Laurens Spoelstra obtained his bachelor's and master's degree in Biomedical Engineering with a specialization in Bioengineering Technologies from the University of Twente in 2020 and 2022. During his master's assignment, he worked on developing and designing a Joint-on-chip multi-organ-on-chip platform to study arthritis. After winning the TGS Award 2022 for the continuation of this project, he is now working as a PhD Candidate in a collaboration of the DBE (Prof. Karperien), AMBER (Prof. Le Gac), and BIOS (Prof. Segerink) groups.

In his PhD project, Laurens will optimize existing synovium-on-chip and cartilage-on-chip platforms on both the biological and engineering levels with the end goal to combine them into a first-of-a-kind Joint-on-Chip platform to study chondro-synovial crosstalk in the Joint-on-Chip, to increase our understanding of arthritis and to assist in future drug development.

Expertise

  • Engineering

    • Fluidics
    • Computer Aided Design
    • Pneumatics
    • Microfluidic Platform
  • Immunology and Microbiology

    • Arthritis
    • Synovium
    • Porosity
  • Computer Science

    • Printed Circuit Board

Organisations

Publications

2026

A Synovium-on-Chip Platform to Study Multicellular Interactions in Arthritis (2026)Advanced healthcare materials, 15(15). Article e04857. Spoelstra, L. R., Semmekrot, F. R., Araújo-Gomes, N., Wijnperle, D., Helsen, M. M. A., Van Den Bosch, M. H. J., Segerink, L. I., Le Gac, S. & Karperien, M.https://doi.org/10.1002/adhm.202504857

2025

Connecting the D.O.T.S.: Design of fluidic circuit boards for multi-OoC platforms using CAD Tools for Standardization (2025)In 2025 IEEE/ACM International Conference On Computer Aided Design (ICCAD). IEEE. Spoelstra, L. R., Kramer, M., Rietveld, J., Loessberg-Zahl, J. T. & Segerink, L.https://doi.org/10.1109/ICCAD66269.2025.11240924Automated routing for fluidic and pneumatic channels in standardized microfluidic platforms using CAD software (2025)[Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025. Spoelstra, L. R., Kramer, M., Karperien, M., Le Gac, S. & Segerink, L.Computational toolset for fluidic network-to-layout translation applied in FCB design for chemical gradients in parallelized organ-on-chips (2025)[Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025. Spoelstra, L. R., Emmerich, M., Rietveld, J., Berendsen, J. T. W., Loessberg-Zahl, J. T., Wille, R. & Segerink, L.The Joint-on-Chip: A multi-Organ-on-Chip Model for Studying Inter-Tissue Crosstalk in Arthritis (2025)[Contribution to conference › Poster] 1st Dutch Osteoarthritis Research Day, OA Research Day NL. Spoelstra, L. R., Semmekrot, F. R., Serrano-Larrea, C., Le, T., Le Gac, S., Segerink, L. & Karperien, M.

2023

Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Spoelstra, L. R., Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M., Karperien, M., Segerink, L. & Le Gac, S.

2021

A Multiplexable Plasmonic Hairpin-DNA Sensor Based On Target-specific Tether Dynamics (2021)ACS sensors, 6(12), 4297–4303. van Dongen, J. E., Spoelstra, L. R., Berendsen, J. T. W., Loessberg-Zahl, J. T., Eijkel, J. C. T. & Segerink, L. I.https://doi.org/10.1021/acssensors.1c02097

Research profiles

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