Nienke Bosschaart is an adjunct professor in Biomedical Photonic Imaging with a focus on innovative diagnostic techniques for mother and child care. Her research aims to develop novel methods for i) noninvasive blood analysis in newborns and ii) human lactation research. Nienke Bosschaart has been awarded with an ERC Starting grant from the European Research Council (2022), as well as a Vidi (2021) and Veni (2014) grant from the Dutch Research Council. She graduated in Biomedical Engineering at the University of Twente (2007) and received her PhD at the department of Biomedical Engineering and Physics of the Amsterdam UMC (2012) under the supervision of Prof.dr. Ton van Leeuwen and Prof.dr. Maurice Aalders. Since 2015, she works at the Biomedical Photonic Imaging group of the University of Twente.
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Expertise
Biochemistry, Genetics and Molecular Biology
- Optics
- Hemoglobin
- Spectrum
Physics
- Coherence
Medicine and Dentistry
- Optical Coherence Tomography
- Tissues
- Bilirubin
- Spectroscopic Imaging
Organisations
My research focuses on the development of optical diagnostic tools for mother and child care. I am working on two major research themes:
Publications
Jump to: 2024 | 2023 | 2022 | 2021 | 2020
2024
Human milk fat globule size distributions: Comparison between laser diffraction and 3D confocal laser scanning microscopy (2024)Food Research International, 198. Article 115282. Verveld, W., de Wolf, J. R., Legtenberg, C. G., Knop, T. & Bosschaart, N.https://doi.org/10.1016/j.foodres.2024.115282Diffuse optical spectroscopy of lactating and non-lactating human mammary physiology (2024)Biomedical optics express, 15(9), 5429-5441. Boamfa, A., Coverstone, C., Abdalsalam, O., Flavia de Almeida Barreto, A., Wei, A., de Wolf, J. R., Schoustra, S. M., O’Sullivan, T. D. & Bosschaart, N.https://doi.org/10.1364/BOE.527944Experimental and theoretical investigation of the Leidenfrost dynamics of solid carbon dioxide discs sublimating on a solid substrate (2024)International journal of heat and mass transfer, 224. Article 125300. Purandare, A. S., Cuartas-Vélez, C., Smeman, N., Schremb, M., Bosschaart, N. & Vanapalli, S.https://doi.org/10.1016/j.ijheatmasstransfer.2024.125300Shining light on hyperbilirubinemia: Optical diagnosis and therapy (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Dam-Vervloet, A. J.https://doi.org/10.3990/1.9789036561037Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation (2024)Pediatric Research (E-pub ahead of print/First online). Dam-Vervloet, A. J., Morsink, C. F., Krommendijk, M. E., Nijholt, I. M., van Straaten, H. L. M., Poot, L. & Bosschaart, N.https://doi.org/10.1038/s41390-024-03081-yDiffuse Optical Spectroscopy of Lactating and Non-lactating Mammary Physiology (2024)In Optical Tomography and Spectroscopy, OT and S 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics (Optical Tomography and Spectroscopy, OT and S 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics). Optical Society of America. Boamfa, A., Coverstone, C., Abdalsalam, O., Flavia de Almeida Barreto, A., Wei, A., de Wolf, J. R., Schoustra, S. M., O’Sullivan, T. D. & Bosschaart, N.Inertial Ballistic Microfluidics as a Platform for Biomedical and Chemical Engineering Applications (2024)In 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems (µTAS 2024). van der Ven, D. L., Cuartas Velez, C. A., Bansal, R., Bosschaart, N. & Fernández Rivas , D.
2023
Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography (2023)Biomedical optics express, 14(11), 5642-5655. Cuartas Velez, C. A., Middelkamp, H. H. T., van den Berg, A., van der Meer, A. & Bosschaart, N.https://doi.org/10.1364/BOE.500434Design and characterization of color printed polyurethane films as biomedical phantom layers (2023)Biomedical optics express, 14(9), 4485-4506. Morsink, C. F., Dam-Vervloet, A. J., Krommendijk, M. E., Kaya, M., Cuartas-Vélez, C., Knop, T., Francis, K. J. & Bosschaart, N.https://doi.org/10.1364/BOE.491695Visible-light spectroscopic optical coherence tomography: applications and technology (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Cuartas Velez, C. A.https://doi.org/10.3990/1.9789036557368Quantification of cephalocaudal progression of jaundice in preterm infants (2023)Pediatric Research, 94, 239-245. Dam-Vervloet, A. J., de Boer, F. A., Nijholt, I. M., Poot, L., Bosschaart, N. & van Straaten, H. L. M.https://doi.org/10.1038/s41390-022-02396-y
2022
Irradiance footprint of phototherapy devices: a comparative study (2022)Pediatric Research, 92, 453-458. Dam-Vervloet, A. J., Bosschaart, N., van Straaten, H. L. M., Poot, L. & Hulzebos, C. V.https://doi.org/10.1038/s41390-021-01795-xNew directions for optical breast imaging and sensing: Multimodal cancer imaging and lactation research (2022)Current Opinion in Biomedical Engineering, 22. Article 100380. Bosschaart, N. & Manohar, S.https://doi.org/10.1016/j.cobme.2022.100380
2021
Diffuse optical spectroscopic imaging of the human lactating breast (2021)In European Conferences on Biomedical Optics, ECBO 2021. Article ETu3C.1. The Optical Society. Bosschaart, N., de Wolf, J. R., Schoustra, S. M., van der Hoek, M., Leproux, A., Abdalsalam, O., Chen, W.-P., McLaren, C. E., Tromberg, B. J. & O’Sullivan, T. D.https://opg.optica.org/abstract.cfm?uri=ECBO-2021-ETu3C.1Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography (2021)Scientific reports, 11(1). Article 8680. Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W. & Bosschaart, N.https://doi.org/10.1038/s41598-021-88063-4Evaluation of the changes in human milk lipid composition and conformational state with Raman spectroscopy during a breastfeed (2021)Biomedical optics express, 12(7), 3934-3947. de Wolf, J. R., Lenferink, A., Lenferink, A., Otto, C. & Bosschaart, N.https://doi.org/10.1364/BOE.427646Inter-device reproducibility of transcutaneous bilirubin meters (2021)Pediatric Research, 89(4), 770-775. Dam-Vervloet, A. J., van Erk, M. D., Doorn, N., Lip, S. G. J., Timmermans, N. A., Vanwinsen, L., de Boer, F. A., van Straaten, H. L. M. & Bosschaart, N.https://doi.org/10.1038/s41390-020-01118-6Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structure (2021)Lab on a chip, 21(2), 272-283. Arik, Y. B., Buijsman, W., Loessberg-Zahl, J. T., Cuartas Velez, C. A., Veenstra, C., Logtenberg, S., Grobbink, A. M., Bergveld, P., Gagliardi, G., den Hollander, A. I., Bosschaart, N., van den Berg, A., Passier, R. & van der Meer, A.https://doi.org/10.1039/d0lc00639dChanges in human milk lipid composition and conformational state during a single breastfeed (2021)In European Conferences on Biomedical Optics, ECBO 2021: Advances in Microscopic Imaging III. Article ETu2A.26 (SPIE Conference Proceedings; Vol. 11922). The Optical Society. de Wolf, J. R., Lenferink, A., Lenferink, A. T. M., Otto, C. & Bosschaart, N.https://doi.org/10.1117/12.2615815Diffuse optical spectroscopic imaging of the human lactating breast (2021)In Diffuse Optical Spectroscopy and Imaging VIII. Article 119200N (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11920). SPIE. Bosschaart, N., de Wolf, J. R., Schoustra, S. M., van der Hoek, M., Leproux, A., Abdalsalam, O., Chen, W.-P., McLaren, C. E., Tromberg, B. J. & O'Sullivan, T. D.https://doi.org/10.1117/12.2615233Quantification of total haemoglobin concentrations in human whole-blood based on the optical density with spectroscopic optical coherence tomography (2021)In European Conferences on Biomedical Optics, ECBO 2021. Article EW3C.6. The Optical Society. Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W. & Bosschaart, N.https://opg.optica.org/abstract.cfm?URI=ECBO-2021-EW3C.6Quantification of total haemoglobin concentrations in human whole-blood based on the optical density with spectroscopic optical coherence tomography (2021)In Optical Coherence Imaging Techniques and Imaging in Scattering Media IV. Article 119240R (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11924). SPIE. Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W. & Bosschaart, N.https://doi.org/10.1117/12.2616058
2020
Visible light spectroscopic optical coherence tomography for applications in neonatal healthcare (2020)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Veenstra, C.https://doi.org/10.3990/1.9789036549875Dependency of the optical scattering properties of human milk on casein content and common sample preparation methods (2020)Journal of biomedical optics, 25(4). Article 045001. Veenstra, C., Every, D. E., Petersen, W., van Goudoever, J. B., Steenbergen, W. & Bosschaart, N.https://doi.org/10.1117/1.JBO.25.4.045001
Research profiles
Affiliated study programs
Courses academic year 2024/2025
Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.
Courses academic year 2023/2024
Current projects
Noninvasive blood analysis
In this project, we use optical spectroscopy and visible light sOCT (spectroscopic optical coherence tomography) to noninvasively quantify the concentrations of bilirubin and hemoglobin in the blood of newborns.
Human milk and lactation
In this project, we use our optical technologies to learn more about the composition of breast milk and the physiology of lactation.
In the press
Videos
- Universiteit van Nederland, Waarom lukt borstvoeding soms niet?, October (2022)
Books
- Dolf Jansen en Jim Jansen, PromovendA tot Z, ISBN: 9789464042085, Fontaine Uitgevers, November (2022)
Articles
- Campus Magazine, De UT-pijler: Gezondheid van vrouwen, Michaela Nesvarova, August (2022)
- Ouders van Nu, Nieuw in de maak: sensor die meet hoe veel borstvoeding je baby binnenkrijgt, Carin Röst, August (2022)
- Het Parool, Nienke Bosschaart: ‘Op een congres over borstvoeding in Florence beleefde ik een aha-moment’, Jim Jansen, August (2022)
- Algemeen Dagblad, New Scientist, We weten bitter weinig over moedermelk, Jim Jansen, April (2022)
- Nederlands Dagblad, Wat gebeurt er in de borst tijdens het voeden? Dat weet (nu nog) niemand, Eymeke Verhoeven, January (2022)
- U-Today, Methods to help women breastfeed, Michaela Nesvarova, January (2022)
- SPIE International Society for Optics and Photonics, Women in Optics planner – featured page, Alison Walker (2022)
- University of Twente, ERC Starting Grant voor drie UT-wetenschappers, January (2022)
- European Research Council, ERC Starting Grants – Project Highlights, Pioneering methods to help women breastfeed, January (2022)
- University of Twente, Drie UT-onderzoekers ontvangen NWO Vidi-financiering, July (2021)
- NWO, NWO-Vidi van 800.000 euro voor 78 ervaren onderzoekers, July (2021)
- U-Today, Aan de Borreltafel: Bijna iedereen vindt babietjes leuk, Enith Vlooswijk, July (2021)
- University of Twente, Featured Scientists: Dr.ir. Nienke Bosschaart, Michaela Nesvarova, August (2020)
- U-Today, Moedermelk ontwikkelde zich enorm in miljoenen jaren evolutie, Ditta op den Dries, March (2019)
- University of Twente, Zeven vrouwelijke UT-wetenschappers in Viva 400, October (2018)
- De Ingenieur: Ingenieurstalent, De Babybeamer, Marc Seijlhouwer, September (2018)
- De Maatschappij, Jaarcongres 2018 met een Koninklijk tintje, Pierre van Aalst, September (2018)
- University of Twente, Studentgedreven werkbezoek onderwijsminister Van Engelshoven aan Universiteit Twente, February (2018)
- U-Today, Rising Star Nienke Bosschaart: All about babies, Michaela Nesvarova, May (2017)
- MIRA mag, Sparring partners: Painless optic ‘prick’, Kees de Rijk, issue 2 (2016)
- Medisch Contact, Meten zonder prikken, Danka Stuijver, January (2015)
- RTV Noord Holland radio, interview on Veni grant award in ‘NH Spitstijd’, Aart van Eldik, 29 July (2014)
- NWO, Veni 2014, July (2014)
- Kennislink, Slimme techniek spoort pijnloos geelzucht op, Robert Visscher, 16 October (2013)
- De Telegraaf, Bloedonderzoek zonder prikken, 12 October (2013)
- Technologiestichting STW – Technologisch Toptalent, Meten met licht, Sybe Rispens, vol. 9 (2013)
- AMC Magazine, Babies meten zonder prikken, Anne Koeleman, issue 9 (2013)
- Technisch Weekblad, Bloedwaarden meten zonder prikken, Marianne Vincken, issue 41 (2013)
Address
University of Twente
Horst Complex (building no. 20), room ZH262
De Horst 2
7522 LW Enschede
Netherlands
University of Twente
Horst Complex ZH262
P.O. Box 217
7500 AE Enschede
Netherlands
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