M.A.W. Meteling MSc (Marieke)

Researcher
TNW-BET-DBE
Horst - Zuidhorst ZH147
m.a.w.meteling@utwente.nl
+31534893470
Business card

Marieke Meteling studied Biomedical Engineering at the University of Twente, starting in 2014. After obtaining her bachelor’s degree in 2017, she continued with the master programme at the University of Twente, specialising in Bionanotechnology and Advanced Biomanufacturing. During her internship at the Molecular Cell Biology group at Sahlgrenska Academy, Sweden, she studied the chondrogenesis of induced pluripotent stem cells (iPSCs) under different culture conditions. Her master thesis focused on elucidating the mechanism behind microaggregate shrinkage. In December 2019 she graduated Cum Laude at the Developmental BioEngineering group of the University of Twente.

In March 2020 she started her PhD in the Developmental BioEngineering group under the supervision of dr. Jeroen Leijten. Her project focussed on elucidating the effect of the 3D cellular microenvironment on cell behaviour. 

Since April 2024 she works as a Postdoc on the LoaD project (NWA-NWO) under the shared supervision of Gijsje Koenderink (TU Delft), Gerjo van Osch (Erasmus MC) and Jeroen Leijten (UT). Her project focusses on studying the influence of the mechanical microenvironment on cell behaviour of chondrocytes. By engineering small microniches for single cells, she studies the cell behaviour on the single cell level. 

Expertise

  • Medicine and Dentistry

    • Crowding
    • Drive
    • Osteoarthritis
    • Pathology
    • Cell Function

  • Biochemistry, Genetics and Molecular Biology

    • Molecular Crowding
    • Cell Level
    • Chondrocyte

Organisations

Publications

2026

Guiding cell behaviour via intracellular crowding (2026)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Meteling, M. A. W.https://doi.org/10.3990/1.9789036570107Intracellular crowding links dimensionality to cell fate through a mechano-metabolic signalling axis (2026)[Other contribution › Other contribution]. Meteling, M., van Loo, B., Suurmond, C., Mulders, R., Wijngaarden, R., Govindaraj, K., Geris, L., Meulenbelt, I., Ramos, Y. F. M., Teixera, L. M. & Leijten, J.https://doi.org/10.64898/2026.01.20.700361

2025

Bioxolography Using Diphenyliodonium Chloride and N-Vinylpyrrolidone Enables Rapid High-Resolution Volumetric 3D Printing of Spatially Encoded Living Matter (2025)Advanced materials, 37(37). Article 2501052. Wolfel, A., Johnbosco, C., Anspach, A., Meteling, M., Olijve, J., König, N. F. & Leijten, J.https://doi.org/10.1002/adma.202501052Covalent On-Cell Conjugation of Biomaterials Through Oxidative Phenolic Coupling Regulates Stem Cell Fate via Intracellular Biophysical Programming (2025)Advanced functional materials, 35(17). Article 2418963. Johnbosco, C., Becker, M., Willemen, N., Meteling, M., Govindaraj, K., Kamperman, T. & Leijten, J.https://doi.org/10.1002/adfm.202418963High-Throughput Single-Cell Analysis of Local Nascent Protein Deposition in 3D Microenvironments via Extracellular Protein Identification Cytometry (EPIC) (2025)Advanced materials, 37(6). Article 2415981. Meteling, M., Johnbosco, C., Wolfel, A., Conceição, F., Govindaraj, K., Teixeira, L. M. & Leijten, J.https://doi.org/10.1002/adma.202415981High‐Throughput Single‐Cell Analysis of Local Nascent Protein Deposition in 3D Microenvironments via Extracellular Protein Identification Cytometry (EPIC) (Adv. Mater. 6/2025): Graphical Abstract (2025)Advanced materials, 37(6). Meteling, M., Johnbosco, C., Wolfel, A., Conceição, F., Govindaraj, K., Moreira Teixeira, L. & Leijten, J.https://doi.org/10.1002/adma.202570044

2024

443-Physiological intracellular molecular crowding renormalizes osteoarthritic chondrocytes towards a healthy phenotype (2024)Osteoarthritis and cartilage, 32(Suppl. 1), S311-S312. Govindaraj, K., Meteling, M., Post, J. & Leijten, J.https://doi.org/10.1016/j.joca.2024.02.456Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology (2024)Advanced science, 11(11). Article 2306722. Govindaraj, K., Meteling, M., van Rooij, J., Becker, M., van Wijnen, A. J., van den Beucken, J. J. J. P., Ramos, Y. F. M., van Meurs, J., Post, J. N. & Leijten, J.https://doi.org/10.1002/advs.202306722

2023

Altered intracellular molecular crowding plays a key role in osteoarthritis pathology (2023)[Contribution to conference › Poster] 47th FEBS Congress 2023. Govindaraj, K., Meteling, M. A. W. & Leijten, J.

2022

Osmolarity-Induced altered intracellular molecular crowding drives osteoarthritis pathology (2022)Osteoarthritis and cartilage, 30(Suppl. 1), S24-S25. Govindaraj, K., Meteling, M., Becker, M., Post, J. & Leijten, J.https://doi.org/10.1016/j.joca.2022.02.021

Research profiles

Address

University of Twente

Horst - Zuidhorst (building no. 28), room ZH147
De Horst 2
7522 LW Enschede
Netherlands

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