dr. L.S. Moreira Teixeira Leijten (Liliana)

Dr. Liliana Moreira Teixeira earned her BSc in Applied Biology at the University of Minho (Portugal), during which she performed internships in immunology at Leiden University Medical School (The Netherlands) and in biomaterials at the 3B's Research Group (Portugal). Afterwards, she obtained her MSc degree in Biomedical Engineering at the Faculty of Engineering of the University of Porto (Portugal). Her PhD degree was earned at the University of Twente (The Netherlands), in Prof. C. van Blitterswijk’s Tissue Regeneration group, on injectable 3D matrices for cartilage regeneration, followed by a post-doctoral term at Prometheus, KU Leuven (Belgium), with Prof. F. Luyten. Subsequently, Dr. Liliana joined the Wyss Institute, Harvard Medical School (USA), as a post-doctoral fellow, with Prof. D. Ingber, working on organs-on-chips. Afterwards, she worked as senior post-doctoral researcher at the MERLN Institute (The Netherlands). Currently, she is an Assistant Professor at the Department of Developmental BioEngineering (DBE), University of Twente. Dr. Liliana coordinates a collaborative project between DBE and the Department of Equine Sciences / Regenerative Medicine Utrecht, Utrecht University, focused on the development of Joint-on-chip platforms.

Faculty of Science and Technology (TNW), Advanced Organ bioengineering and Therapeutics (AOT)

Research interests:

1) Development of bioengineered micro-systems – (multi-) organs-on-chip platforms

E.g. Join-on-chip project coordinator

2) Advance precision and personalized (onco-) medicine - state-of-the-art micro-devices;

3) Creating (micro-) building blocks for modular tissue engineering.

Baptista, D. , Moreira Teixeira, L. , Barata, D. , Tahmasebi Birgani, Z., King, J., van Riet, S. , Pasman, T. , Poot, A. A. , Stamatialis, D., Rottier, R. J., Hiemstra, P. S., Carlier, A. , van Blitterswijk, C. , Habibović, P., Giselbrecht, S. , & Truckenmüller, R. (2022). 3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes. ACS Biomaterials Science and Engineering, 8(6), 2684-2699. https://doi.org/10.1021/acsbiomaterials.1c01463

Calejo, I. , Heinrich, M. A., Zambito, G., Mezzanotte, L. , Prakash, J. , & Teixeira, L. M. (2022). Advancing Tumor Microenvironment Research by Combining Organs-on-Chips and Biosensors. In Microfluidics and Biosensors in Cancer Research: Applications in Cancer Modeling and Theranostics (pp. 171-203). (Advances in Experimental Medicine and Biology; Vol. 1379). Springer Gabler. https://doi.org/10.1007/978-3-031-04039-9_7

Paggi, C. A. , Moreira Teixeira, L. , le Gac, S. , & Karperien, M. (2022). Joint-on-chip platforms: entering a new era of in vitro models for arthritis. Nature reviews rheumatology, 18, 217-231. https://doi.org/10.1038/s41584-021-00736-6

Ahmed, H. M. M. A. M. , & Moreira Teixeira, L. S. (2022). New Endeavors of (Micro)Tissue Engineering: Cells Tissues Organs on-Chip and Communication Thereof. Cells tissues organs, 211(6). https://doi.org/10.1159/000516356

Moreira Teixeira Leijten, L. S., & Mezzanotte, L. (2021). New bioimaging avenues for organs-on-chips by integration of bioluminescence. View, 2(6), [20200177]. https://doi.org/10.1002/VIW.20200177

Farzin, A., Hassan, S. , Moreira Teixeira, L. S. , Gurian, M. , Crispim, J. F., Manhas, V., Carlier, A., Bae, H., Geris, L., Noshadi, I., Ryon Shin, S. , & Leijten, J. (2021). Self-Oxygenation of Tissues Orchestrates Full-Thickness Vascularization of Living Implants. Advanced functional materials, 31(42), [2100850]. https://doi.org/10.1002/adfm.202100850

Baptista, D. , Teixeira, L. M. , Birgani, Z. T., van Riet, S. , Pasman, T. , Poot, A. , Stamatialis, D., Rottier, R. J., Hiemstra, P. S. , Habibović, P. , van Blitterswijk, C., Giselbrecht, S. , & Truckenmüller, R. (2021). 3D alveolar in vitro model based on epithelialized biomimetically curved culture membranes. Biomaterials, 266, [120436]. https://doi.org/10.1016/j.biomaterials.2020.120436

Rodrigues, J. , Heinrich, M. A. , Teixeira, L. M. , & Prakash, J. (2021). 3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions. Trends in cancer, 7(3), 249-264. https://doi.org/10.1016/j.trecan.2020.10.009

Paggi, C. A. , Hendriks, J. , Moreira Teixeira Leijten, L. S. , Karperien, M. , & le Gac, S. (2020). Mechanical stimulation increases ECM production by chondrocytes in a cartilage-on-a-chip platform. In Proceedings of the 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 [T4-454.e]

Paggi, C. A., Zakharova, M. , Segerink, L. , le Gac, S. , Moreira Teixeira Leijten, L. S. , & Karperien, M. (2020). Synovial membrane on chip: a new tool to study co-culture response to mechanical stimulation. In Proceedings of the 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 [Th8-854.e]

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Bachelor

Biomedische Technologie

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