L. Fresiello PhD (Libera)

Assistant Professor

About Me

In January 2022, I was appointed as Assistant Professor in the Cardiovascular and Respiratory Physiology group (CRPH) at the faculty of Science and Technology of the University of Twente.

I obtained my Master degree in Biomedical Engineering at the Univ. Campus Bio-Medico of Rome and my II level Master degree in Clinical Engineering at the Univ. of Florence. I obtained a PhD in Biomedical Engineering at the Nalecz Institute of Biocybernetics and Biomedical Engineering in Warsaw, in collaboration with the Institute of Clinical Physiology of the National Research Council in Italy. For my post-doc, I joined the group of Cardiac Surgery of KU Leuven in Belgium, thanks to a Marie Curie scholarship. I was also visiting researcher at the Center for Medical Physics and Biomedical Engineering of the Medical Univ. of Vienna, thanks to the Frans Van de Werf scholarship.

During my research career, I realized the complexity of developing and testing new cardiovascular therapies and of optimizing them to different pathophysiological conditions. Simulation can constitute a solution for these challenges, so dedicate my energy to the realization of high fidelity cardiovascular simulators to expedite more effective and personalized therapeutic strategies to treat cardiovascular diseases. Simulators are also powerful tools to improve education in healthcare, by providing more effective teaching and training to medical and paramedical students. 

I strongly believe interdisciplinarity is a key factor for a successful research in cardiovascular modelling I conduct my activity in strict collaboration with clinicians, covering several activities (clinical studies, in vivo studies, data collection and analysis), and then translate the acquired pathophysiological and clinical knowhow into simulators.



Medicine & Life Sciences
Cardiovascular Models
Heart-Assist Devices
Engineering & Materials Science
Left Ventricular Assist Devices


Kelly, N. S., McCree, D. , Fresiello, L., Brynedal Ignell, N., Cookson, A. N., Najar, A., Perkins, I. L., & Fraser, K. H. (2022). Video-based valve motion combined with computational fluid dynamics gives stable and accurate simulations of blood flow in the Realheart total artificial heart. Artificial organs, 46(1), 57-70. https://doi.org/10.1111/aor.14056
Colasanti, S., Piemonte, V., Devolder, E., Zieliński, K., Vandendriessche, K., Meyns, B. , & Fresiello, L. (2021). Development of a computational simulator of the extracorporeal membrane oxygenation and its validation with in vitro measurements. Artificial organs, 45(4), 399-410. https://doi.org/10.1111/aor.13842
Ferrari, G., Di Molfetta, A., Zieliński, K., Cusimano, V., Darowski, M., Kozarski, M. , & Fresiello, L. (2021). Assessment of the VAD – Native ventricle pumping system by an equivalent pump: A computational model based procedure. Biocybernetics and biomedical engineering, 41(4), 1365-1377. https://doi.org/10.1016/j.bbe.2021.05.006
Rocchi, M. , Fresiello, L., Meyns, B., Jacobs, S., Gross, C., Pauls, J. P., Graefe, R., Stecka, A., Kozarski, M., & Zieliński, K. (2021). A Compliant Model of the Ventricular Apex to Study Suction in Ventricular Assist Devices. ASAIO journal (American Society for Artificial Internal Organs : 1992), 67(10), 1125-1133. https://doi.org/10.1097/MAT.0000000000001370
Fresiello, L., & Zieliński, K. (2020). Hemodynamic Modelling and Simulations for Mechanical Circulatory Support. In JH. Karimov , K. Fukamachi, & RC. Starling (Eds.), Mechanical Support for Heart Failure: Current Solutions and New Technologies (pp. 429-447) https://doi.org/10.1007/978-3-030-47809-4_26
Telyshev, D., Denisov, M., Markov, A. , Fresiello, L., Verbelen, T., & Selishchev, S. (2020). Energetics of blood flow in Fontan circulation under VAD support. Artificial organs, 44(1), 50-57. https://doi.org/10.1111/aor.13564
Gross, C., Moscato, F., Schlöglhofer, T., Maw, M., Meyns, B., Marko, C., Wiedemann, D., Zimpfer, D., Schima, H. , & Fresiello, L. (2020). LVAD speed increase during exercise, which patients would benefit the most? A simulation study. Artificial organs, 44(3), 239-247. https://doi.org/10.1111/aor.13569
Vandersmissen, K., Jacobs, S. , Fresiello, L., Gerits, K., Roppe, M., Van den Bossche, K., Droogne, W., & Meyns, B. (2020). Weight evolution after implantation of left ventricular assist device: Do we need to interfere? International journal of artificial organs, 43(10), 671-676. https://doi.org/10.1177/0391398820906554
Gross, C. , Fresiello, L., Schlöglhofer, T., Dimitrov, K., Marko, C., Maw, M., Meyns, B., Wiedemann, D., Zimpfer, D., Schima, H., & Moscato, F. (2020). Hemodynamic exercise responses with a continuous-flow left ventricular assist device: Comparison of patients’ response and cardiorespiratory simulations. PLoS ONE, 15(3), [e0229688]. https://doi.org/10.1371/journal.pone.0229688

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University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3181
Hallenweg 5
7522NH  Enschede
The Netherlands

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University of Twente
Faculty of Science and Technology
Technohal  3181
P.O. Box 217
7500 AE Enschede
The Netherlands

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