J.T. Loessberg-Zahl | People Pages: Find employees & contact details | University of Twente

Expertise

Engineering
- Concentration Profile
- Gel
- Hydrogel
- Microfluidics
- Laminar Flows
- Microfluidic Device
Biochemistry, Genetics and Molecular Biology
- Molecule
Medicine and Dentistry
- Organ-on-a-Chip

Organisations

The goal of the VESCEL project is to produce working vascular systems from human induced pluripotent stem cells. The vessels on a chip will be a platform for both drug screening and the study of vascular disease in a personalized system. The resulting devises should help reduce the need for animal testing and clinical studies.

My part in this project is the development of 3D printed vascular networks. After being cultured with endothelial cells, the printed structures will mimic the capillary networks found in natural tissues. This technique will not only provide a platform for studying the vascular system, but will produce fine structures which can support higher cell densities than currently possible in three dimensional tissue analogs.

Publications

2022

Systematic characterization of cleanroom-free fabricated macrovalves, demonstrating pumps and mixers for automated fluid handling tuned for organ-on-chip applications, Article 54. Bossink, E. G. B. M., Vollertsen, A. R., Loessberg-Zahl, J. T., Meer, A. D. v. d., Segerink, L. I. & Odijk, M.https://doi.org/10.1038/s41378-022-00378-yA metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis, Article 100219. Conceição, F., Sousa, D. M., Loessberg-Zahl, J., Vollertsen, A. R., Neto, E., Søe, K., Paredes, J., Leferink, A. & Lamghari, M.https://doi.org/10.1016/j.mtbio.2022.100219

2021

A Multiplexable Plasmonic Hairpin-DNA Sensor Based On Target-specific Tether Dynamics, 4297–4303. van Dongen, J. E., Spoelstra, L. R., Berendsen, J. T. W., Loessberg-Zahl, J. T., Eijkel, J. C. T. & Segerink, L. I.https://doi.org/10.1021/acssensors.1c02097On-chip electrocatalytic NO sensing using ruthenium oxide nanorods, Article 129631. Tanumihardja, E., Paradelo Rodríguez, A., Loessberg-Zahl, J. T., Mei, B., Olthuis, W. & van den Berg, A.https://doi.org/10.1016/j.snb.2021.129631Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structure, 272-283. Arik, Y. B., Buijsman, W., Loessberg-Zahl, J. T., Cuartas Velez, C. A., Veenstra, C., Logtenberg, S., Grobbink, A. M., Bergveld, P., Gagliardi, G., den Hollander, A. I., Bosschaart, N., van den Berg, A., Passier, R. & van der Meer, A.https://doi.org/10.1039/d0lc00639d

2020

Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning, Article 1112. Loessberg-Zahl, J. T., Beumer, J., van den Berg, A., Eijkel, J. C. T. & van der Meer, A. D.https://doi.org/10.3390/mi11121112Exploring Voltage Mediated Delamination of Suspended 2D Materials as a Cause of Commonly Observed Breakdown, 430-435. Loessberg-Zahl, J., de Bruijn, D. S., van den Beld, W. T. E., Dollekamp, E., Grady, E., Keerthi, A., Bomer, J., Radha, B., Zandvliet, H. J. W., Bol, A. A., van den Berg, A. & Eijkel, J. C. T.https://doi.org/10.1021/acs.jpcc.9b08500

2019

Developing microfluidic tooling for 3D cell-culture. University of Twente. Loessberg-Zahl, J. T.https://doi.org/10.3990/1.9789036549202Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution, Article 1902393. Offeddu, G. S., Possenti, L., Loessberg-Zahl, J. T., Zunino, P., Roberts, J., Han, X., Hickman, D., Knutson, C. G. & Kamm, R. D.https://doi.org/10.1002/smll.201902393Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusionIn 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019 (pp. 1530-1531). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D., van den Berg, A., van der Meer, A. & Eijkel, J. C. T.

Research profiles

Address

University of Twente

Carré (building no. 15)
Hallenweg 23
7522 NH Enschede
Netherlands

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Organisations