dr.ir. N. Bosschaart (Nienke)

Nienke Bosschaart is an adjunct professor in Biomedical Photonic Imaging with a focus on innovative diagnostic techniques for mother and child care. Her research aims to develop novel methods for i) noninvasive blood analysis in newborns and ii) human lactation research. Nienke Bosschaart has been awarded with an ERC Starting grant from the European Research Council (2022), as well as a Vidi (2021) and Veni (2014) grant from the Dutch Research Council. She graduated in Biomedical Engineering at the University of Twente (2007) and received her PhD at the department of Biomedical Engineering and Physics of the Amsterdam UMC (2012) under the supervision of Prof.dr. Ton van Leeuwen and Prof.dr. Maurice Aalders. Since 2015, she works at the Biomedical Photonic Imaging group of the University of Twente.

For more info about Nienke Bosschaart on the 'Featured Scientists' page, click below:

Medicine & Life Sciences

# Bilirubin
# Optical Coherence Tomography

Physics & Astronomy

# Milk
# Tomography

Engineering & Materials Science

# Hemoglobin
# Human Milk
# Optical Tomography
# Tissue

Faculty of Science and Technology (TNW), Biomedical Photonic Imaging (BMPI)

My research focuses on the development of optical diagnostic tools for mother and child care. I am working on two major research themes:

1. Noninvasive blood analysis

2. Human milk and lactation

Bosschaart, N. , & Manohar, S. (2022). New directions for optical breast imaging and sensing: Multimodal cancer imaging and lactation research. Current Opinion in Biomedical Engineering, 22, [100380]. https://doi.org/10.1016/j.cobme.2022.100380

Bosschaart, N. , de Wolf, J. R. , Schoustra, S. M., van der Hoek, M., Leproux, A., Abdalsalam, O., Chen, W-P., McLaren, C. E., Tromberg, B. J., & O'Sullivan, T. D. (2021). Diffuse optical spectroscopic imaging of the human lactating breast. In D. Contini, Y. Hoshi, & T. D. O'Sullivan (Eds.), Diffuse Optical Spectroscopy and Imaging VIII [119200N] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11920). SPIE Press. https://doi.org/10.1117/12.2615233

Cuartas-Vélez, C. , Veenstra, C. , Kruitwagen, S. , Petersen, W. , & Bosschaart, N. (2021). Quantification of total haemoglobin concentrations in human whole-blood based on the optical density with spectroscopic optical coherence tomography. In B. J. Vakoc, M. Wojtkowski, & Y. Yasuno (Eds.), Optical Coherence Imaging Techniques and Imaging in Scattering Media IV [119240R] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11924). SPIE Press. https://doi.org/10.1117/12.2616058

Bosschaart, N. , de Wolf, J. R. , Schoustra, S. M., van der Hoek, M., Leproux, A., Abdalsalam, O., Chen, W-P., McLaren, C. E., Tromberg, B. J., & O’Sullivan, T. D. (2021). Diffuse optical spectroscopic imaging of the human lactating breast. In European Conferences on Biomedical Optics, ECBO 2021 [ETu3C.1] The Optical Society. https://opg.optica.org/abstract.cfm?uri=ECBO-2021-ETu3C.1

Cuartas-Vélez, C. , Veenstra, C. , Kruitwagen, S. , Petersen, W. , & Bosschaart, N. (2021). Quantification of total haemoglobin concentrations in human whole-blood based on the optical density with spectroscopic optical coherence tomography. In European Conferences on Biomedical Optics, ECBO 2021 [EW3C.6] The Optical Society. https://opg.optica.org/abstract.cfm?URI=ECBO-2021-EW3C.6

de Wolf, J. R., Lenferink, A. , Lenferink, A. T. M. , Otto, C. , & Bosschaart, N. (2021). Changes in human milk lipid composition and conformational state during a single breastfeed. In E. Beaurepaire, A. Ben-Yakar, & Y. Park (Eds.), European Conferences on Biomedical Optics, ECBO 2021: Advances in Microscopic Imaging III [ETu2A.26] (SPIE Conference Proceedings; Vol. 11922). The Optical Society. https://doi.org/10.1117/12.2615815

Dam-Vervloet, A. J. , Bosschaart, N., van Straaten, H. L. M., Poot, L., & Hulzebos, C. V. (2021). Irradiance footprint of phototherapy devices: a comparative study. Pediatric Research. https://doi.org/10.1038/s41390-021-01795-x

de Wolf, J. R., Lenferink, A. , Lenferink, A. , Otto, C. , & Bosschaart, N. (2021). Evaluation of the changes in human milk lipid composition and conformational state with Raman spectroscopy during a breastfeed. Biomedical optics express, 12(7), 3934-3947. https://doi.org/10.1364/BOE.427646

Cuartas-Vélez, C. , Veenstra, C. , Kruitwagen, S. , Petersen, W. , & Bosschaart, N. (2021). Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography. Scientific reports, 11(1), [8680]. https://doi.org/10.1038/s41598-021-88063-4

Arik, Y. B. , Buijsman, W. , Loessberg-Zahl, J. T. , Cuartas Velez, C. A. , Veenstra, C., Logtenberg, S., Grobbink, A. M. , Bergveld, P., Gagliardi, G., den Hollander, A. I. , Bosschaart, N. , van den Berg, A. , Passier, R. , & van der Meer, A. (2021). Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structure. Lab on a chip, 21(2), 272-283. https://doi.org/10.1039/d0lc00639d

Dam-Vervloet, A. J., van Erk, M. D. , Doorn, N., Lip, S. G. J., Timmermans, N. A., Vanwinsen, L., de Boer, F. A., van Straaten, H. L. M. , & Bosschaart, N. (2021). Inter-device reproducibility of transcutaneous bilirubin meters. Pediatric Research, 89(4), 770-775. https://doi.org/10.1038/s41390-020-01118-6

Veenstra, C. , Every, D. E. , Petersen, W., van Goudoever, J. B. , Steenbergen, W. , & Bosschaart, N. (2020). Dependency of the optical scattering properties of human milk on casein content and common sample preparation methods. Journal of biomedical optics, 25(4), [045001]. https://doi.org/10.1117/1.JBO.25.4.045001

Veenstra, C. (2020). Visible light spectroscopic optical coherence tomography for applications in neonatal healthcare. University of Twente. https://doi.org/10.3990/1.9789036549875

van Erk, M. D., Dam-Vervloet, A. J., de Boer, F. A., Boomsma, M. F., Straaten, H. V. , & Bosschaart, N. (2019). How skin anatomy influences transcutaneous bilirubin determinations: an in vitro evaluation. Pediatric Research, 86(4), 471-477. https://doi.org/10.1038/s41390-019-0471-z

Veenstra, C. , Kruitwagen, S., Groener, D. , Petersen, W. , Steenbergen, W. , & Bosschaart, N. (2019). Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography. Scientific reports, 9(1), [15115]. https://doi.org/10.1038/s41598-019-51721-9

Veenstra, C., Lenferink, A. , Petersen, W. , Steenbergen, W. , & Bosschaart, N. (2019). Optical properties of human milk. Biomedical optics express, 10(8), 4059-4074. [361809]. https://doi.org/10.1364/BOE.10.004059

Bosschaart, N., Leproux, A., Abdalsalam, O., Chen, W-P., McLaren, C. E., Tromberg, B. J., & O'Sullivan, T. D. (2019). Diffuse optical spectroscopic imaging for the investigation of human lactation physiology: a case study on mammary involution. Journal of biomedical optics, 24(5), 056006. [056006]. https://doi.org/10.1117/1.JBO.24.5.056006

van der Hoek, M., den Haan, L., Kaspers, A. , Steenbergen, W. , & Bosschaart, N. (2019). Cutaneous perfusion of the human lactating breast: a pilot study with laser Doppler perfusion monitoring. Physiological measurement, 40(5), [05NT01]. https://doi.org/10.1088/1361-6579/ab1ad7

Veenstra, C. , Petersen, W. , Vellekoop, I. M. , Steenbergen, W. , & Bosschaart, N. (2018). Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography. Biomedical optics express, 9(8), 3581-3589. [327320]. https://doi.org/10.1364/BOE.9.003581

Veenstra, C., Jeurink, L. , Vellekoop, I. , & Bosschaart, N. (2017). Spectroscopic optical coherence tomography for absorption quantification in the blue wavelength region. Abstract from SPIE Photonics West 2017, San Francisco, California, United States.

Veenstra, C., Jeurink, L. , Vellekoop, I. M. , & Bosschaart, N. (2017). Quantification of bilirubin concentrations by visible light spectroscopic optical coherence tomography. Abstract from European Conferences on Biomedical Optics, EBCO 2017, Munster, Germany.

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