Laurens Spoelstra obtained his bachelor's and master's degree in Biomedical Engineering with a specialization in Bioengineering Technologies from the University of Twente in 2020 and 2022. During his master's assignment, he worked on developing and designing a Joint-on-chip multi-organ-on-chip platform to study arthritis. After winning the TGS Award 2022 for the continuation of this project, he is now working as a PhD Candidate in a collaboration of the DBE (Prof. Karperien), AMBER (Prof. Le Gac), and BIOS (Prof. Segerink) groups.

In his PhD project, Laurens will optimize existing synovium-on-chip and cartilage-on-chip platforms on both the biological and engineering levels with the end goal to combine them into a first-of-a-kind Joint-on-Chip platform to study chondro-synovial crosstalk in the Joint-on-Chip, to increase our understanding of arthritis and to assist in future drug development.

Expertise

  • Biochemistry, Genetics and Molecular Biology

    • DNA Hairpin
    • Accuracy
    • DNA
  • Chemistry

    • Deoxyribonucleic Acid
    • Sensor
    • Molecule
    • Concentration
    • Liquid Film

Organisations

Publications

2023

Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Spoelstra, L. R., Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M., Karperien, M., Segerink, L. & Le Gac, S.

2021

A Multiplexable Plasmonic Hairpin-DNA Sensor Based On Target-specific Tether Dynamics (2021)ACS sensors, 6(12), 4297–4303. van Dongen, J. E., Spoelstra, L. R., Berendsen, J. T. W., Loessberg-Zahl, J. T., Eijkel, J. C. T. & Segerink, L. I.https://doi.org/10.1021/acssensors.1c02097

Research profiles

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