J.T. Loessberg-Zahl (Joshua)

Engineering & Materials Science

# Cell Culture
# Gels
# Hydrogels
# Laminar Flow
# Membranes
# Microfluidics
# Molecules
# Polydimethylsiloxane

Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), Biomedical and Environmental Sensorsystems (BIOS)

The goal of the VESCEL project is to produce working vascular systems from human induced pluripotent stem cells. The vessels on a chip will be a platform for both drug screening and the study of vascular disease in a personalized system. The resulting devises should help reduce the need for animal testing and clinical studies.

My part in this project is the development of 3D printed vascular networks. After being cultured with endothelial cells, the printed structures will mimic the capillary networks found in natural tissues. This technique will not only provide a platform for studying the vascular system, but will produce fine structures which can support higher cell densities than currently possible in three dimensional tissue analogs.

Conceição, F., Sousa, D. M. , Loessberg-Zahl, J. , Vollertsen, A. R., Neto, E., Søe, K., Paredes, J. , Leferink, A., & Lamghari, M. (2022). A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis. Materials Today Bio, 13, Article 100219. https://doi.org/10.1016/j.mtbio.2022.100219

Bossink, E. G. B. M. , Vollertsen, A. R. , Loessberg-Zahl, J. T. , Meer, A. D. V. D. , Segerink, L. I. , & Odijk, M. (2022). Systematic characterization of cleanroom-free fabricated macrovalves, demonstrating pumps and mixers for automated fluid handling tuned for organ-on-chip applications. Microsystems & nanoengineering, 8, Article 54. https://doi.org/10.1038/s41378-022-00378-y

van Dongen, J. E. , Spoelstra, L. R. , Berendsen, J. T. W. , Loessberg-Zahl, J. T. , Eijkel, J. C. T. , & Segerink, L. I. (2021). A Multiplexable Plasmonic Hairpin-DNA Sensor Based On Target-specific Tether Dynamics. ACS sensors, 6(12), 4297–4303. https://doi.org/10.1021/acssensors.1c02097

Tanumihardja, E. , Paradelo Rodríguez, A. , Loessberg-Zahl, J. T. , Mei, B. , Olthuis, W. , & van den Berg, A. (2021). On-chip electrocatalytic NO sensing using ruthenium oxide nanorods. Sensors and Actuators B: Chemical, 334, Article 129631. https://doi.org/10.1016/j.snb.2021.129631

Arik, Y. B., Buijsman, W. , Loessberg-Zahl, J. T. , Cuartas Velez, C. A. , Veenstra, C., Logtenberg, S., Grobbink, A. M. , Bergveld, P., Gagliardi, G., den Hollander, A. I. , Bosschaart, N. , van den Berg, A. , Passier, R. , & van der Meer, A. (2021). Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structure. Lab on a chip, 21(2), 272-283. https://doi.org/10.1039/d0lc00639d

Loessberg-Zahl, J. T., Beumer, J. , van den Berg, A. , Eijkel, J. C. T. , & van der Meer, A. D. (2020). Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning. Micromachines, 11(12), Article 1112. https://doi.org/10.3390/mi11121112

Loessberg-Zahl, J. , de Bruijn, D. S. , van den Beld, W. T. E. , Dollekamp, E., Grady, E., Keerthi, A. , Bomer, J., Radha, B. , Zandvliet, H. J. W., Bol, A. A. , van den Berg, A. , & Eijkel, J. C. T. (2020). Exploring Voltage Mediated Delamination of Suspended 2D Materials as a Cause of Commonly Observed Breakdown. The Journal of physical chemistry C, 124(1), 430-435. https://doi.org/10.1021/acs.jpcc.9b08500

Offeddu, G. S., Possenti, L. , Loessberg-Zahl, J. T., Zunino, P., Roberts, J., Han, X., Hickman, D., Knutson, C. G., & Kamm, R. D. (2019). Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution. Small, 15(46), Article 1902393. https://doi.org/10.1002/smll.201902393

Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D. , van den Berg, A. , van der Meer, A. , & Eijkel, J. C. T. (2019). Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusion. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019 (pp. 1530-1531). The Chemical and Biological Microsystems Society.

Atak, N. , Berendsen, J. T. W. , Loessberg-Zahl, J. T. , & Segerink, L. I. (2019). S microfluidic device to investigate chemotactic behavior of spermatozoa. Poster session presented at ESHRE Annual Meeting, Vienna, Austria.

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+31534898962

j.t.loessberg-zahl@utwente.nl

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University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré (building no. 15)
Hallenweg 21
7522NH Enschede
The Netherlands

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University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré
P.O. Box 217
7500 AE Enschede
The Netherlands

Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), Biomedical and Environmental Sensorsystems (BIOS)

University of Twente Drienerlolaan 5
7522 NB Enschede

+31 (0)53 489 9111
info@utwente.nl
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