dr.ir. L. Fresiello MEng (Libera)

Assistant Professor
TNW-BIS-CRPH
l.fresiello@utwente.nl
+31534894357
Business card

In January 2022, I was appointed as Assistant Professor in the Cardiovascular and Respiratory Physiology group (CRPH) at the faculty of Science and Technology of the University of Twente.

I obtained my Master degree in Biomedical Engineering at the Univ. Campus Bio-Medico of Rome and my II level Master degree in Clinical Engineering at the Univ. of Florence. I obtained a PhD in Biomedical Engineering at the Nalecz Institute of Biocybernetics and Biomedical Engineering in Warsaw, in collaboration with the Institute of Clinical Physiology of the National Research Council in Italy. For my post-doc, I joined the group of Cardiac Surgery of KU Leuven in Belgium, thanks to a Marie Curie scholarship. I was also visiting researcher at the Center for Medical Physics and Biomedical Engineering of the Medical Univ. of Vienna, thanks to the Frans Van de Werf scholarship.

During my research career, I realized the complexity of developing and testing new cardiovascular therapies and of optimizing them to different pathophysiological conditions. Simulation can constitute a solution for these challenges, so I dedicate my energy to the realization of high fidelity cardiovascular simulators to expedite more effective and personalized therapeutic strategies to treat cardiovascular diseases. Simulators are also powerful tools to improve education in healthcare, by providing more effective teaching and training to medical and paramedical students. 

I strongly believe interdisciplinarity is a key factor for a successful research in cardiovascular modelling.  I conduct my activity in strict collaboration with clinicians, covering several activities (clinical studies, in vivo studies, data collection and analysis), and then translate the acquired pathophysiological and clinical knowhow into simulators.

Expertise

  • Medicine and Dentistry

    • Patient
    • Cardiovascular System
    • Pump
    • Left Ventricular Assist Device
    • Hemodynamic
    • Ventricular Assist Device
    • Hybrid
    • Heart Output

Organisations

Publications

2025

A Physiological-Model-Based Neural Network Framework for Blood Pressure Estimation from Photoplethysmography Signals (2025)In 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE. Zhang, Y., Fresiello, L., Veltink, P. H., Donker, D. W. & Wang, Y.https://doi.org/10.1109/EMBC58623.2025.11251595Modeling age and sex variations of arterial pressure and cardiac hemodynamics in a virtual population using a 01-1D cardiovascular simulator (2025)American journal of physiology : Heart and circulatory physiology, 329(5), H1212-H1228. Wardhana, G., van Loon, L. M., Potters, J.-W., Fransen, A., Lafort, A., Kilic, Y., Donker, D. W. & Fresiello, L.https://doi.org/10.1152/ajpheart.00387.2025Physiological-Model-Based Neural Network for Heart Rate Estimation during Daily Physical Activities (2025)[Working paper › Preprint]. ArXiv.org. Zhang, Y., Fresiello, L., Veltink, P. H., Donker, D. W. & Wang, Y.https://doi.org/10.48550/arXiv.2506.10144Effects of chronic volume deprivation on the ventricle (2025)Interdisciplinary cardiovascular and thoracic surgery, 40(6). Article ivaf124. Cools, B., Rega, F., Van De Bruaene, A., Van Hecke, M., Fresiello, L., Devleeschauwer, S., Brown, S., Claus, P. & Gewillig, M.https://doi.org/10.1093/icvts/ivaf124A Physiological-Model-Based Neural Network Framework for Blood Pressure Estimation from Photoplethysmography Signals (2025)[Working paper › Preprint]. ArXiv.org. Zhang, Y., Fresiello, L., Veltink, P. H., Donker, D. W. & Wang, Y.https://doi.org/10.48550/arXiv.2502.03731Activation of a Soft Robotic Left Ventricular Phantom Embedded in a Closed-Loop Cardiovascular Simulator: A Computational and Experimental Analysis (2025)Cardiovascular engineering and technology, 16, 34-51. Article 967449. Demeersseman, N., Rocchi, M., Fehervary, H., Collazo, G. F., Meyns, B., Fresiello, L. & Famaey, N.https://doi.org/10.1007/s13239-024-00755-wLVAD Physiology (2025)In Mechanical Circulatory Support (pp. 59-83). Springer Science + Business Media. Rocchi, M., Chivukula, V. K., Palmieri, L., Fresiello, L. & Amarelli, C.https://doi.org/10.1007/978-3-030-86172-8_6-1The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study (2025)ASAIO Journal, 71(1), 11-20. Chan, C. H. H., Passmore, M. R., Tronstad, O., Seale, H., Bouquet, M., White, N., Teruya, J., Hogan, A., Platts, D., Chan, W., Dashwood, A. M., McGiffin, D. C., Maiorana, A. J., Hayward, C. S., Simmonds, M. J., Tansley, G. D., Suen, J. Y., Fraser, J. F., Meyns, B., … Jacobs, S.https://doi.org/10.1097/MAT.0000000000002246

2024

Physiological control for left ventricular assist devices based on deep reinforcement learning (2024)Artificial organs, 48(12), 1418-1429. Fernández-Zapico, D., Peirelinck, T., Deconinck, G., Donker, D. W. & Fresiello, L.https://doi.org/10.1111/aor.14845Preclinical evaluation (2024)In Mechanical Circulatory and Respiratory Support (pp. 771-812). Elsevier. Stephens, A. F., Prahl Wittberg, L., Jacobs, S., Roggenkamp, J., Arens, J. & Fresiello, L.

Research profiles

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