Carré

L.R. Spoelstra MSc (Laurens)

Researcher
EEMCS-EE-BIOS
Carré C2411
l.r.spoelstra@utwente.nl
+31534899010
Business card

Laurens Spoelstra obtained his bachelor's and master's degree in Biomedical Engineering with a specialization in Bioengineering Technologies from the University of Twente in 2020 and 2022. During his master's assignment, he worked on developing and designing a Joint-on-chip multi-organ-on-chip platform to study arthritis. After winning the TGS Award 2022 for the continuation of this project, he continued as a PhD candidate in a collaboration of the DBE (Prof. Karperien), AMBER (Prof. Le Gac), and BIOS (Prof. Segerink) groups, focusing on modular microfluidics and standardized organ-on-chip platforms for studying Arthritis in vitro. He submitted his PhD thesis in September 2026 and is currently working as a postdoctoral researcher at the BIOS Lab on a Chip group.

Expertise

  • Engineering

    • Fluidics
    • Computer Aided Design
    • Pneumatics
    • Microfluidic Platform

  • Immunology and Microbiology

    • Arthritis
    • Synovium
    • Porosity

  • Computer Science

    • Printed Circuit Board

Organisations

Publications

2026

A Synovium-on-Chip Platform to Study Multicellular Interactions in Arthritis (2026)Advanced healthcare materials, 15(15). Article e04857. Spoelstra, L. R., Semmekrot, F. R., Araújo-Gomes, N., Wijnperle, D., Helsen, M. M. A., Van Den Bosch, M. H. J., Segerink, L. I., Le Gac, S. & Karperien, M.https://doi.org/10.1002/adhm.202504857

2025

Connecting the D.O.T.S.: Design of fluidic circuit boards for multi-OoC platforms using CAD Tools for Standardization (2025)In 2025 IEEE/ACM International Conference On Computer Aided Design (ICCAD). IEEE. Spoelstra, L. R., Kramer, M., Rietveld, J., Loessberg-Zahl, J. T. & Segerink, L.https://doi.org/10.1109/ICCAD66269.2025.11240924Automated routing for fluidic and pneumatic channels in standardized microfluidic platforms using CAD software (2025)[Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025. Spoelstra, L. R., Kramer, M., Karperien, M., Le Gac, S. & Segerink, L.Computational toolset for fluidic network-to-layout translation applied in FCB design for chemical gradients in parallelized organ-on-chips (2025)[Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025. Spoelstra, L. R., Emmerich, M., Rietveld, J., Berendsen, J. T. W., Loessberg-Zahl, J. T., Wille, R. & Segerink, L.The Joint-on-Chip: A multi-Organ-on-Chip Model for Studying Inter-Tissue Crosstalk in Arthritis (2025)[Contribution to conference › Poster] 1st Dutch Osteoarthritis Research Day, OA Research Day NL. Spoelstra, L. R., Semmekrot, F. R., Serrano-Larrea, C., Le, T., Le Gac, S., Segerink, L. & Karperien, M.

2023

Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Spoelstra, L. R., Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M., Karperien, M., Segerink, L. & Le Gac, S.

2021

A Multiplexable Plasmonic Hairpin-DNA Sensor Based On Target-specific Tether Dynamics (2021)ACS sensors, 6(12), 4297–4303. van Dongen, J. E., Spoelstra, L. R., Berendsen, J. T. W., Loessberg-Zahl, J. T., Eijkel, J. C. T. & Segerink, L. I.https://doi.org/10.1021/acssensors.1c02097

Research profiles

Courses academic year 2026/2027

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Address

University of Twente

Carré (building no. 15), room C2411
Hallenweg 23
7522 NH Enschede
Netherlands

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