dr. L.M. van Loon MSc (Lex)

Assistant Professor
TNW-BIS-CRPH
l.m.vanloon@utwente.nl
+31534896917
Business card

I am an part-time assistant professor within the CRPH group and Technical Physician at the UMC Utrecht, with an interest in clinical decision support. Currently I work on challenges in acute care data analysis and prediction by using deterministic model combined with machine learning capabilities (physics informed machine learning -> towards a medical digital twin.

Interesed in doing an internship or want to collaborate: please reach out.

Expertise

  • Medicine and Dentistry

    • Septic Shock
    • Esmolol
    • Experimental Septic Shock
    • Heart Arrest
    • Mean Arterial Pressure

  • Pharmacology, Toxicology and Pharmaceutical Science

    • Lipopolysaccharide
    • Hypertensive Factor
    • Inflammation

Organisations

Publications

2025

Modeling age and sex variations of arterial pressure and cardiac hemodynamics in a virtual population using a 01-1D cardiovascular simulator (2025)American journal of physiology : Heart and circulatory physiology, 329(5), H1212-H1228. Wardhana, G., van Loon, L. M., Potters, J.-W., Fransen, A., Lafort, A., Kilic, Y., Donker, D. W. & Fresiello, L.https://doi.org/10.1152/ajpheart.00387.2025Challenges in zero-flow blood pressure as a measure of mean circulatory filling pressure: Experimental and computational perspectives (2025)Physiological Reports, 13(19), e70599. Article e70599. van Loon, L. M., Mulder, M. P., Dort, D. I. M., van der Hoeven, J. G., Donker, D. W. & Lemson, J.https://doi.org/10.14814/phy2.70599Context-specific clinical applicability of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients: A systematic review and meta-analysis (2025)European journal of anaesthesiology, 42(8), 737-746. Mulder, M. P., Potters, J.-W., van Loon, L. M., Rumindo, K., Hallbäck, M., Maksuti, E., Donker, D. W. & Diez, C.https://doi.org/10.1097/EJA.0000000000002181Beyond the numbers: the importance of contextual data when reusing blood pressure data from electronic health records (2025)Frontiers in Digital Health, 7. Article 1664213. Grünewald, M. E., Koomen, E., van Loon, L. M., Gupta, A., Vernooij, R. W. M., van Solinge, W. W., Kappen, T. & Haitjema, S.https://doi.org/10.3389/fdgth.2025.1664213

2024

Understanding the complexity of cardiogenic shock management: the added value of advanced computational modeling (2024)Current Opinion in Critical Care, 30(4), 340-343. Meuwese, C. L., van Loon, L. M. & Donker, D. W.https://doi.org/10.1097/MCC.0000000000001164Computational modeling of heart failure in microgravity transitions (2024)Frontiers in Physiology, 15. Article 1351985. Wilson, S. L., Schulte, K. M., Steins, A., Gruen, R. L., Tucker, E. M. & van Loon, L. M.https://doi.org/10.3389/fphys.2024.1351985

Research profiles

Courses academic year 2025/2026

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2024/2025

Current PhD students
UMC Utrecht - Ruben Zoodsma
University of Amsterdam - Joeri van de Sande

Current Technical Medicine student rojects:
M3 - UMC Utrecht - Intensive Care - Kim van der Tak
Project title: Fluid Resuscitation and Vasopressor Therapy in Hemodynamic Unstable ICU Patients

M3 - UMC Utrecht - Intensive Care - Arno Fennema  
Project title:  Prognostic value of pulse pressure features in venoarterial extracorporeal membrane oxygenation weaning, a research proposal

M3 - UMC Utrecht - Cardioanesthesiology - Daan Imholz
Project title: Optimization of ex vivo lung perfusion using perfusion and ventilation modelling

M3 - WKZ / UMC Utrecht - Anesthesiology - Myrna van Veen
Project title: Cerebral Hemodynamics in Neonates During Congenital Heart Surgery.

Previous Technical Medicine student projects:
M3 - UMC Utrecht - Intensive Care - Kimmia Azampanah
Project title: A digital twin for cardiac monitoring in patients receiving venoarterial extracorporeal membrane oxygenation

M3 - UMC Utrecht - Intensive Care - Catharina Jansen
Project title: Predictive model for successful weaning in VA-ECMO treatment

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