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M.A. Heinrich MSc (Marcel)

PhD Candidate

About Me

My personal goal is to combine biology and chemistry with engineering strategies to develop novel models and create innovative treatments for cancer.

In 2011, I started my study Biomedical Technologies at the University of Twente, where I obtained my Bachelors degree in 2014. Afterwards I continued the Master Biomedical Engineering in Twente, with special focus on Bionanotechnology & Advanced Biomanufacturing. During that time I developed a particular interest in nanomedicine and targeted therapeutics.

In 2016, I obtained my Masters degree cum laude with an average grade of 9.1/10. My final assigment was performed in the group of Jai Prakash under supervision of Jonas Schnittert and had the title "Lipoxin A4 as potential agent to inhibit the tumor-promoting effects of pancreatic stellate cells in the tumor microenvironment". The final grade for my thesis was a 10/10.
For my Master thesis I was awarded the KNCV Golden Master Award 2016 from the Royal Netherlands Chemical Society for the best Master thesis in a (bio)chemistry related field in the Netherlands.  Furthermore I achieved the 2nd place in the Twente Graduate School Award for excellent Master students at the University of Twente.

During an internship in 2015/2016, performed in the Khademhosseini Lab at the Harvard Medical School/ Massachusetts Institute of Technology in Boston, MA, USA, I was able to gain great experience in the field of 3D Bioprinting for tissue engineering and regenerative medicine. The internsuip was a great experience for me and I gained a lot of experinece for my future career. The internship (as part of my Master program) was eventually graded a 10/10.

I started my PhD project in the group of Jai Prakash in 2017. The NWO-KWF funded project is performed together with the group of Prof. Dr. Raymond Schiffelers at the University Medical Center (UMC) Utrecht.

Expertise

Extrusion
Bioprinting
Fabrication
Gelatin
Gels
Pancreatic Neoplasms
Lipids
Lipoxins
Neoplasms

Research

I am currently working on the (targeted) modulation of the glioblastoma microenvironment. Glioblastoma Multiforme (GBM) is the most common type of brain cancer with a devastating survival time of approx. 1.5 years after diagnosis. Currently, the only effective treatment of GBM is the resection of the tumor. However, a full resection of the tumor is nearly impossible as the tumor can reach deep into the brain and a healthy brain tissue might be harmed during the surgery.
The approach taken in this project is to implant radiation therapy and chemotherapeutic agents locally in the brain after tumor resection and create a micro-environment that attacks remaining tumor cells and prevents tumor proliferation and recurrence.

Publications

Recent
Rocca, M., Fragasso, A., Liu, W., Heinrich, M. A., & Zhang, Y. S. (2018). Embedded Multimaterial Extrusion Bioprinting. SLAS Technology, 23(2), 154-163. DOI: 10.1177/2472630317742071
Liu, W., Zhang, Y. S., Heinrich, M. A., De Ferrari, F., Jang, H. L., Bakht, S. M., ... Khademhosseini, A. (2017). Rapid Continuous Multimaterial Extrusion Bioprinting. Advanced materials, 29(3). DOI: 10.1002/adma.201604630
Liu, W., Heinrich, M. A., Zhou, Y., Akpek, A., Hu, N., Liu, X., ... Zhang, Y. S. (2017). Extrusion Bioprinting of Shear-Thinning Gelatin Methacryloyl Bioinks. Advanced healthcare materials, 6(12), [1601451]. DOI: 10.1002/adhm.201601451

UT Research Information System

Google Scholar Link

In the press

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst - Zuidhorst (building no. 28), room 253
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst - Zuidhorst  253
P.O. Box 217
7500 AE Enschede
The Netherlands

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