dr.ir. J. Rouwkema (Jeroen)

Jeroen Rouwkema is currently an Associate Professor in the Department of Biomechanical Engineering at the University of Twente. Jeroen received his doctoral degree from the University of Twente under the supervision of prof. Clemens van Blitterswijk. Prior to this, he worked 6 months in the lab of prof. Robert (Bob) Langer at MIT, USA. Between 2014 and 2015 he was also appointed as a Visiting Researcher at Harvard Medical School, USA, in the group of Prof. Ali Khademhosseini.

His expertise and interests are tissue engineering, vascularization, and the role that biomechanical signals play in these processes. He has published in multiple high-impact journals, including Nature Biotechnology (IF 41.5), Advanced Materials (IF19.0), TRENDS in Biotechnology (4x, IF 12.0), and PNAS (2x, IF 9.7). He has directed approximately € 3 million in research funding.

Jeroen has received a VENI fellowship from NWO, as well as an International Outgoing Fellowship, which is part of the Marie Skłodowska-Curie actions of the European Commission. In 2017 he received a European Research Council (ERC) Advanced grant and in 2019 an ERC Proof of Concept grant. In 2017 he also received the TERMIS EU Robert Brown Early Career Principal Investigator Award.

For more info about Jeroen Rouwkema on the 'Featured Scientists' page, click below:

Engineering & Materials Science

# Biomaterials
# Hydrogels
# Intercellular Signaling Peptides And Proteins
# Scaffolds
# Tissue
# Tissue Engineering

Agriculture & Biology

# Blood Vessels

Medicine & Life Sciences

# Tissue Engineering

Faculty of Engineering Technology (ET), Engineering Organ Support Technologies (EOST)

Dr. Rouwkema focuses on tuning the local mechanical and chemical micro-environment in order to control development and organization of vascularized engineered tissues. Adding a vascular network to an engineered tissue is a promising method to enhance tissue integration and survival after implantation. The engineered vascular network can connect to the vasculature of the patient, resulting in a faster perfusion with blood and therefore a better supply of nutrients and oxygen.

For more information see the following website: http://www.vascularizationlab.com/

Padmanaban, P. , Rouwkema, J., Kerstholt, M., & Merks , R. M. H. (2022). Simulate before you stimulate: predictive cell-based models for tissue engineering applications. 121-121. Poster session presented at EMBO Workshop Building networks: engineering in vascular biology, Barcelona , Netherlands.

Farjam, P. , Hekman, E. E. G. , Rouwkema, J. , & Verkerke, G. J. (2022). Bone fixation techniques for managing joint disorders and injuries: A review study. Journal of the mechanical behavior of biomedical materials, 126, [104982]. https://doi.org/10.1016/j.jmbbm.2021.104982

Trikalitis, V. D. , Stein, F. , Kandar, A. K., Rangel, V., Perea Paizal, J., Stimac, M. , & Rouwkema, J. (2021). Motile Bioactive Embedding Baths based on Biomaterial Hydrogel Particles. Poster session presented at TERMIS WC 2021 , Maastricht, Netherlands.

Rana, D. , Kandar, A. , Salehi-Nik, N., Inci, I. , Koopman, B. , & Rouwkema, J. (2022). Spatiotemporally controlled, aptamers-mediated growth factor release locally manipulates microvasculature formation within engineered tissues. Bioactive Materials, 12, 71-84. https://doi.org/10.1016/j.bioactmat.2021.10.024

Padmanaban, P. , Chizari, A. , Knop, T. , Zhang, J. , Trikalitis, V. D. , Koopman, B. , Steenbergen, W. , & Rouwkema, J. (2021). Assessment of flow within developing chicken vasculature and biofabricated vascularized tissues using multimodal imaging techniques. Scientific reports, 11, 1-14. [18251]. https://doi.org/10.1038/s41598-021-97008-w

Mohanty, S. , Zhang, J., McNeill, J. M., Kuenen, T., Linde, F. P. , Rouwkema, J. , & Misra, S. (2021). Acoustically-actuated bubble-powered rotational micro-propellers. Sensors and Actuators B: Chemical, 347, [130589]. https://doi.org/10.1016/j.snb.2021.130589

Silva, A. L., Babo, P. S., Rodrigues, M. T., Gonçalves, A. I., Novoa-Carballal, R., Pires, R. A. , Rouwkema, J., Reis, R. L., & Gomes, M. E. (2021). Hyaluronic Acid Oligomer Immobilization as an Angiogenic Trigger for the Neovascularization of TE Constructs. ACS Applied Bio Materials, 4(8), 6023-6035. https://doi.org/10.1021/acsabm.1c00291

Kaya, M. , Stein, F. , Rouwkema, J. , Khalil, I. S. M. , & Misra, S. (2021). Serial imaging of micro-agents and cancer cell spheroids in a microfluidic channel using multicolor fluorescence microscopy. PLoS ONE, 16(6), [e0253222]. https://doi.org/10.1371/journal.pone.0253222

Vroemen, P. A. M. M. , Sinha, R., Gamardo, A. S. , Rouwkema, J. , Moroni, L., Webers, C. A. B., & Gorgels, T. G. M. F. (2020). The effects of pressure and strain on neuronal cells. Acta Ophthalmologica, 98(S264), 20-20. https://doi.org/10.1111/aos.14387

Rana, D. , Trikalitis, V. D., Rangel, V. R. , Kandar, A. K. , & Rouwkema, J. (Accepted/In press). Patterning Self-Organizing Microvascular Networks within Engineered Matrices. Abstract from 29th Annual Meeting Netherlands Society for Biomaterials and Tissue Engineering, Netherlands.

Rana, D. , Trikalitis, V. D., Rangel, V. R. , Salehi Nik, N. , & Rouwkema, J. (Accepted/In press). Engineering Patterned Aptamer-Functionalized Hydrogels for Controlling Vascularization. Abstract from 11th World Biomaterials Congress, WBC 2020.

Rana, D. , Trikalitis, V. D., Rangel, V. R. , Kandar, A. K. , Salehi Nik, N. , & Rouwkema, J. (2020). 3D-Bioprinted Aptamer-Functionalized Bio-inks for Spatiotemporally Controlled Growth Factor Delivery. 26-26. Abstract from TERMIS-EU Meeting 2020, Manchester, United Kingdom. https://www.ecmconferences.org/abstracts/2020/Collection1/c1.html

Rana, D. , Kandar, A. , Salehi-Nik, N., Inci, I. , Koopman, B. , & Rouwkema, J. (2020). Aptamer based spatiotemporally controlled growth factor patterning for tunable local microvascular network formation in engineered tissues. bioRxiv. https://doi.org/10.1101/2020.09.22.308619

Sacchi, M. , Bansal, R. , & Rouwkema, J. (2020). Bioengineered 3D Models to Recapitulate Tissue Fibrosis. Trends in biotechnology, 38(6), 623-636. https://doi.org/10.1016/j.tibtech.2019.12.010

Babo, P. S., Silva, C. R., Silva, A. L., Domingues, R. M. A. , Rouwkema, J., Reis, R. L., & Gomes, M. E. (2019). Revascularization promoted by platelet pro-angiogenic factors or hyaluronan oligomers – A step towards endodontic regeneration using injectable systems. 1633-1633. Abstract from TERMIS European Chapter Meeting 2019, Rhodes, Greece.

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