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prof.dr. J. Hofmeijer (Jeannette)

Full Professor

About Me

General information

Jeannette Hofmeijer studied Medicine and Philosophy at Radboud University Nijmegen. She received her master’s degree in Medicine cum laude in 1998. She was trained as a neurologist and as intensive care physician at University Medical Center Utrecht. Meanwhile, she obtained a PhD at the Biomedical MR Imaging and Spectroscopy Group of Utrecht University on the topic of edema formation in cerebral ischemia (2007). Since 2008, she combines her work as a vascular neurologist in Rijnstate Hospital (Arnhem) with a research and teaching position at University of Twente. She was appointed professor of Translational Neurophysiology in 2019.

Research interests

Hofmeijer studies the effects of ischemia on the brain. Cerebral ischemia is of particular interest in patients with brain infarction or after cardiac arrest. These conditions are leading causes of disability, worldwide. Apart from acute reperfusion therapies, effective treatments to promote cerebral recovery are unavailable.

Hofmeijer exploits her dual position at hospital and UT to combine clinical with fundamental research on cerebral ischemia. She believes that the combination of systematic observation in patients and targeted experimentation holds strong potential to provide new, clinically relevant, pathophysiological insights, that assist in the development of novel diagnostics or treatments. For example, by combining clinical EEG registrations and experimental in vitro studies, her research group positioned synaptic failure as a key pathological mechanisms after cardiac arrest and brain infarction. Neuronal stimulation effectively improved neuronal recovery under experimental in vitro conditions and is currently investigated in phase 2 and 3 clinical trials in comatose patients after cardiac arrest.

Hofmeijer established the Dutch-Belgian TELSTAR consortium and is principle investigator of various state of the art multicenter clinical trials to test new treatments and diagnostics in comatose patients after cardiac arrest (amongst other www.telstartrial.nl, www.grecotrial.nl). Her research is supported by grants from ZonMW, NWO, Hartstichting, and Hersenstichting. She sits on national guideline committees for treatment of ischemic stroke and coma after cardiac arrest and chairs the jury of the two-yearly science award of the Netherlands Neurovascular Society.

Expertise

Medicine & Life Sciences
Coma
Computed Tomography Angiography
Electroencephalography
Heart Arrest
Registries
Stroke
Therapeutics
Thrombectomy

Publications

Recent
Kauw, F. , Bernsen, M. L. E., Dankbaar, J. W., de Jong, H. W. A. M., Kappelle, L. J., Velthuis, B. K., van der Worp, H. B., van der Lugt, A., Roos, Y. B. W. E. M., Yo, L. S. F., van Walderveen, M. A. A. , Hofmeijer, J., & Bennink, E. (2022). Cerebrospinal fluid volume improves prediction of malignant edema after endovascular treatment of stroke. International journal of stroke. https://doi.org/10.1177/17474930221094693
MR CLEAN Registry and PRESTO investigators (2022). Diagnostic performance of an algorithm for automated large vessel occlusion detection on CT angiography. Journal of NeuroInterventional Surgery, 14(8), 794-798. https://doi.org/10.1136/neurintsurg-2021-017842
MR CLEAN Registry Investigators (2022). Hospital Variation in Time to Endovascular Treatment for Ischemic Stroke: What Is the Optimal Target for Improvement? Journal of the American Heart Association, 11(1), [e022192]. https://doi.org/10.1161/JAHA.121.022192
Su, R., van der Sluijs, M., Cornelissen, S. A. P., Lycklama, G. , Hofmeijer, J., Majoie, C. B. L. M., van Doormaal, P. J., van Es, A. C. G. M., Ruijters, D., Niessen, W. J., van der Lugt, A., & van Walsum, T. (2022). Spatio-temporal deep learning for automatic detection of intracranial vessel perforation in digital subtraction angiography during endovascular thrombectomy. Medical image analysis, 77, [102377]. https://doi.org/10.1016/j.media.2022.102377
Verdijk, J. P. A. J., van Kessel, M. A., Oud, M., Kellner, C. H. , Hofmeijer, J., Verwijk, E., & van Waarde, J. A. (2022). Pharmacological interventions to diminish cognitive side effects of electroconvulsive therapy: A systematic review and meta-analysis. Acta Psychiatrica Scandinavica, 145(4), 343-356. https://doi.org/10.1111/acps.13397
Pham, S. D. T., Keijzer, H. M. , Ruijter, B. J., Seeber, A. A., Scholten, E., Drost, G., van den Bergh, W. M., Kornips, F. H. M., Foudraine, N. A., Beishuizen, A., Blans, M. J. , Hofmeijer, J. , van Putten, M. J. A. M. , & Tjepkema-Cloostermans, M. C. (2022). Outcome Prediction of Postanoxic Coma: A Comparison of Automated Electroencephalography Analysis Methods. Neurocritical care, 37(SUPPL 2), 248-258. https://doi.org/10.1007/s12028-022-01449-8

UT Research Information System

Courses Academic Year  2022/2023

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.
 

Courses Academic Year  2021/2022

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3381
Hallenweg 5
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Technohal  3381
P.O. Box 217
7500 AE Enschede
The Netherlands