M. Frega PhD (Monica)

Medicine & Life Sciences

# Brunner Syndrome
# Electrodes
# In Vitro Techniques
# Induced Pluripotent Stem Cells
# Kleefstra Syndrome
# Neurons

Engineering & Materials Science

# Electrodes
# Neurons

Faculty of Science and Technology (TNW), Clinical Neurophysiology (CNPH)

Hu, M. , Frega, M., Tolner, E. A., van den Maagdenberg, A. M. J. M. , Frimat, J. P. , & le Feber, J. (2022). MEA-ToolBox: an Open Source Toolbox for Standardized Analysis of Multi-Electrode Array Data. Neuroinformatics, 20(4), 1077-1092. https://doi.org/10.1007/s12021-022-09591-6

Taxis Di Bordonia E Valnigra, D. , Hassink, G. C. , Levers, M. R. , Frega, M. , Hofmeijer, J. , van Putten, M. J. A. M. , & Le Feber, J. (2022). The Association between Hypoxia-Induced Low Activity and Apoptosis Strongly Resembles That between TTX-Induced Silencing and Apoptosis. International journal of molecular sciences, 23(5), [2754]. https://doi.org/10.3390/ijms23052754

van Rhijn, J. R., Shi, Y., Bormann, M., Mossink, B. , Frega, M., Recaioglu, H., Hakobjan, M., Klein Gunnewiek, T., Schoenmaker, C., Palmer, E., Faivre, L., Kittel-Schneider, S., Schubert, D., Brunner, H., Franke, B., & Nadif Kasri, N. (2022). Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons. Neurobiology of disease, 163, [105587]. https://doi.org/10.1016/j.nbd.2021.105587

Linda, K., Lewerissa, E. I., Verboven, A. H. A., Gabriele, M. , Frega, M., Klein Gunnewiek, T. M., Devilee, L., Ulferts, E., Hommersom, M., Oudakker, A., Schoenmaker, C., van Bokhoven, H., Schubert, D., Testa, G., Koolen, D. A., de Vries, B. B. A., & Nadif Kasri, N. (2022). Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Autophagy, 18(2), 423-442. https://doi.org/10.1080/15548627.2021.1936777

Mossink, B., van Rhijn, J. R., Wang, S., Linda, K., Vitale, M. R., Zöller, J. E. M., van Hugte, E. J. H., Bak, J., Verboven, A. H. A., Selten, M., Negwer, M., Latour, B. L., van der Werf, I., Keller, J. M., Klein Gunnewiek, T. M., Schoenmaker, C., Oudakker, A., Anania, A., Jansen, S., ... Nadif Kasri, N. (2022). Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks. Molecular Psychiatry, 27, 1-18. https://doi.org/10.1038/s41380-021-01117-x

Muzzi, L., Di Lisa, D., Arnaldi, P., Aprile, D., Pastorino, L., Martinoia, S. , & Frega, M. (2021). Rapid generation of functional engineered 3D human neuronal assemblies: Network dynamics evaluated by micro-electrodes arrays. Journal of neural engineering, 18(6), [066030]. https://doi.org/10.1088/1741-2552/ac3e02

Mossink, B., Verboven, A. H. A., van Hugte, E. J. H., Klein Gunnewiek, T. M., Parodi, G., Linda, K., Schoenmaker, C., Kleefstra, T., Kozicz, T., van Bokhoven, H., Schubert, D., Nadif Kasri, N. , & Frega, M. (2021). Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro. Stem cell reports, 16(9), 2182-2196. https://doi.org/10.1016/j.stemcr.2021.07.001

Muzzi, L., Falappa, M., Maccione, A., di Lisa, D. , Frega, M., & Martinoia, S. (2021). Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array. In 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 (pp. 123-127). [9441261] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2021). IEEE Computer Society Press. https://doi.org/10.1109/NER49283.2021.9441261

Pires Monteiro, S. , Voogd, E. , Muzzi, L., De Vecchis, G., Mossink, B. , Levers, M. , Hassink, G. , van Putten, M. , Le Feber, J. , Hofmeijer, J. , & Frega, M. (2021). Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra. Journal of neural engineering, 18(3), [036016]. https://doi.org/10.1088/1741-2552/abe68a

Shi, Y., Rhijn, J-R. V., Bormann, M., Mossink, B. , Frega, M., Recaioglu, H., Hakobjan, M., Klein Gunnewiek, T., Schoenmaker, C., Palmer, E., Faivre, L., Kittel-Schneider, S., Schubert, D., Brunner, H., Franke, B., & Nadif Kasri, N. (2020). Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity. bioRxiv. https://doi.org/10.1101/2020.10.28.359224

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