J.T. Loessberg-Zahl (Joshua)



Engineering & Materials Science
Cell Culture
Laminar Flow


The goal of the VESCEL project is to produce working vascular systems from human induced pluripotent stem cells. The vessels on a chip will be a platform for both drug screening and the study of vascular disease in a personalized system. The resulting devises should help reduce the need for animal testing and clinical studies.

My part in this project is the development of 3D printed vascular networks. After being cultured with endothelial cells, the printed structures will mimic the capillary networks found in natural tissues. This technique will not only provide a platform for studying the vascular system, but will produce fine structures which can support higher cell densities than currently possible in three dimensional tissue analogs.


Conceição, F., Sousa, D. M. , Loessberg-Zahl, J. , Vollertsen, A. R., Neto, E., Søe, K., Paredes, J. , Leferink, A., & Lamghari, M. (2022). A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis. Materials Today Bio, 13, Article 100219. https://doi.org/10.1016/j.mtbio.2022.100219
Offeddu, G. S., Possenti, L. , Loessberg-Zahl, J. T., Zunino, P., Roberts, J., Han, X., Hickman, D., Knutson, C. G., & Kamm, R. D. (2019). Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution. Small, 15(46), Article 1902393. https://doi.org/10.1002/smll.201902393
Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D. , van den Berg, A. , van der Meer, A. , & Eijkel, J. C. T. (2019). Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusion. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019 (pp. 1530-1531). The Chemical and Biological Microsystems Society.
Atak, N. , Berendsen, J. T. W. , Loessberg-Zahl, J. T. , & Segerink, L. I. (2019). S microfluidic device to investigate chemotactic behavior of spermatozoa. Poster session presented at ESHRE Annual Meeting, Vienna, Austria.

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University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré (building no. 15)
Hallenweg 21
7522NH  Enschede
The Netherlands

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University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
P.O. Box 217
7500 AE Enschede
The Netherlands