dr.ir. L. Fresiello MEng (Libera)

Assistant Professor

About Me

In January 2022, I was appointed as Assistant Professor in the Cardiovascular and Respiratory Physiology group (CRPH) at the faculty of Science and Technology of the University of Twente.

I obtained my Master degree in Biomedical Engineering at the Univ. Campus Bio-Medico of Rome and my II level Master degree in Clinical Engineering at the Univ. of Florence. I obtained a PhD in Biomedical Engineering at the Nalecz Institute of Biocybernetics and Biomedical Engineering in Warsaw, in collaboration with the Institute of Clinical Physiology of the National Research Council in Italy. For my post-doc, I joined the group of Cardiac Surgery of KU Leuven in Belgium, thanks to a Marie Curie scholarship. I was also visiting researcher at the Center for Medical Physics and Biomedical Engineering of the Medical Univ. of Vienna, thanks to the Frans Van de Werf scholarship.

During my research career, I realized the complexity of developing and testing new cardiovascular therapies and of optimizing them to different pathophysiological conditions. Simulation can constitute a solution for these challenges, so dedicate my energy to the realization of high fidelity cardiovascular simulators to expedite more effective and personalized therapeutic strategies to treat cardiovascular diseases. Simulators are also powerful tools to improve education in healthcare, by providing more effective teaching and training to medical and paramedical students. 

I strongly believe interdisciplinarity is a key factor for a successful research in cardiovascular modelling I conduct my activity in strict collaboration with clinicians, covering several activities (clinical studies, in vivo studies, data collection and analysis), and then translate the acquired pathophysiological and clinical knowhow into simulators.



Medicine & Life Sciences
Cardiovascular Models
Heart-Assist Devices
Engineering & Materials Science
Left Ventricular Assist Devices


Mulder, M. P. , Fresiello, L., Rumindo, K., Jalde, F., Hallbäck, M., Maksuti, E. , & Donker, D. W. (Accepted/In press). A computational platform for virtual patient trials of fluid responsiveness prediction in septic shock phenotypes. Abstract from ESICM LIVES Forum Conference 2023, Utrecht, Netherlands.
Duinmeijer, W. C. , Fresiello, L., Swol, J., Torrella, P., Riera, J., Obreja, V., Puślecki, M., Dąbrowski, M. , Arens, J. , & Halfwerk, F. R. (2023). Simulators and Simulations for Extracorporeal Membrane Oxygenation: An ECMO Scoping Review. Journal of Clinical Medicine, 12(5), [1765]. https://doi.org/10.3390/jcm12051765
Rocchi, M., Ingram, M., Claus, P., D'hooge, J., Meyns, B. , & Fresiello, L. (2023). Use of 3D anatomical models in mock circulatory loops for cardiac medical device testing. Artificial organs, 47(2), 260-272. https://doi.org/10.1111/aor.14433
Fresiello, L., Muthiah, K., Goetschalckx, K., Hayward, C., Rocchi, M., Bezy, M., Pauls, J. P., Meyns, B. , Donker, D. W., & Zieliński, K. (2022). Initial clinical validation of a hybrid in silico—in vitro cardiorespiratory simulator for comprehensive testing of mechanical circulatory support systems. Frontiers in Physiology, 13, [967449]. https://doi.org/10.3389/fphys.2022.967449
Mulder, M. P. , Fresiello, L. , & Donker, D. W. (2022). Computational models for hemodynamic management in critically ill patients: a systematic review. 10. Abstract from Virtual Physiological Human Conference, VPH 2022, Porto, Portugal.
Van Edom, C., Jacobs, S. , Fresiello, L., Vandersmissen, K., Vandenbriele, C., Droogné, W., & Meyns, B. (2022). Long-term evolution of N-terminal pro-brain natriuretic peptide levels and exercise capacity in 132 left ventricular assist device recipients. European Journal of Cardio-thoracic Surgery, 62(2), [ezac053]. https://doi.org/10.1093/ejcts/ezac053
Oppersma, E., Geraats, S., Heikens, N. H., Welleweerd, A., Woerts, C. A. , Fresiello, L., Meuwese, C. L. , & Donker, D. W. (2022). Finite Element Modeling of Pulmonary Mechanics in Severe ARDS: Explaining the Inclination Angle? American journal of respiratory and critical care medicine, 206(6), 798-799. https://doi.org/10.1164/rccm.202205-0931LE
Fresiello, L., Najar, A., Brynedal Ignell, N., Zieliński, K., Rocchi, M., Meyns, B., & Perkins, I. L. (2022). Hemodynamic characterization of the Realheart® total artificial heart with a hybrid cardiovascular simulator. Artificial organs, 46(8), 1585-1596. https://doi.org/10.1111/aor.14223
Rocchi, M. , Fresiello, L., Jacobs, S., Dauwe, D., Droogne, W., & Meyns, B. (2022). Potential of Medical Management to Mitigate Suction Events in Ventricular Assist Device Patients. ASAIO Journal, 68(6), 814-821. https://doi.org/10.1097/MAT.0000000000001573

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Courses Academic Year  2022/2023

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2021/2022

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3181
Hallenweg 5
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Technohal  3181
P.O. Box 217
7500 AE Enschede
The Netherlands

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