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J.M. Rivera Arbelaez MSc (José)

PhD Candidate

About Me

 José Manuel Rivera Arbelaéz is a Ph.D. candidate at the Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) of the University of Twente, The Netherlands. He is part of the BIOS lab on a chip group lead by Prof. Albert van den Berg and Applied Stem Cell Technologies (AST) lead by Prof. Robert Passier. His research focuses on the development of a heart-on-chip model for drug discovery and disease modeling.

Research

“The goal of this project is to create a more realistic cardiac model by vascularizing a 3D cardiac tissue on-chip. The project consists in combining human induced pluripotent stem cell (hiPSC) derived cardiac 3D tissues and hiPSC derived endothelial cells with integrated sensors and electrical measurements of Field Potential and TEER on-chip. Such technology will allow us to study functional and molecular changes to the endothelial cell layer or cardiac tissue when either one of those structures are challenged by disease-inducing chemical, genetic or physical factors.”

Publications

Other Contributions
A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness. Ribeiro MC Slaats RH Schwach V Rivera-Arbelaez JM Tertoolen LGJ van Meer BJ Molenaar R Mummery CL Claessens MMAE Passier R
DOI:  10.1016/j.yjmcc.2020.03.008

Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Horst Complex (building no. 20), room ZH125
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Horst Complex  ZH125
P.O. Box 217
7500 AE Enschede
The Netherlands

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