Jeroen Rouwkema is an Associate Professor in the Department of Biomechanical Engineering at the University of Twente, where he is the PI of the Vascularization Lab. Jeroen received his doctoral degree from the University of Twente under the supervision of prof. Clemens van Blitterswijk. Prior to this, he worked 6 months in the lab of prof. Robert (Bob) Langer at MIT, USA. Between 2014 and 2015 he was also appointed as a Visiting Researcher at Harvard Medical School, USA, in the group of Prof. Ali Khademhosseini.
His lab focuses on tuning the local mechanical and chemical micro-environment in order to control tissue development and organization. His main focus in this is cardiac tissue development and the inclusion of vascular structures. Adding a vascular network to an engineered tissue is a promising method to enhance tissue integration and survival after implantation. The engineered vascular network can connect to the vasculature of the patient, resulting in a faster perfusion with blood and therefore a better supply of nutrients and oxygen. The lab consists of three pillars, which each concentrate on a specific aspect to reach the common goal:
- To develop novel bioengineering technologies, such as 3D bioprinting and growth factor patterning technology, enabling the combination of multiple distinct cellular environments within a single tissue construct.
- To develop computational models to predict the mechanical and chemical micro-environment due to external deformations and fluid flows, and subsequent models to predict tissue development based on this environment.
- To develop micro-bioreactor systems to experimentally elucidate the effects of multiple combined mechanical and chemical signals on cell behavior and tissue development.
Jeroen has received a VENI fellowship from NWO, as well as an International Outgoing Fellowship, which is part of the Marie Skłodowska-Curie actions of the European Commission. In 2017 he received a European Research Council (ERC) Consolidator grant and in 2019 and in 2021 an ERC Proof of Concept grant. In 2017 he also received the TERMIS EU Robert Brown Early Career Principal Investigator Award.
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Expertise
Medicine and Dentistry
- Tissues
- Cells
- Vascularity
- Tissue Engineering
- Vascular Network
Biochemistry, Genetics and Molecular Biology
- Vascularization
- Growth Factor
- Aptamer
Organisations
Dr. Rouwkema focuses on tuning the local mechanical and chemical micro-environment in order to control development and organization of vascularized engineered tissues. Adding a vascular network to an engineered tissue is a promising method to enhance tissue integration and survival after implantation. The engineered vascular network can connect to the vasculature of the patient, resulting in a faster perfusion with blood and therefore a better supply of nutrients and oxygen.
For more information see the following website: http://www.vascularizationlab.com/
Publications
2024
2023
2022
Other contributions
Collaborations
- Lorenzo Moroni, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University
- Albert van den Berg, the BIOS Lab-on-a-Chip group, University of Twente
- Ying Yang, Keele University, Stoke-on-Trent, UK
- Ali Khademhosseini, Harvard – MIT Health Science and Technology, Cambridge, USA
Full searches
Research profiles
Affiliated study programs
Courses academic year 2024/2025
Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.
- 193640999 - Internship BME
- 193650999 - Masters Assignment
- 195799152 - Internship
- 201300004 - Robotics for Medical Applications
- 202000250 - Internship
- 202200116 - Capita Selecta Robotics
- 202200119 - Academic Skills Project
- 202200120 - Internship ROB
- 202200122 - MSc-Thesis Project
- 202400318 - M12 BSc Assignment BMT
- 202400720 - SmartBio
Courses academic year 2023/2024
- 191150460 - Biomechanical Eng. - Capita Selecta
- 191199152 - Internship
- 193640999 - Internship BME
- 193650999 - Masters Assignment
- 195799152 - Internship
- 201300004 - Robotics for Medical Applications
- 201600327 - Tissue Engineering
- 202000250 - Internship
- 202000880 - M12 BSc Assignment BMT
- 202100080 - 3D bioprinting
- 202300231 - M4 Implant design
- 202300353 - Internship (CSE/SET)
Current projects
Address
University of Twente
Horst Complex (building no. 20), room W106
De Horst 2
7522 LW Enschede
Netherlands
University of Twente
Horst Complex W106
P.O. Box 217
7500 AE Enschede
Netherlands
Organisations
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