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dr. L.I. Segerink (Loes)

Associate Professor

About Me

My research focuses on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases.

Expertise

Microfluidics
Microfluidics
Equipment And Supplies
Electrodes
Fabrication
Electric Impedance
Chips
Lab-On-A-Chip
Technology
Acoustic Impedance
Fabrication
Membranes
Membranes

Research

The focus of this theme is on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases. Microfluidics are a perfect tool for this, since dimensions comparable to single cells are used, low sample volumes are needed and multiple functionalities can be integrated in one platform. As an example electrodes can be integrated in in these devices, making electrical measurements on single cells such as sperm cells, or a tissue layer like the blood-brain barrier possible. By carefully analyzing these electrical signals, information about the morphology of the sperm cell or tightness of the tissue layer can be retrieved, which can be used to gain information about the semen quality or the functioning of the blood-brain barrier. Additional useful information can be retrieved form (automated) optical analysis using for instance fluorescence or bright field microscopy. So using these and other (new) techniques in combination with microfluidics, biomedical microdevices are developed that can finally be of use in the clinic. There are collaborations with other research groups at this and other universities, but also with doctors at the hospital, making it an applied multidisciplinary research area.

Publications

Recent
Bosschieter, J., Bach, S., Bijnsdorp, I., Segerink, L., Rurup, W. F., van Splunter, A., ... Nieuwenhuijzen, J. A. (2018). A protocol urine collection and storage prior to DNA methylation analysis. PLoS ONE, 13(8), [e0200906]. DOI: 10.1371/journal.pone.0200906
Bosschieter, J., Lutz, C., Segerink, L. I., Vis, A. N., Zwarthoff, E. C., Van Moorselaar, R. J. A., ... Nieuwenhuijzen, J. A. (2018). The diagnostic accuracy of methylation markers in urine for the detection of bladder cancer: A systematic review. Epigenomics, 10(5), 673-687. DOI: 10.2217/epi-2017-0156
Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D., & Segerink, L. (2018). Membranes for Organs-on-Chips. In D. Stamatialis (Ed.), Biomedical Membranes and (Bio)Artificial Organs (pp. 295-321). (World Scientific Series in Membrane Science and Technology: Biological and Biomimetic Applications, Energy and the Environment: ; Vol. 2). World Scientific. DOI: 10.1142/9789813223974_0011
Papadimitriou, V., Segerink, L., van den Berg, A., & Eijkel, J. C. T. (2017). Continuous Extraction Depletion Zone Isotachophoresis (Edz-ITP). 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017, Savannah, United States.
van der Helm, M. W., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., ... Segerink, L. (2017). Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1114-1115). Savannah: Chemical and Biological Microstystems Society.

UT Research Information System

Google Scholar Link

Projects

Selected projects:

  • Microfluidics systems for semen analysis;
  • Blood-brain barrier chip;
  • Nanopil 2.0 or early cancer diagnostics.

See for more details: department website

In the press

Video/TV

Articles

Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics & Computer Science
Carré (building no. 15), room C2415
Hallenweg 23
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics & Computer Science
Carré  C2415
P.O. Box 217
7500 AE Enschede
The Netherlands