Dr.ing. J.N. Post | People Pages: Find employees & contact details | University of Twente

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Expertise

Medicine and Dentistry
- Chondrocyte
- Cartilage
- Mesenchymal Stem Cell
- Differentiation
- Osteoarthritis
Biochemistry, Genetics and Molecular Biology
- Stem Cell
- Gene Expression
- Stromal Cell

Organisations

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Publications

Jump to: 2026 | 2025 | 2024 | 2023 | 2022

2026

Molecular insights into heart field-specific cardiomyocyte differentiation - A computational study: Boolean model of cardiac development (2026)PLoS ONE, 21(1), e0340054. Article e0340054. Zeegelaar, R., Limana, F., Argyris, G. & Post, J. N.https://doi.org/10.1371/journal.pone.0340054

2025

Identification of models describing gene expression data leveraging machine learning methods (2025)Interface focus, 15(3). Article 20250014. Jansen Klomp, L. F., Queirolo, E., Post, J. N., Meijer, H. G. E. & Brune, C.https://doi.org/10.1098/rsfs.2025.0014DANSE: a pipeline for dynamic modelling of time-series multi-omics data (2025)[Working paper › Preprint]. bioRxiv. Klomp, L. F. J., Yan, X., Snabel, R. R., Veenstra, G. J. C., Meijer, H. G. E. & Post, J. N.https://doi.org/10.1101/2025.07.04.663170Molecular profiling of oxygen's impact on chondrocytes: Insights from mass spectrometry imaging (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Bakker, B.https://doi.org/10.3990/1.9789036565783

2024

Molecular mechanisms of heart field specific cardiomyocyte differentiation- a computational modeling approach (2024)[Working paper › Preprint]. bioRxiv. Argyris, G., Zeegelaar, R. & Post, J. N.https://doi.org/10.1101/2024.12.19.629328Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis (2024)Journal of cellular physiology, 239(12). Article e31443. Govindaraj, K., Kannan, S., Coutinho de Almeida, R., Jansen Klomp, L., Karperien, M., Meulenbelt, I. & Post, J. N.https://doi.org/10.1002/jcp.31443443-Physiological intracellular molecular crowding renormalizes osteoarthritic chondrocytes towards a healthy phenotype (2024)Osteoarthritis and cartilage, 32(Suppl. 1), S311-S312. Govindaraj, K., Meteling, M., Post, J. & Leijten, J.https://doi.org/10.1016/j.joca.2024.02.456TF-FRAP reveals number of cells in a subpopulation in hMSCs determines its differentiation potential (2024)Osteoarthritis and cartilage, 32(Supplement 1), S471-S471. Govindaraj, K., Kannan, S., Karperien, M. & Post, J.https://doi.org/10.1016/j.joca.2024.02.701Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology (2024)Advanced science, 11(11). Article 2306722. Govindaraj, K., Meteling, M., van Rooij, J., Becker, M., van Wijnen, A. J., van den Beucken, J. J. J. P., Ramos, Y. F. M., van Meurs, J., Post, J. N. & Leijten, J.https://doi.org/10.1002/advs.202306722Amyloid Scaffolds for Cartilage Tissue Regeneration (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Dalen, M. C. E.https://doi.org/10.3990/1.9789036560757

2023

Choice of Protein, Not Its Amyloid-Fold, Determines the Success of Amyloid-Based Scaffolds for Cartilage Tissue Regeneration (2023)ACS Omega, 8(27), 24198-24209. Dalen, M. C. E. v., Karperien, M., Claessens, M. M. A. E. & Post, J. N.https://doi.org/10.1021/acsomega.3c00151Mapping RUNX2 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells (2023)[Working paper › Preprint]. bioRxiv. Govindaraj, K., Kannan, S., Karperien, M. & Post, J. N.https://doi.org/10.1101/2023.03.30.534618

2022

Simulating differentiation from iPS cells to chondrocytes (2022)[Contribution to conference › Poster] Bioinformatics & Systems Biology Conference, BioSB 2022. Jansen Klomp, L., Coutinho de Almeida, R., Meulenbelt, I., Post, J. N. & Meijer, H. G. E.

Research profiles

Courses academic year 2025/2026

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2024/2025

Address

University of Twente

Horst Complex (building no. 20), room ZH134
De Horst 2
7522 LW Enschede
Netherlands

Navigate to location

Organisations