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BSc Physics 1985, BSc Astronomy 1985, MSc Physics and Astrophysics 1988, PhD Nijmegen 1992) joined University of Twente in 1999. Full Professor Physical and Medical Acoustics in the Physics of Fluids group with research interests in micro- and nanofluidics for medicine and nanotechnology industry. 


  • Physics

    • Bubbles
    • Ultrasound
    • Acoustics
    • Contrast
    • Droplet
    • Frequencies
    • Model
    • Responses


My research interests lie in the experimental observation of the exciting world of bubbles and jets in multiphase flow phenomena such as air entrainment, sonoluminescence and cavitation.

I am particularly interested in the physics of bubbles and drops used in medical applications, both in imaging and in therapy, and in the physics and control of bubbles and droplets in microfluidics.


Ultrasound Particle Image Velocimetry to Investigate Potential Hemodynamic Causes of Limb Thrombosis After Endovascular Aneurysm Repair With the Anaconda DeviceJournal of Endovascular Therapy (E-pub ahead of print/First online). Mirgolbabaee, H., Velde, L. v. d., Geelkerken, R. H., Versluis, M., Jebbink, E. G. & Reijnen, M. M. P. J.https://doi.org/10.1177/15266028231219988An anthropomorphic thyroid phantom for ultrasound-guided radiofrequency ablation of nodulesMedical physics, Article 16906 (E-pub ahead of print/First online). Boers, T., Brink, W., Bianchi, L., Saccomandi, P., van Hespen, J., Wennemars, G., Braak, S., Versluis, M. & Manohar, S.https://doi.org/10.1002/mp.16906Dependence of sonoporation efficiency on microbubble size: An in vitro monodisperse microbubble studyJournal of controlled release, 363, 747-755. van Elburg, B., Deprez, J., van den Broek, M., De Smedt, S. C., Versluis, M., Lajoinie, G., Lentacker, I. & Segers, T.https://doi.org/10.1016/j.jconrel.2023.09.047A unifying Rayleigh-Plesset-type equation for bubbles in viscoelastic media. ArXiv.org. Oratis, A. T., Dijs, K., Lajoinie, G., Versluis, M. & Snoeijer, J. H.https://doi.org/10.48550/arXiv.2311.00484Microbubble formation by flow focusing: Role of gas and liquid properties, and channel geometryJournal of fluid mechanics, 972, Article A27. Cleve, S., Lassus, A., Diddens, C., Van Elburg, B., Gaud, E., Cherkaoui, S., Versluis, M., Segers, T. & Lajoinie, G.https://doi.org/10.1017/jfm.2023.704

Research profiles

Affiliated study programs

Courses academic year 2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2022/2023

Project area: High-speed imaging techniques down to the nanoseconds timescale reveal the physics of bubble and droplet behavior in acoustic and microfluidic applications for medicine and for  nanotechnology industry.

Current projects


All of our research is always curiosity-driven. Over the years we have solved some long-standing secrets and misconcep-tions in animal bioacoustics, granular flow, and shear-thinning fluids. These include the origin of the sound of the snapping shrimp, the granular jet formed when a steel ball is dropped into loose very fine sand and the physical explanation of the leaping of shampoo when it is poured into a dish of the fluid.

High-speed Imaging

The quantification of flow phenomena require specialized and sophisticated techniques resolving the highest spatial and temporal resolution. We have developed a range of high-resolution high-speed imaging systems ranging from a basic 25 fps video frame rate up to 25 million frames per second for the truly unique Brandaris 128 ultra high-speed imaging facility, including unprecedented high-speed fluorescence imaging


Optical tweezers have found many useful and intriguing applications, ranging from physics to biology. Nowadays, several optical tweezers-based techniques have been developed to perform experiments on micro- and nanoscale systems with well-controlled experimental conditions. In particular, the ability to exert picoNewton forces on micron-sized particles and bubbles is now routinely applied to fields as diverse as the physics of colloids, the study of biomolecular complexes at the single-molecule level and the measurement of cellular mechanical properties.

Inkjet printing

Piezo drop-on-demand inkjet printers are used in an increasing number of applications for their reliable deposition of droplets onto a substrate. The technology is used to create droplets of a few picoliters with drop repetition rates in the order of 10kHz. However, entrapment of an air microbubble into the ink channel can severely impede the productivity and reliability of a printing system. The air bubble disturbs the channel acoustics resulting in disrupted drop formation or temporally failure of the jetting process.

Lab-on-a-Chip Microfluidics

The formation of microscopically small droplets and bubbles with an accurately controlled and narrow size distribution is crucial in a wide variety of products and applications. For example, in medical applications such as diagnostic ultrasound imaging, targeted drug delivery, and drug inhalation therapy, but also in inkjet printing, cosmetics and in the modern food industry.

Ultrasound Cleaning

Cleaning with ultrasound is a well-known and widely used technique, but why and how it works remains unclear until today. In endodontic therapy ultrasonic irrigation improves the success rate of a root canal treatment from 60% to 90%. In IC semiconductor chip cleaning the role of activated bubble is important, however a physical understanding how to improve the cleaning process is lacking.

Ultrasound Therapy

Activated bubbles close to cells can induce cell membrane poration, or sonoporation, allowing local drug and gene delivery. Here we study the interaction of bubbles with cell membranes, pore formation and uptake of model drugs. We also try to clarify the fundamental physical mechanisms underlying the drug delivery potential of liquid perfluorocarbon cavitation nanodroplets.

Ultrasound Imaging

Medical ultrasound imaging is greatly enhanced by the use of ultrasound contrast microbubbles which act as a blood pool agent. Here we study the interaction of the bubbles with ultrasound to improve diagnostic imaging protocols. The detection of targeted single microbubbles allows for disease-specific molecular imaging with ultrasound.


University of Twente

Horst Complex (building no. 20), room ME260
De Horst 2
7522 LW Enschede

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