dr.ing. J.N. Post (Janine)

My research is aimed toward understanding the mechanisms regulating cartilage hypertrophy and degenerative cartilage diseases. For this I employ a variety of molecular biology, biochemical and biophysical techniques in combination with computational modeling to understand signaling pathways important in the development, maintenance and loss of cartilage homeostasis.

Medicine & Life Sciences

# Cartilage
# Chondrocytes
# Joints
# Mesenchymal Stem Cells
# Osteoarthritis

Engineering & Materials Science

# Cartilage
# Proteins
# Stem Cells

Faculty of Science and Technology (TNW), Developmental BioEngineering (DBE)

Govindaraj, K. , Khurana, S. , Karperien, M. , & Post, J. N. (2021). Mapping SOX9 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells. bioRxiv. https://doi.org/10.1101/2021.11.29.470107

Khurana, S. , Schivo, S. , Plass, J. R. M., Mersinis, N. , Scholma, J., Kerkhofs, J. , Zhong, L. , van de Pol, J. , Langerak, R., Geris, L. , Karperien, M. , & Post, J. N. (2021). An ECHO of cartilage: In silico prediction of combinatorial treatments to switch between transient and permanent cartilage phenotypes with ex vivo validation. Frontiers in bioengineering and biotechnology, 9, [732917]. https://doi.org/10.3389/fbioe.2021.732917

van Dalen, M. C. E. , Vaneyck, J. , Semerdzhiev, S. A. , Karperien, M. , Post, J. N. , & Claessens, M. M. A. E. (2021). Protein adsorption enhances energy dissipation in networks of lysozyme amyloid fibrils. Langmuir, 37(24), 7349–7355. https://doi.org/10.1021/acs.langmuir.1c00657

Khurana, S., Huisman, J. , Schivo, S. , & Post, J. N. (2021). Quantitative molecular models for biological processes: Modeling of signal transduction networks with animo. In A. J. van Wijnen, & M. S. Ganshina (Eds.), Osteoporosis and Osteoarthritis (pp. 141-161). (Methods in Molecular Biology; Vol. 2221). Humana Press Inc.. https://doi.org/10.1007/978-1-0716-0989-7_10

Govindaraj, K. , & Post, J. N. (2021). Using FRAP to quantify changes in transcription factor dynamics after cell stimulation: Cell culture, FRAP, data analysis, and visualization. In A. J. van Wijnen, & M. S. Ganshina (Eds.), Osteoporosis and Osteoarthritis (pp. 109-139). (Methods in Molecular Biology; Vol. 2221). Humana Press Inc.. https://doi.org/10.1007/978-1-0716-0989-7_9

Fu, Y. , Paggi, C. A., Dudakovic, A., van Wijnen, A. J. , Post, J. N. , & Karperien, M. (2021). Engineering cartilage tissue by co-culturing of chondrocytes and mesenchymal stromal cells. In A. J. van Wijnen, & M. S. Ganshina (Eds.), Osteoporosis and Osteoarthritis (pp. 53-70). (Methods in Molecular Biology; Vol. 2221). Humana Press Inc.. https://doi.org/10.1007/978-1-0716-0989-7_5

Huang, X. , Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S. , Hendriks, J. , Post, J. N. , & Karperien, M. (2021). The expressions of dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity. Cartilage, 12(4), 496-504. https://doi.org/10.1177/1947603519841676

Govindaraj, K. , Karperien, M. , & Post, J. N. (2020). Single cell SOX9 dynamics reveals differential DNA binding in subpopulations of hPCs. Osteoarthritis and cartilage, 28(Supplement 1), S86-S87. https://doi.org/10.1016/j.joca.2020.02.131

Govindaraj, K. (2020). Quantifying Transcriptional Dynamics by TF-FRAP. University of Twente. https://doi.org/10.3990/1.9789036550765

Schivo, S. , Khurana, S. , Govindaraj, K. , Scholma, J., Kerkhofs, J. , Zhong, L. , Huang, X. , Pol, J. V. D. , Langerak, R., Wijnen, A. J. V., Geris, L. , Karperien, M. , & Post, J. N. (2020). ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease. Cellular Signalling, 68, [109471]. https://doi.org/10.1016/j.cellsig.2019.109471

Govindaraj, K. , Karperien, M. , & Post, J. N. (2019). Changes in SOX9 and RUNX2 protein activity correlate to the health state of hPCs. Osteoarthritis and cartilage, 27(Supplement 1), S190-S191. [257]. https://doi.org/10.1016/j.joca.2019.02.292

Khurana, S., Bokkers, A., Geijs, D. J. , Schivo, S. , Karperien, M. , & Post, J. N. (2019). In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression. Osteoarthritis and cartilage, 27(suppl. 1), S193-S194. https://doi.org/10.1016/j.joca.2019.02.297

Huang, X. , Zhong, L. , Hendriks, J. , Post, J. N. , & Karperien, M. (2019). Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension. Journal of orthopaedic research, 37(1), 84-93. https://doi.org/10.1002/jor.24142

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