General information

Jeannette Hofmeijer studied Medicine and Philosophy at Radboud University Nijmegen. She received her master’s degree in Medicine cum laude in 1998. She was trained as a neurologist and as intensive care physician at University Medical Center Utrecht. Meanwhile, she obtained a PhD at the Biomedical MR Imaging and Spectroscopy Group of Utrecht University on the topic of edema formation in cerebral ischemia (2007). Since 2008, she combines her work as a vascular neurologist in Rijnstate Hospital (Arnhem) with a research and teaching position at University of Twente. She was appointed professor of Translational Neurophysiology in 2019.

Research interests

Hofmeijer studies the effects of ischemia on the brain. Cerebral ischemia is of particular interest in patients with brain infarction or after cardiac arrest. These conditions are leading causes of disability, worldwide. Apart from acute reperfusion therapies, effective treatments to promote cerebral recovery are unavailable.

Hofmeijer exploits her dual position at hospital and UT to combine clinical with fundamental research on cerebral ischemia. She believes that the combination of systematic observation in patients and targeted experimentation holds strong potential to provide new, clinically relevant, pathophysiological insights, that assist in the development of novel diagnostics or treatments. For example, by combining clinical EEG registrations and experimental in vitro studies, her research group positioned synaptic failure as a key pathological mechanisms after cardiac arrest and brain infarction. Neuronal stimulation effectively improved neuronal recovery under experimental in vitro conditions and is currently investigated in phase 2 and 3 clinical trials in comatose patients after cardiac arrest.

Hofmeijer established the Dutch-Belgian TELSTAR consortium and is principle investigator of various state of the art multicenter clinical trials to test new treatments and diagnostics in comatose patients after cardiac arrest (amongst other www.telstartrial.nl, www.grecotrial.nl). Her research is supported by grants from ZonMW, NWO, Hartstichting, and Hersenstichting. She sits on national guideline committees for treatment of ischemic stroke and coma after cardiac arrest and chairs the jury of the two-yearly science award of the Netherlands Neurovascular Society.

Expertise

  • Medicine and Dentistry

    • Patient
    • Therapeutic Procedure
    • Heart Arrest
    • Apoplexy
    • Brain Ischemia
    • Inpatient
  • Neuroscience

    • Ischemic Stroke
    • Stroke

Organisations

Ancillary activities

  • Rijnstate Hospitalmedical doctor
  • Rijnstate Hospital, Arnhemmedical doctor

Publications

2024
Ghrelin for Neuroprotection in Post-Cardiac Arrest Coma: A Randomized Clinical TrialJAMA Neurology (E-pub ahead of print/First online). Nutma, S., Beishuizen, A., Van Den Bergh, W. M., Foudraine, N. A., Le Feber, J., Filius, P. M. G., Cornet, A. D., Van Der Palen, J., Van Putten, M. J. A. M. & Hofmeijer, J.https://doi.org/10.1001/jamaneurol.2024.1088Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomyEuropean stroke journal (E-pub ahead of print/First online). van der Meij, A., Holswilder, G., Bernsen, M. L. E., van Os, H. J. A., Hofmeijer, J., Spaander, F. H. M., Martens, J. M., van den Wijngaard, I. R., Lingsma, H. F., Konduri, P. R., BLM Majoie, C., Schonewille, W. J., Dippel, D. W. J., Kruyt, N. D., Nederkoorn, P. J., van Walderveen, M. A. A. & Wermer, M. J. H.https://doi.org/10.1177/23969873241231125The end is just the beginning: Unraveling the postictal state. University of Twente. Pottkämper, J. C. M.https://doi.org/10.3990/1.9789036559607Restoration of postictal cortical activity after electroconvulsive therapy relates to recovery of orientation in person, place and timeEuropean Psychiatry, 67(1), Article e16. Stuiver, S., Pottkämper, J. C. M., Verdijk, J. P. A. J., Ten Doesschate, F., Van Putten, M. J. A. M., Hofmeijer, J. & Van Waarde, J. A.https://doi.org/10.1192/j.eurpsy.2024.10Sex differences in outcomes after endovascular treatment in posterior circulation stroke: results from the MR CLEAN RegistryJournal of NeuroInterventional Surgery, Article jnis-2023-021086 (E-pub ahead of print/First online). Ali, M., Dekker, L., Ali, M., Van Zwet, E. W., Hofmeijer, J., Nederkoorn, P. J., Majoie, C. B. L. M., van Es, A. C. G. M., Uyttenboogaart, M., van der Meij, A., van Walderveen, M. A. A., Visser, M. C., Dippel, D. W. J., Schonewille, W. J., van den Wijngaard, I. R., Kruyt, N. D. & Wermer, M. J. H.https://doi.org/10.1136/jnis-2023-021086Cognitive screening and rehabilitation after cardiac arrest: only a few hurdles to takeNetherlands heart journal, 32, 63-66. van Til, J. A., Hemels, M. E. W. & Hofmeijer, J.https://doi.org/10.1007/s12471-023-01838-4
2023
Additional predictive value of optic nerve sheath diameter for neurological prognosis after cardiac arrest: a prospective cohort studyThe Ultrasound Journal, 15(1), Article 46 (E-pub ahead of print/First online). Verhulst, M. M. L. H., Visser, I. M., Keijzer, H. M., de Kruijf, N. L. M., Peters, E. J. G., Wilbers, T., Peelen, R. V., Hofmeijer, J. & Blans, M. J.https://doi.org/10.1186/s13089-023-00344-3Handling missing values in the analysis of between-hospital differences in ordinal and dichotomous outcomes: A simulation studyBMJ quality and safety, 32(12), Article 016387, 742-749. Van Linschoten, R. C. A., Amini, M., Van Leeuwen, N., Eijkenaar, F., Den Hartog, S. J., Nederkoorn, P. J., Hofmeijer, J., Emmer, B. J., Postma, A. A., Van Zwam, W., Roozenbeek, B., Dippel, D. & Lingsma, H. F.https://doi.org/10.1136/bmjqs-2023-016387Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trialsThe Lancet Neurology, 22(12), 1140-1149. Al-Shahi Salman, R., Stephen, J., Tierney, J. F., Lewis, S. C., Newby, D. E., Parry-Jones, A. R., White, P. M., Connolly, S. J., Benavente, O. R., Dowlatshahi, D., Cordonnier, C., Viscoli, C. M., Sheth, K. N., Kamel, H., Veltkamp, R., Larsen, K. T., Hofmeijer, J., Kerkhoff, H., Schreuder, F. H. B. M., … Kwon, S. U.https://doi.org/10.1016/S1474-4422(23)00315-0The International Cardiac Arrest Research Consortium Electroencephalography DatabaseCritical care medicine, 51(12), 1802-1811. Amorim, E., Zheng, W. L., Ghassemi, M. M., Aghaeeaval, M., Kandhare, P., Karukonda, V., Lee, J. W., Herman, S. T., Sivaraju, A., Gaspard, N., Hofmeijer, J., Van Putten, M. J. A. M., Sameni, R., Reyna, M. A., Clifford, G. D. & Westover, M. B.https://doi.org/10.1097/CCM.0000000000006074

Research profiles

Courses academic year 2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2022/2023

Address

University of Twente

Technohal (building no. 18), room 3381
Hallenweg 5
7522 NH Enschede
Netherlands

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