dr. M.C. van Maaren (Marissa)

Assistant Professor

About Me

I am a clinical epidemiologist and assistant professor of oncology care at the University of Twente. I also have an external positition at the Netherlands Comprehensive Cancer Organisation (IKNL). I obtained my PhD in 2018 at the University of Twente. My thesis was entitled: “Local management of early breast cancer and clinical risk prediction of survival”. In this thesis I mainly focused on 1) the evaluation of breast-conserving therapy and mastectomy in the daily breast cancer population, in which I worked with several methodologies suitable for observational research, and 2) development and validation of prediction models for use in daily clinical practice.

My current research activities include research on long-term outcomes following a variety of treatments for breast cancer. I am involved in the registration of pathologically confirmed recurrences in the Netherlands Cancer Registry (NCR), which is hosted by IKNL. I am part of the NABOR project team working on a by ZonMW subsidised research on personalised breast cancer follow-up. Here I am responsible for the development/update of the INFLUENCE 3.0 prediction tool that estimates the risk of locoregional recurrence and second primary breast cancer, for which I use the data from IKNL.

I teach on research methodology and quality of care in several modules within the BMT/BME and GZW/HS bachelor and master programmes. Besides, I am co-developer of a new learning line in the BMT bachelor on methodology and statistics.

Furthermore, I am a board member of the Netherlands Epidemiology Society (VvE) in which I focus on advanced epidemiological methods: how do we make sure epidemiologists within and outside of academia know of these methodologies and how can we spread our knowledge. In addition, I am member and coordinator of the national breast cancer working groups (NABON-BOOG) scientific evaluation committee of NCR data requests.




Medicine & Life Sciences
Breast Neoplasms
Inflammatory Breast Neoplasms
Neoplasm Metastasis


Neven, A. , van Maaren, M. C., Schreuder, K., Kranse, R., Struikmans, H., Poortmans, P. M., Bartelink, H., Collette, L., Liu, L. , & Siesling, S. (2022). Representativeness of trial participants: linking the EORTC boost-no boost trial to the Netherlands cancer registry. Journal of clinical epidemiology, 148, 54-64. https://doi.org/10.1016/j.jclinepi.2022.04.014
Ragusi, M. A. A., van der Velden, B. H. M. , van Maaren, M. C., van der Wall, E. , van Gils, C. H., Pijnappel, R. M., Gilhuijs, K. G. A., & Elias, S. G. (2022). Population-based estimates of overtreatment with adjuvant systemic therapy in early breast cancer patients with data from the Netherlands and the USA. Breast cancer research and treatment, 193(1), 161-173. https://doi.org/10.1007/s10549-022-06550-2
Moossdorff, M., Vane, M. L. G., van Nijnatten, T. J. A. , van Maaren, M. C., Goorts, B., Heuts, E. M., Strobbe, L. J. A. , & Smidt, M. L. (2021). Conditional local recurrence risk: the effect of event-free years in different subtypes of breast cancer. Breast cancer research and treatment, 186(3), 863-870. https://doi.org/10.1007/s10549-020-06040-3
Völkel, V. , Hueting, T. A. , Draeger, T. , van Maaren, M. C., de Munck, L., Strobbe, L. J. A., Sonke, G. S., Schmidt, M. K., van Hezewijk, M. , Groothuis-Oudshoorn, C. G. M. , & Siesling, S. (2021). Improved risk estimation of locoregional recurrence, secondary contralateral tumors and distant metastases in early breast cancer: the INFLUENCE 2.0 model. Breast cancer research and treatment, 189, 817-826. https://doi.org/10.1007/s10549-021-06335-z
Vane, M. L. G., Moossdorff, M. , van Maaren, M. C., van Kuijk, S. M. J., van Nijnatten, T. J. A., van Roozendaal, L. M., Boerma, E. J. G., de WIlt, J. H. W. , & Smidt, M. L. (2021). Conditional regional recurrence risk: The effect of event-free years in different subtypes of breast cancer. European journal of surgical oncology, 47(6), 1292-1298. https://doi.org/10.1016/j.ejso.2020.11.122
van der Meer, D. J., Kramer, I. , van Maaren, M. C., van Diest, P. J., Linn, S. C., Maduro, J. H., Strobbe, L. J. A. , Siesling, S., Schmidt, M. K., & Voogd, A. C. (2021). Comprehensive trends in incidence, treatment, survival and mortality of first primary invasive breast cancer stratified by age, stage and receptor subtype in the Netherlands between 1989 and 2017. International journal of cancer, 148(9), 2289-2303. https://doi.org/10.1002/ijc.33417

UT Research Information System

Contact Details

Visiting Address

University of Twente
Faculty of Behavioural, Management and Social Sciences
Technohal (building no. 18), room 3304
Hallenweg 5
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Behavioural, Management and Social Sciences
Technohal  3304
P.O. Box 217
7500 AE Enschede
The Netherlands