José Manuel Rivera Arbelaéz is a Ph.D. candidate at the Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) of the University of Twente, The Netherlands. He is part of the BIOS lab on a chip group lead by Prof. Albert van den Berg and Applied Stem Cell Technologies (AST) lead by Prof. Robert Passier. His research focuses on the development of a heart-on-chip model for drug discovery and disease modeling.
“The goal of this project is to create a more realistic cardiac model by vascularizing a 3D cardiac tissue on-chip. The project consists in combining human induced pluripotent stem cell (hiPSC) derived cardiac 3D tissues and hiPSC derived endothelial cells with integrated sensors and electrical measurements of Field Potential and TEER on-chip. Such technology will allow us to study functional and molecular changes to the endothelial cell layer or cardiac tissue when either one of those structures are challenged by disease-inducing chemical, genetic or physical factors.”