dr.ir. L. Fresiello MEng (Libera)

Assistant Professor

About Me

In January 2022, I was appointed as Assistant Professor in the Cardiovascular and Respiratory Physiology group (CRPH) at the faculty of Science and Technology of the University of Twente.

I obtained my Master degree in Biomedical Engineering at the Univ. Campus Bio-Medico of Rome and my II level Master degree in Clinical Engineering at the Univ. of Florence. I obtained a PhD in Biomedical Engineering at the Nalecz Institute of Biocybernetics and Biomedical Engineering in Warsaw, in collaboration with the Institute of Clinical Physiology of the National Research Council in Italy. For my post-doc, I joined the group of Cardiac Surgery of KU Leuven in Belgium, thanks to a Marie Curie scholarship. I was also visiting researcher at the Center for Medical Physics and Biomedical Engineering of the Medical Univ. of Vienna, thanks to the Frans Van de Werf scholarship.

During my research career, I realized the complexity of developing and testing new cardiovascular therapies and of optimizing them to different pathophysiological conditions. Simulation can constitute a solution for these challenges, so dedicate my energy to the realization of high fidelity cardiovascular simulators to expedite more effective and personalized therapeutic strategies to treat cardiovascular diseases. Simulators are also powerful tools to improve education in healthcare, by providing more effective teaching and training to medical and paramedical students. 

I strongly believe interdisciplinarity is a key factor for a successful research in cardiovascular modelling I conduct my activity in strict collaboration with clinicians, covering several activities (clinical studies, in vivo studies, data collection and analysis), and then translate the acquired pathophysiological and clinical knowhow into simulators.



Medicine & Life Sciences
Cardiovascular Models
Heart-Assist Devices
Engineering & Materials Science
Left Ventricular Assist Devices


Numan, L., Wösten, M., Moazeni, M., Aarts, E., Van der Kaaij, N. P. , Fresiello, L., Asselbergs, F. W., & Van Laake, L. W. (2023). Circadian rhythms in pump parameters of patients on contemporary left ventricular assist device support. Artificial organs. Advance online publication. https://doi.org/10.1111/aor.14628
Bornoff, J., Najar, A. , Fresiello, L., Finocchiaro, T., Perkins, I. L., Gill, H., Cookson, A. N., & Fraser, K. H. (2023). Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart. Scientific reports, 13(1), Article 5734. Advance online publication. https://doi.org/10.1038/s41598-023-32141-2
Rocchi, M., Gross, C., Moscato, F., Schlöglhofer, T., Meyns, B. , & Fresiello, L. (2023). An in vitro model to study suction events by a ventricular assist device: validation with clinical data. Frontiers in Physiology, 14, Article 1155032. https://doi.org/10.3389/fphys.2023.1155032
Pladet, L., Luijken, K. , Fresiello, L., dos Reis Miranda, D., Hermens, J. A., Smeden, M. V., Cremer, O. , Donker, D. W., & Meuwese, C. L. (2023). Clinical decision support for ExtraCorporeal Membrane Oxygenation: Will we fly by wire? Perfusion (United Kingdom), 38(1_suppl), 68-81. Advance online publication. https://doi.org/10.1177/02676591231163688
Warnaar, R. , Mulder, M. P. , Fresiello, L., Cornet, A. D., Heunks, L. M. A. , Donker, D. W. , & Oppersma, E. (2023). Clinical readiness of virtual patient models for individualised mechanical ventilation: a systematic literature review. Poster session presented at ESICM LIVES Forum Conference 2023, Utrecht, Netherlands.
Mulder, M. P. , Fresiello, L., Rumindo, K., Jalde, F., Hallbäck, M., Maksuti, E. , & Donker, D. W. (Accepted/In press). A computational platform for virtual patient trials of fluid responsiveness prediction in septic shock phenotypes. Abstract from ESICM LIVES Forum Conference 2023, Utrecht, Netherlands.
Duinmeijer, W. C. , Fresiello, L., Swol, J., Torrella, P., Riera, J., Obreja, V., Puślecki, M., Dąbrowski, M. , Arens, J. , & Halfwerk, F. R. (2023). Simulators and Simulations for Extracorporeal Membrane Oxygenation: An ECMO Scoping Review. Journal of Clinical Medicine, 12(5), Article 1765. https://doi.org/10.3390/jcm12051765
Rocchi, M., Ingram, M., Claus, P., D'hooge, J., Meyns, B. , & Fresiello, L. (2023). Use of 3D anatomical models in mock circulatory loops for cardiac medical device testing. Artificial organs, 47(2), 260-272. Advance online publication. https://doi.org/10.1111/aor.14433

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Courses Academic Year  2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2022/2023

Contact Details

Visiting Address

University of Twente
Drienerlolaan 5
7522 NB Enschede
The Netherlands

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Mailing Address

University of Twente
P.O. Box 217
7500 AE Enschede
The Netherlands

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