Guest staff

drs. K.H. Kho MD (Kuan Hua)

Researcher (Guest)
TNW-BIS-CNPH
k.h.kho@utwente.nl
+31534896775
Business card

Kuan Kho studied Medicine and Psychology in Nijmegen. Initially working as a researcher in neuropsychology, he was involved in clinical work and served as a neurosurgical resident at the University Medical Center Utrecht (Utrecht, NL), Haaglanden Medisch Centrum (The Hague, NL), and University Hospitals Leuven, (Leuven, B) always combining his background in neuropsychology with clinical neurosurgery. In 2014 he was appointed as a consultant neurosurgeon at Medisch Spectrum Twente (Enschede, NL). His main focus is functional neurosurgery and intra-operative neuromonitoring (deep brain stimulation, vagus nerve stimulation, awake craniotomies)

Expertise

  • Neuroscience

    • Subdural Hematoma

  • Medicine and Dentistry

    • Patient
    • Surgery
    • Therapeutic Procedure
    • Dexamethasone
    • Cohort Analysis
    • Temporal Lobe
    • Inpatient

Organisations

A student of brain-behaviour relationships, Kuan Kho recognizes that patients with brain lesions and neurosurgical procedures may provide rare opportunities to study this in detail. As a clinician he is interested in the use of implants for restoring neural function or for invasive recording of brain signals for diagnosis. Research questions come from his daily work in consulting and operating on patients with cerebral or spinal disorders, and research includes the use of continuous recording of EEG and Deep Brain signals in epilepsy patients to learn about the cerebral connections underlying disease and cognitive functions.

Publications

Jump to: 2025 | 2024 | 2023 | 2022 | 2021

2025

Individualized cortical thickness asymmetry in autism spectrum disorder and schizophrenia (2025)Molecular Psychiatry (E-pub ahead of print/First online). Martín Echave, M., Schnack, H. G., Díaz-Caneja, C. M., Pina-Camacho, L., Janssen, N., Gordaliza, P. M., Kho, K. H., Buimer, E. E. L., van Haren, N. E. M., Cahn, W., Kahn, R. S., Hulshoff Pol, H. E., Arango, C. & Janssen, J.https://doi.org/10.1038/s41380-025-03359-5Independent Predictors for Operative Treatment of Chronic Subdural Hematoma (2025)Acta Neurologica Scandinavica, 2025(1). Article 2759676. Reimer, J. M. B., Brohet, R. M., Jacobs, B., Blaauw, J., Arntz, R. M., Kho, K. H., Groen, R. J. M., Foumani, M., van der Naalt, J. & den Hertog, M. H.https://doi.org/10.1155/ane/2759676Ultra-long-term subcutaneous EEG recordings in ten epilepsy patients: Experiences and circadian rhythms in epileptiform discharges (2025)Epilepsy and Behavior Reports, 31. Article 100781. van Norden, S. J., Kho, K. H., Meppelink, A. M., Ardesch, J. J., Tjepkema-Cloostermans, M. C. & van Putten, M. J. A. M.https://doi.org/10.1016/j.ebr.2025.100781

2024

Individualized cortical thickness asymmetry in autism spectrum disorder and schizophrenia (2024)[Working paper › Preprint]. MedRxiv. Martín Echave, M., Schnack, H. G., Díaz-Caneja, C. M., Pina-Camacho, L., Janssen, N., Gordaliza, P. M., Kho, K. H., Buimer, E. E. L., van Haren, N. E. M., Cahn, W., Kahn, R. S., Hulshoff Pol, H. E., Arango, C. & Janssen, J.https://doi.org/10.1101/2024.11.06.24316751Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma (2024)In Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings (pp. 34-44) (Lecture Notes in Computer Science; Vol. 15002). Springer. Imre, B., Thibeau-Sutre, E., Reimer, J., Kho, K. & Wolterink, J. M.https://doi.org/10.1007/978-3-031-72069-7_4Management of an acute intracranial emergency in pregnancy (2024)BMJ Case Reports, 17. Article e258066. Brokkelkamp, P., Baalman, J. H., Driesse, M. J. & Kho, K. H.https://doi.org/10.1136/bcr-2023-258066Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma (2024)[Working paper › Preprint]. ArXiv.org. Imre, B., Thibeau-Sutre, E., Reimer, J., Kho, K. & Wolterink, J. M.https://doi.org/10.48550/arXiv.2403.19415

2023

Dexamethasone versus Surgery for Chronic Subdural Hematoma (2023)New England journal of medicine, 388(24), 2230-2240. Miah, I. P., Holl, D. C., Blaauw, J., Lingsma, H. F., den Hertog, H. M., Jacobs, B., Kruyt, N. D., van der Naalt, J., Polinder, S., Groen, R. J. M., Kho, K. H., van Kooten, F., Dirven, C. M. F., Peul, W. C., Jellema, K., Dammers, R. & van der Gaag, N. A.https://doi.org/10.1056/NEJMoa2216767QUality of life and Economic evaluation after neuroSTimulation for Epilepsy (QUESTE) in adolescents and adults with drug-resistant epilepsy: Protocol for a multicentre, prospective observational cohort study in the Netherlands (2023)BMJ open, 13(6). Article e071575. Smeets, J. J. A. S., Rijkers, K., Ackermans, L., Schijns, O., Van Mastrigt, G. A. P. G., Rouhl, R., Wagner, G. L., Van Kuijk, S., Nelissen, J., Van Straaten, I. E. C. W., Kho, K., Snoeijen-Schouwenaars, F., Meppelink, A. M., Klinkenberg, S. & Majoie, H. J. M.https://doi.org/10.1136/bmjopen-2023-071575Safety and technical efficacy of early minimally invasive endoscopy-guided surgery for intracerebral haemorrhage: the Dutch Intracerebral haemorrhage Surgery Trial pilot study (2023)Acta neurochirurgica, 165(6), 1585-1596. Sondag, L., Schreuder, F. H. B. M., Pegge, S. A. H., Coutinho, J., Dippel, D. W. J., Janssen, P. M., Vandertop, W. P., Boogaarts, H. D., Dammers, R., Klijn, C. J. M., Boiten, J., Brouwers, P. J. A. M., den Hertog, M. H., Janssen, P. M., Jolink, W. M. T., Kappelle, L. J., Kho, K. H., Koot, R. W., de Kort, P. L. M., … Can, A.https://doi.org/10.1007/s00701-023-05599-2Choice of Implantable Pulse Generators for Deep Brain Stimulation: An Overview of Clinical Practice (2023)Stereotactic and functional neurosurgery, 101(2), 135-145. Willems, Y. R., Van Der Gaag, N. A., Kho, K. H., Tveiten, Ø. V., Krüger, M. T. & Jakobs, M.https://doi.org/10.1159/000529495The cognitive status of chronic subdural hematoma patients after treatment: an exploratory study (2023)Acta neurochirurgica, 165(3), 701-709. Blaauw, J., Hertog, H. M. d., Holl, D. C., Thüss, N. S., van der Gaag, N. A., Jellema, K., Dammers, R., Kho, K. H., Groen, R. J. M., Lingsma, H. F., Jacobs, B. & van der Naalt, J.https://doi.org/10.1007/s00701-023-05508-7

2022

Mortality after chronic subdural hematoma is associated with frailty (2022)Acta neurochirurgica, 164(12), 3133-3141. Blaauw, J., Jacobs, B., Hertog, H. M. d., van der Gaag, N. A., Jellema, K., Dammers, R., Kho, K. H., Groen, R. J. M., van der Naalt, J. & Lingsma, H. F.https://doi.org/10.1007/s00701-022-05373-wStudy protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics—a prospective multicenter cohort study (2022)BMC Medical Genomics, 15(1). Article 233. van Opijnen, M. P., Broekman, M. L. D., de Vos, F. Y. F., Cuppen, E., van der Hoeven, J. J. M., van Linde, M. E., Compter, A., Beerepoot, L. V., van den Bent, M. J., Vos, M. J., Fiebrich, H. B., Koekkoek, J. A. F., Hoeben, A., Kho, K. H., Driessen, C. M. L., Jeltema, H. R., Robe, P. A. J. T. & Maas, S. L. N.https://doi.org/10.1186/s12920-022-01343-4External validation of prognostic models predicting outcome after chronic subdural hematoma (2022)Acta neurochirurgica, 164(10), 2719-2730. Holl, D. C., Mikolic, A., Blaauw, J., Lodewijkx, R., Foppen, M., Jellema, K., van der Gaag, N. A., den Hertog, H. M., Jacobs, B., van der Naalt, J., Verbaan, D., Kho, K. H., Dirven, C. M. F., Dammers, R., Lingsma, H. F. & van Klaveren, D.https://doi.org/10.1007/s00701-022-05216-8Transient neurological deficit in patients with chronic subdural hematoma: a retrospective cohort analysis (2022)Journal of neurology, 269(6), 3180-3188. Blaauw, J., den Hertog, H. M., van Zundert, J. M., van der Gaag, N. A., Jellema, K., Dammers, R., Kho, K. H., Groen, R. J. M., Lingsma, H. F., van der Naalt, J. & Jacobs, B.https://doi.org/10.1007/s00415-021-10925-8National survey on the current practice and attitudes toward the management of chronic subdural hematoma (2022)Brain and Behavior, 12(3), e2463. Article e2463. Holl, D. C., Blaauw, J., Ista, E., Dirven, C. M. F., Kho, K. H., Jellema, K., van der Gaag, N. A., Miah, I. P., den Hertog, H. M., van der Naalt, J., Jacobs, B., Verbaan, D., Polinder, S., Lingsma, H. F. & Dammers, R.https://doi.org/10.1002/brb3.2463Spinal Cord Stimulation and Urinary Dysfunction (2022)Pain medicine, 23(7), 1204-1211. Smeijers, S., Kho, K. H., De Vlieger, J., Van Hoylandt, A., Nuttin, B. & Theys, T.https://doi.org/10.1093/pm/pnac019Presenting symptoms and functional outcome of chronic subdural hematoma patients (2022)Acta Neurologica Scandinavica, 145(1), 38-46. Blaauw, J., Meelis, G. A., Jacobs, B., van der Gaag, N. A., Jellema, K., Kho, K. H., Groen, R. J. M., van der Naalt, J., Lingsma, H. F. & den Hertog, H. M.https://doi.org/10.1111/ane.13518

2021

Dr. Jan Holsheimer 1941-2021 (2021)Neuromodulation, 24(4), 609. Lenders, M. W. P. M., Kho, K. H., de Vos, C. C. & Elands, A.https://doi.org/10.1111/ner.13416

Other contributions

Peer-reviewed journal papers

  • Kho, KH, Verkes, RJ, Eling, P, Zwarts, MJ, Ellenbroek, B, & van Luijtelaar, G (2003). P50 gating is not affected by selective attention. Journal of Psychophysiology,17, 23-29.
  • Kho, KH, Leijten, FSS, Rutten, GJM, Vermeulen, J, van Rijen, PC, & Ramsey, NF (2005). Discrepant findings between Wada test and electrocortical stimulation with regard to language function, predicted by functional MRI. Journal of Neurosurgery,102,169–173.
  • Kho, KH, Blijham, P, & Zwarts, MJ (2005). Meralgia paresthetica after strenous excercise. Muscle and Nerve, 31, 761-763
  • Kho, KH, van den Bergh, WM, Spetgens, WP, & Leijten, FS (2006). Figuring out drawing induced epilepsy. Neurology, 66, 723-726. (discussion 619)
  • Ramsey, NF, van den Heuvel, MP, Kho, KH, & Leijten, FS (2006). Towards human BCI applications based on cognitive brain systems : an investigation of neural signals recorded from the dorsolateral prefrontal cortex. IEEE Trans Neural Syst Rehabil Eng, 14, 214-217
  • Kho, KH, Duffau, H, Gatignol, P, Leijten, FS, Ramsey, NF, & Rutten GJ. (2007). Language switching in two bilingual patients during the Wada test and intraoperative electrocortical stimulation. Brain and Language, 101, 31-37.
  • Kho, KH, Rutten, GJ, Leijten, FS, van der Schaaf, A, van Rijen, PC, & Ramsey, NF (2007). Working memory deficits after resection of dorsolateral prefrontal cortex predicted by functional MRI and electrocortical stimulation mapping, Journal of Neurosurgery, 106 (6 Suppl), 501-505.
  • Cats, EA, Kho, KH, van Nieuwenhuizen, O, van Veelen, CWM, Gosselaar, PH, & van Rijen PC (2007). Seizure-freedom after functional hemispherectomy, a possible role for the insular cortex. The Dutch experience. Journal of Neurosurgery, 107 (4 Suppl),275-280.
  • Kho, KH, van Veelen, NMJ, Beerepoot, LJ, & Sommer IEC (2007). A vanishing lesion in the temporal lobe associated with severe and medication-resistant psychosis. Cognitive and Behavioral Neurology, 20, 232-234
  • Kho, KH, Indefrey, P, Hagoort, P, van Veelen, CWM, van Rijen, PC, & Ramsey, NF (2008). Unimpaired syntactic and prosodic comprehension in epilepsy patients after surgical removal of the anterior temporal cortex. Neuropsychologia, 46, 1170-1178.
  • Broekman, MLD, Hoving, EW, Kho, KH, Speleman, L, Han, KS, & Hanlo PW (2008). Nasal encephalocele in a child with Beckwith Wiedemann Syndrome. Journal of Neurosurgery: Pediatrics, 1, 485-487.
  • Daenekindt, T, Weyns, F, Kho, KH, Peuskens, D, Engelborghs, K, & Wuyts, J (2008). Giant intracranial capillary hemangioma associated with enlarged head circumference in a newborn. Journal of Neurosurgery: Pediatrics, 1, 488-492.
  • Theys, T, Kho, KH, Siemons, W, & Thijs, V (2009). A matter of taste. Journal of neurology, neurosurgery, and psychiatry, 80, 139-140.
  • Theys, T, Kho, KH, & Nuttin B (2009). A vaginal CSF leak. Neurology,72,1446.
  • Zijlmans, M, van Eijsden, P, Ferrier, CH, Kho, KH, van Rijen, PC, & Leijten, FS (2009). Illusory shadow person causing paradoxical gaze deviations during temporal lobe seizures. J Neurol Neurosurg Psychiatry, 80, 686-688.
  • Theys, T, Van Cauter, S, Kho, KH, Vijverman, AC, Peeters, RR, Sunaert, S, & van Loon J (2012). Neural correlates of recovery from Foix-Chavany-Marie syndrome. J Neurol, 260, 415-420
  • De Vleeschouwer, S. Van Cauter, S, Kovacs, S, Van Hecke, W, Van Driel, G, Van Paesschen, W, Kho, KH, & Sunaert, S (2014). Validation of intra-operative DTI fiber tracking in eloquent brain surgery. World neurosurgery, 80, 658–659. 
  • Theys, T, & Kho, KH (2014). The saddle and the horse’s tail: cauda equina syndrome. JAMA Neurol, 71, 914-915.
  • Kho, KH, & Janssen, N. (2016). Intermanual transfer in an artist with Parkinson's disease. Neurocase, 22, 119-121.
  • van Essen, TA, de Ruiter, GC, Kho, KH, & Peul, WC. (2017). Neurosurgical Treatment Variation of Traumatic Brain Injury: Evaluation of Acute Subdural Hematoma Management in Belgium and The Netherlands. J Neurotrauma, 34, 881-889.
  • Holl, DC, Volovici, V, Dirven, CMF, Peul, WC, van Kooten, F, Jellema, K, van der Gaag NA, Miah IP, Kho KH, den Hertog HM, Lingsma HF, & Dammers R; Dutch Chronic Subdural Hematoma Research Group (DSHR) (2018). Pathophysiology and Nonsurgical Treatment of Chronic Subdural Hematoma: From Past to Present to Future. World Neurosurg, 116, 402-411.
  • Miah IP, Holl DC, Peul WC, Walchenbach R, Kruyt N, de Laat K, Koot RW, Volovici V, Dirven CMF, van Kooten F, Kho KH, den Hertog HM, van der Naalt J, Jacobs B, Groen RJM, Lingsma HF, Dammers R, Jellema K, & van der Gaag NA; Dutch Subdural Hematoma Research Group (DSHR). (2018) Dexamethasone therapy versus surgery for chronic subdural haematoma (DECSA trial): study protocol for a randomised controlled trial. Trials, 19, 575.
  • Kho, KH, Leijten, QH, & Dorresteijn, LDA (2019). A Parkinson’s Disease patient without corpus callosum. Journal of Parkinson’s Disease, 9, 441-442.
  • Holl DC, Volovici V, Dirven CMF, van Kooten F, Miah IP, Jellema K, Peul WC, van der Gaag NA, Kho KH, den Hertog HM, Dammers R, & Lingsma HF (2019). Corticosteroid treatment compared with surgery in chronic subdural hematoma: a systematic review and meta-analysis. Acta Neurochir (Wien). 161,1231-1242.
  • van Dartel D, Schelhaas HJ, Colon AJ, Kho KH, de Vos CC. (2020) Breath analysis in detecting epilepsy. J Breath Res.14
  • Blaauw J, Jacobs B, den Hertog HM, van der Gaag NA, Jellema K, Dammers R, Lingsma HF, van der Naalt J, Kho KH, & Groen RJM (2020). Neurosurgical and Perioperative Management of Chronic Subdural Hematoma. Front Neurol. 550.
  • Blaauw J, Meelis GA, Jacobs B, van der Gaag NA, Jellema K, Kho KH, Groen RJM, van der Naalt J, Lingsma HF, & den Hertog HM (2022). Presenting symptoms and functional outcome of chronic subdural hematoma patients. Acta Neurol Scand, 145, 38-46.
  • Blaauw J, den Hertog HM, van Zundert JM, van der Gaag NA, Jellema K, Dammers R, Kho KH, Groen RJM, Lingsma HF, van der Naalt J, & Jacobs B (2022). Transient neurological deficit in patients with chronic subdural hematoma: a retrospective cohort analysis. J Neurol, in press

 

Other contributions

  • Lenders MWPM, Kho KH, de Vos CC, Elands A. (2021). Dr. Jan Holsheimer 1941-2021. Neuromodulation,24, 609.

Research profiles

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