Horst Complex

L.S. Koch PhD (Lena)

Researcher
TNW-BET-AST
Horst Complex ZH125
l.s.koch@utwente.nl
+31534898154
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Workdays
even
odd
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on campus
work from home
out of office

Expertise

  • Biochemistry, Genetics and Molecular Biology

    • Embryoid Body
    • Induced Pluripotent Stem Cell

  • Chemistry

    • Polycarbonate
    • Pore Size

  • Medicine and Dentistry

    • Aging
    • Culture
    • Organoid
    • Tissues

Organisations

The brain is connected to the gastrointestinal tract through bi-directional biochemical signaling pathways which are largely regulated by the composition of the microbiome. My goal is to develop a gut-brain axis on a chip (GBOC) to enable to study the complex interplay between the gut microbiome and brain health. The envisaged microfluidic controlled chip set-up recapitulates the two major barriers separating the brain and the gastrointestinal tract: the gut-blood barrier and the blood-brain barrier making use of human pluripotent stem cell-derived technology. The strength of the developed GBOC technology will be demonstrated with a proof-of-concept model of the impact of microbiota variation on neuronal functioning.

This project is part of the Netherlands Organ-on-a-chip Initiative - NOCI.

https://noci-organ-on-chip.nl/

Publications

2025

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling (2025)Frontiers in bioengineering and biotechnology, 13. Article 1515340. Papamichail, L., Koch, L. S., Veerman, D., Broersen, K. & van der Meer, A. D.https://doi.org/10.3389/fbioe.2025.1515340

2024

The Gut-Brain Axis on Chip to unravel Inter-Tissue Interactions (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Koch, L. S.https://doi.org/10.3990/1.9789036563253Standardizing designed and emergent quantitative features in microphysiological systems (2024)Nature Biomedical Engineering, 8, 941-962. Nahon, D., Moerkens, R., Aydogmus, H., Lendemeijer, B., Martínez-Silgado, A., Stein, J., Dostanić, M., Frimat, J.-P., Gontan, C., de Graaf, M. N. S., Hu, M., Kasi, D., Koch, L. S., Le, K., Lim, S., Middelkamp, H. H. T., Mooiweer, J., Montreux-Ragot, P., Niggl, E., … Mummery, C. L.https://doi.org/10.1038/s41551-024-01236-0

2023

Robust Tissue Fabrication for Long-Term Culture of iPSC-Derived Brain Organoids for Aging Research (2023)Journal of visualized experiments, 2023(195). Article e64586. Koch, L. S., Buentello, D. C. & Broersen, K.https://doi.org/10.3791/64586

2022

Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies (2022)PLoS ONE, 17(5 May). Article e0262062. Buentello, D. C., Koch, L. S., Trujillo-De Santiago, G., Alvarez, M. M. & Broersen, K.https://doi.org/10.1371/journal.pone.0262062

2021

Transwell-Integrated 2 µm Thick Transparent Polydimethylsiloxane Membranes with Controlled Pore Sizes and Distribution to Model the Blood-Brain Barrier (2021)Advanced Materials Technologies, 6(12). Article 2100138. Zakharova, M., Tibbe, M. P., Koch, L. S., Le-The, H., Leferink, A. M., van den Berg, A., van der Meer, A. D., Broersen, K. & Segerink, L. I.https://doi.org/10.1002/admt.202100138

Other contributions

Choy Buentello, D., Koch, L. S., Trujillo-de Santiago, G., Alvarez, M. M., & Broersen, K. (2022). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. Plos one, 17(5), e0262062.

Research profiles

Address

University of Twente

Horst Complex (building no. 20), room ZH125
De Horst 2
7522 LW Enschede
Netherlands

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