L.S. Koch MSc (Lena)

Expertise

• Biochemistry, Genetics and Molecular Biology

  • Embryoid Body
  • Induced Pluripotent Stem Cell

• Chemistry

  • Polycarbonate
  • Pore Size

• Medicine and Dentistry

  • Aging
  • Culture
  • Organoid
  • Tissues

Organisations

The brain is connected to the gastrointestinal tract through bi-directional biochemical signaling pathways which are largely regulated by the composition of the microbiome. My goal is to develop a gut-brain axis on a chip (GBOC) to enable to study the complex interplay between the gut microbiome and brain health. The envisaged microfluidic controlled chip set-up recapitulates the two major barriers separating the brain and the gastrointestinal tract: the gut-blood barrier and the blood-brain barrier making use of human pluripotent stem cell-derived technology. The strength of the developed GBOC technology will be demonstrated with a proof-of-concept model of the impact of microbiota variation on neuronal functioning.

This project is part of the Netherlands Organ-on-a-chip Initiative - NOCI.

https://noci-organ-on-chip.nl/

Publications

Other contributions

Choy Buentello, D., Koch, L. S., Trujillo-de Santiago, G., Alvarez, M. M., & Broersen, K. (2022). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. Plos one, 17(5), e0262062.

Research profiles

Address

University of Twente

Horst Complex (building no. 20), room ZH125
De Horst 2
7522 LW Enschede
Netherlands

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Organisations