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prof.dr.ir. L.I. Segerink (Loes)

Full Professor

About Me

My research focuses on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases.

Expertise

Engineering & Materials Science
Acoustic Impedance
Blood-Brain Barrier
Dna
Microfluidics
Photonic Crystals
Medicine & Life Sciences
Electric Impedance
Microfluidics
Physics & Astronomy
Chips

Ancillary Activities

  • NWO
    committee member NWO faculty of impact
  • Elsevier
    Editor sensors and actuators A

Research

The focus of this theme is on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases. Microfluidics are a perfect tool for this, since dimensions comparable to single cells are used, low sample volumes are needed and multiple functionalities can be integrated in one platform. As an example electrodes can be integrated in in these devices, making electrical measurements on single cells such as sperm cells, or a tissue layer like the blood-brain barrier possible. By carefully analyzing these electrical signals, information about the morphology of the sperm cell or tightness of the tissue layer can be retrieved, which can be used to gain information about the semen quality or the functioning of the blood-brain barrier. Additional useful information can be retrieved form (automated) optical analysis using for instance fluorescence or bright field microscopy. So using these and other (new) techniques in combination with microfluidics, biomedical microdevices are developed that can finally be of use in the clinic. There are collaborations with other research groups at this and other universities, but also with doctors at the hospital, making it an applied multidisciplinary research area.

Publications

Recent
Spoelstra, L. R. , Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M. , Karperien, M. , Segerink, L. , & Le Gac, S. (2023). Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis. Poster session presented at NanoBioTech Montreux 2023, Montreux, Switzerland.
Kruit, S. A. (2023). Microfluidic Impedance Cytometry for Single Sperm Analysis: Towards Morphology Characterization. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036558341
Rivera-Arbeláez, J. M., Keekstra, D., Cofiño-Fabres, C., Boonen, T., Dostanic, M., ten Den, S. A., Vermeul, K., Mastrangeli, M. , van den Berg, A. , Segerink, L. I., Ribeiro, M. C. , Strisciuglio, N. , & Passier, R. (2023). Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking. Bioengineering and Translational Medicine, 8(3), Article e10513. https://doi.org/10.1002/btm2.10513
Rivera Arbeláez, J. M. (2023). Following the dots: Versatile and modular approach for engineering and analyzing three-dimensional cardiac tissues. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036555272
Rivera Arbelaez, J. M., Kutucu, C., Snippert, D., Dannenberg, M., Cofino Fabres, C. , van den Berg, A. , Ribeiro, M. , Passier, R. , & Segerink, L. (2022). Effect of continuous electrical stimulation on engineered 3D cardiac tissues using hPSCs in a versatile platform. Abstract from NanoBioTech-Montreux Conference 2022, Montreux, Switzerland.
Kolkman, R. W. (2022). Enrichment of hypermethylated DNA on chip for cancer diagnostics. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036554855

UT Research Information System

Google Scholar Link

Projects

Selected projects:

  • Microfluidics systems for semen analysis;
  • Blood-brain barrier chip;
  • Nanopil 2.0 or early cancer diagnostics.

See for more details: department website

In the press

Video/TV

Articles

Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré (building no. 15), room C2415
Hallenweg 21
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Carré  C2415
P.O. Box 217
7500 AE Enschede
The Netherlands