Carré

prof.dr.ir. L.I. Segerink (Loes)

Full Professor
EEMCS-EE-BIOS
Carré C2249
l.i.segerink@utwente.nl
+31534894541
Business card

My research focuses on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases.

Expertise

  • Chemistry

    • Microfluidics
    • Procedure
    • Deoxyribonucleic Acid
    • Concentration
    • Device

  • Physics

    • Electrodes
    • Organ
    • Spermatozoa

Organisations

Ancillary activities

  • ElsevierEditor sensors and actuators A
  • NWOcommittee NWO

The focus of this theme is on the development of microfluidic systems for (bio)-medical applications, thereby increasing the knowledge of biological systems and improving the diagnostics and treatment of diseases. Microfluidics are a perfect tool for this, since dimensions comparable to single cells are used, low sample volumes are needed and multiple functionalities can be integrated in one platform. As an example electrodes can be integrated in in these devices, making electrical measurements on single cells such as sperm cells, or a tissue layer like the blood-brain barrier possible. By carefully analyzing these electrical signals, information about the morphology of the sperm cell or tightness of the tissue layer can be retrieved, which can be used to gain information about the semen quality or the functioning of the blood-brain barrier. Additional useful information can be retrieved form (automated) optical analysis using for instance fluorescence or bright field microscopy. So using these and other (new) techniques in combination with microfluidics, biomedical microdevices are developed that can finally be of use in the clinic. There are collaborations with other research groups at this and other universities, but also with doctors at the hospital, making it an applied multidisciplinary research area.

Publications

2025

A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two‐Step Reaction (2025)Advanced science. Article e11811 (E-pub ahead of print/First online). Yao, J., Huang, S., Xie, S., Liu, Z., Deng, Y., Carnevale, L., Jin, M., Segerink, L. I., Wang, D., Shui, L. & Pud, S.https://doi.org/10.1002/advs.202511811Dupless: Toward a patient-friendly approach for erectile dysfunction nature differentiation – a study of 291 penile duplex Doppler ultrasound assessments (2025)Andrology, 13(8), 2257-2264. Torenvlied, H. J., de Jager, K. E., Segerink, L. I., Pelger, R. C. M. & Beck, J. J. H.https://doi.org/10.1111/andr.70017From Prototype to Clinical Practice: How to Validate Novel Instruments for Non-Invasive Erectile Dysfunction Diagnostics? (2025)Andrology (E-pub ahead of print/First online). Torenvlied, H. J., Pelger, R. C. M., Segerink, L. I. & Beck, J. J. H.https://doi.org/10.1111/andr.70135Engineering Morphologies of Metal-Based Colloidal Assemblies via Colloid Jamming at Liquid–Liquid Interfaces (2025)Small, 21(38). Article e06425. Yao, J., Xie, S., Huang, S., Xu, W., Li, J., Liu, Z., Jin, M., Segerink, L. I., Shui, L. & Pud, S.https://doi.org/10.1002/smll.202506425Optical technologies for multiparametric heart failure management beyond the hospital (2025)Talanta, 297(Part B). Article 128640 (E-pub ahead of print/First online). Vidal, M., Assunção, A. S., Mesquita-Bastos, J., Pereira, S. O., Segerink, L. I., Morrin, A. & Leitão, C.https://doi.org/10.1016/j.talanta.2025.128640Protoplasts under stress: Investigating the effect of compression on protoplasts using microfluidics (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Bugakova, D.https://doi.org/10.3990/1.9789036565950Self-assembly of colloidal particles within microdroplets: Mechanisms and applications (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Yao, J.https://doi.org/10.3990/1.9789036566728A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two-Step Reaction (2025)[Working paper › Preprint]. ChemRxiv (Accepted/In press). Yao, J., Huang, S., Xie, S., Liu, Z., Deng, Y., Carnevale, L., Jin, M., Segerink, L. I., Wang, D., Shui, L. & Pud, S.https://doi.org/10.26434/chemrxiv-2025-ttvjqEngineering Morphologies of Metal-Based Colloidal Assemblies via Colloid Jamming at Liquid-Liquid Interfaces (2025)[Working paper › Preprint]. ArXiv.org. Yao, J., Xie, S., Huang, S., Xu, W., Li, J., Liu, Z., Jin, M., Segerink, L. I., Shui, L. & Pud, S.https://doi.org/10.48550/arXiv.2505.06026A Robust Synthesis of Fluorosurfactants with Tunable Functions via a Two-Step Reaction (2025)[Working paper › Preprint]. ArXiv.org. Yao, J., Huang, S., Xie, S., Liu, Z., Deng, Y., Carnevale, L., Jin, M., Segerink, L. I., Wang, D., Shui, L. & Pud, S.https://doi.org/10.48550/arXiv.2505.11508

Research profiles

Affiliated study programs

Courses academic year 2025/2026

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2024/2025

Selected projects:

  • Microfluidics systems for semen analysis;
  • Technological developments in organ-on-chips
  • Early cancer diagnostics
  • Biomarker detection using microfluidic systems
  • Protoplast research on a chip

See for more details: department website

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University of Twente

Carré (building no. 15), room C2249
Hallenweg 23
7522 NH Enschede
Netherlands

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