prof.dr. J. Hofmeijer (Jeannette)

General information

Jeannette Hofmeijer studied Medicine and Philosophy at Radboud University Nijmegen. She received her master’s degree in Medicine cum laude in 1998. She was trained as a neurologist and as intensive care physician at University Medical Center Utrecht. Meanwhile, she obtained a PhD at the Biomedical MR Imaging and Spectroscopy Group of Utrecht University on the topic of edema formation in cerebral ischemia (2007). Since 2008, she combines her work as a vascular neurologist in Rijnstate Hospital (Arnhem) with a research and teaching position at University of Twente. She was appointed professor of Translational Neurophysiology in 2019.

Research interests

Hofmeijer studies the effects of ischemia on the brain. Cerebral ischemia is of particular interest in patients with brain infarction or after cardiac arrest. These conditions are leading causes of disability, worldwide. Apart from acute reperfusion therapies, effective treatments to promote cerebral recovery are unavailable.

Hofmeijer exploits her dual position at hospital and UT to combine clinical with fundamental research on cerebral ischemia. She believes that the combination of systematic observation in patients and targeted experimentation holds strong potential to provide new, clinically relevant, pathophysiological insights, that assist in the development of novel diagnostics or treatments. For example, by combining clinical EEG registrations and experimental in vitro studies, her research group positioned synaptic failure as a key pathological mechanisms after cardiac arrest and brain infarction. Neuronal stimulation effectively improved neuronal recovery under experimental in vitro conditions and is currently investigated in phase 2 and 3 clinical trials in comatose patients after cardiac arrest.

Hofmeijer established the Dutch-Belgian TELSTAR consortium and is principle investigator of various state of the art multicenter clinical trials to test new treatments and diagnostics in comatose patients after cardiac arrest (amongst other www.telstartrial.nl, www.grecotrial.nl). Her research is supported by grants from ZonMW, NWO, Hartstichting, and Hersenstichting. She sits on national guideline committees for treatment of ischemic stroke and coma after cardiac arrest and chairs the jury of the two-yearly science award of the Netherlands Neurovascular Society.

Medicine & Life Sciences

# Coma
# Computed Tomography Angiography
# Electroencephalography
# Heart Arrest
# Registries
# Stroke
# Therapeutics
# Thrombectomy

Faculty of Science and Technology (TNW), Clinical Neurophysiology (CNPH)

Rijnstate Hospital
medical doctor

Collaboration of Controlled Randomised Trials of Long-Term Oral Antithrombotic Agents After Spontaneous Intracranial Haemorrhage (COCROACH) (2023). Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials. The Lancet Neurology, 22(12), 1140-1149. https://doi.org/10.1016/S1474-4422(23)00315-0

Stuiver, S. , Pottkämper, J. C. M. , Verdijk, J. P. A. J., ten Doesschate, F., Aalbregt, E. , van Putten, M. J. A. M. , Hofmeijer, J., & van Waarde, J. A. (2023). Cortical excitation/inhibition ratios in patients with major depression treated with electroconvulsive therapy: an EEG analysis. European Archives of Psychiatry and Clinical Neuroscience. Advance online publication. https://doi.org/10.1007/s00406-023-01708-5

IRIS collaborators (2023). Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials. The Lancet, 402(10406), 965-974. https://doi.org/10.1016/S0140-6736(23)01142-X

Horn, J., Admiraal, M. , & Hofmeijer, J. (2023). Diagnosis and management of seizures and myoclonus after cardiac arrest. European Heart Journal: Acute Cardiovascular Care, 12(8), 525-531. Advance online publication. https://doi.org/10.1093/ehjacc/zuad086

Van Linschoten, R. C. A., Amini, M., Van Leeuwen, N., Eijkenaar, F., Den Hartog, S. J., Nederkoorn, P. J. , Hofmeijer, J., Emmer, B. J., Postma, A. A., Van Zwam, W., Roozenbeek, B., Dippel, D., & Lingsma, H. F. (2023). Handling missing values in the analysis of between-hospital differences in ordinal and dichotomous outcomes: A simulation study. BMJ quality and safety, Article 016387. Advance online publication. https://doi.org/10.1136/bmjqs-2023-016387

Hofmeijer, J., Ham, F., & Kwakkel, G. (2023). Evidence of rTMS for Motor or Cognitive Stroke Recovery: Hype or Hope? Stroke, 54(10), 2500-2511. Advance online publication. https://doi.org/10.1161/STROKEAHA.123.043159

Cliteur, M. P., van der Kolk, A. G., Hannink, G. , Hofmeijer, J., Jolink, W. M. T. , Klijn, C. J. M. , & Schreuder, F. H. B. M. (2023). Anakinra in cerebral haemorrhage to target secondary injury resulting from neuroinflammation (ACTION): Study protocol of a phase II randomised clinical trial. European stroke journal. Advance online publication. https://doi.org/10.1177/23969873231200686

Amorim, E., Zheng, W. L., Jing, J., Ghassemi, M. M., Lee, J. W., Wu, O., Herman, S. T., Pang, T., Sivaraju, A., Gaspard, N., Hirsch, L. , Ruijter, B. J. , Tjepkema-Cloostermans, M. C. , Hofmeijer, J. , van Putten, M. J. A. M., & Westover, M. B. (2023). Neurophysiology State Dynamics Underlying Acute Neurologic Recovery After Cardiac Arrest. Neurology, 101(9), e940-e952. https://doi.org/10.1212/WNL.0000000000207537

Hund, H. M., Boodt, N., Hansen, D., Haffmans, W. A., Lycklama à Nijeholt, G. J. , Hofmeijer, J., Dippel, D. W. J., van der Lugt, A., van Es, A. C. G. M., van Beusekom, H. M. M., & on behalf of the MR CLEAN Registry Investigators (2023). Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank. Neuroradiology, 65(5), 933-943. Advance online publication. https://doi.org/10.1007/s00234-023-03115-y

Glimmerveen, A. , Verhulst, M., Verbunt, J., van Heugten, C. , & Hofmeijer, J. (2023). Predicting long-term cognitive impairments in survivors after cardiac arrest: A systematic review. Journal of rehabilitation medicine, 55, Article jrm00368. https://doi.org/10.2340/jrm.v55.3497

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