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prof.dr.ir. L.I. Segerink (Loes)

Full Professor

About Me

My research focuses on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases.

Expertise

Microfluidics
Microfluidics
Acoustic Impedance
Acoustic Impedance
Microfluidics
Electric Impedance
Equipment And Supplies
Electrodes

Ancillary Activities

  • Elsevier
    associate editor Sensors and actuators A
  • NWO/ZonMW
    NWO Create2Solve
  • NWO/TTW
    NWO TTW Veni committee

Research

The focus of this theme is on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases. Microfluidics are a perfect tool for this, since dimensions comparable to single cells are used, low sample volumes are needed and multiple functionalities can be integrated in one platform. As an example electrodes can be integrated in in these devices, making electrical measurements on single cells such as sperm cells, or a tissue layer like the blood-brain barrier possible. By carefully analyzing these electrical signals, information about the morphology of the sperm cell or tightness of the tissue layer can be retrieved, which can be used to gain information about the semen quality or the functioning of the blood-brain barrier. Additional useful information can be retrieved form (automated) optical analysis using for instance fluorescence or bright field microscopy. So using these and other (new) techniques in combination with microfluidics, biomedical microdevices are developed that can finally be of use in the clinic. There are collaborations with other research groups at this and other universities, but also with doctors at the hospital, making it an applied multidisciplinary research area.

Publications

Recent
van Dongen, J. E. , Berendsen, J. T. W. , Eijkel, J. C. T. , & Segerink, L. (2021). Towards a Multiplexed Barcode CRISPR/Cas12a-Assisted Platform for the Identification and Quantification of Single CpG Methylation Sites. Poster session presented at The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
(µTAS 2021), Palm Springs, United States.
Paggi, C. A. , Zakharova, M. , Segerink, L. , le Gac, S. , Moreira Teixeira Leijten, L. S. , & Karperien, M. (2020). Synovial membrane on chip: a new tool to study co-culture response to mechanical stimulation. In Proceedings of the 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 [Th8-854.e]
Hentschel, A., Nieuwenhuijzen, J. A., Bosschieter, J., van Splunter, A. P., Lissenberg-Witte, B. I., van der Voorn, P. , Segerink, L., van Moorselaar, R. J. A., & Steenbergen, R. D. M. (2020). Comparative Analysis of Urine Fractions for Optimal Bladder Cancer Detection Using DNA Methylation Markers. Cancers, 12(4), [859]. https://doi.org/10.3390/cancers12040859

UT Research Information System

Google Scholar Link

Projects

Selected projects:

  • Microfluidics systems for semen analysis;
  • Blood-brain barrier chip;
  • Nanopil 2.0 or early cancer diagnostics.

See for more details: department website

In the press

Video/TV

Articles

Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré (building no. 15), room C2415
Hallenweg 23
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré  C2415
P.O. Box 217
7500 AE Enschede
The Netherlands