M. Frega PhD (Monica)

Assistant Professor


Medicine & Life Sciences
In Vitro Techniques
Induced Pluripotent Stem Cells
Kleefstra Syndrome
Engineering & Materials Science
Stem Cells


van Rhijn, J. R., Shi, Y., Bormann, M., Mossink, B. , Frega, M., Recaioglu, H., Hakobjan, M., Klein Gunnewiek, T., Schoenmaker, C., Palmer, E., Faivre, L., Kittel-Schneider, S., Schubert, D., Brunner, H., Franke, B., & Nadif Kasri, N. (2022). Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons. Neurobiology of disease, 163, [105587]. https://doi.org/10.1016/j.nbd.2021.105587
Linda, K., Lewerissa, E. I., Verboven, A. H. A., Gabriele, M. , Frega, M., Klein Gunnewiek, T. M., Devilee, L., Ulferts, E., Hommersom, M., Oudakker, A., Schoenmaker, C., van Bokhoven, H., Schubert, D., Testa, G., Koolen, D. A., de Vries, B. B. A., & Nadif Kasri, N. (2022). Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Autophagy, 18(2), 423-442. https://doi.org/10.1080/15548627.2021.1936777
Mossink, B., van Rhijn, J. R., Wang, S., Linda, K., Vitale, M. R., Zöller, J. E. M., van Hugte, E. J. H., Bak, J., Verboven, A. H. A., Selten, M., Negwer, M., Latour, B. L., van der Werf, I., Keller, J. M., Klein Gunnewiek, T. M., Schoenmaker, C., Oudakker, A., Anania, A., Jansen, S., ... Nadif Kasri, N. (2022). Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks. Molecular Psychiatry, 27, 1-18. https://doi.org/10.1038/s41380-021-01117-x
Muzzi, L., Di Lisa, D., Arnaldi, P., Aprile, D., Pastorino, L., Martinoia, S. , & Frega, M. (2021). Rapid generation of functional engineered 3D human neuronal assemblies: Network dynamics evaluated by micro-electrodes arrays. Journal of neural engineering, 18(6), [066030]. https://doi.org/10.1088/1741-2552/ac3e02
Mossink, B., Verboven, A. H. A., van Hugte, E. J. H., Klein Gunnewiek, T. M., Parodi, G., Linda, K., Schoenmaker, C., Kleefstra, T., Kozicz, T., van Bokhoven, H., Schubert, D., Nadif Kasri, N. , & Frega, M. (2021). Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro. Stem cell reports, 16(9), 2182-2196. https://doi.org/10.1016/j.stemcr.2021.07.001
Muzzi, L., Falappa, M., Maccione, A., di Lisa, D. , Frega, M., & Martinoia, S. (2021). Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array. In 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 (pp. 123-127). [9441261] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2021). IEEE Computer Society Press. https://doi.org/10.1109/NER49283.2021.9441261
Klein Gunnewiek, T. M., Van Hugte, E. J. H. , Frega, M., Guardia, G. S., Foreman, K., Panneman, D., Mossink, B., Linda, K., Keller, J. M., Schubert, D., Cassiman, D., Rodenburg, R., Vidal Folch, N., Oglesbee, D., Perales-Clemente, E., Nelson, T. J., Morava, E., Nadif Kasri, N., & Kozicz, T. (2020). m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity. Cell reports, 31(3), [107538]. https://doi.org/10.1016/j.celrep.2020.107538
Frega, M., Selten, M., Mossink, B., Keller, J. M., Linda, K., Moerschen, R., Qu, J., Koerner, P., Jansen, S., Oudakker, A., Kleefstra, T., van Bokhoven, H., Zhou, H., Schubert, D., & Nadif Kasri, N. (2020). Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. Cell reports, 30(1), 173-186.e6. https://doi.org/10.1016/j.celrep.2019.12.002

UT Research Information System

Courses Academic Year  2021/2022

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses Academic Year  2020/2021

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Technohal (building no. 18), room 3383
Hallenweg 5
7522NH  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Technohal  3383
P.O. Box 217
7500 AE Enschede
The Netherlands