Given names:

Academic titles:
Dr. Ir.

Present function:   
Associate professor department of Molecules and Materials University of Twente, NL

BibliographyJos Paulusse is associate professor at the University of Twente (Netherlands) and group leader at the Department of Molecules and Materials. Jos Paulusse obtained his PhD from Eindhoven University of Technology in 2006 under supervision of Prof. Rint Sijbesma and Prof. Bert Meijer. He worked with Prof. Craig Hawker as a postdoctoral fellow at the University of California, Santa Barbara. He continued his academic career as assistant professor at Wageningen University in 2009 and in 2012 continued his research at the University of Twente. From 2016 to 2020 he held a part-time position at the Department of Nuclear Medicine and Molecular Imaging at the University Medical Center Groningen. He was co-founder of the start-up company SpectriS-dot in 2015, which commercializes silicon nanoparticles, and he founded IntriS in 2023, which develops well-defined polymer nanoparticles. Jos chairs the biennial European Symposium on Controlled Drug Delivery. He is currently associate professor, and his research group develops nanomaterials for early diagnosis and treatment of diseases. These materials include well-defined polymer nanogels for drug encapsulation and controlled release, as well as silicon nanoparticles for application as hybrid imaging modalities.



  • 2002-2006 - Ph.D. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, NL
  • 1995-2002 - MSc. Laboratory of Homogeneous Catalysis and Coordination Chemistry, Eindhoven University of Technology, NL

Professional Experience

  • 2012-Present - Associate professor, department of Molecules and Materials, Principal Investigator, University of Twente, Enschede (NL)
  • 2016-2020 - Assistant professor, department of Nuclear Medicine and Molecular¬†imaging part-time appointment, University Medical Center Groningen (NL)
  • 2009-201 - Assistant professor, Laboratory of Organic Chemistry, Wageningen University, Wageningen (NL)
  • 2007-2008 - Post-Doctoral Fellow, Materials Research Laboratory, University of California, Santa Barbara (USA)
  • 2006-2007 - Post-Doctoral Scientist, Laboratory of Macromolecular & Organic¬†Chemistry,¬†Eindhoven University of Technology, Eindhoven (NL)

Selected Research Grants

  1. NWO Take off grant I & II: silicon quantum dots
  2. TURBO grant: Self-healing dental fillings
  3. Pioneers in Healthcare grant: Electromechanical stimulation of the heart
  4. EIT Raw Materials: silicon quantum dots
  5. TKI Chemistry: hyperpolarized silicon nanoparticles
  6. TKI LSH: Nanoparticles for brain delivery
  7. UvA Proof of Concept grant: silicon quantum dots
  8. ZonMw grant within Delta Plan Dementia Program
  9. EuroNanoMed III project 'NANOpheles'
  10. Rubicon postdoctoral fellowship

Organizational Responsibilities

  • 2023-Present - Founder of IntriS b.v.,¬†Development of Functional Polymer Nanoparticles
  • 2021-Present - Member of Faculty Council¬†
  • 2018-2021 -Coordinator Industrial Relations, Founding member of Benelux-France Local Chapter,¬†Controlled Release Society
  • 2015-Present - Co-founder,¬†SpectriS-Dot B.V.,¬†Development of sustainable, non-toxic silicon¬†Quantum¬†dots
  • 2014-Present - Chair of organizing committee,¬†European Symposium on Controlled Drug Delivery
  • 2013-2020 - Treasurer, Netherlands Society for Biomaterials and Tissue Engineering
  • 2003-Present - Member of¬†American Chemical Society, Polymeric Materials Science¬†&¬†Engineering Division, Polymer Division, Colloids Division
  • 1995-Present - Member of¬†Royal Dutch Chemistry Association


  • Chemistry

    • Surface
    • Nanoparticle
    • Silicon
    • Polymer Chain
  • Pharmacology, Toxicology and Pharmaceutical Science

    • Polymer
    • Poly(amidoamine)
  • Material Science

    • Polymer Nanoparticles
    • Monolayers



Post-polymerization functionalized sulfonium nanogels for gene deliveryRSC Applied Polymers (E-pub ahead of print/First online). Kusmus, D. N. M., Van veldhuisen, T., Michel-Souzy, S., Cornelissen, J. J. L. M. & Paulusse, J. M. J.
Conceptual Modeling Enables Systems Thinking in Sustainable Chemistry and Chemical EngineeringJournal of chemical education, 100(12), 4577-4584. Krab - Hüsken, L. E., Pei, L., de Vries, P. G., Lindhoud, S., Paulusse, J. M. J., Jonkheijm, P. & Wong, A. S. Y. single-chain polymer nanoparticles. University of Twente. Paats, J.-W. D. polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriersNature communications, 14(1), Article 4351. Koshkina, O., Rheinberger, T., Flocke, V., Windfelder, A., Bouvain, P., Hamelmann, N. M., Paulusse, J. M. J., Gojzewski, H., Flögel, U. & Wurm, F. R. of viral protein-based hybrid nanomaterials mediated by a macromolecular glueJournal of Materials Chemistry B, 11(33), 7933-7941. Cao, S., Peeters, S., Michel-Souzy, S., Hamelmann, N., Paulusse, J. M. J., Yang, L. L. & Cornelissen, J. J. L. M. polymer nanoparticles in biomedical applicationsJournal of controlled release, 356, 26-42. Hamelmann, N. M. & Paulusse, J. M. J. Polymer Nanoparticles Targeting the Ookinete Stage of Malaria ParasitesACS Infectious Diseases, 9(1), 56-64. Hamelmann, N. M., Paats, J. W. D., Avalos-Padilla, Y., Lantero, E., Spanos, L., Siden-Kiamos, I., Fernàndez-Busquets, X. & Paulusse, J. M. J.
Enhancing Cellular Internalization of Single-Chain Polymer Nanoparticles via Polyplex FormationBiomacromolecules, 23(12), 5036-5042. Hamelmann, N. M., Uijttewaal, S., Hujaya, S. D. & Paulusse, J. M. J. sized nanogels via crosslinking polymerizationRSC advances, 12(45), 29423-29432. Kusmus, D. N. M., van Veldhuisen, T. W., Khan, A., Cornelissen, J. J. L. M. & Paulusse, J. M. J. Polymer Nanoparticles in Controlled Drug Delivery. University of Twente. Hamelmann, N. M. Proof of Photoluminescence from Mechanochemically Synthesized 1-Octene-Capped Quantum-Confined Silicon Nanoparticles: Implications for Light-Emission ApplicationsACS Omega, 7(28), 24881-24887. Goyal, A., Van Der Laan, M., Troglia, A., Lin, M., Agarwal, H., Van De Groep, J., Bliem, R., Paulusse, J. M. J., Schall, P. & Dohnalova, K. Layer-by-Layer FilmsIn Chemoresponsive Materials / Smart Materials for Chemical and Biological Stimulation. Royal Society of Chemistry. Hujaya, S. D., Wohl, B. M., Engbersen, J. F. J. & Paulusse, J. M. J. Poly(ethylenimine-propylenimine) Random Copolymers for Gene Delivery: From Polymer Synthesis to Efficient Transfection with High Serum ToleranceBiomacromolecules, 23(6), 2459-2470. Elzes, M. R., Mertens, I., Sedlacek, O., Verbraeken, B., Doensen, A. C. A., Mees, M. A., Glassner, M., Jana, S., Paulusse, J. M. J. & Hoogenboom, R. micro- and nanoparticles: preparation, functionalization and hyperpolarized magnetic resonance imaging. University of Twente. Lin, M. modification of polymeric nanogels. University of Twente. Kusmus, D. N. M.-T.

Research profiles

Affiliated study programs

Courses academic year 2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2022/2023

Media appearances:


University of Twente

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