Technohal

prof.dr. J. Hofmeijer (Jeannette)

Full Professor
TNW-BIS-CNPH
Technohal 3381
j.hofmeijer@utwente.nl
+31534894835
Business card

General information

Jeannette Hofmeijer studied Medicine and Philosophy at Radboud University Nijmegen. She received her masterā€™s degree in Medicine cum laude in 1998. She was trained as a neurologist and as intensive care physician at University Medical Center Utrecht. Meanwhile, she obtained a PhD at the Biomedical MR Imaging and Spectroscopy Group of Utrecht University on the topic of edema formation in cerebral ischemia (2007). Since 2008, she combines her work as a vascular neurologist in Rijnstate Hospital (Arnhem) with a research and teaching position at University of Twente. She was appointed professor of Translational Neurophysiology in 2019.

Research interests

Hofmeijer studies the effects of ischemia on the brain. Cerebral ischemia is of particular interest in patients with brain infarction or after cardiac arrest. These conditions are leading causes of disability, worldwide. Apart from acute reperfusion therapies, effective treatments to promote cerebral recovery are unavailable.

Hofmeijer exploits her dual position at hospital and UT to combine clinical with fundamental research on cerebral ischemia. She believes that the combination of systematic observation in patients and targeted experimentation holds strong potential to provide new, clinically relevant, pathophysiological insights, that assist in the development of novel diagnostics or treatments. For example, by combining clinical EEG registrations and experimental in vitro studies, her research group positioned synaptic failure as a key pathological mechanisms after cardiac arrest and brain infarction. Neuronal stimulation effectively improved neuronal recovery under experimental in vitro conditions and is currently investigated in phase 2 and 3 clinical trials in comatose patients after cardiac arrest.

Hofmeijer established the Dutch-Belgian TELSTAR consortium and is principle investigator of various state of the art multicenter clinical trials to test new treatments and diagnostics in comatose patients after cardiac arrest (amongst other www.telstartrial.nl, www.grecotrial.nl). Her research is supported by grants from ZonMW, NWO, Hartstichting, and Hersenstichting. She sits on national guideline committees for treatment of ischemic stroke and coma after cardiac arrest and chairs the jury of the two-yearly science award of the Netherlands Neurovascular Society.

Expertise

  • Medicine and Dentistry

    • Patient
    • Therapeutic Procedure
    • Heart Arrest
    • Apoplexy
    • Brain Ischemia
    • Inpatient

  • Neuroscience

    • Ischemic Stroke
    • Stroke

Organisations

Ancillary activities

  • Rijnstate Hospitalmedical doctor
  • Rijnstate Hospital, Arnhemmedical doctor

Publications

2025

Brain topology and cognitive outcomes after cardiac arrest: A graph theoretical analysis of fMRI data (2025)Neuroimage: Reports, 5(1). Article 100244. Verhulst, M. M. L. H., Lange, P., Tuladhar, A. M., Tewarie, P., van Gils, P. C. W., van Heugten, C., Bonnes, J., Delnoij, T., Helmich, R. & Hofmeijer, J.https://doi.org/10.1016/j.ynirp.2025.100244Effects of hyperglycemia on neuronal network function in an in vitro model of the ischemic penumbra (2025)Brain research, 1849. Article 149370. Kersten, C. J. B. A., Vrielink, T. H., den Hertog, H. M., Hofmeijer, J. & le Feber, J.https://doi.org/10.1016/j.brainres.2024.149370Cerebral Ischemia-on-a-Chip: Investigating Neuronal Responses to Hypoxia and Treatment (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Voogd, E.https://doi.org/10.3990/1.9789036564762Ghrelin for neuroprotection in post-cardiac arrest coma: a 1-year follow-up of cognitive and psychosocial outcomes (2025)European Heart Journal: Acute Cardiovascular Care, 14(1), 5-11. Van Gils, P., Nutma, S., Meeske, K., van Heugten, C., van den Bergh, W., Foudraine, N., le Feber, J., Filius, M., van Putten, M., Beishuizen, B. & Hofmeijer, J.https://doi.org/10.1093/ehjacc/zuae119

2024

Multimodal Deep Learning for Functional Outcome Prediction in Endovascular Therapy (2024)In Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries - 9th International Workshop, BrainLes 2023, and 3rd International Workshop, SWITCH 2023, Held in Conjunction with MICCAI 2023, Revised Selected Papers (pp. 144-153) (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 14668 LNCS). Springer. te Nijenhuis, F., Su, R., van Doormaal, P. J., Hofmeijer, J., Martens, J., van Zwam, W., van der Lugt, A. & van Walsum, T.https://doi.org/10.1007/978-3-031-76160-7_14Sex differences in outcomes after endovascular treatment in posterior circulation stroke: results from the MR CLEAN Registry (2024)Journal of NeuroInterventional Surgery, 17(e1), e74-e82. Article jnis-2023-021086. Ali, M., Dekker, L., Ali, M., Van Zwet, E. W., Hofmeijer, J., Nederkoorn, P. J., Majoie, C. B. L. M., van Es, A. C. G. M., Uyttenboogaart, M., van der Meij, A., van Walderveen, M. A. A., Visser, M. C., Dippel, D. W. J., Schonewille, W. J., van den Wijngaard, I. R., Kruyt, N. D. & Wermer, M. J. H.https://doi.org/10.1136/jnis-2023-021086Hypothermia improves neuronal network recovery in a human-derived in vitro model of oxygen-deprivation (2024)PLoS ONE, 19(12). Article e0314913. Voogd, E. J. H. F., Thijs, M., Levers, M. R., Hofmeijer, J. & Frega, M.https://doi.org/10.1371/journal.pone.0314913Evolution of glucose levels in patients with anterior circulation acute ischemic stroke treated with endovascular therapy using continuous glucose monitoring (2024)Journal of Stroke and Cerebrovascular Diseases, 33(12). Article 108103. Kersten, C. J. B. A., Zandbergen, A. A. M., Fokkert, M. J., Slingerland, R. J., Knottnerus, I. L. H., van der Molen, M., Wijlens, M. L. B., Hofmeijer, J. & den Hertog, H. M.https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.108103Functional connectivity in restingā€state networks relates to shortā€term global cognitive functioning in cardiac arrest survivors (2024)Human brain mapping, 45(15). Article e26769. Verhulst, M. M. L. H., Keijzer, H. M., van Gils, P. C. W., van Heugten, C. M., Meijer, F. J. A., Tonino, B. A. R., Bonnes, J. L., Delnoij, T. S. R., Hofmeijer, J. & Helmich, R. C.https://doi.org/10.1002/hbm.26769Long term functioning with poor neurologic outcome after cardiac arrest (2024)Resuscitation, 203. Article 110375. Nutma, S., Roesink, O., van Heugten, C. M. & Hofmeijer, J.https://doi.org/10.1016/j.resuscitation.2024.110375

Research profiles

Courses academic year 2024/2025

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2023/2024

Address

University of Twente

Technohal (building no. 18), room 3381
Hallenweg 5
7522 NH Enschede
Netherlands

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