prof.dr. J. Hofmeijer (Jeannette)

General information

Jeannette Hofmeijer studied Medicine and Philosophy at Radboud University Nijmegen. She received her master’s degree in Medicine cum laude in 1998. She was trained as a neurologist and as intensive care physician at University Medical Center Utrecht. Meanwhile, she obtained a PhD at the Biomedical MR Imaging and Spectroscopy Group of Utrecht University on the topic of edema formation in cerebral ischemia (2007). Since 2008, she combines her work as a vascular neurologist in Rijnstate Hospital (Arnhem) with a research and teaching position at University of Twente. She was appointed professor of Translational Neurophysiology in 2019.

Research interests

Hofmeijer studies the effects of ischemia on the brain. Cerebral ischemia is of particular interest in patients with brain infarction or after cardiac arrest. These conditions are leading causes of disability, worldwide. Apart from acute reperfusion therapies, effective treatments to promote cerebral recovery are unavailable.

Hofmeijer exploits her dual position at hospital and UT to combine clinical with fundamental research on cerebral ischemia. She believes that the combination of systematic observation in patients and targeted experimentation holds strong potential to provide new, clinically relevant, pathophysiological insights, that assist in the development of novel diagnostics or treatments. For example, by combining clinical EEG registrations and experimental in vitro studies, her research group positioned synaptic failure as a key pathological mechanisms after cardiac arrest and brain infarction. Neuronal stimulation effectively improved neuronal recovery under experimental in vitro conditions and is currently investigated in phase 2 and 3 clinical trials in comatose patients after cardiac arrest.

Hofmeijer established the Dutch-Belgian TELSTAR consortium and is principle investigator of various state of the art multicenter clinical trials to test new treatments and diagnostics in comatose patients after cardiac arrest (amongst other www.telstartrial.nl, www.grecotrial.nl). Her research is supported by grants from ZonMW, NWO, Hartstichting, and Hersenstichting. She sits on national guideline committees for treatment of ischemic stroke and coma after cardiac arrest and chairs the jury of the two-yearly science award of the Netherlands Neurovascular Society.

Medicine & Life Sciences

# Coma
# Computed Tomography Angiography
# Electroencephalography
# Heart Arrest
# Registries
# Stroke
# Therapeutics
# Thrombectomy

Faculty of Science and Technology (TNW), Clinical Neurophysiology (CNPH)

Rijnstate Hospital
medical doctor
Rijnstate Hospital, Arnhem
medical doctor

van der Meij, A., Holswilder, G. , Bernsen, M. L. E., van Os, H. J. A. , Hofmeijer, J., Spaander, F. H. M., Martens, J. M., van den Wijngaard, I. R., Lingsma, H. F., Konduri, P. R., BLM Majoie, C., Schonewille, W. J., Dippel, D. W. J., Kruyt, N. D., Nederkoorn, P. J., van Walderveen, M. A. A., & Wermer, M. J. H. (2024). Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy. European stroke journal. Advance online publication. https://doi.org/10.1177/23969873241231125

Stuiver, S. , Pottkämper, J. C. M. , Verdijk, J. P. A. J., Ten Doesschate, F. , Van Putten, M. J. A. M. , Hofmeijer, J., & Van Waarde, J. A. (2024). Restoration of postictal cortical activity after electroconvulsive therapy relates to recovery of orientation in person, place and time. European Psychiatry, 67(1), Article e16. https://doi.org/10.1192/j.eurpsy.2024.10

the MR CLEAN Registry Investigators (2024). Sex differences in outcomes after endovascular treatment in posterior circulation stroke: results from the MR CLEAN Registry. Journal of NeuroInterventional Surgery, Article jnis-2023-021086. Advance online publication. https://doi.org/10.1136/jnis-2023-021086

Pottkämper, J. C. M. (2024). The end is just the beginning: Unraveling the postictal state. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036559607

van Til, J. A., Hemels, M. E. W. , & Hofmeijer, J. (2024). Cognitive screening and rehabilitation after cardiac arrest: only a few hurdles to take. Netherlands heart journal, 32, 63-66. https://doi.org/10.1007/s12471-023-01838-4

Reyna, M. A., Amorim, E., Sameni, R., Weigle, J., Elola, A., Rad, A. B., Seyedi, S., Kwon, H., Zheng, W. L., Ghassemi, M. M. , Van Putten, M. J. A. M. , Hofmeijer, J., Gaspard, N., Sivaraju, A., Herman, S. T., Lee, J. W., Westover, M. B., & Clifford, G. D. (2023). Predicting Neurological Recovery from Coma After Cardiac Arrest: The George B. Moody PhysioNet Challenge 2023. In Computing in Cardiology, CinC 2023 (Computing in Cardiology). IEEE.

Voogd, E. J. H. F. , Doorn, N. , Levers, M. R. , Hofmeijer, J. , & Frega, M. (2023). Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells. Journal of neural engineering, 20(6), 1741-2552. Article 066038. https://doi.org/10.1088/1741-2552/ad17f3

Tewarie, P. K. B. , Tjepkema-Cloostermans, M. C., Abeysuriya, R. G. , Hofmeijer, J. , & van Putten, M. J. A. M. (2023). Preservation of thalamocortical circuitry is essential for good recovery after cardiac arrest. PNAS Nexus, 2(5), Article pgad119. https://doi.org/10.1093/pnasnexus/pgad119

Verhulst, M. M. L. H., Visser, I. M., Keijzer, H. M., de Kruijf, N. L. M., Peters, E. J. G., Wilbers, T., Peelen, R. V. , Hofmeijer, J., & Blans, M. J. (2023). Additional predictive value of optic nerve sheath diameter for neurological prognosis after cardiac arrest: a prospective cohort study. The Ultrasound Journal, 15(1), Article 46. Advance online publication. https://doi.org/10.1186/s13089-023-00344-3

Pottkämper, J. C. M. , Verdijk, J. P. A. J., Aalbregt, E. , Stuiver, S., van de Mortel, L. , Norris, D. G. , van Putten, M. J. A. M. , Hofmeijer, J., van Wingen, G. A., & van Waarde, J. A. (2023). Changes in postictal cerebral perfusion are related to the duration of electroconvulsive therapy-induced seizures. Epilepsia. Advance online publication. https://doi.org/10.1111/epi.17831

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