TNW-BET-DBE

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Expertise

  • Medicine and Dentistry

    • Chondrocyte
    • Cartilage
    • Mesenchymal Stem Cell
    • Differentiation
    • Osteoarthritis
  • Biochemistry, Genetics and Molecular Biology

    • Stem Cell
    • Gene Expression
    • Stromal Cell

Organisations

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Publications

2024
Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis PathologyAdvanced science, 11(11), Article 2306722. Govindaraj, K., Meteling, M., van Rooij, J., Becker, M., van Wijnen, A. J., van den Beucken, J. J. J. P., Ramos, Y. F. M., van Meurs, J., Post, J. N. & Leijten, J.https://doi.org/10.1002/advs.202306722Amyloid Scaffolds for Cartilage Tissue Regeneration. University of Twente. van Dalen, M. C. E.https://doi.org/10.3990/1.9789036560757
2023
2022
2021
Mapping SOX9 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells. bioRxiv. Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N.https://doi.org/10.1101/2021.11.29.470107An ECHO of cartilage: In silico prediction of combinatorial treatments to switch between transient and permanent cartilage phenotypes with ex vivo validationFrontiers in bioengineering and biotechnology, 9, Article 732917. Khurana, S., Schivo, S., Plass, J. R. M., Mersinis, N., Scholma, J., Kerkhofs, J., Zhong, L., van de Pol, J., Langerak, R., Geris, L., Karperien, M. & Post, J. N.https://doi.org/10.3389/fbioe.2021.732917The expressions of dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severityCartilage, 12(4), 496-504. Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M.https://doi.org/10.1177/1947603519841676Protein adsorption enhances energy dissipation in networks of lysozyme amyloid fibrilsLangmuir, 37(24), 7349–7355. van Dalen, M. C. E., Vaneyck, J., Semerdzhiev, S. A., Karperien, M., Post, J. N. & Claessens, M. M. A. E.https://doi.org/10.1021/acs.langmuir.1c00657Engineering cartilage tissue by co-culturing of chondrocytes and mesenchymal stromal cellsIn Osteoporosis and Osteoarthritis (pp. 53-70). Humana Press. Fu, Y., Paggi, C. A., Dudakovic, A., van Wijnen, A. J., Post, J. N. & Karperien, M.https://doi.org/10.1007/978-1-0716-0989-7_5Using FRAP to quantify changes in transcription factor dynamics after cell stimulation: Cell culture, FRAP, data analysis, and visualizationIn Osteoporosis and Osteoarthritis (pp. 109-139). Humana Press. Govindaraj, K. & Post, J. N.https://doi.org/10.1007/978-1-0716-0989-7_9

Research profiles

Courses academic year 2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2022/2023

Address

University of Twente

Horst Complex (building no. 20), room ZH134
De Horst 2
7522 LW Enschede
Netherlands

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