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prof.dr. J. Hofmeijer (Jeannette)

Full Professor

About Me

General information

Jeannette Hofmeijer studied Medicine and Philosophy at Radboud University Nijmegen. She received her master’s degree in Medicine cum laude in 1998. She was trained as a neurologist and as intensive care physician at University Medical Center Utrecht. Meanwhile, she obtained a PhD at the Biomedical MR Imaging and Spectroscopy Group of Utrecht University on the topic of edema formation in cerebral ischemia (2007). Since 2008, she combines her work as a vascular neurologist in Rijnstate Hospital (Arnhem) with a research and teaching position at University of Twente. She was appointed professor of Translational Neurophysiology in 2019.

Research interests

Hofmeijer studies the effects of ischemia on the brain. Cerebral ischemia is of particular interest in patients with brain infarction or after cardiac arrest. These conditions are leading causes of disability, worldwide. Apart from acute reperfusion therapies, effective treatments to promote cerebral recovery are unavailable.

Hofmeijer exploits her dual position at hospital and UT to combine clinical with fundamental research on cerebral ischemia. She believes that the combination of systematic observation in patients and targeted experimentation holds strong potential to provide new, clinically relevant, pathophysiological insights, that assist in the development of novel diagnostics or treatments. For example, by combining clinical EEG registrations and experimental in vitro studies, her research group positioned synaptic failure as a key pathological mechanisms after cardiac arrest and brain infarction. Neuronal stimulation effectively improved neuronal recovery under experimental in vitro conditions and is currently investigated in phase 2 and 3 clinical trials in comatose patients after cardiac arrest.

Hofmeijer established the Dutch-Belgian TELSTAR consortium and is principle investigator of various state of the art multicenter clinical trials to test new treatments and diagnostics in comatose patients after cardiac arrest (amongst other www.telstartrial.nl, www.grecotrial.nl). Her research is supported by grants from ZonMW, NWO, Hartstichting, and Hersenstichting. She sits on national guideline committees for treatment of ischemic stroke and coma after cardiac arrest and chairs the jury of the two-yearly science award of the Netherlands Neurovascular Society.

Expertise

Medicine & Life Sciences
Brain Diseases
Coma
Electroencephalography
Heart Arrest
Hypoxia
Infarction
Stroke
Therapeutics

Publications

Recent
TELSTAR Investigators (2022). Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest. The New England journal of medicine, 386(8), 724-734. https://doi.org/10.1056/NEJMoa2115998
Zheng, W. L., Amorim, E., Jing, J., Wu, O., Ghassemi, M., Lee, J. W., Sivaraju, A., Pang, T., Herman, S. T., Gaspard, N. , Ruijter, B. J. , Tjepkema-Cloostermans, M. C. , Hofmeijer, J. , Van Putten, M., & Westover, B. (2022). Predicting Neurological Outcome from Electroencephalogram Dynamics in Comatose Patients after Cardiac Arrest with Deep Learning. IEEE transactions on biomedical engineering, 69(5), 1813 - 1825. https://doi.org/10.1109/TBME.2021.3139007
Bernsen, M. L. E., Kauw, F., Martens, J. M., van der Lugt, A., Yo, L. S. F., van Walderveen, M. A. A., Roos, Y. B. W. E. M., van der Worp, H. B., Dankbaar, J. W. , & Hofmeijer, J. (2022). Malignant infarction after endovascular treatment: Incidence and prediction. International journal of stroke, 17(2), 198-206. https://doi.org/10.1177/17474930211006290
Schreuder, F. H. B. M., van Nieuwenhuizen, K. M. , Hofmeijer, J., Vermeer, S. E., Kerkhoff, H., Zock, E., Luijckx, G. J., Messchendorp, G. P., van Tuijl, J., Bienfait, H. P., Booij, S. J., van den Wijngaard, I. R., Remmers, M. J. M., Schreuder, A. H. C. M. L., Dippel, D. W., Staals, J., Brouwers, P. J. A. M., Wermer, M. J. H., Coutinho, J. M., ... APACHE-AF Trial Investigators (2021). Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF): a randomised, open-label, phase 2 trial. The Lancet Neurology, 20(11), 907-916. https://doi.org/10.1016/S1474-4422(21)00298-2
Samuels, N., van de Graaf, R. A., van den Berg, C. A. L., Uniken Venema, S. M., Bala, K., van Doormaal, P. J., van der Steen, W., Witvoet, E., Boiten, J., den Hertog, H., Schonewille, W. J. , Hofmeijer, J., Schreuder, F., Schreuder, T. A. H. C. M. L., van der Worp, H. B., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Burke, J. F., van Es, A. C. G. M., ... Dippel, D. W. J. (2021). Blood pressure in the first 6 hours following endovascular treatment for ischemic stroke is associated with outcome. Stroke, 52(11), 3514-3522. https://doi.org/10.1161/STROKEAHA.120.033657
Zheng, W. L., Amorim, E., Jing, J., Ge, W., Hong, S., Wu, O., Ghassemi, M., Lee, J. W., Sivaraju, A., Pang, T., Herman, S. T., Gaspard, N. , Ruijter, B. J., Sun, J. , Tjepkema-Cloostermans, M. C. , Hofmeijer, J. , van Putten, M. J. A. M., & Westover, M. B. (2021). Predicting neurological outcome in comatose patients after cardiac arrest with multiscale deep neural networks. Resuscitation, 169, 86-94. https://doi.org/10.1016/j.resuscitation.2021.10.034

UT Research Information System

Courses Academic Year  2021/2022

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.
 

Courses Academic Year  2020/2021

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3381
Hallenweg 5
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Technohal  3381
P.O. Box 217
7500 AE Enschede
The Netherlands