Expertise

  • Engineering

    • Concentration Profile
    • Gel
    • Hydrogel
    • Microfluidics
    • Laminar Flows
    • Microfluidic Device
  • Biochemistry, Genetics and Molecular Biology

    • Molecule
  • Medicine and Dentistry

    • Organ-on-a-Chip

Organisations

The goal of the VESCEL project is to produce working vascular systems from human induced pluripotent stem cells. The vessels on a chip will be a platform for both drug screening and the study of vascular disease in a personalized system. The resulting devises should help reduce the need for animal testing and clinical studies.

My part in this project is the development of 3D printed vascular networks. After being cultured with endothelial cells, the printed structures will mimic the capillary networks found in natural tissues. This technique will not only provide a platform for studying the vascular system, but will produce fine structures which can support higher cell densities than currently possible in three dimensional tissue analogs.

Publications

2022
2021
2020
2019
Developing microfluidic tooling for 3D cell-culture. University of Twente. Loessberg-Zahl, J. T.https://doi.org/10.3990/1.9789036549202Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule DistributionSmall, 15(46), Article 1902393. Offeddu, G. S., Possenti, L., Loessberg-Zahl, J. T., Zunino, P., Roberts, J., Han, X., Hickman, D., Knutson, C. G. & Kamm, R. D.https://doi.org/10.1002/smll.201902393Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusionIn 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019 (pp. 1530-1531). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D., van den Berg, A., van der Meer, A. & Eijkel, J. C. T.

Research profiles

Address

University of Twente

Carré (building no. 15)
Hallenweg 23
7522 NH Enschede
Netherlands

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