dr. M. Zakharova (Mariia)



Engineering & Materials Science
Blood-Brain Barrier
Pore Size
Medicine & Life Sciences
Blood-Brain Barrier
Equipment And Supplies


Multiplexed Organ on a Chip

The main limitation of the current drug testing is the lack of appropriate models that adequately mimic the human environment. Conventional cell culturing and animal models are not suitable for correct drug testing being either too simple or not physiologically relevant to the human organism. Therefore, an organ-on-a-chip (OOC) system has gained a significant interest among the scientist as an alternative to the conventional studies of the human organs and its reaction on different stimuli (e.g. drugs). However, one of the significant disadvantages of existing OOC models is their low throughput, thus, it is not possible to test different experimental stimuli in parallel, limiting readout possibilities.

The aim of this research is to develop a parallelized, standardized and automated model suitable for multiplexing of organ-on-a-chip systems with further integrated sensors for simultaneous, real-time analysis of the effect of different stimuli on the barrier function. This high-throughput screening platform may enhance the drug screening process and help to minimize the animal experiments.

Contact Details

Visiting Address

University of Twente
Drienerlolaan 5
7522 NB Enschede
The Netherlands

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Mailing Address

University of Twente
P.O. Box 217
7500 AE Enschede
The Netherlands