Horst Complex

prof.dr.ir. N. Bosschaart (Nienke)

adjunct professor
TNW-BIS-BMPI
Horst Complex ZH264
n.bosschaart@utwente.nl
+31534893877
Business card

Nienke Bosschaart is an adjunct professor in Biomedical Photonic Imaging with a focus on innovative diagnostic techniques for mother and child care. Her research aims to develop novel methods for i) noninvasive blood analysis in newborns and ii) human lactation research. Nienke Bosschaart has been awarded with an ERC Starting grant from the European Research Council (2022), as well as a Vidi (2021) and Veni (2014) grant from the Dutch Research Council. She graduated in Biomedical Engineering at the University of Twente (2007) and received her PhD at the department of Biomedical Engineering and Physics of the Amsterdam UMC (2012) under the supervision of Prof.dr. Ton van Leeuwen and Prof.dr. Maurice Aalders. Since 2015, she works at the Biomedical Photonic Imaging group of the University of Twente.

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Expertise

  • Biochemistry, Genetics and Molecular Biology

    • Optics
    • Hemoglobin
    • Spectrum

  • Medicine and Dentistry

    • Optical Coherence Tomography
    • Tissues
    • Hemoglobin Determination
    • Bilirubin

  • Physics

    • Coherence

Organisations

Publications

Jump to: 2025 | 2024 | 2023 | 2022 | 2021

2025

Optical and physical properties of human milk (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. de Wolf, J. R.https://doi.org/10.3990/1.9789036570022Effect of skin color and other skin properties on the delivered light dose in phototherapy for neonatal hyperbilirubinemia (2025)Annals of the Entomological Society of America, 2(3). Article 032508. Dam-Vervloet, A. J., Foppen, R., Hulzebos, C. V. & Bosschaart, N.https://doi.org/10.1117/1.BIOS.2.3.032508Monte Carlo simulation platform for laser Doppler flowmetry (2025)Journal of biomedical optics, 30(8). Article 087002. Thompson, D., Verveld, W., Lajoinie, G., Versluis, M., Steenbergen, W. & Bosschaart, N.https://doi.org/10.1117/1.JBO.30.8.087002Development of simulated human milk ultrafiltrate (SHMUF) for analysis of native particles in human milk (2025)Scientific reports, 15(1). Article 11500. de Wolf, J. R., Paulusse, J. M. J. & Bosschaart, N.https://doi.org/10.1038/s41598-025-95733-0Non-invasive quantification of total hemoglobin concentrations by visible-light spectroscopic optical coherence tomography: a validation study on healthy volunteers (2025)Biomedical optics express, 16(4), 1569-1581. Cuartas-Vélez, C., Gómez-Gallego, I. & Bosschaart, N.https://doi.org/10.1364/BOE.549671

2024

Human milk fat globule size distributions: Comparison between laser diffraction and 3D confocal laser scanning microscopy (2024)Food Research International, 198. Article 115282. Verveld, W., de Wolf, J. R., Legtenberg, C. G., Knop, T. & Bosschaart, N.https://doi.org/10.1016/j.foodres.2024.115282The Refractive Index of Human Milk Serum: Natural Variations and Dependency on Macronutrient Concentrations (2024)Foods, 13(24). Article 4124. de Wolf, J. R., Ali, K., Legtenberg, C. G., Verveld, W. & Bosschaart, N.https://doi.org/10.3390/foods13244124Diffuse optical spectroscopy of lactating and non-lactating human mammary physiology (2024)Biomedical optics express, 15(9), 5429-5441. Boamfa, A., Coverstone, C., Abdalsalam, O., Flavia de Almeida Barreto, A., Wei, A., de Wolf, J. R., Schoustra, S. M., O’Sullivan, T. D. & Bosschaart, N.https://doi.org/10.1364/BOE.527944Experimental and theoretical investigation of the Leidenfrost dynamics of solid carbon dioxide discs sublimating on a solid substrate (2024)International journal of heat and mass transfer, 224. Article 125300. Purandare, A. S., Cuartas-Vélez, C., Smeman, N., Schremb, M., Bosschaart, N. & Vanapalli, S.https://doi.org/10.1016/j.ijheatmasstransfer.2024.125300Shining light on hyperbilirubinemia: Optical diagnosis and therapy (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Dam-Vervloet, A. J.https://doi.org/10.3990/1.9789036561037The Refractive Index of Human Milk Whey: Natural Variations and Dependency on Macronutrient Concentrations (2024)[Working paper › Preprint]. Social Science Research Network (SSRN). de Wolf, J. R., Ali, K., Legtenberg, C. G., Verveld, W. & Bosschaart, N.https://doi.org/10.2139/ssrn.4757365Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation (2024)Pediatric Research, 97(5), 1706–1710 (E-pub ahead of print/First online). Dam-Vervloet, A. J., Morsink, C. F., Krommendijk, M. E., Nijholt, I. M., van Straaten, H. L. M., Poot, L. & Bosschaart, N.https://doi.org/10.1038/s41390-024-03081-yDiffuse Optical Spectroscopy of Lactating and Non-lactating Mammary Physiology (2024)In Optical Tomography and Spectroscopy, OT and S 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics (Optical Tomography and Spectroscopy, OT and S 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics). Optical Society of America. Boamfa, A., Coverstone, C., Abdalsalam, O., Flavia de Almeida Barreto, A., Wei, A., de Wolf, J. R., Schoustra, S. M., O’Sullivan, T. D. & Bosschaart, N.Inertial Ballistic Microfluidics as a Platform for Biomedical and Chemical Engineering Applications (2024)In 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems (µTAS 2024). van der Ven, D. L., Cuartas Velez, C. A., Bansal, R., Bosschaart, N. & Fernández Rivas , D.

2023

Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography (2023)Biomedical optics express, 14(11), 5642-5655. Cuartas Velez, C. A., Middelkamp, H. H. T., van den Berg, A., van der Meer, A. & Bosschaart, N.https://doi.org/10.1364/BOE.500434Design and characterization of color printed polyurethane films as biomedical phantom layers (2023)Biomedical optics express, 14(9), 4485-4506. Morsink, C. F., Dam-Vervloet, A. J., Krommendijk, M. E., Kaya, M., Cuartas-Vélez, C., Knop, T., Francis, K. J. & Bosschaart, N.https://doi.org/10.1364/BOE.491695Visible-light spectroscopic optical coherence tomography: applications and technology (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Cuartas Velez, C. A.https://doi.org/10.3990/1.9789036557368Quantification of cephalocaudal progression of jaundice in preterm infants (2023)Pediatric Research, 94, 239-245. Dam-Vervloet, A. J., de Boer, F. A., Nijholt, I. M., Poot, L., Bosschaart, N. & van Straaten, H. L. M.https://doi.org/10.1038/s41390-022-02396-y

2022

Irradiance footprint of phototherapy devices: a comparative study (2022)Pediatric Research, 92, 453-458. Dam-Vervloet, A. J., Bosschaart, N., van Straaten, H. L. M., Poot, L. & Hulzebos, C. V.https://doi.org/10.1038/s41390-021-01795-xNew directions for optical breast imaging and sensing: Multimodal cancer imaging and lactation research (2022)Current Opinion in Biomedical Engineering, 22. Article 100380. Bosschaart, N. & Manohar, S.https://doi.org/10.1016/j.cobme.2022.100380

2021

Diffuse optical spectroscopic imaging of the human lactating breast (2021)In European Conferences on Biomedical Optics, ECBO 2021. Article ETu3C.1. The Optical Society. Bosschaart, N., de Wolf, J. R., Schoustra, S. M., van der Hoek, M., Leproux, A., Abdalsalam, O., Chen, W.-P., McLaren, C. E., Tromberg, B. J. & O’Sullivan, T. D.https://opg.optica.org/abstract.cfm?uri=ECBO-2021-ETu3C.1Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography (2021)Scientific reports, 11(1). Article 8680. Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W. & Bosschaart, N.https://doi.org/10.1038/s41598-021-88063-4Evaluation of the changes in human milk lipid composition and conformational state with Raman spectroscopy during a breastfeed (2021)Biomedical optics express, 12(7), 3934-3947. de Wolf, J. R., Lenferink, A., Lenferink, A., Otto, C. & Bosschaart, N.https://doi.org/10.1364/BOE.427646Inter-device reproducibility of transcutaneous bilirubin meters (2021)Pediatric Research, 89(4), 770-775. Dam-Vervloet, A. J., van Erk, M. D., Doorn, N., Lip, S. G. J., Timmermans, N. A., Vanwinsen, L., de Boer, F. A., van Straaten, H. L. M. & Bosschaart, N.https://doi.org/10.1038/s41390-020-01118-6Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structure (2021)Lab on a chip, 21(2), 272-283. Arik, Y. B., Buijsman, W., Loessberg-Zahl, J. T., Cuartas Velez, C. A., Veenstra, C., Logtenberg, S., Grobbink, A. M., Bergveld, P., Gagliardi, G., den Hollander, A. I., Bosschaart, N., van den Berg, A., Passier, R. & van der Meer, A.https://doi.org/10.1039/d0lc00639d

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University of Twente

Horst Complex (building no. 20), room ZH264
De Horst 2
7522 LW Enschede
Netherlands

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