About Me
My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.
Expertise
Medicine & Life Sciences
# Cartilage
# Chondrocytes
# Joints
# Mesenchymal Stem Cells
# Osteoarthritis
Engineering & Materials Science
# Cartilage
# Proteins
# Stem Cells
Organisations
Research
My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.
Publications
Recent
Dalen, M. C. E. V.
, Karperien, M.
, Claessens, M. M. A. E.
, & Post, J. N. (2023).
Choice of Protein, Not Its Amyloid-Fold, Determines the Success of Amyloid-Based Scaffolds for Cartilage Tissue Regeneration.
ACS Omega,
8(27), 24198-24209. Advance online publication.
https://doi.org/10.1021/acsomega.3c00151
Jansen Klomp, L., Coutinho de Almeida, R., Meulenbelt, I.
, Post, J. N.
, & Meijer, H. G. E. (2022).
Simulating differentiation from iPS cells to chondrocytes. Poster session presented at Bioinformatics & Systems Biology Conference, BioSB 2022, Lunteren, Netherlands.
Post, J. N., Loerakker, S., Merks, R. M. H., & Carlier, A. (2022).
Implementing Computational Modeling in Tissue Engineering: Where Disciplines Meet.
Tissue Engineering - Part A,
28(11-12), 542-554. Advance online publication.
https://doi.org/10.1089/ten.tea.2021.0215
Govindaraj, K., Meteling, M., Becker, M.
, Post, J.
, & Leijten, J. (2022).
Osmolarity-Induced altered intracellular molecular crowding drives osteoarthritis pathology.
Osteoarthritis and cartilage,
30(Suppl. 1), S24-S25.
https://doi.org/10.1016/j.joca.2022.02.021
Khurana, S., Schivo, S.
, Plass, J. R. M., Mersinis, N.
, Scholma, J., Kerkhofs, J.
, Zhong, L.
, van de Pol, J.
, Langerak, R., Geris, L.
, Karperien, M.
, & Post, J. N. (2021).
An ECHO of cartilage: In silico prediction of combinatorial treatments to switch between transient and permanent cartilage phenotypes with ex vivo validation.
Frontiers in bioengineering and biotechnology,
9, Article 732917.
https://doi.org/10.3389/fbioe.2021.732917
Khurana, S., Huisman, J., Schivo, S.
, & Post, J. N. (2021).
Quantitative molecular models for biological processes: Modeling of signal transduction networks with animo. In A. J. van Wijnen, & M. S. Ganshina (Eds.),
Osteoporosis and Osteoarthritis (pp. 141-161). (Methods in Molecular Biology; Vol. 2221). Humana Press Inc.. Advance online publication.
https://doi.org/10.1007/978-1-0716-0989-7_10
Govindaraj, K.
, & Post, J. N. (2021).
Using FRAP to quantify changes in transcription factor dynamics after cell stimulation: Cell culture, FRAP, data analysis, and visualization. In A. J. van Wijnen, & M. S. Ganshina (Eds.),
Osteoporosis and Osteoarthritis (pp. 109-139). (Methods in Molecular Biology; Vol. 2221). Humana Press Inc.. Advance online publication.
https://doi.org/10.1007/978-1-0716-0989-7_9
Fu, Y.
, Paggi, C. A., Dudakovic, A., van Wijnen, A. J.
, Post, J. N.
, & Karperien, M. (2021).
Engineering cartilage tissue by co-culturing of chondrocytes and mesenchymal stromal cells. In A. J. van Wijnen, & M. S. Ganshina (Eds.),
Osteoporosis and Osteoarthritis (pp. 53-70). (Methods in Molecular Biology; Vol. 2221). Humana Press Inc..
https://doi.org/10.1007/978-1-0716-0989-7_5
Huang, X.
, Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S.
, Hendriks, J.
, Post, J. N.
, & Karperien, M. (2021).
The expressions of dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity.
Cartilage,
12(4), 496-504. Advance online publication.
https://doi.org/10.1177/1947603519841676
Govindaraj, K.
, Karperien, M.
, & Post, J. N. (2020).
Single cell SOX9 dynamics reveals differential DNA binding in subpopulations of hPCs.
Osteoarthritis and cartilage,
28(Supplement 1), S86-S87.
https://doi.org/10.1016/j.joca.2020.02.131
UT Research Information System
Google Scholar Link
Courses Academic Year 2023/2024
Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.
Courses Academic Year 2022/2023
Contact Details
Visiting Address
University of Twente
Faculty of Science and Technology
Horst Complex
(building no. 20), room ZH134
De Horst 2
7522LW Enschede
The Netherlands
Mailing Address
University of Twente
Faculty of Science and Technology
Horst Complex
ZH134
P.O. Box 217
7500 AE Enschede
The Netherlands