Dr.ing. J.N. Post | People Pages: Find employees & contact details | University of Twente

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Expertise

Biochemistry, Genetics and Molecular Biology
- Chondrocyte
- Stem Cell
- SOX9
- Computer Simulation
- Transcription Factors
- Stromal Cell
Veterinary Science and Veterinary Medicine
- Cartilage
Computer Science
- Interactivity

Organisations

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Publications

Jump to: 2026 | 2025 | 2024

2026

Investigating transcription factor dynamics in health and disease using FRAP (2026)FEBS letters (E-pub ahead of print/First online). Govindaraj, K., Garzon, C. V., Velasco, J. J. & Post, J. N.https://doi.org/10.1002/1873-3468.70405Modelling stem cell differentiation related processes: A practical overview for biologists (2026)FEBS letters (E-pub ahead of print/First online). Zeegelaar, R., Yan, X., Klomp, L. J., Schivo, S. & Post, J. N.https://doi.org/10.1002/1873-3468.70395Computational modelling of stem cell differentiation towards chondrocytes (2026)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Jansen Klomp, L.https://doi.org/10.3990/1.9789036572545Molecular insights into heart field-specific cardiomyocyte differentiation - A computational study: Boolean model of cardiac development (2026)PLoS ONE, 21(1). Article e0340054. Zeegelaar, R., Limana, F., Argyris, G. & Post, J. N.https://doi.org/10.1371/journal.pone.0340054

2025

DANSE: A pipeline for dynamic modelling of time-series multi-omics data (2025)BMC bioinformatics, 27(1). Article 28 (E-pub ahead of print/First online). Jansen Klomp, L. F., Yan, X., Snabel, R. R., Veenstra, G. J. C., Meijer, H. G. E. & Post, J. N.https://doi.org/10.1186/s12859-025-06354-3Identification of models describing gene expression data leveraging machine learning methods (2025)Interface focus, 15(3). Article 20250014. Jansen Klomp, L. F., Queirolo, E., Post, J. N., Meijer, H. G. E. & Brune, C.https://doi.org/10.1098/rsfs.2025.0014DANSE: a pipeline for dynamic modelling of time-series multi-omics data (2025)[Working paper › Preprint]. bioRxiv. Klomp, L. F. J., Yan, X., Snabel, R. R., Veenstra, G. J. C., Meijer, H. G. E. & Post, J. N.https://doi.org/10.1101/2025.07.04.663170Molecular profiling of oxygen's impact on chondrocytes: Insights from mass spectrometry imaging (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Bakker, B.https://doi.org/10.3990/1.9789036565783MODELING CARTILAGE FATE: ADVANCING OA TREATMENTS AND CHONDROCYTE DIFFERENTIATION (2025)Osteoarthritis and cartilage, 33(Supplement), S108. Klomp, L. J., Schivo, S., Kannan, S., Meijer, H. & Post, J.https://doi.org/10.1016/j.joca.2025.02.146

2024

Molecular mechanisms of heart field specific cardiomyocyte differentiation- a computational modeling approach (2024)[Working paper › Preprint]. bioRxiv. Argyris, G., Zeegelaar, R. & Post, J. N.https://doi.org/10.1101/2024.12.19.629328Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis (2024)Journal of cellular physiology, 239(12). Article e31443. Govindaraj, K., Kannan, S., Coutinho de Almeida, R., Jansen Klomp, L., Karperien, M., Meulenbelt, I. & Post, J. N.https://doi.org/10.1002/jcp.31443443-Physiological intracellular molecular crowding renormalizes osteoarthritic chondrocytes towards a healthy phenotype (2024)Osteoarthritis and cartilage, 32(Suppl. 1), S311-S312. Govindaraj, K., Meteling, M., Post, J. & Leijten, J.https://doi.org/10.1016/j.joca.2024.02.456TF-FRAP reveals number of cells in a subpopulation in hMSCs determines its differentiation potential (2024)Osteoarthritis and cartilage, 32(Supplement 1), S471-S471. Govindaraj, K., Kannan, S., Karperien, M. & Post, J.https://doi.org/10.1016/j.joca.2024.02.701

Research profiles

Courses academic year 2026/2027

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2025/2026

Courses academic year 2024/2025

Address

University of Twente

Horst Complex (building no. 20), room ZH134
De Horst 2
7522 LW Enschede
Netherlands

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