Technohal

dr.ir. L. Alic (Lejla)

Associate Professor
TNW-MID-MD&I
Technohal 2186
l.alic@utwente.nl
+31534898731
Business card

Lejla currently holds the position of Associate Professor at the Department of Magnetic Detection and Imaging. Her expertise lies in the fields of medical imaging, computer vision, medical devices, and laparoscopy, as evidenced by her (co-)authorship of over 70 publications (excluding conference abstracts).

Lejla pursued her studies in Electrical Engineering at Delft University of Technology. Under the guidance of Prof. Babuska, she successfully completed her undergraduate program focusing on fuzzy clustering of medical signals. She also worked alongside Dr. ir. van Wijk van Brievingh, Prof. Ince, and Prof. Lelieveldt exploring the analysis of colonoscopy images. In 2013 she obtained het PhD from Erasmus Universiteit Rotterdam (Biomedical imaging Group Rotterdam) supervised by Prof. Niessen. Her research in this period encompassed a wide range of methods for assessing cancer treatment outcomes using pre-clinical and clinical data. Her doctoral thesis, titled ‘Quantification of tumour heterogeneity in MRI’, was defended within two graduate schools: Advanced School for Computing and Imaging and Molecular Medicine.

Throughout her academic journey, Lejla has held research fellowships at esteemed institutions, including Leiden University Medical Center (Division of Image Processing), Academic Medical Center University of Amsterdam (Experimental Anaesthesiology), Engineering Science at the University of Oxford (Robotics Research Group, led by Sir. Brady), Texas A&M University at Qatar (Department of Electrical and Computer Engineering). Additionally, she served as a scientific researcher and project leader at TNO, a renowned Dutch contract research institute. In 2019, she assumed the role of Assistant Professor at the Department of Magnetic Detection and Imaging at the University of Twente.

Expertise

  • Biochemistry, Genetics and Molecular Biology

    • Magnetic Resonance Imaging
    • Magnetism
    • Iron
    • Contrast

  • Medicine and Dentistry

    • Patient
    • Tissues
    • Magnetic Nanoparticle
    • Lymph Node

Organisations

Lejla currently holds the position of Associate Professor at the Department of Magnetic Detection and Imaging. Her expertise lies in the fields of medical imaging, computer vision, medical devices, and laparoscopy, as evidenced by her (co-)authorship of over 70 publications (excluding conference abstracts).

Publications

Jump to: 2024 | 2023 | 2022 | 2021

2024

Engineered SPIONs functionalized with endothelin a receptor antagonist ameliorate liver fibrosis by inhibiting hepatic stellate cell activation (2024)Bioactive Materials, 39, 406-426. ten Hove, M., Smyris, A., Booijink, R., Wachsmuth, L., Hansen, U., Alic, L., Faber, C., Hӧltke, C. & Bansal, R.https://doi.org/10.1016/j.bioactmat.2024.05.034Sentinel Lymph Node Mapping in Prostate Cancer: Magnetic Route (2024)JU Open Plus, 2(8). Article e00081. Molenaar, L., Roelink, H. J. H., Stomps, S., Haken, B. t., Hulsbergen-van de Kaa, C., Braak, S., Veltman, J., Alic, L. & Broeders, I. A. M. J.https://doi.org/10.1097/JU9.0000000000000183Amide proton transfer weighted imaging in pediatric neuro-oncology: initial experience (2024)NMR in biomedicine, 37(6). Article e5122. Obdeijn, I. V., Wiegers, E. C., Alic, L., Plasschaert, S. L. A., Kranendonk, M. E. G., Hoogduin, H. M., Klomp, D. W. J., Wijnen, J. P. & Lequin, M. H.https://doi.org/10.1002/nbm.5122Technical innovations in breast cancer surgery (2024)[Thesis › PhD Thesis - Research external, graduation UT]. University of Twente. Christenhusz, A.https://doi.org/10.3990/1.9789036561556

2023

Influence of Nanoparticle Coating on the Differential Magnetometry and Wireless Actuation of Biohybrid Microrobots (2023)In 2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) (pp. 2653-2658). IEEE. Magdanz, V., Cumming, J. R., Salamzadeh, S., Tesselaar, S., Alic, L., Abelmann, L. & S.M. Khalil, I.https://doi.org/10.1109/IROS55552.2023.10341258Performance of a Nonlinear Magnetic Handheld Probe for Intraoperative Sentinel Lymph Node Detection: A Phantom Study (2023)Annals of surgical oncology, 30(13), 8735-8742. Nieuwenhuis, E. R., Mir, N., Horstman-van de Loosdrecht, M. M., Meeuwis, A. P. W., de Bakker, M. G. J., Scheenen, T. W. J. & Alic, L.https://doi.org/10.1245/s10434-023-14166-zRecovery of dilute (bio-based) volatile fatty acids by adsorption with magnetic hyperthermal swing desorption (2023)Separation and purification technology, 323. Article 124273. Elhami, V., Hempenius, M. A., Vancso, G. J., Krooshoop, E. J. G., Alic, L., Qian, X., Jebur, M., Wickramasinghe, R. & Schuur, B.https://doi.org/10.1016/j.seppur.2023.124273Look-up table for assessment of iron content in Magtrace® samples based on Sentimag® (2023)[Dataset Types › Dataset]. 4TU.Centre for Research Data. Salamzadeh, S., Christenhusz, A. & Alic, L.https://doi.org/10.4121/2ad11693-4d07-488f-936e-a3d4d9430ae0Resolving power phantom for nanoparticles (2023)[Dataset Types › Dataset]. 4TU.Centre for Research Data. Alic, L., Horstman - van de Loosdrecht, M. & Mocking-Nieuwenhuis, E.https://doi.org/10.4121/20193302Radiofrequency localization of nonpalpable breast cancer in a multicentre prospective cohort study: feasibility, clinical acceptability, and safety (2023)Breast cancer research and treatment, 201, 67-75. Christenhusz, A., den Dekker, B. M., van Dalen, T., Jongen, L., van der Schaaf, M. C., Alic, L., ten Haken, B., Pijnappel, R. M. & Dassen, A. E.https://doi.org/10.1007/s10549-023-07006-xDifferentiating between giant cell arteritis and atherosclerosis on [18F]FDG-PET: An explainable machine learning approach (2023)In 2023 IEEE 36th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 870-875) (Proceedings - IEEE Symposium on Computer-Based Medical Systems; Vol. 2023-June). IEEE. Vries, H. S., Van Praagh, G. D., Nienhuis, P. H., Bouhali, O., Slart, R. H. J. A. & Alic, L.https://doi.org/10.1109/CBMS58004.2023.00334Differential Magnetometry: Selective Magnetometry for In Vivo Use (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Waanders, S.https://doi.org/10.3990/1.9789036556934Settings of DiffMag handheld probe for maximal detection depth aiming perioperative lymph node harvesting (2023)International Journal on Magnetic Particle Imaging, 9(1, suppl. 1). Article 2303052. Salamzadeh, S., Krooshoop, H. J. G., ten Haken, B. & Alic, L.https://doi.org/10.18416/IJMPI.2023.2303052Near-Infrared Spectral Similarity between Ex Vivo Porcine and In Vivo Human Tissue (2023)Life, 13(2). Article 357. Vries, E. d., Alic, L., Schols, R. M., Emanuel, K. S., Wieringa, F. P., Bouvy, N. D. & Tuijthof, G. J. M.https://doi.org/10.3390/life13020357Intracerebral Hemorrhage Segmentation on Noncontrast Computed Tomography Using a Masked Loss Function U-Net Approach (2023)Journal of Computer Assisted Tomography, 47(1), 93-101. Coorens, N. A., Lipman, K. G., Krishnam, S. P., Tan, C. O., Alic, L. & Gupta, R.https://doi.org/10.1097/RCT.0000000000001380

2022

Excitation coil for sentinel lymph node harvesting: design, digital twin and prototype (2022)Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2022, 4402-4406. Molenaar, L., Horstman-van de Loosdrecht, M. M., Krooshoop, H. J. G., Wesselink, R. J. H., Ten Haken, B., Broeders, I. A. M. J. & Alic, L.https://doi.org/10.1109/EMBC48229.2022.9871415Quantification of Magnetic Nanoparticles in ex vivo Colorectal Lymph Nodes (2022)Nano LIFE, 12(03). Article 2250006. Molenaar, L., Loosdrecht, M. M. H. v. d., Alic, L., Baarlen, J. v., Meijerink, J. J. H. J., Haken, B. t., Broeders, I. A. M. J. & Lips, D. J.https://doi.org/10.1142/S1793984422500064Magnetic identification of sentinel lymph nodes in the head and neck: Reaching leaves (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Nieuwenhuis, E. R.https://doi.org/10.3990/1.9789036554114Tuning Excitation Field Frequency for Magnetic Particle Sensing using Superparamagnetic Quantifier (2022)Journal of biomedical nanotechnology, 18(8), 1994-2000. Horstman - van de Loosdrecht, M. M., Kahmann, T., Ludwig, F. & Alic, L.https://doi.org/10.1166/jbn.2022.3406A Comprehensive Grading System for a Magnetic Sentinel Lymph Node Biopsy Procedure in Head and Neck Cancer Patients (2022)Cancers, 14(3). Article 678. Nieuwenhuis, E. R., Kolenaar, B., Hof, J. J., Baarlen, J. v., van Bemmel, A. J. M., Christenhusz, A., Scheenen, T. W. J., ten Haken, B., de Bree, R. & Alic, L.https://doi.org/10.3390/cancers14030678Breast MRI in patients after breast conserving surgery with sentinel node procedure using a superparamagnetic tracer (2022)European radiology experimental, 6(1). Article 3. Christenhusz, A., Pouw, J. J., Simonis, F. F. J., Douek, M., Ahmed, M., Klaase, J. M., Dassen, A. E., Klazen, C. A. H., van der Schaaf, M. C., ten Haken, B. & Alic, L.https://doi.org/10.1186/s41747-021-00257-7Advancing intraoperative magnetic tracing using 3D freehand magnetic particle imaging (2022)International journal of computer assisted radiology and surgery, 17(1), 211-218. Azargoshasb, S., Molenaar, L., Rosiello, G., Buckle, T., van Willigen, D. M., van de Loosdrecht, M. M., Welling, M. M., Alic, L., van Leeuwen, F. W. B., Winter, A. & van Oosterom, M. N.https://doi.org/10.1007/s11548-021-02458-2Changing iron content and excitation field: Comparative study of Synomag® nanoparticles (2022)International Journal on Magnetic Particle Imaging, 8(1). Article 2203053. Alic, L., Riahi, K., Horstman-van de Loosdrecht, M. M., Rietberg, M., Perez y Perez, J., Dijkstra, C. & ten Haken, B.https://doi.org/10.18416/ijmpi.2022.2203053Laparoscopic Probe for Sentinel Lymph Node Harvesting using Magnetic Nanoparticles (2022)IEEE transactions on biomedical engineering, 69(1), 286-293. van de Loosdrecht, M., Molenaar, L., Krooshoop, E., Haken, B. t., Meijerink, J., Alic, L. & Broeders, I. A. M. J.https://doi.org/10.1109/TBME.2021.3092437

2021

Modelling of dynamic behaviour in magnetic nanoparticles (2021)Nanomaterials, 11(12). Article 3396. Rietberg, M., Waanders, S., Horstman-Van de Loosdrecht, M. M., Wildeboer, R. R., Haken, B. T. & Alic, L.https://doi.org/10.3390/nano11123396

Research profiles

Address

University of Twente

Technohal (building no. 18), room 2186
Hallenweg 5
7522 NH Enschede
Netherlands

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