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L.S. Koch MSc (Lena)

PhD Candidate

Expertise

Engineering & Materials Science
Astrocytes
Blood-Brain Barrier
Cell Culture
Membranes
Polydimethylsiloxane
Pore Size
Chemistry
Permeability
Pore Size

Research

The brain is connected to the gastrointestinal tract through bi-directional biochemical signaling pathways which are largely regulated by the composition of the microbiome. My goal is to develop a gut-brain axis on a chip (GBOC) to enable to study the complex interplay between the gut microbiome and brain health. The envisaged microfluidic controlled chip set-up recapitulates the two major barriers separating the brain and the gastrointestinal tract: the gut-blood barrier and the blood-brain barrier making use of human pluripotent stem cell-derived technology. The strength of the developed GBOC technology will be demonstrated with a proof-of-concept model of the impact of microbiota variation on neuronal functioning.

This project is part of the Netherlands Organ-on-a-chip Initiative - NOCI.

https://noci-organ-on-chip.nl/

UT Research Information System

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst Complex (building no. 20), room ZH125
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst Complex  ZH125
P.O. Box 217
7500 AE Enschede
The Netherlands

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