dr.ir. J.M.J. Paulusse (Jos)

Associate Professor

About Me

Given names: Jos
Academic titles: prof. dr. ir.
Birth date and place: 
Present function:    Associate professor department of Molecules and Materials
University of Twente, NL


Jos Paulusse is associate professor at the University of Twente (Netherlands) and group leader at the Department of Molecules and Materials. Jos Paulusse obtained his PhD from Eindhoven University of Technology in 2006 under supervision of Prof. Rint Sijbesma and Prof. Bert Meijer. He worked with Prof. Craig Hawker as a postdoctoral fellow at the University of California, Santa Barbara. He continued his academic career as assistant professor at Wageningen University in 2009 and in 2012 continued his research at the University of Twente. From 2016 to 2020 he held a part-time position at the Department of Nuclear Medicine and Molecular Imaging at the University Medical Center Groningen. He is co-founder of the start-up company SpectriS-dot, which commercializes silicon nanoparticles and chairs the biennial European Symposium on Controlled Drug Delivery. He is currently associate professor, and his research group develops nanomaterials for early diagnosis and treatment of diseases. These materials include well-defined polymer nanogels for drug encapsulation and controlled release, as well as silicon nanoparticles for application as hybrid imaging modalities.


2002-2006   Ph.D. Laboratory of Macromolecular and Organic Chemistry, Eindhoven
  University of Technology, NL
1995-2002   MSc. Laboratory of Homogeneous Catalysis and Coordination Chemistry,
  Eindhoven University of Technology, NL


Professional Experience

2012-Present   Associate professor, department of Molecules and Materials, Principal
  Investigator, University of Twente, Enschede (NL)
2016-2020   Assistant professor, department of Nuclear Medicine and Molecular 
  imaging part-time appointment, University Medical Center Groningen (NL)
2009-2011   Assistant professor, Laboratory of Organic Chemistry, Wageningen
  University, Wageningen (NL)
2007-2008   Post-Doctoral Fellow, Materials Research Laboratory, University of
  California, Santa Barbara (USA)
2006-2007   Post-Doctoral Scientist, Laboratory of Macromolecular & Organic 
  Chemistry, Eindhoven University of Technology, Eindhoven (NL)


Research Grants

  1. TURBO grant 80k self-healing dental filling (2017)
  2. ZONMW grant 300k within Dementia Delta Plan Program. ‘Novel nanocarrier system will be developed to cross blood-brain-barrier and deliver a combination of medicines that tackle Alzheimer’s disease in multiple ways’. (2014)

Organizational Responsibilities

2018-2020   Member of Society for Nuclear Medicine and Molecular Imaging
2018-2021   Coordinator Industrial Relations, Founding member of Benelux-France
  Local Chapter, Controlled Release Society
2015-Present   Co-founder, SpectriS-Dot B.V., Development of sustainable, non-toxic
  silicion Quantum dots
2014-Present   Head of organizing committee, European Symposium on Controlled
  Drug Delivery
2013-2020   Treasurer, Netherlands Society for Biomaterials and Tissue Engineering
2003-Present   Member of American Chemical Society, Polymeric Materials Science 
  & Engineering Division, Polymer Division, Colloids Division
1995-Present   Member of Royal Dutch Chemistry Association


Engineering & Materials Science
Poly(Amido Amine)
Medicine & Life Sciences


Paats, J-W. D. (2023). Pentafluorophenyl-based single-chain polymer nanoparticles. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036557665
Hamelmann, N. M., Paats, J. W. D., Avalos-Padilla, Y., Lantero, E., Spanos, L., Siden-Kiamos, I., Fernàndez-Busquets, X. , & Paulusse, J. M. J. (2023). Single-Chain Polymer Nanoparticles Targeting the Ookinete Stage of Malaria Parasites. ACS Infectious Diseases, 9(1), 56-64. https://doi.org/10.1021/acsinfecdis.2c00336
Hujaya, S. D., Wohl, B. M. , Engbersen, J. F. J. , & Paulusse, J. M. J. (2022). Responsive Layer-by-Layer Films. In Chemoresponsive Materials / Smart Materials for Chemical and Biological Stimulation (Edition 2 ed.). (Smart Materials Series). Royal Society of Chemistry. https://doi.org/10.1039/9781839166136-00170
Elzes, M. R., Mertens, I., Sedlacek, O., Verbraeken, B., Doensen, A. C. A., Mees, M. A., Glassner, M., Jana, S. , Paulusse, J. M. J., & Hoogenboom, R. (2022). Linear Poly(ethylenimine-propylenimine) Random Copolymers for Gene Delivery: From Polymer Synthesis to Efficient Transfection with High Serum Tolerance. Biomacromolecules, 23(6), 2459-2470. https://doi.org/10.1021/acs.biomac.2c00210
Goyal, A., Van Der Laan, M., Troglia, A., Lin, M., Agarwal, H., Van De Groep, J., Bliem, R. , Paulusse, J. M. J., Schall, P., & Dohnalova, K. (2022). Microscopic Proof of Photoluminescence from Mechanochemically Synthesized 1-Octene-Capped Quantum-Confined Silicon Nanoparticles: Implications for Light-Emission Applications. ACS Omega, 7(28), 24881-24887. https://doi.org/10.1021/acsomega.2c03396
Kusmus, D. N. M., van Veldhuisen, T. W., Khan, A. , Cornelissen, J. J. L. M. , & Paulusse, J. M. J. (2022). Uniquely sized nanogels via crosslinking polymerization. RSC advances, 12(45), 29423-29432. https://doi.org/10.1039/d2ra04123e
Hamelmann, N. M. (2022). Single-Chain Polymer Nanoparticles in Controlled Drug Delivery. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036554398

UT Research Information System


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Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Carré (building no. 15), room C4211
Hallenweg 23
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Carré  C4211
P.O. Box 217
7500 AE Enschede
The Netherlands