About Me
My research focuses on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases.
Expertise
Organisations
Ancillary Activities
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Elsevier
Editor Sensors and Actuators A -
ZonMW
assessment committee ZonMW
Research
The focus of this theme is on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases. Microfluidics are a perfect tool for this, since dimensions comparable to single cells are used, low sample volumes are needed and multiple functionalities can be integrated in one platform. As an example electrodes can be integrated in in these devices, making electrical measurements on single cells such as sperm cells, or a tissue layer like the blood-brain barrier possible. By carefully analyzing these electrical signals, information about the morphology of the sperm cell or tightness of the tissue layer can be retrieved, which can be used to gain information about the semen quality or the functioning of the blood-brain barrier. Additional useful information can be retrieved form (automated) optical analysis using for instance fluorescence or bright field microscopy. So using these and other (new) techniques in combination with microfluidics, biomedical microdevices are developed that can finally be of use in the clinic. There are collaborations with other research groups at this and other universities, but also with doctors at the hospital, making it an applied multidisciplinary research area.
Publications
UT Research Information System
Google Scholar Link
Courses Academic Year 2023/2024
Courses Academic Year 2022/2023
Projects
Selected projects:
- Microfluidics systems for semen analysis;
- Blood-brain barrier chip;
- Nanopil 2.0 or early cancer diagnostics.
See for more details: department website
In the press
Video/TV
- TEDx Amsterdam Women, Loes Segerink ontwikkelt vruchtbaarheidstest voor mannen, TEDx praatje, Amsterdam http://www.tedxamsterdamwomen.nl/talks-2013/tedxamswomen-talk-dr-loes-segerink/ 6 december 2013
- Embryo on chip Televisieuitzending Labyrint 31 maart 2013
http://www.wetenschap24.nl/programmas/labyrint/labyrint-tv/2013/maart/Embryo-on-a-chip.html http://www.wetenschap24.nl/programmas/labyrint/nieuws/2013/Nano/Extra-beeldmateriaal.html - Video touch Universiteit Twente, Comfortabel thuistesten http://www.utwente.nl/touch/2012-10/spermatest/ (video filmpje)
- NOS op 3, Zijn mannelijke spermacellen sneller dan vrouwelijke, 25 November 2011, http://nos.nl/op3/video/316459-zijn-mannelijke-spermacellen-sneller-dan-vrouwelijke.html
- RTV oost, En dan nog even dit, TV opname, 2 November 2011
- Nienke Andersson, NU! Sperma-thuistest in de maak, Science flash http://www.wetenschap24.nl/programmas/scienceflash/Reportages/2010/sperma-thuistest-in-de-maak.html 15 February 2010
- Ray van Ravensberg, Tim Anemaet, Liset Vliegen, Marijn Groen, Marc Jan Eijkholt, CSI: UT, Tube your future 2010, 2nd price (de zilveren walvis), http://www.tubeyourfuture.nl/filmpjes/central-sperm-investigation-ut 2010
- Lidy Knol, Thuis testen Nanovideohunt movie http://www.nanovideohunt.nl and http://nanovideohunt.hyves.nl/ 2010
Articles
- There has been a lot of media attention. A selection is given below:
- Thuistest voor spermakwaliteit, TCTubantia, 9 November 2008
- Collin Barras, Home test for sperm count could leave men in a mess, New Scientist, 2010, 2746, 10-10. Internet: http://www.newscientist.com/article/mg20527463.600-home-test-for-sperm-count-could-leave-men-in-a-mess.html 8 February 2010
- Mannen kunnen thuis vruchtbaarheid testen, http://www.volkskrant.nl/wetenschap/article1348226.ece/Mannen_kunnen_thuis_vruchtbaarheid_testen , 11 February 2010
- Mannen kunnen thuis vruchtbaarheid testen, http://www.nu.nl/wetenschap/2182529/mannen-kunnen-thuis-vruchtbaarheid-testen.html, 11 February 2010
- Arjen Dijkgraaf, [Zaad op een chip] UT ontwikkelt thuistest voor mannelijke vruchtbaarheid, C2W http://www.c2w.nl/zaad-op-een-chip.82161.lynkx , 15 February 2010
- Bo Blanckenburg, Spermateller, Kennislink, http://www.kennislink.nl/publicaties/spermateller 15 February 2010
- Laura Schalkwijk, Man kan zijn sperma straks thuis testen, Algemeen Dagblad 17 February 2010, page 4
- Canary Pete, Mannen kunnen thuis vruchtbaarheid testen, Medisch contact nr 07, 18 February 2010. Cartoon
- Tonie Mudde, Spermateller, Quest Extra Klein, kleiner, kleinst (attachement Quest July 2010), page 45
- Jim Heirbaut, Dossier microsystemen, De ingenieur nr 17, jaargang 122, 29 October 2010
- Maarten Everblij, Meester & Gezel(7), Volkskrant, 10 October 2011
- STW, Simon Stevin leerling prijzen uitgereikt, 7 October 2011, http://www.stw.nl/nl/content/simon-stevin-prijzen-2011-uitgereikt
- Fertility on a chip, testing male fertility too? In: Health at university of Twente, , 96-97, 2011
- Algemeen Dagblad, Betere thuistest voor sperma, 28 October 2011
- Nu.nl, Thuistest met chip voor sperma. 27 October 2011, http://www.nu.nl/gezondheid/2652675/thuistest-met-chip-sperma.html
- Suzanne Bremmers, Nieuwe chip meet vruchtbaarheid, MEDnet, 28 October 2011, http://www.mednet.nl/nieuws/id5563-nieuwe-chip-meet-vruchtbaarheid-.html
- Judith Withmer, Talent, Elsevier, 30 November 2011
- Jeroen Akkermans, Compacte vruchtbaarheidschip, De Ingenieur 2011
- Tc Tubantia, Loes helpt, de doe-het-zelfdokter is een succes. Front page Tc Tubantia 9 April 2013
- STW, Twaalf onderzoekers uit STW-kring in de prijzen bij de Veni’s 2013. 23 July2013. http://www.stw.nl/nl/content/twaalf-onderzoekers-uit-stw-kring-de-prijzen-bij-de-veni%E2%80%99s-2013
Contact Details
Visiting Address
University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré
(building no. 15), room C2415
Hallenweg 23
7522NH Enschede
The Netherlands
Mailing Address
University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré
C2415
P.O. Box 217
7500 AE Enschede
The Netherlands