dr.ir. J.M.J. Paulusse (Jos)

Associate Professor

About Me

Given names: Jos
Academic titles: Dr. Ir.
Present function:    Associate professor department of Molecules and Materials
University of Twente, NL


Jos Paulusse is associate professor at the University of Twente (Netherlands) and group leader at the Department of Molecules and Materials. Jos Paulusse obtained his PhD from Eindhoven University of Technology in 2006 under supervision of Prof. Rint Sijbesma and Prof. Bert Meijer. He worked with Prof. Craig Hawker as a postdoctoral fellow at the University of California, Santa Barbara. He continued his academic career as assistant professor at Wageningen University in 2009 and in 2012 continued his research at the University of Twente. From 2016 to 2020 he held a part-time position at the Department of Nuclear Medicine and Molecular Imaging at the University Medical Center Groningen. He was co-founder of the start-up company SpectriS-dot in 2015, which commercializes silicon nanoparticles, and he founded IntriS in 2023, which develops well-defined polymer nanoparticles. Jos chairs the biennial European Symposium on Controlled Drug Delivery. He is currently associate professor, and his research group develops nanomaterials for early diagnosis and treatment of diseases. These materials include well-defined polymer nanogels for drug encapsulation and controlled release, as well as silicon nanoparticles for application as hybrid imaging modalities.


2002-2006   Ph.D. Laboratory of Macromolecular and Organic Chemistry, Eindhoven
  University of Technology, NL
1995-2002   MSc. Laboratory of Homogeneous Catalysis and Coordination Chemistry,
  Eindhoven University of Technology, NL


Professional Experience

2012-Present   Associate professor, department of Molecules and Materials, Principal
  Investigator, University of Twente, Enschede (NL)
2016-2020   Assistant professor, department of Nuclear Medicine and Molecular 
  imaging part-time appointment, University Medical Center Groningen (NL)
2009-2011   Assistant professor, Laboratory of Organic Chemistry, Wageningen
  University, Wageningen (NL)
2007-2008   Post-Doctoral Fellow, Materials Research Laboratory, University of
  California, Santa Barbara (USA)
2006-2007   Post-Doctoral Scientist, Laboratory of Macromolecular & Organic 
  Chemistry, Eindhoven University of Technology, Eindhoven (NL)


Selected Research Grants

  1. NWO Take off grant I & II: silicon quantum dots
  2. TURBO grant: Self-healing dental fillings
  3. Pioneers in Healthcare grant: Electromechanical stimulation of the heart
  4. EIT Raw Materials: silicon quantum dots
  5. TKI Chemistry: hyperpolarized silicon nanoparticles
  6. TKI LSH: Nanoparticles for brain delivery
  7. UvA Proof of Concept grant: silicon quantum dots
  8. ZonMw grant within Delta Plan Dementia Program
  9. EuroNanoMed III project 'NANOpheles'
  10. Rubicon postdoctoral fellowship

Organizational Responsibilities

2023-Present   Founder of IntriS b.v., Development of Functional Polymer Nanoparticles
2021-Present   Member of Faculty Council 
2018-2021   Coordinator Industrial Relations, Founding member of Benelux-France
  Local Chapter, Controlled Release Society
2015-Present   Co-founder, SpectriS-Dot B.V., Development of sustainable, non-toxic
  silicon Quantum dots
2014-Present   Chair of organizing committee, European Symposium on Controlled
  Drug Delivery
2013-2020   Treasurer, Netherlands Society for Biomaterials and Tissue Engineering
2003-Present   Member of American Chemical Society, Polymeric Materials Science 
  & Engineering Division, Polymer Division, Colloids Division
1995-Present   Member of Royal Dutch Chemistry Association


Engineering & Materials Science
Poly(Amido Amine)
Medicine & Life Sciences


Paats, J.-W. D. (2023). Pentafluorophenyl-based single-chain polymer nanoparticles. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036557665
Hamelmann, N. M., Paats, J. W. D., Avalos-Padilla, Y., Lantero, E., Spanos, L., Siden-Kiamos, I., Fernàndez-Busquets, X. , & Paulusse, J. M. J. (2023). Single-Chain Polymer Nanoparticles Targeting the Ookinete Stage of Malaria Parasites. ACS Infectious Diseases, 9(1), 56-64. https://doi.org/10.1021/acsinfecdis.2c00336
Hujaya, S. D., Wohl, B. M. , Engbersen, J. F. J. , & Paulusse, J. M. J. (2022). Responsive Layer-by-Layer Films. In Chemoresponsive Materials / Smart Materials for Chemical and Biological Stimulation (Edition 2 ed.). (Smart Materials Series). Royal Society of Chemistry. https://doi.org/10.1039/9781839166136-00170
Elzes, M. R., Mertens, I., Sedlacek, O., Verbraeken, B., Doensen, A. C. A., Mees, M. A., Glassner, M., Jana, S. , Paulusse, J. M. J., & Hoogenboom, R. (2022). Linear Poly(ethylenimine-propylenimine) Random Copolymers for Gene Delivery: From Polymer Synthesis to Efficient Transfection with High Serum Tolerance. Biomacromolecules, 23(6), 2459-2470. https://doi.org/10.1021/acs.biomac.2c00210
Goyal, A., Van Der Laan, M., Troglia, A., Lin, M., Agarwal, H., Van De Groep, J., Bliem, R. , Paulusse, J. M. J., Schall, P., & Dohnalova, K. (2022). Microscopic Proof of Photoluminescence from Mechanochemically Synthesized 1-Octene-Capped Quantum-Confined Silicon Nanoparticles: Implications for Light-Emission Applications. ACS Omega, 7(28), 24881-24887. https://doi.org/10.1021/acsomega.2c03396
Kusmus, D. N. M., van Veldhuisen, T. W., Khan, A. , Cornelissen, J. J. L. M. , & Paulusse, J. M. J. (2022). Uniquely sized nanogels via crosslinking polymerization. RSC advances, 12(45), 29423-29432. https://doi.org/10.1039/d2ra04123e
Hamelmann, N. M. (2022). Single-Chain Polymer Nanoparticles in Controlled Drug Delivery. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036554398
Lin, M. (2022). Silicon-based micro- and nanoparticles: preparation, functionalization and hyperpolarized magnetic resonance imaging. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036553476
Kusmus, D. N. M.-T. (2022). Functional modification of polymeric nanogels. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036552837

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Courses Academic Year  2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2022/2023


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Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Carré (building no. 15), room C4211
Hallenweg 21
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Carré  C4211
P.O. Box 217
7500 AE Enschede
The Netherlands