prof.dr.ir. N. Bosschaart (Nienke)

adjunct professor
TNW-BIS-BMPI
Horst Complex ZH262
n.bosschaart@utwente.nl
+31534893877
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Nienke Bosschaart is an adjunct professor in Biomedical Photonic Imaging with a focus on innovative diagnostic techniques for mother and child care. Her research aims to develop novel methods for i) noninvasive blood analysis in newborns and ii) human lactation research. Nienke Bosschaart has been awarded with an ERC Starting grant from the European Research Council (2022), as well as a Vidi (2021) and Veni (2014) grant from the Dutch Research Council. She graduated in Biomedical Engineering at the University of Twente (2007) and received her PhD at the department of Biomedical Engineering and Physics of the Amsterdam UMC (2012) under the supervision of Prof.dr. Ton van Leeuwen and Prof.dr. Maurice Aalders. Since 2015, she works at the Biomedical Photonic Imaging group of the University of Twente.

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Expertise

  • Biochemistry, Genetics and Molecular Biology

    • Optics
    • Hemoglobin
    • Spectrum

  • Physics

    • Coherence

  • Medicine and Dentistry

    • Optical Coherence Tomography
    • Tissues
    • Bilirubin
    • Spectroscopic Imaging

Organisations

My research focuses on the development of optical diagnostic tools for mother and child care. I am working on two major research themes:

1. Noninvasive blood analysis

2. Human milk and lactation

Publications

2024
Experimental and theoretical investigation of the Leidenfrost dynamics of solid carbon dioxide discs sublimating on a solid substrateInternational journal of heat and mass transfer, 224, Article 125300. Purandare, A. S., Cuartas-Vélez, C., Smeman, N., Schremb, M., Bosschaart, N. & Vanapalli, S.https://doi.org/10.1016/j.ijheatmasstransfer.2024.125300Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluationPediatric Research (E-pub ahead of print/First online). Dam-Vervloet, A. J., Morsink, C. F., Krommendijk, M. E., Nijholt, I. M., van Straaten, H. L. M., Poot, L. & Bosschaart, N.https://doi.org/10.1038/s41390-024-03081-y
2023
Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomographyBiomedical optics express, 14(11), 5642-5655. Cuartas Velez, C. A., Middelkamp, H. H. T., van den Berg, A., van der Meer, A. & Bosschaart, N.https://doi.org/10.1364/BOE.500434Visible-light spectroscopic optical coherence tomography: applications and technology. University of Twente. Cuartas Velez, C. A.https://doi.org/10.3990/1.9789036557368Design and characterization of color printed polyurethane films as biomedical phantom layersBiomedical optics express, 14(9), 4485-4506. Morsink, C. F., Dam-Vervloet, A. J., Krommendijk, M. E., Kaya, M., Cuartas-Vélez, C., Knop, T., Francis, K. J. & Bosschaart, N.https://doi.org/10.1364/BOE.491695Quantification of cephalocaudal progression of jaundice in preterm infantsPediatric Research, 94, 239-245 (E-pub ahead of print/First online). Dam-Vervloet, A. J., de Boer, F. A., Nijholt, I. M., Poot, L., Bosschaart, N. & van Straaten, H. L. M.https://doi.org/10.1038/s41390-022-02396-y
2022
Irradiance footprint of phototherapy devices: a comparative studyPediatric Research, 92, 453-458. Dam-Vervloet, A. J., Bosschaart, N., van Straaten, H. L. M., Poot, L. & Hulzebos, C. V.https://doi.org/10.1038/s41390-021-01795-xNew directions for optical breast imaging and sensing: Multimodal cancer imaging and lactation researchCurrent Opinion in Biomedical Engineering, 22, Article 100380. Bosschaart, N. & Manohar, S.https://doi.org/10.1016/j.cobme.2022.100380
2021
Diffuse optical spectroscopic imaging of the human lactating breastIn European Conferences on Biomedical Optics, ECBO 2021, Article ETu3C.1. The Optical Society. Bosschaart, N., de Wolf, J. R., Schoustra, S. M., van der Hoek, M., Leproux, A., Abdalsalam, O., Chen, W.-P., McLaren, C. E., Tromberg, B. J. & O’Sullivan, T. D.https://opg.optica.org/abstract.cfm?uri=ECBO-2021-ETu3C.1Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomographyScientific reports, 11(1), Article 8680. Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W. & Bosschaart, N.https://doi.org/10.1038/s41598-021-88063-4Evaluation of the changes in human milk lipid composition and conformational state with Raman spectroscopy during a breastfeedBiomedical optics express, 12(7), 3934-3947. de Wolf, J. R., Lenferink, A., Lenferink, A., Otto, C. & Bosschaart, N.https://doi.org/10.1364/BOE.427646Inter-device reproducibility of transcutaneous bilirubin metersPediatric Research, 89(4), 770-775. Dam-Vervloet, A. J., van Erk, M. D., Doorn, N., Lip, S. G. J., Timmermans, N. A., Vanwinsen, L., de Boer, F. A., van Straaten, H. L. M. & Bosschaart, N.https://doi.org/10.1038/s41390-020-01118-6Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structureLab on a chip, 21(2), 272-283. Arik, Y. B., Buijsman, W., Loessberg-Zahl, J. T., Cuartas Velez, C. A., Veenstra, C., Logtenberg, S., Grobbink, A. M., Bergveld, P., Gagliardi, G., den Hollander, A. I., Bosschaart, N., van den Berg, A., Passier, R. & van der Meer, A.https://doi.org/10.1039/d0lc00639dChanges in human milk lipid composition and conformational state during a single breastfeedIn European Conferences on Biomedical Optics, ECBO 2021: Advances in Microscopic Imaging III, Article ETu2A.26. The Optical Society. de Wolf, J. R., Lenferink, A., Lenferink, A. T. M., Otto, C. & Bosschaart, N.https://doi.org/10.1117/12.2615815Quantification of total haemoglobin concentrations in human whole-blood based on the optical density with spectroscopic optical coherence tomographyIn European Conferences on Biomedical Optics, ECBO 2021, Article EW3C.6. The Optical Society. Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W. & Bosschaart, N.https://opg.optica.org/abstract.cfm?URI=ECBO-2021-EW3C.6Quantification of total haemoglobin concentrations in human whole-blood based on the optical density with spectroscopic optical coherence tomographyIn Optical Coherence Imaging Techniques and Imaging in Scattering Media IV, Article 119240R. SPIE. Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W. & Bosschaart, N.https://doi.org/10.1117/12.2616058Diffuse optical spectroscopic imaging of the human lactating breastIn Diffuse Optical Spectroscopy and Imaging VIII, Article 119200N. SPIE. Bosschaart, N., de Wolf, J. R., Schoustra, S. M., van der Hoek, M., Leproux, A., Abdalsalam, O., Chen, W.-P., McLaren, C. E., Tromberg, B. J. & O'Sullivan, T. D.https://doi.org/10.1117/12.2615233
2020
Visible light spectroscopic optical coherence tomography for applications in neonatal healthcare. University of Twente. Veenstra, C.https://doi.org/10.3990/1.9789036549875Dependency of the optical scattering properties of human milk on casein content and common sample preparation methodsJournal of biomedical optics, 25(4), Article 045001. Veenstra, C., Every, D. E., Petersen, W., van Goudoever, J. B., Steenbergen, W. & Bosschaart, N.https://doi.org/10.1117/1.JBO.25.4.045001
2019
Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomographyScientific reports, 9(1), Article 15115. Veenstra, C., Kruitwagen, S., Groener, D., Petersen, W., Steenbergen, W. & Bosschaart, N.https://doi.org/10.1038/s41598-019-51721-9How skin anatomy influences transcutaneous bilirubin determinations: an in vitro evaluationPediatric Research, 86(4), 471-477. van Erk, M. D., Dam-Vervloet, A. J., de Boer, F. A., Boomsma, M. F., Straaten, H. v. & Bosschaart, N.https://doi.org/10.1038/s41390-019-0471-zOptical properties of human milkBiomedical optics express, 10(8), Article 361809, 4059-4074. Veenstra, C., Lenferink, A., Petersen, W., Steenbergen, W. & Bosschaart, N.https://doi.org/10.1364/BOE.10.004059

Research profiles

In the press

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Books

  • Dolf Jansen en Jim Jansen, PromovendA tot Z, ISBN: 9789464042085, Fontaine Uitgevers, November (2022)

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University of Twente

Horst Complex (building no. 20), room ZH262
De Horst 2
7522 LW Enschede
Netherlands

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