As a biomedical microtechnologist, I am passionate about integrating promising upcoming micromaterials and (micro)technologies into the fields of medical biology, cell-based therapies and clinical diagnostics. After my PhD in Tissue Engineering at University of Twente, I performed postdocs at KU Leuven and Harvard-MIT, where I became subgroup leader, after which I accepted a Tenure track position at University of Twente. I have a Visible research track, strong expertise and experimental background in: I) tissue engineering, II) microfluidic technology, III) organs-on-a-chip, IV) (stem) cell biology; and V) biomimetic biomaterials. This has led to numerous papers in high-ranked journals including Cell Stem Cell, Nature Communications, Small, Advanced Functional Materials, and PNAS. I have had the honour to have been awarded with Veni, Vidi, and ERC Starting grants as well as multiple early career and presentation awards.  

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Expertise

  • Medicine and Dentistry

    • Cartilage
    • Cells
    • Mesenchymal Stem Cell
    • Chondrocyte
    • Tissues
    • Osteoarthritis
  • Biochemistry, Genetics and Molecular Biology

    • Stem Cell
  • Chemistry

    • Microfluidics

Organisations

Publications

2024

Injectable Self-Oxygenating Cardio-Protective and Tissue Adhesive Silk-Based Hydrogel for Alleviating Ischemia After Mi Injury (2024)Small, 20(32). Article 2312261. Hassan, S., Rezaei, Z., Luna, E., Yilmaz-Aykut, D., Lee, M. C., Perea, A. M., Jamaiyar, A., Bassous, N., Hirano, M., Tourk, F. M., Choi, C., Becker, M., Yazdi, I., Fan, K., Avila-Ramirez, A. E., Ge, D., Abdi, R., Fisch, S., Leijten, J., … Shin, S. R.https://doi.org/10.1002/smll.202312261Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels (2024)Small (E-pub ahead of print/First online). Husch, J. F. A., Araújo-Gomes, N., Willemen, N. G. A., Cofiño-Fabrés, C., van Creij, N., Passier, R., Leijten, J. & van den Beucken, J. J. J. P.https://doi.org/10.1002/smll.202403272Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (2024)Advanced materials, 36(28). Article 2308949. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J.https://doi.org/10.1002/adma.202308949Engineering Synthetic Erythrocytes as Next-Generation Blood Substitutes (2024)Advanced functional materials, 34(28). Article 2315879. Gomes, F. L., Jeong, S. H., Shin, S. R., Leijten, J. & Jonkheijm, P.https://doi.org/10.1002/adfm.202315879Towards single-cell bioprinting: micropatterning tools for organ-on-chip development (2024)Trends in biotechnology, 42(6), 739-759. Bosmans, C., Ginés Rodriguez, N., Karperien, M., Malda, J., Moreira Teixeira, L., Levato, R. & Leijten, J.https://doi.org/10.1016/j.tibtech.2023.11.014An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs (2024)Bio-Design and Manufacturing, 7(3), 240-261. Jeong, S. H., Hiemstra, J., Blokzijl, P. V., Damian-Ferrara, R., dos Santos, D. M., da Fonseca, J. H. L., Kang, M. H., Kim, J., Yilmaz-Aykut, D., Cham-Pérez, M. L. L., Leijten, J. & Shin, S. R.https://doi.org/10.1007/s42242-024-00281-7Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology (2024)Advanced science, 11(11). Article 2306722. Govindaraj, K., Meteling, M., van Rooij, J., Becker, M., van Wijnen, A. J., van den Beucken, J. J. J. P., Ramos, Y. F. M., van Meurs, J., Post, J. N. & Leijten, J.https://doi.org/10.1002/advs.202306722Scalable production of 3D microtissues using novel microfluidic technologies (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Loo, S. R.https://doi.org/10.3990/1.9789464960372

2023

Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules (2023)Nature communications, 14. Article 6685. van Loo, S. R., ten Den, S. A., Araújo-Gomes, N., de Jong, V., Snabel, R., Schot, M. R., Rivera Arbelaez, J. M., Veenstra, G. J., Passier, R., Kamperman, T. & Leijten, J.https://doi.org/10.1038/s41467-023-42297-0Single-Step Biofabrication of In Situ Spheroid-Forming Compartmentalized Hydrogel for Clinical-Sized Cartilage Tissue Formation (2023)Advanced healthcare materials, 12(27). Article 2300095. van Loo, B., Schot, M., Gurian, M., Kamperman, T. & Leijten, J.https://doi.org/10.1002/adhm.202300095

Research profiles

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