dr. J.C.H. Leijten (Jeroen)

Associate Professor
TNW-BET-DBE
jeroen.leijten@utwente.nl
+31534894576
Business card

As a biomedical microtechnologist, I am passionate about integrating promising upcoming micromaterials and (micro)technologies into the fields of medical biology, cell-based therapies and clinical diagnostics. After my PhD in Tissue Engineering at University of Twente, I performed postdocs at KU Leuven and Harvard-MIT, where I became subgroup leader, after which I accepted a Tenure track position at University of Twente. I have a Visible research track, strong expertise and experimental background in: I) tissue engineering, II) microfluidic technology, III) organs-on-a-chip, IV) (stem) cell biology; and V) biomimetic biomaterials. This has led to numerous papers in high-ranked journals including Cell Stem Cell, Nature Communications, Small, Advanced Functional Materials, and PNAS. I have had the honour to have been awarded with Veni, Vidi, and ERC Starting grants as well as multiple early career and presentation awards.  

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Expertise

  • Medicine and Dentistry

    • Cartilage
    • Cells
    • Mesenchymal Stem Cell
    • Chondrocyte
    • Tissues
    • Osteoarthritis
    • Differentiation

  • Biochemistry, Genetics and Molecular Biology

    • Stem Cell

Organisations

Publications

2025

Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model (2025)Journal of Cartilage & Joint Preservation, 5(2). Article 100233. Piluso, S., Li, Y., Texeira, L. M., Padmanaban, P., Rouwkema, J., Leijten, J., van Weeren, R., Karperien, M. & Malda, J.https://doi.org/10.1016/j.jcjp.2025.100233Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation (2025)Materials Today Bio, 32. Article 101728. Pereira Dos Santos Conceição, F., Meneses, J., Lebre, F., Becker, M., Araújo-Gomes, N., Vos, R., Ribeiro, A. R., Alfaro-Moreno, E., Leijten, J. & Moreira Teixeira, L.https://doi.org/10.1016/j.mtbio.2025.101728Covalent On-Cell Conjugation of Biomaterials Through Oxidative Phenolic Coupling Regulates Stem Cell Fate via Intracellular Biophysical Programming (2025)Advanced functional materials, 35(17). Article 2418963. Johnbosco, C., Becker, M., Willemen, N., Meteling, M., Govindaraj, K., Kamperman, T. & Leijten, J.https://doi.org/10.1002/adfm.202418963ATPS-enabled single-step printing of chemically and mechanically on-demand tunable perfusable channels in ejectable constructs (2025)Biofabrication, 17(2). Article 025027. Becker, M., Gomes, F., Porsul, I. & Leijten, J.https://doi.org/10.1088/1758-5090/adbcdcOPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility (2025)ACS applied materials & interfaces, 17(12), 18179-18193. Fernandes Gomes, F. L., Wasserberg, D., Edelbroek, R., van Weerd, J., Jonkheijm, P. & Leijten, J.https://doi.org/10.1021/acsami.5c02103High-Throughput Single-Cell Analysis of Local Nascent Protein Deposition in 3D Microenvironments via Extracellular Protein Identification Cytometry (EPIC) (2025)Advanced materials, 37(6). Article 2415981. Meteling, M., Johnbosco, C., Wolfel, A., Conceição, F., Govindaraj, K., Teixeira, L. M. & Leijten, J.https://doi.org/10.1002/adma.202415981Synergistic effect of Hypoxic Conditioning and Cell-Tethering Colloidal Gels enhanced Productivity of MSC Paracrine Factors and Accelerated Vessel Regeneration (2025)Advanced materials, 37(3). Article 2408488. Lee, M. C., Lee, J. S., Kim, S., Jamaiyar, A., Wu, W., Gonzalez, M. L., Durán, T. C. A., Madrigal-Salazar, A. D., Bassous, N., Carvalho, V., Choi, C., Kim, D. S., Seo, J. W., Rodrigues, N., Teixeira, S. F. C. F., Alkhateeb, A. F., Soto, J. A. L., Hussain, M. A., Leijten, J., … Shin, S. R.https://doi.org/10.1002/adma.202408488Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration (2025)Pharmaceutics, 17(1). Article 64. Gomes, F. L., Conceição, F., Teixeira, L. M., Leijten, J. & Jonkheijm, P.https://doi.org/10.3390/pharmaceutics17010064Bioxolography Using Diphenyliodonium Chloride and N-Vinylpyrrolidone Enables Rapid High-Resolution Volumetric 3D Printing of Spatially Encoded Living Matter (2025)Advanced materials (Accepted/In press). Wolfel, A., Johnbosco, C., Anspach, A., Meteling, M., Olijve, J., König, N. F. & Leijten, J.https://doi.org/10.1002/adma.202501052

2024

Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels (2024)Small, 20(46). Article 2403272. Husch, J. F. A., Araújo-Gomes, N., Willemen, N. G. A., Cofiño-Fabrés, C., van Creij, N., Passier, R., Leijten, J. & van den Beucken, J. J. J. P.https://doi.org/10.1002/smll.202403272

Research profiles

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