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M. Frega PhD (Monica)

Assistant Professor

Expertise

Medicine & Life Sciences
Brunner Syndrome
Electrodes
In Vitro Techniques
Induced Pluripotent Stem Cells
Kleefstra Syndrome
Neurons
Engineering & Materials Science
Electrodes
Neurons

Publications

Recent
van Rhijn, J. R., Shi, Y., Bormann, M., Mossink, B. , Frega, M., Recaioglu, H., Hakobjan, M., Klein Gunnewiek, T., Schoenmaker, C., Palmer, E., Faivre, L., Kittel-Schneider, S., Schubert, D., Brunner, H., Franke, B., & Nadif Kasri, N. (2022). Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons. Neurobiology of disease, 163, [105587]. https://doi.org/10.1016/j.nbd.2021.105587
Linda, K., Lewerissa, E. I., Verboven, A. H. A., Gabriele, M. , Frega, M., Klein Gunnewiek, T. M., Devilee, L., Ulferts, E., Hommersom, M., Oudakker, A., Schoenmaker, C., van Bokhoven, H., Schubert, D., Testa, G., Koolen, D. A., de Vries, B. B. A., & Nadif Kasri, N. (2022). Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Autophagy, 18(2), 423-442. https://doi.org/10.1080/15548627.2021.1936777
Mossink, B., van Rhijn, J. R., Wang, S., Linda, K., Vitale, M. R., Zöller, J. E. M., van Hugte, E. J. H., Bak, J., Verboven, A. H. A., Selten, M., Negwer, M., Latour, B. L., van der Werf, I., Keller, J. M., Klein Gunnewiek, T. M., Schoenmaker, C., Oudakker, A., Anania, A., Jansen, S., ... Nadif Kasri, N. (2022). Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks. Molecular Psychiatry, 27, 1-18. https://doi.org/10.1038/s41380-021-01117-x
Muzzi, L., Di Lisa, D., Arnaldi, P., Aprile, D., Pastorino, L., Martinoia, S. , & Frega, M. (2021). Rapid generation of functional engineered 3D human neuronal assemblies: Network dynamics evaluated by micro-electrodes arrays. Journal of neural engineering, 18(6), [066030]. https://doi.org/10.1088/1741-2552/ac3e02
Mossink, B., Verboven, A. H. A., van Hugte, E. J. H., Klein Gunnewiek, T. M., Parodi, G., Linda, K., Schoenmaker, C., Kleefstra, T., Kozicz, T., van Bokhoven, H., Schubert, D., Nadif Kasri, N. , & Frega, M. (2021). Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro. Stem cell reports, 16(9), 2182-2196. https://doi.org/10.1016/j.stemcr.2021.07.001
Muzzi, L., Falappa, M., Maccione, A., di Lisa, D. , Frega, M., & Martinoia, S. (2021). Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array. In 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 (pp. 123-127). [9441261] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2021). IEEE Computer Society Press. https://doi.org/10.1109/NER49283.2021.9441261
Shi, Y., Rhijn, J-R. V., Bormann, M., Mossink, B. , Frega, M., Recaioglu, H., Hakobjan, M., Klein Gunnewiek, T., Schoenmaker, C., Palmer, E., Faivre, L., Kittel-Schneider, S., Schubert, D., Brunner, H., Franke, B., & Nadif Kasri, N. (2020). Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity. bioRxiv. https://doi.org/10.1101/2020.10.28.359224

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Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3383
Hallenweg 5
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Technohal  3383
P.O. Box 217
7500 AE Enschede
The Netherlands