L. Fresiello PhD (Libera)

Assistant Professor

About Me

In January 2022, I was appointed as Assistant Professor in the Cardiovascular and Respiratory Physiology group (CRPH) at the faculty of Science and Technology of the University of Twente.

I obtained my Master degree in Biomedical Engineering at the Univ. Campus Bio-Medico of Rome and my II level Master degree in Clinical Engineering at the Univ. of Florence. I obtained a PhD in Biomedical Engineering at the Nalecz Institute of Biocybernetics and Biomedical Engineering in Warsaw, in collaboration with the Institute of Clinical Physiology of the National Research Council in Italy. For my post-doc, I joined the group of Cardiac Surgery of KU Leuven in Belgium, thanks to a Marie Curie scholarship. I was also visiting researcher at the Center for Medical Physics and Biomedical Engineering of the Medical Univ. of Vienna, thanks to the Frans Van de Werf scholarship.

During my research career, I realized the complexity of developing and testing new cardiovascular therapies and of optimizing them to different pathophysiological conditions. Simulation can constitute a solution for these challenges, so dedicate my energy to the realization of high fidelity cardiovascular simulators to expedite more effective and personalized therapeutic strategies to treat cardiovascular diseases. Simulators are also powerful tools to improve education in healthcare, by providing more effective teaching and training to medical and paramedical students. 

I strongly believe interdisciplinarity is a key factor for a successful research in cardiovascular modelling I conduct my activity in strict collaboration with clinicians, covering several activities (clinical studies, in vivo studies, data collection and analysis), and then translate the acquired pathophysiological and clinical knowhow into simulators.



Medicine & Life Sciences
Cardiovascular Models
Heart-Assist Devices
Engineering & Materials Science
Left Ventricular Assist Devices


Van Edom, C., Jacobs, S. , Fresiello, L., Vandersmissen, K., Vandenbriele, C., Droogné, W., & Meyns, B. (2022). Long-term evolution of N-terminal pro-brain natriuretic peptide levels and exercise capacity in 132 left ventricular assist device recipients. European Journal of Cardio-thoracic Surgery, 62(2), [ezac053]. https://doi.org/10.1093/ejcts/ezac053
Oppersma, E., Geraats, S., Heikens, N. H., Welleweerd, A., Woerts, C. A. , Fresiello, L., Meuwese, C. L. , & Donker, D. W. (2022). Finite Element Modeling of Pulmonary Mechanics in Severe ARDS: Explaining the Inclination Angle? American journal of respiratory and critical care medicine. https://doi.org/10.1164/rccm.202205-0931LE
Fresiello, L., Najar, A., Brynedal Ignell, N., Zieliński, K., Rocchi, M., Meyns, B., & Perkins, I. L. (2022). Hemodynamic characterization of the Realheart® total artificial heart with a hybrid cardiovascular simulator. Artificial organs, 46(8), 1585-1596. https://doi.org/10.1111/aor.14223
Rocchi, M. , Fresiello, L., Jacobs, S., Dauwe, D., Droogne, W., & Meyns, B. (2022). Potential of Medical Management to Mitigate Suction Events in Ventricular Assist Device Patients. ASAIO Journal, 68(6), 814-821. https://doi.org/10.1097/MAT.0000000000001573
Kelly, N. S., McCree, D. , Fresiello, L., Brynedal Ignell, N., Cookson, A. N., Najar, A., Perkins, I. L., & Fraser, K. H. (2022). Video-based valve motion combined with computational fluid dynamics gives stable and accurate simulations of blood flow in the Realheart total artificial heart. Artificial organs, 46(1), 57-70. https://doi.org/10.1111/aor.14056
Colasanti, S., Piemonte, V., Devolder, E., Zieliński, K., Vandendriessche, K., Meyns, B. , & Fresiello, L. (2021). Development of a computational simulator of the extracorporeal membrane oxygenation and its validation with in vitro measurements. Artificial organs, 45(4), 399-410. https://doi.org/10.1111/aor.13842
Ferrari, G., Di Molfetta, A., Zieliński, K., Cusimano, V., Darowski, M., Kozarski, M. , & Fresiello, L. (2021). Assessment of the VAD – Native ventricle pumping system by an equivalent pump: A computational model based procedure. Biocybernetics and biomedical engineering, 41(4), 1365-1377. https://doi.org/10.1016/j.bbe.2021.05.006
Rocchi, M. , Fresiello, L., Meyns, B., Jacobs, S., Gross, C., Pauls, J. P., Graefe, R., Stecka, A., Kozarski, M., & Zieliński, K. (2021). A Compliant Model of the Ventricular Apex to Study Suction in Ventricular Assist Devices. ASAIO journal (American Society for Artificial Internal Organs : 1992), 67(10), 1125-1133. https://doi.org/10.1097/MAT.0000000000001370

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University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3181
Hallenweg 5
7522NH  Enschede
The Netherlands

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University of Twente
Faculty of Science and Technology
Technohal  3181
P.O. Box 217
7500 AE Enschede
The Netherlands

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