Expertise
Organisations
Research
The brain is connected to the gastrointestinal tract through bi-directional biochemical signaling pathways which are largely regulated by the composition of the microbiome. My goal is to develop a gut-brain axis on a chip (GBOC) to enable to study the complex interplay between the gut microbiome and brain health. The envisaged microfluidic controlled chip set-up recapitulates the two major barriers separating the brain and the gastrointestinal tract: the gut-blood barrier and the blood-brain barrier making use of human pluripotent stem cell-derived technology. The strength of the developed GBOC technology will be demonstrated with a proof-of-concept model of the impact of microbiota variation on neuronal functioning.
This project is part of the Netherlands Organ-on-a-chip Initiative - NOCI.
https://noci-organ-on-chip.nl/
Publications
UT Research Information System
Contact Details
Visiting Address
University of Twente
Faculty of Science and Technology
Horst Complex
(building no. 20), room ZH125
De Horst 2
7522LW Enschede
The Netherlands
Mailing Address
University of Twente
Faculty of Science and Technology
Horst Complex
ZH125
P.O. Box 217
7500 AE Enschede
The Netherlands
Working days
| Week | Monday | Tuesday | Wednesday | Thursday | Friday |
| Even | |||||
| Odd |