dr. L.O. Bonino da Silva Santos MSc (Luiz)

Associate Professor

About Me

I'm currently working as Associate Professor at the Semantic, Cybersecurity and Service group at the University of Twente and at the BioSemantics group, in the department of Human Genetics at the Leiden University Medical Center.

My main research topics are the FAIR principles, semantic interoperability, ontology-driven conceptual modelling and intelligent systems design. Since 2014 I have been closely involved in designing and leading the implementation of a number of technologies and approaches to support the realisation of the FAIR principles.


Data Management
Machine Learning
Work Flow
Social Sciences
Medical Data


Together with my position at the University of Twente, I am also Associate Professor in the BioSemantics Group at the Leiden University Medica Center, in Leiden, the Netherlands.

Since 2014 I have been closely involved in the FAIR principles (findable, accessible, interoperable and reusable) movement. More specifically, I have participated in the research, design and development of a number of approaches and technologies to enable and/or facilitate the realisation of the FAIR principles such as FAIR metrics, FAIR Data Point, FAIRifier, FAIR Data Train and FAIR Digital Objects Framework.


Valle Sousa, I. , Prince Sales, T., Guerra, E. , Olavo Bonino da Silva Santos, L. , & Guizzardi, G. (2024). What Do I Get from Modeling? An Empirical Study on Using Structural Conceptual Models. In H. A. Proper, L. Pufahl, D. Karastoyanova, M. van Sinderen, & J. Moreira (Eds.), Enterprise Design, Operations, and Computing: 27th International Conference, EDOC 2023, Groningen, The Netherlands, October 30 – November 3, 2023, Proceedings (pp. 21-38). (Lecture Notes in Computer Science; Vol. 14367). Springer. https://doi.org/10.1007/978-3-031-46587-1_2
Bonino da Silva Santos, L. O. , Sales, T. P. , Fonseca, C. M. , & Guizzardi, G. (2023). Towards a Conceptual Model for the FAIR Digital Object Framework. In T. Hahmann, A. Galton, M. M. Hedblom, & N. Aussenac-Gilles (Eds.), Formal Ontology in Information Systems: Proceedings of the 13th International Conference (FOIS 2023) (pp. 227-241). (Frontiers in Artificial Intelligence and Applications; Vol. 377). IOS. https://doi.org/10.3233/FAIA231131
Bernabé, C. H. , Sales, T. P., Schultes, E., van Ulzen, N., Jacobsen, A. , da Silva Santos, L. O. B., Mons, B., & Roos, M. (2023). A goal-oriented method for FAIRification planning. CEUR workshop proceedings, 3618.
Bernabé, C. H., Queralt-Rosinach, N., Silva Souza, V. E. , Bonino da Silva Santos, L. O., Mons, B., Jacobsen, A., & Roos, M. (2023). The use of foundational ontologies in biomedical research. Journal of Biomedical Semantics, 14(1), Article 21. https://doi.org/10.1186/s13326-023-00300-z
Sales, T. P., Barcelos, P. P. F. , Fonseca, C. M., Souza, I. V., Romanenko, E., Bernabé, C. H. , Bonino da Silva Santos, L. O., Fumagalli, M., Kritz, J., Almeida, J. P. A. , & Guizzardi, G. (2023). A FAIR catalog of ontology-driven conceptual models. Data & knowledge engineering, 147, Article 102210. https://doi.org/10.1016/j.datak.2023.102210
Bernasconi, A., García Simon, A. , Guizzardi, G. , Santos, L. O. B. D. S., & Storey, V. C. (2023). Ontological Representation of FAIR Principles: A Blueprint for FAIRer Data Sources. In M. Indulska, I. Reinhartz-Berger, C. Cetina, & O. Pastor (Eds.), Advanced Information Systems Engineering: 35th International Conference, CAiSE 2023, Zaragoza, Spain, June 12–16, 2023, Proceedings (pp. 261-277). (Lecture Notes in Computer Science; Vol. 13901 LNCS). Springer. https://doi.org/10.1007/978-3-031-34560-9_16
Stiksma, F. (2023). Lifetime extension assessment of collected washing machines. [EngD Thesis, University of Twente]. University of Twente.
Benhamed, O. M., Burger, K., Kaliyaperumal, R. , Santos, L. O. B. D. S. (Ed.), Suchánek, M., Slifka, J., & Wilkinson, M. D. (2023). The FAIR Data Point: Interfaces and Tooling. Data Intelligence, 5(1), 184-201. https://doi.org/10.1162/dint_a_00161
Santos, L. O. B. D. S., Burger, K., Kaliyaperumal, R., & Wilkinson, M. D. (Ed.) (2023). FAIR Data Point: A FAIR-Oriented Approach for Metadata Publication. Data Intelligence, 5(1), 163-183. https://doi.org/10.1162/dint_a_00160
Bernabé, C. H., Queralt Rosinach, N., Silva Souza, V. E. , Bonino da Silva Santos, L. O., Jacobsen, A., Mons, B., & Roos, M. (2022). The use of Foundational Ontologies in Bioinformatics. In SWAT4HCLS 2022 (CEUR workshop proceedings; Vol. 3127). https://ceur-ws.org/Vol-3127/paper-5.pdf
Schultes, E., Magagna, B., Kuhn, T., Suchánek, M. , Bonino da Silva Santos, L., & Mons, B. (2022). The Comparative Anatomy of Nanopublications and FAIR Digital Objects. Research Ideas and Outcomes, 8, Article e94150. https://doi.org/10.3897/rio.8.e94150
Schultes, E., Roos, M. , Bonino da Silva Santos, L. O. , Guizzardi, G., Bouwman, J., Hankemeier, T., Baak, A., & Mons, B. (2022). FAIR Digital Twins for Data-Intensive Research. Frontiers in Big Data, 5, Article 883341. https://doi.org/10.3389/fdata.2022.883341
Soares, F. M., Corrêa, F. E. , Pires, L. F. , da Silva Santos, L. O. B., Drucker, D. P., Braghetto, K. R., de Abreu Moreira, D., Delbem, A. C. B., da Silva, R. F., da Silva Lopes, C. O., & Saraiva, A. M. (2022). Building a Community-Based FAIR Metadata Schema for Brazilian Agriculture and Livestock Trading Data. In SEMPDW 2022 (CEUR workshop proceedings; Vol. 3235). https://ceur-ws.org/Vol-3235/paper26.pdf
Graciano Martinez, V. , Pires, L. F. , Santos, L. , Moreira, J. , & Souza, R. (2021). A Framework for Staging Personal Health Trains in the Cloud. In F. J. D. Mayo, M. Marchiori, & J. Filipe (Eds.), Proceedings of the 17th International Conference on Web Information Systems and Technologies, WEBIST 2021, October 26-28, 2021 (pp. 133-144). (Proceedings of the International Conference on Web Information Systems and Technologies; Vol. 2021, No. 17). SCITEPRESS. https://doi.org/10.5220/0010712800003058
Nakagawa, P. I. , Ferreira Pires, L. , Rebelo Moreira, J. L. , & Olavo Bonino, L. (2021). Towards Semantic Description of Explainable Machine Learning Workflows. In Proceedings - 2021 IEEE 25th International Enterprise Distributed Object Computing Conference Workshops, EDOCW 2021 (pp. 236-244). (Proceedings - IEEE International Enterprise Distributed Object Computing Workshop, EDOCW). IEEE. https://doi.org/10.1109/EDOCW52865.2021.00054
Kaliyaperumal, R., Queralt Rosinach, N., Burger, K. , Bonino Da Silva Santos, L. O., Hanauer, M., & Roos, M. (2021). Enabling FAIR Discovery of Rare Disease Digital Resources. In D. Hayn, G. Schreier, & M. Baumgartner (Eds.), Navigating Healthcare Through Challenging Times - Proceedings of dHealth 2021 - Health Informatics Meets Digital Health (pp. 144-146). (Studies in Health Technology and Informatics; Vol. 279). IOS. https://doi.org/10.3233/SHTI210101

UT Research Information System

Google Scholar Link

Courses Academic Year  2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2022/2023

Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Zilverling (building no. 11), room 2005
Hallenweg 19
7522NH  Enschede
The Netherlands

Navigate to location

Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Zilverling  2005
P.O. Box 217
7500 AE Enschede
The Netherlands

Social Media