L.S. Koch MSc (Lena)

Researcher
TNW-BET-AST
Horst Complex ZH125
l.s.koch@utwente.nl
+31534898154
Business card
Workdays
even
odd
M
T
W
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F
on campus
work from home
out of office

Expertise

  • Biochemistry, Genetics and Molecular Biology

    • Embryoid Body
    • Induced Pluripotent Stem Cell

  • Chemistry

    • Polycarbonate
    • Pore Size

  • Medicine and Dentistry

    • Aging
    • Culture
    • Organoid
    • Tissues

Organisations

The brain is connected to the gastrointestinal tract through bi-directional biochemical signaling pathways which are largely regulated by the composition of the microbiome. My goal is to develop a gut-brain axis on a chip (GBOC) to enable to study the complex interplay between the gut microbiome and brain health. The envisaged microfluidic controlled chip set-up recapitulates the two major barriers separating the brain and the gastrointestinal tract: the gut-blood barrier and the blood-brain barrier making use of human pluripotent stem cell-derived technology. The strength of the developed GBOC technology will be demonstrated with a proof-of-concept model of the impact of microbiota variation on neuronal functioning.

This project is part of the Netherlands Organ-on-a-chip Initiative - NOCI.

https://noci-organ-on-chip.nl/

Publications

2023
Robust Tissue Fabrication for Long-Term Culture of iPSC-Derived Brain Organoids for Aging Research, Article e64586. Koch, L. S., Buentello, D. C. & Broersen, K.https://doi.org/10.3791/64586
2022
Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies, Article e0262062. Buentello, D. C., Koch, L. S., Trujillo-De Santiago, G., Alvarez, M. M. & Broersen, K.https://doi.org/10.1371/journal.pone.0262062
2021
Transwell-Integrated 2 µm Thick Transparent Polydimethylsiloxane Membranes with Controlled Pore Sizes and Distribution to Model the Blood-Brain Barrier, Article 2100138. Zakharova, M., Tibbe, M. P., Koch, L. S., Le-The, H., Leferink, A. M., van den Berg, A., van der Meer, A. D., Broersen, K. & Segerink, L. I.https://doi.org/10.1002/admt.202100138

Other contributions

Choy Buentello, D., Koch, L. S., Trujillo-de Santiago, G., Alvarez, M. M., & Broersen, K. (2022). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. Plos one, 17(5), e0262062.

Research profiles

Address

University of Twente

Horst Complex (building no. 20), room ZH125
De Horst 2
7522 LW Enschede
Netherlands

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