Multifunctional polyesters as new candidate materials for biomedical applications. Synthesis and structural characterization.¬†Macromolecular symposia, 197, 289-301.
  • Signori, F., Solaro, R., Chiellini, E., Lips, P.A.M., Dijkstra, P.J. and Feijen, J. (2003). Synthesis and characterization of segmented poly(ether ester)s containing H bonding units.¬†Macromolecular chemistry and physics, 204(16), 1971-1981.
  • Signori, F., Fiumi, C, Bizzarri, R., Chiellini, E., Solaro, R. and Chiellini, F. (2003). Nanospheres from amphiphilic graft copolymers for targeted protein release.¬†Proceedings of the Seventh European Symposium on Controlled Drug Delivery. Vol. 87. Journal of controlled release (pp. 246-250).
  • Westerhausen, M., Schneiderbauer, S., Kneifel, A.N., S√∂ltl, Y., Mayer, P., N√∂th, H., Zhong, Z., Dijkstra, P.J. and Feijen, J. (2003). Organocalcium compounds with catalytic activity for the ring-opening polymerization of lactones.¬†European journal of inorganic chemistry, 18, 3432-3439.
  • Zhong, Z., Dijkstra, P.J. and Feijen, J. (2003). Controlled and stereoselective polymerization of lactide: kinetics, selectivity and microstructures.¬†Journal of the American Chemical Society, 125, 11291-11298.
  • Zhong, Z., Dijkstra, P.J. and Feijen, J. (2003). Determination of the stereoselectivity factor for an asymmetric enantiomerdifferentiating polymerization: a revisit. Macromolecules, 36, 8198-8200.
  • Zhong, Z., Schneiderbauer, S., Dijkstra, P.J., Westerhausen, M. and Feijen, J. (2003). Single-site calcium initiators for the controlled ringopening polymerization of lactides and lactones.¬†Polymer bulletin, 51, 175-182.
  • Zijpp, Y.J.T. van der, Poot, A.A. and Feijen, J. (2003). ICAM-1 and VCAM-1 expression by endothelial cells grown on fibronectin-coated TCPS and PS.¬†Journal of biomedical materials research, 65A(1), 51-59.
  • Zuiderduin, W.C.J., Homminga, D.S., Huetink, J. and Gaymans, R.J. (2003). Influence of molecular weight on the fracture properties of aliphatic polyketone terpolymers.¬†Polymer, 44, 6361-6370.
  • Zuiderduin, W.C.J., Westzaan, C., Huetink, J. and Gaymans, R.J. (2003). Thoughening of polypropylene with calcium carbonate particles.¬†Polymer, 44, 261-275.
  • Zweers, M.L.T., Grijpma, D.W., Engbers, G.H.M. and Feijen, J. (2003). The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size.¬†Journal of biomedical materials research, 66B(2), 559-566.
  • Zweers, M.L.T., Grijpma, D.W., Engbers, G.H.M. and Feijen, J. (2003). Biodegradable nanoparticles for local drug delivery. In Feijen, J. Prof.dr. and Sam, A.P. Dr. (Ed.),¬†Proceedings of the Seventh European Symposium on Controlled Drug Delivery. Vol. 87.Journal of controlled release (pp.252-254).

DISSERTATIONS

2010

  • Mark ten Breteler (2010, June 10) Stereoselective Polymerization of Lactones. Properties of Stereocomplexed PLA Building Blocks. University of Twente Promotor: Prof.dr. J. Feijen; Assistent-promotor: dr. P.J. Dijkstra ISBN 978-90-365-3045-3
  • Erhan Bat (2010, May 28) Elastomeric networks based on trimethylene carbonate polymers for biomedical applications University of Twente Promotor: Prof.dr. J. Feijen and Prof.dr.D.W. Grijpma ISBN 978-90-365-3039-2
  • Ferry Melchels (2010, May 21) Preparation of advanced porous structures by stereolithography for application in tissue engineering University of Twente Promotor: Prof.dr. J. Feijen and Prof.dr.D.W. Grijpma ISBN 978-90-365-3019-4
  • Andries van der Meer (2010, March 10) Microfluidic¬†technology in vascular research: The endothelial responce to shear stress¬†University of Twente Promotor: Prof.dr. I. Vermes and Prof.dr. J. Feijen; Assistent-promotor: dr. A.A. Poot ISBN 978-90-365-2978-5

2009

  • Rong Jin (2009, December 18)¬†Injectable hydrogels for cartilage tissue engineering¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistent-promotores: dr. P.J. Dijkstra and dr. M. Karperien ISBN 978-90-365-2920-4
  • Yan Song (2009, November 6)¬†Porous tubular poly(trimethylene carbonate) scaffolds for vascular tissue engineering¬†University of Twente Promotor: Prof.dr. J. Feijen and prof.dr. D.W. Grijpma; Assistent-promotores: dr. A.A. Poot ISBN 978-90-365-2825-2
  • Hongzhi Du (2009, September 3)¬†Single-site salen and salan aluminium complexes for the stereoselective polymerization of lactides¬†University of Twente Promotor: Prof.dr. J. Feijen and prof.dr. X. Chen; Assistent-promotores: dr. P.J. Dijkstra ISBN 978-90-365-2862-7

2008

  • Ir. E.H.A. Nijhuis (2008, September 19) ¬†Hyperthermia-induced apoptosis¬†University of Twente Promotor: Prof.dr. I. Vermes and Prof.dr. J. Feijen; Assistent-promotor: dr. A.A. Poot ISBN 978-90-365-2707-1
  • Chao Lin (2008, April 25) ¬†Bioreducible polycamido amines for non-viral gene delivery¬†University of Twente Promotor: Prof.dr. J.F.J. Engbersen and Prof.dr. J. Feijen; Assistent-promotor: Prof.dr. Z. Zhong ISBN 978-90-365-2651-7
  • Mw. Ir. I.W. Velthoen (2008, April 11)¬†Thermo-responsive hydrogels based on branched block copolymers¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistent-promotor: dr. P.J. Dijkstra ISBN 978-90-365-2646-3
  • Mw. L. Yang (2008, February 15)¬†Mechanical properties of collagen fibrils and elastic fibers explored by AFM. University of Twente Promotor: Prof.dr. J. Feijen; Assistent-promotor: dr. P.J. Dijkstra and dr.ir. M.L. Bennink ISBN 978-90-365-2623-4

2007

  • Everaerts, F.J.L. (2007, October 19)¬†A novel approach in cross-linking of bioprosthetic heart valves¬†University of Twente Promotor: Prof.dr. J. Feijen ISBN 978-90-365-2536-7
  • Hiemstra, C. (2007, June 1)¬†In situ forming biodegradable hydrogels and their application for protein delivery¬†University of Twente Promotor: Prof.dr. J. Feijen. Copromotor: Prof.dr. Z. Zhong ISBN 978-90-9021890-8
  • Siebum, B. (2007, May 11)¬†Heparinized crosslinked collagen structures for hematopoietic stem cell expansion and differentiation¬†University of Twente Promoter: Prof.dr. J. Feijen; Assistent-promotor: dr. A.A. Poot; Referent: Prof.dr. D.W. Grijpma and dr.R. Torensma ISBN 978-90-365-2505-3
  • Tan, B.-H. (2007, January 25) ¬†Linoleic acid functionalized amphiphilic block copolumers application in waterborne coatings.¬†University of Twente Promoter: Prof.dr. J. Feijen and Prof.dr. D.W. Grijpma ISBN 978-90-365-2463-6

2006

  • Husken, D. (2006, December 7)¬†Hydrophilic segmented block copolymers based on poly(ethylene oxide)¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistent-promotor: dr. R.J. Gaymans ¬†ISBN 90-365-2438-5
  • Zhang, Z. (2006, January 20) ¬†Biodegradable block copolymers based on trimethylene carbonate, lactides, and poly(ethylene glycol)¬†University of Twente Promotor: Prof.dr. J. Feijen, Prof.dr. D.W. Grijpma ISBN 90-365-2299-4
  • Biemond, G.J.E. (2006, February 16) ¬†Hydrogen bonding in segmented block copolymers¬†University of Twente Promotor: Prof.dr. J.Feijen; Assistant promotor: Dr. R.J. Gaymans¬†ISBN 90-365-2301-X

2005

  • Buttafoco, L. (February 18, 2005)¬†Collagen-based scaffolds for tissue engineering of small-diameter blood vessels¬†University of Twente Promotor: Prof.dr. J. Feijen, Prof.dr. I. Vermes; Assistant promotor: Dr. A.A. Poot ISBN: 90-365-2135-1
  • Engbers-Buijtenhuijs, P. (April 1, 2005)¬†Biological characterization of tissue-engineered vascular grafts¬†University of Twente Promotors: Prof.dr. I. Vermes, Prof.dr. J. Feijen; Assistant promotor: Dr. A.A. Poot ISBN: 90-365-2163-7
  • Lips, P.A.M. (January 28, 2005)¬†Aliphatic segmented poly(ester amide)s based on symmetrical bisamide-diols¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. P.J. Dijkstra ISBN: 90-365-2129-7

2004

  • Claase, M.B. (February 13, 2004).¬†Cell-seeded scaffold based on poly(ethylene oxide) and poly(butylene terephthalate) block copolymers for one tissue engineering ¬†University of Twente Promotor: Prof.Dr. J. Feijen. Copromotor: Dr. D.W. Grijpma. ¬†ISBN 90-365-2000-2
  • Rijt, J.A.J. van der (October 13, 2004). ¬†Micromechanical testing of single collagen type I fibrils University of Twente Promotor: Prof.Dr. J. Feijen; Copromotor: Dr. M.L. Bennink. ISBN 90-365-2082-7
  • Schuur, J.M. van der (February 6, 2004).¬†Poly(propylene oxide) based segmented blockcopolymers¬†University of Twente Promotor: Prof.dr. J. Feijen; Copromotor: Dr. R.J. Gaymans ISBN 90-365-2012-6

2003

  • Meng, F. (2003, September 10)¬†Artificial cells based on biodegradable polymersomes¬†University of Twente Promotor: Prof.dr. J. Feijen ISBN 90-365-19497
  • Zijpp, Y.J.T. van der (2003, January 10) Expression of leukocyte adhesion molecules by endothelial cells cultured on polymer surfaces¬†University of Twente Promotor: Prof.Dr. J. Feijen; Assistant promotor: Dr. A.A. Poot; Referent: Dr. G.H.M. Engbers ISBN 90-365-1761-3
  • Zweers, M.L.T. (2003, January 31)¬†Biodegradable nanoparticles for intravascular drug delivery¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. G.H.M. Engbers; Referent: Dr. D.W. Grijpma ISBN 90-365-1849-0

2002

  • Deschamps, A.A. (2002, November 13)¬†Segmented poly(ether ester)s and poly(ether ester amide)s for use in tissue engineering¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. D.W. Grijpma ISBN 90-365-182-7
  • Krijgsman, J. J. (2002, November 1)¬†Engineering polymers with uniform crystallisable units. Segmented copolymers based on poly (2,6-dimethyl-1,4-phenylene ether)¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. R.J. Gaymans ISBN 90-365-1812-1
  • P√™go, A.P. (2002, November 27)¬†Biodegradable polymers based on trimethylene carbonate for tissue engineering applications¬†University of Twente¬†Promotor: Prof.dr. J. Feijen, Prof.Dr. E. Marani; Assistant promotor: Dr. D.W. Grijpma ISBN 90-365-1831-8
  • Zhong, Z. (2002, November 15)¬†Novel calcium & aluminum-based initiators for the controlled ringopening polymerization of lactides and lactones¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. P.J. Dijkstra ISBN 90-365-1829-6

2001

  • Olde Riekerink, M.B. (2001, September 21)¬†Structural and chemical modification of polymer surfaces by gas plasma etching¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr.ir. G.H.M. Engbers, Dr.ir. J.G.A. Terlingen ISBN 90 365 1643 9.

2000

  • Groenewoud, L.M.H. (2000, November 10).¬†Transparent and conductive polymer layers by gas plasma techniques¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr.ir. G.H.M. Engbers Referent: Dr.ir. J.G.A. Terlingen ISBN 90-365-1516-5.
  • Niesten, M.C.E.J. (2000, June 30).¬†Polyether based segmented copolymers with uniform aramid unit.¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. R.J. Gaymans¬†ISBN 90-365-1144-1.
  • Topp, M.D.C. (2000, April 28).¬†Temperature sensitive micelles based on block copolymers of ethylene glycol and Nisopropylacrylamide¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. P.J. Dijkstra ISBN 90-365-1443-6.

1999

  • Bezemer, J.M. (1999, October 10)¬†Protein release systems based on biodegradable amphiphilic multiblock copolymers¬†University of Twente Promotor: Prof.dr. C.A. van Blitterswijk, Prof.dr. J. Feijen; Assistant promotor: Dr. D.W. Grijpma ISBN 90-365-1352-1
  • Kuijpers, A.J. (1999, October 29) ¬†Gelatin-chondroitin sulphate hydrogels for controlled release of antibacterial proteins¬†University of Twente Promotor: Prof.dr. J. Dankert, Prof.dr. J. Feijen; assistent promotor: Dr.ir. G.H.M. Engbers ISBN 90-365-1358-8
  • Bouma, K. (1999, June 11)¬†Polyesteramides based on PET¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistent promotor: Dr R.J. Gaymans ISBN 90-365-1285-9
  • Wissink, M.J.B. (1999, June 18)¬†Endothelialization of collagen matrices. Effects of crosslinking, heparin immobilization and bFGF loading¬†University of Twente Promotor: Prof.dr. J. Feijen, Prof.dr. W.G. van Aken Assistent promotor: Dr. A.A. Poot; Referent: Dr.ir. G.H.M. Engbers¬†ISBN 90-365-1315-4
  • Krijgsveld, J. (1999, November)¬†Thrombocidins, microbicidal proteins of human blood platelets¬†University of Amsterdam Promotor: Prof.dr. J. Dankert and Prof.dr. J. Feijen; Copromotor: dr. S.A.J. Zaat ISBN 90-9013214-7
  • Schrooyen, P. (1999, april 23) ¬†Feather keratins : modification and film formation¬†University of Twente promotor: Prof.dr. A. Bantjes, Prof.dr. J. Feijen; assistent promotor: dr. P.J. Dijkstra¬†ISBN 90-365-1302-2

1998

  • Zeeman, R. (1998, November 6)¬†Cross-linking of collagen-based materials University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. P.J. Dijkstra ISBN 90-365-1207-7
  • Bos, G.W. (1998, August 21)¬†Albumin-heparin matrices loaded with growth factor as substrates for endothelial cell seeding¬†University of Twente promotors: Prof.dr. J. Feijen, Prof.dr. W.G. van Aken; Assistent promotor: Dr. A.A. Poot ISBN 90-365-1166-6
  • Klomp, A.J.A. (1998 October 2)¬†Design of surface modified poly(ethylene terephthalate) non-wovens for the removal of leukocytes from platelet concentrates¬†University of Twente promotor: Prof.dr. J. Feijen; Assisstent promotor: Dr.ir. G.H.M. Engbers. ISBN 90-9011921-3
  • Stapert, H.R. (1998, September)¬†Environmentally degradable polyesters, poly(ester-amide)s and poly(ester-urethane)s¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: dr. P.J. Dijkstra ISBN 90-365-1189-5

1997

  • Takens, G.A.J. (1997, January 9) ¬†Functionalization of polymeric surfaces by oxidative gas plasma treatment ¬†University of Twente Promotor: Prof.dr. J. Feijen; Assisstent promotor: Dr.ir. J.G.A. Terlingen ISBN 90-9010168-3
  • Zee, M. Van der (1997, May 23) ¬†Structure-biodegradability relationships of polymeric materials ¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistent promotor: Dr.ir. H. Feil ISBN 90-365-0958-0
  • Stevels, W.M (1997, January 31) ¬†Ring-opening polymerization of lactones by yttrium alkoxides¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistent promotor: dr. P.J. Dijkstra ISBN 90-9010230-2
  • Walle, G.A.M. van der (1997, October 10)¬†Erosion behavior of poly(triorganotin methacrylate)s and polyanhydrides¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistent promotor: Dr. P.J. Dijkstra ISBN 90-365-9574-6

1996

  • Lens, J-P. (1996, December 5)¬†Gas plasma immobilization of surfactants to improve the blood compatibility of polymeric surfaces¬†University of Twente Promotor: Prof.dr. J. Feijen; Assisstent promotor: Dr.ir. J.G.A. Terlingen. ¬†ISBN 90-9009984-0
  • Serrano, P.J. M. (1996, February)¬†Alternating polyesteramides based on 1,4-butylene terephthalamide¬†University of Twente Promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. R.J. Gaymans ISBN 90-9008136-4

1995

  • Kamp, K.W.H.J. van der (1995, May )¬†The interactions of blood with polymeric materials : design of novel in vitro tests and in vivo evaluation of heparinized polymeric materials ¬†University of Groningen promotor: Prof.dr. Lie, Prof.dr. J. Feijen; ref. Rakhorst/van everen. ISBN 90-9007408-2
  • Delden, C.J. van (1995, November 10) ¬†On the anticoagulant activity of heparinized surfaces : the influence of heparin immobilization and protein adsorption ¬†University of Twente Promotor: Prof.dr. J. Feijen; Assisstent promotor: Dr.ir. G.H.M. Engbers ISBN 90-9008664-1
  • Bennekom, A.C.M. van (1995, April 7)¬†Fast crystallizing polyesteramides ¬†University of Twente Promotor: Prof.dr. J. Bussink; Co-promotor: Prof.dr. J. Feijen; Assistant promotor: Dr. R.J. Gaymans ISBN 90-9008080-5
  • Starmans, D.A.J. (1995 March 9)¬†Glycosylated heparin as a reporter molecule for affinity-based glucose sensors¬†University of Twente Promotor: Prof.dr. J. Feijen; Assisstent promotor: Dr.ir. G.H.M. Engbers. ISBN 90-9008088-0

1994

  • Feil, dr.ir. H. ( 1994, January 14) Thermosensitive polymers and hydrogels based on N-isopropylacrylamide University of Twente Promotor: Prof.dr. J. Feijen, Prof.dr. S.W. Kim ISBN 90-9006781-7
  • Witte, P. van de (1994, December 16)¬†Polylactide membranes : correlation between phase transitions and morphology¬†University of Twente Promotor: Prof.dr. J. Feijen; Assisstent promotor: dr. J.W.A. van de Berg ISBN 90-9007685-9

1993

  • Terlingen, J.G.A. (1993, January 8)¬†Introduction of functional groups at polymer surfaces by glow discharge techniques.¬†University of TwentePromotors: Prof.dr. J. Feijen and Prof.dr. A.S. Hoffman¬†ISBN 90-9005620-3
  • Bruil, A. (1993, January 22)¬†Leukocyte filters : filtration mechanisms and material design ¬†University of Twente Promotors: Prof.dr. J. Feijen and Prof.dr. P. van Aken: ref. dr. T. Beugeling ISBN 90-9005620-3
  • Olde Damink, L.H.H. (1993, April ¬†Structure and properties of crosslinked dermal sheep collagen¬†University of TwentePromotors: Prof.dr. J. Feijen and Prof.dr. P. Nieuwenhuis; Ass.prom. dr. P.J. Dijkstra ISBN 90-9005924-5
  • Cremers, H.F.M.C. (1993, March 12)¬†Biodegradable ion-exchange microspheres for site-specific delivery of adriamycin¬†University of Twente Promotor: Prof.dr. J. Feijen ISBN 90-9005941-5

1992

  • Luyn, M.J.A. van (1992, June 17)Cytotoxicity testing of biomaterials using methylcellulose cell culture : in vitro studies with in vivo ¬†Verification using dermal sheep collagen¬†University of Groningen Promotors: Prof.dr. P. Nieuwenhuis and Prof.dr. J. Feijen; Referent: dr. P.B. van Wachem ISBN 90-9005113-9
  • Hinrichs, W.L.J. (1992, October 15)¬†Porous polymer structures for tissue regeneration¬†University of Twente Promotors: Prof.dr. J. Feijen and Prof.dr. Ch.R.H. Wildevuur ISBN 90-9005418-9
  • Veld, P.J.A. in‚Äôt (1992, May 1)¬†Biodegradable polyesteramides¬†University of Twente Promotor: Prof.dr. J. Feijen; assistent promotor: Dr. P.J. Dijkstra ISBN 90-9005008-6
  • Esselbrugge, H. (1992, October 2)¬†Biodegradable hollow fibres for controlled drug delivery¬†University of Twente Promotor: Prof.dr. J. Feijen ISBN 90-9005409-X

1991

  • Harkes, G. (1991, November 1)¬†Interaction of Escherichia coli with solid surfaces; adhesion, growth and migration¬†University of Twente Promotor: Prof.dr. J. Feijen, Prof.dr. J. Dankert.

1990

  • Engbers, G.H.M. (1990, June 28)¬†Development of heparinized materials with an improved blood compatibility¬†University of Twente ¬†Promotor: Prof.dr. J. Feijen ISBN 90-9003564-8
  • Damme van, H.S. (1990, October 11)¬†Protein adsorption at solid-liquid interfaces : influence of surface structure, hydrophobicity and charge¬†University of Twente Promotor: Prof.dr. J. Feijen; assistent promotor: dr. T. Beugling ISBN: 90-9003722-5
  • Pratt-Terpstra, J.H. (1990, August)¬†Salivary protein adsorption and oral streptococcal adhesion ¬†University of Groningen Promotor: Prof.dr. Arends, Prof.dr. J. Feijen; referent: Busscher/Weerkamp

1989

  • Vulińá, I. (1989, October 12)¬†Heparin containing block copolymers : synthesis, characterization and blood compatibility¬†University of Twente ¬†Promotor: Prof.dr. J. Feijen ISBN 90-9002988-5

1988

  • ¬†Helder, J. (1988, September 15)¬†Polydepsipeptides: copolymers of a-amino acids and a-hydroxy acids¬†University of Twente Promotor: Prof.dr. J. Feijen; Referent: dr. P.J. Dijkstra ISBN 90-9002383-6

1987

  • Eenink, M.J.D. (1987, February 6) ¬†Synthesis of biodegradable polymers and development of biodegradable hollow fibres for the controlled release of drugs¬†University of Twente Promotor: Prof.dr. J. Feijen; Referent: dr. T. Beugeling.
  • Wachem van, P.B. (1987, Februari 20) ¬†Interactions of cultured human endothelial cells with polymeric surfaces¬†University of Twente Promotors: Prof.dr. P. van Aken, Prof.dr. J. Feijen and Prof.dr. A. Bantjes; ¬†Assistent promotor: Dr. T. Beugeling; Referent: Dr. J.A. van Mourik

1985

  • Lensen, H.G. W. (1985, March 22) ¬†Concurrerende adsorptie van plasma eiwitten aan vast/vloeistof grensvlakken.¬†University of Twente Promotor: Prof.dr. C.A. Smolders; Prof.dr. J. Feijen and prof.dr.ir. P. Bergveld; ¬†Assistent promotor: dr. D. Bargeman
  • Hennink, W.E. (1985, March 8)¬†Albumin-heparin conjugate as a coating for biomaterials.¬†University of Twente Promotors: Prof.dr. J. Feijen and Prof.dr. S.W. Kim
  • Hogt, A.H. (1985, August 30)¬†Adhesion of coagulase-negative staphylococci onto biomaterials¬†University of Twente Promotor: Prof.dr. J. Feijen; Advisor: Drs. J. Dankert

1984

  • Rinsum van, A.C. (1984, August)¬†Diameters of normal and pathological aortic bifurcations and the development of atherosclerosis.¬†University of Groningen¬†Promotor: prof.dr. Kuijer; Copromotor: Prof.dr. A. Bantjes, Prof.dr. J. Feijen
  • Kohn, F.E. (1984, March 30)¬†Development of biodegradable polymers for application in myringoplasty.¬†University of Twente Promotor: Prof.dr. J. Feijen, Prof.dr. L. Feenstra.

1982

  • Olijslager, J. (1982, February 5)¬†The developmnet of test devices for the studt of blood material interactions¬†University of TwentePromotor: Prof.dr. J. Feijen; Copromotor: Prof.Dr. Ch.R.H. Wildevuur; ¬†Coreferent: dr. T. Beugeling
  • Bottema, J.R. (1982, December 15)¬†The microporous tracheal prosthesis.¬†University of Groningen Promotor: Prof.Dr. Ch.R.H. Wildevuur; co-promotor: Prof.dr. J. Feijen, Prof.dr. I. Molenaar

1980

  • Tijssen, J. (1980, October 31)¬†A hemoperfusion column based on coated activated carbon.University of Twente¬†Promotor: Prof.dr. A. Bantjes, Prof.dr. J. Feijen

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