Horst Complex

dr.ing. J.N. Post (Janine)

Associate Professor
TNW-BET-DBE
Horst Complex ZH134
j.n.post@utwente.nl
+31534894205
Business card

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Expertise

  • Medicine and Dentistry

    • Chondrocyte
    • Cartilage
    • Mesenchymal Stem Cell
    • Differentiation
    • Osteoarthritis

  • Biochemistry, Genetics and Molecular Biology

    • Stem Cell
    • Gene Expression
    • Stromal Cell

Organisations

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Publications

Jump to: 2024 | 2023 | 2022 | 2021

2024

Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis (2024)Journal of cellular physiology. Article e31443 (E-pub ahead of print/First online). Govindaraj, K., Kannan, S., Coutinho de Almeida, R., Jansen Klomp, L., Karperien, M., Meulenbelt, I. & Post, J. N.https://doi.org/10.1002/jcp.31443Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology (2024)Advanced science, 11(11). Article 2306722. Govindaraj, K., Meteling, M., van Rooij, J., Becker, M., van Wijnen, A. J., van den Beucken, J. J. J. P., Ramos, Y. F. M., van Meurs, J., Post, J. N. & Leijten, J.https://doi.org/10.1002/advs.202306722Amyloid Scaffolds for Cartilage Tissue Regeneration (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Dalen, M. C. E.https://doi.org/10.3990/1.9789036560757

2023

Choice of Protein, Not Its Amyloid-Fold, Determines the Success of Amyloid-Based Scaffolds for Cartilage Tissue Regeneration (2023)ACS Omega, 8(27), 24198-24209. Dalen, M. C. E. v., Karperien, M., Claessens, M. M. A. E. & Post, J. N.https://doi.org/10.1021/acsomega.3c00151Mapping RUNX2 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells (2023)[Working paper › Preprint]. bioRxiv. Govindaraj, K., Kannan, S., Karperien, M. & Post, J. N.https://doi.org/10.1101/2023.03.30.534618

2022

Simulating differentiation from iPS cells to chondrocytes (2022)[Contribution to conference › Poster] Bioinformatics & Systems Biology Conference, BioSB 2022. Jansen Klomp, L., Coutinho de Almeida, R., Meulenbelt, I., Post, J. N. & Meijer, H. G. E.Implementing Computational Modeling in Tissue Engineering: Where Disciplines Meet (2022)Tissue engineering. Part A, 28(11-12), 542-554. Post, J. N., Loerakker, S., Merks, R. M. H. & Carlier, A.https://doi.org/10.1089/ten.tea.2021.0215Osmolarity-Induced altered intracellular molecular crowding drives osteoarthritis pathology (2022)Osteoarthritis and cartilage, 30(Suppl. 1), S24-S25. Govindaraj, K., Meteling, M., Becker, M., Post, J. & Leijten, J.https://doi.org/10.1016/j.joca.2022.02.021

2021

Mapping SOX9 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells (2021)[Working paper › Preprint]. bioRxiv. Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N.https://doi.org/10.1101/2021.11.29.470107An ECHO of cartilage: In silico prediction of combinatorial treatments to switch between transient and permanent cartilage phenotypes with ex vivo validation (2021)Frontiers in bioengineering and biotechnology, 9. Article 732917. Khurana, S., Schivo, S., Plass, J. R. M., Mersinis, N., Scholma, J., Kerkhofs, J., Zhong, L., van de Pol, J., Langerak, R., Geris, L., Karperien, M. & Post, J. N.https://doi.org/10.3389/fbioe.2021.732917The expressions of dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity (2021)Cartilage, 12(4), 496-504. Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M.https://doi.org/10.1177/1947603519841676Protein adsorption enhances energy dissipation in networks of lysozyme amyloid fibrils (2021)Langmuir, 37(24), 7349–7355. van Dalen, M. C. E., Vaneyck, J., Semerdzhiev, S. A., Karperien, M., Post, J. N. & Claessens, M. M. A. E.https://doi.org/10.1021/acs.langmuir.1c00657Engineering cartilage tissue by co-culturing of chondrocytes and mesenchymal stromal cells (2021)In Osteoporosis and Osteoarthritis (pp. 53-70) (Methods in Molecular Biology; Vol. 2221). Humana Press. Fu, Y., Paggi, C. A., Dudakovic, A., van Wijnen, A. J., Post, J. N. & Karperien, M.https://doi.org/10.1007/978-1-0716-0989-7_5

Research profiles

Courses academic year 2024/2025

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2023/2024

Address

University of Twente

Horst Complex (building no. 20), room ZH134
De Horst 2
7522 LW Enschede
Netherlands

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