Jeroen Rouwkema is an Associate Professor in the Department of Biomechanical Engineering at the University of Twente, where he is the PI of the Vascularization Lab. Jeroen received his doctoral degree from the University of Twente under the supervision of prof. Clemens van Blitterswijk. Prior to this, he worked 6 months in the lab of prof. Robert (Bob) Langer at MIT, USA. Between 2014 and 2015 he was also appointed as a Visiting Researcher at Harvard Medical School, USA, in the group of Prof. Ali Khademhosseini.

His lab focuses on tuning the local mechanical and chemical micro-environment in order to control development and organization of vascularized engineered tissues. Adding a vascular network to an engineered tissue is a promising method to enhance tissue integration and survival after implantation. The engineered vascular network can connect to the vasculature of the patient, resulting in a faster perfusion with blood and therefore a better supply of nutrients and oxygen. The lab consists of three pillars, which each concentrate on a specific aspect to reach the common goal:

  • To develop novel bioengineering technologies, such as 3D bioprinting and growth factor patterning technology, enabling the combination of multiple distinct cellular environments within a single tissue construct.
  • To develop computational models to predict the mechanical and chemical micro-environment due to external deformations and fluid flows, and subsequent models to predict tissue development based on this environment.
  • To develop micro-bioreactor systems to experimentally elucidate the effects of multiple combined mechanical and chemical signals on cell behavior and tissue development.

Jeroen has directed approximately € 3 million in research funding. He has received a VENI fellowship from NWO, as well as an International Outgoing Fellowship, which is part of the Marie Skłodowska-Curie actions of the European Commission. In 2017 he received a European Research Council (ERC) Consolidator grant and in 2019 and in 2021 an ERC Proof of Concept grant. In 2017 he also received the TERMIS EU Robert Brown Early Career Principal Investigator Award.

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Expertise

  • Medicine and Dentistry

    • Tissues
    • Cells
    • Vascularity
    • Tissue Engineering
    • Vascular Network
  • Biochemistry, Genetics and Molecular Biology

    • Growth Factor
    • Aptamer
    • Vascularization

Organisations

Dr. Rouwkema focuses on tuning the local mechanical and chemical micro-environment in order to control development and organization of vascularized engineered tissues. Adding a vascular network to an engineered tissue is a promising method to enhance tissue integration and survival after implantation. The engineered vascular network can connect to the vasculature of the patient, resulting in a faster perfusion with blood and therefore a better supply of nutrients and oxygen.

For more information see the following website: http://www.vascularizationlab.com/ 

Publications

2024
2023
2022
2021

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Address

University of Twente

Horst Complex (building no. 20), room W106
De Horst 2
7522 LW Enschede
Netherlands

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