Technohal

prof.dr. J. Hofmeijer (Jeannette)

Full Professor
TNW-BIS-CNPH
Technohal 3381
j.hofmeijer@utwente.nl
+31534894835
Business card

General information

Jeannette Hofmeijer studied Medicine and Philosophy at Radboud University Nijmegen. She received her master’s degree in Medicine cum laude in 1998. She was trained as a neurologist and as intensive care physician at University Medical Center Utrecht. Meanwhile, she obtained a PhD at the Biomedical MR Imaging and Spectroscopy Group of Utrecht University on the topic of edema formation in cerebral ischemia (2007). Since 2008, she combines her work as a vascular neurologist in Rijnstate Hospital (Arnhem) with a research and teaching position at University of Twente. She was appointed professor of Translational Neurophysiology in 2019.

Research interests

Hofmeijer studies the effects of ischemia on the brain. Cerebral ischemia is of particular interest in patients with brain infarction or after cardiac arrest. These conditions are leading causes of disability, worldwide. Apart from acute reperfusion therapies, effective treatments to promote cerebral recovery are unavailable.

Hofmeijer exploits her dual position at hospital and UT to combine clinical with fundamental research on cerebral ischemia. She believes that the combination of systematic observation in patients and targeted experimentation holds strong potential to provide new, clinically relevant, pathophysiological insights, that assist in the development of novel diagnostics or treatments. For example, by combining clinical EEG registrations and experimental in vitro studies, her research group positioned synaptic failure as a key pathological mechanisms after cardiac arrest and brain infarction. Neuronal stimulation effectively improved neuronal recovery under experimental in vitro conditions and is currently investigated in phase 2 and 3 clinical trials in comatose patients after cardiac arrest.

Hofmeijer established the Dutch-Belgian TELSTAR consortium and is principle investigator of various state of the art multicenter clinical trials to test new treatments and diagnostics in comatose patients after cardiac arrest (amongst other www.telstartrial.nl, www.grecotrial.nl). Her research is supported by grants from ZonMW, NWO, Hartstichting, and Hersenstichting. She sits on national guideline committees for treatment of ischemic stroke and coma after cardiac arrest and chairs the jury of the two-yearly science award of the Netherlands Neurovascular Society.

Expertise

  • Medicine and Dentistry

    • Patient
    • Therapeutic Procedure
    • Brain Ischemia
    • Apoplexy
    • Heart Arrest
    • Inpatient

  • Neuroscience

    • Ischemic Stroke
    • Stroke

Organisations

Ancillary activities

  • Rijnstate Hospitalmedical doctor
  • Rijnstate Hospital, Arnhemmedical doctor
  • Rijnstate HospitalMedical Docter

Publications

2025

Does sex matter in neurons’ response to hypoxic stress? (2025)Journal of Stroke & Cerebrovascular Diseases, 34(11). Article 108444. Voogd, E. J. H. F., Levers, M. R., Hofmeijer, J., Frega, M. & van Putten, M. J. A. M.https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108444From Coma to Cognitive Recovery: Predicting Long-term Outcomes after Cardiac Arrest (2025)[Thesis › PhD Thesis - Research external, graduation UT]. University of Twente. Glimmerveen, A. B.https://doi.org/10.3993/1.9789036567466Correction: Features, Outcome, and Treatment of Postanoxic Status Epilepticus: Pooled Analysis of 3 Cohorts (Neurology (2025) 105 4 DOI: 10.1212/WNL.0000000000213913.) (2025)Neurology, 105(8), e214282. De Stefano, P., Hofmeijer, J., Quintard, H., Damien, C., Misirocchi, F., Caroyer, S., Horn, J., Tromp, S., Kornips, B., Hilkman, D., van Mook, W., Hoedemaekers, C., Annoni, F., Legros, B., Seeck, M., van Putten, M. J. A. M. & Gaspard, N.https://doi.org/10.1212/WNL.0000000000214282Arterial collateral status and treatment effect of intravenous alteplase thrombolysis prior to endovascular treatment in patients with anterior circulation large vessel occlusion: Prespecified analysis of the MR CLEAN-NO IV trial (2025)Journal of NeuroInterventional Surgery, 17(10), 1051-1058. Yang, W., Cavalcante, F., Treurniet, K., Kappelhof, M., Bruggeman, A., Wolff, L., Rinkel, L. A., LeCouffe, N., Jansen, I. G. H., Venkatesh, A., Berkhemer, O. A., van der Hoorn, A., Sprengers, M. E., Emmer, B. J., Coutinho, J., Roos, Y. B. W. E. M., van Zwam, W., van Oostenbrugge, R., Marquering, H. A., … den Hertog, H.https://doi.org/10.1136/jnis-2025-023054Early prediction of long-term cognitive function, emotional distress, and health-related quality of life in cardiac arrest survivors (2025)Resuscitation, 215. Article 110708. Glimmerveen, A. B., Verhulst, M. M. L. H., Delnoij, T., Bonnes, J. L., Keijzer, H. M. & Hofmeijer, J.https://doi.org/10.1016/j.resuscitation.2025.110708The brain beyond heartbeat: Neuroimaging the injured brain after cardiac arrest (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Verhulst, M. M. L. H.https://doi.org/10.3990/1.9789036567305Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR CLEAN Registry Study (2025)Stroke (E-pub ahead of print/First online). Doheim, M. F., Knapen, R. R. M. M., Staals, J., Schonewille, W. J., Dippel, D. W. J., van Es, A. C. G. M., Lingsma, H. F., van der Leij, C., Majoie, C. B., Nogueira, R. G., van Oostenbrugge, R. J., van Zwam, W. H., van der Lugt, A., Roos, Y. B. W. E. M., Boiten, J., Vos, J. A., Jansen, I. G. H., Mulder, M. J. H. L., Goldhoorn, R. J. B., … Voogd, E. J. H. F.https://doi.org/10.1161/STROKEAHA.125.051967Features, Outcome, and Treatment of Postanoxic Status Epilepticus: Pooled Analysis of 3 Cohorts (2025)Neurology, 105(4). Article e213913. De Stefano, P., Hofmeijer, J., Quintard, H., Damien, C., Misirocchi, F., Caroyer, S., Horn, J., Tromp, S., Kornips, B., Hilkman, D., van Mook, W., Hoedemaekers, C., Annoni, F., Legros, B., Seeck, M., Van Putten, M. J. A. M., Gaspard, N., Ruijter, B. J., Keijzer, H. M., … van der Palen, J. A. M.https://doi.org/10.1212/WNL.0000000000213913Outcomes After Thrombectomy for Acute Ischemic Stroke Related to Type of Stent Retriever; a MR CLEAN Registry Study (2025)CardioVascular and Interventional Radiology, 48(8), 1126-1139. Knapen, R. R. M. M., Goldhoorn, R. J. B., Vos, J. A., Emmer, B. J., Uyttenboogaart, M., Hofmeijer, J., Schonewille, W. J., Majoie, C. B., Roos, Y. B. W. E. M., van der Lugt, A., van Dippel, D. W. J., Lingsma, H. F., van der Leij, C., van Oostenbrugge, R. J., van Zwam, W. H., Pinckaers, F., Olthuis, S. G. H., Deniz, R., van der Ende, N. A. M., … de Vries, J.https://doi.org/10.1007/s00270-025-04048-0Postictal resting-state connectivity changes after electroconvulsive therapy-induced seizures (2025)European Archives of Psychiatry and Clinical Neuroscience (E-pub ahead of print/First online). Pottkämper, J. C. M., Verdijk, J. P. A. J., Stuiver, S., ten Doesschate, F., van Putten, M. J. A. M., Hofmeijer, J., van Waarde, J. A. & van Wingen, G. A.https://doi.org/10.1007/s00406-025-02043-7

Research profiles

Courses academic year 2025/2026

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Courses academic year 2024/2025

Address

University of Twente

Technohal (building no. 18), room 3381
Hallenweg 5
7522 NH Enschede
Netherlands

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