I am an enthusiastic computational neuroscience PhD Candidate in the Clinical Neurophysiology group. I specialize in using biophysical models to decipher electrical measurements from in vitro neuronal cultures and the brain of neurology patients.
Expertise
Neuroscience
- Dravet Syndrome
- Stem Cell
- Multielectrode Array
- Electrophysiology
- Neuron
- Brain
Biochemistry, Genetics and Molecular Biology
- Human Induced Pluripotent Stem Cell
Medicine and Dentistry
- Functional Connectivity
Organisations
Publications
2025
From Neuron to Network to Neurology: Deciphering multiscale electrophysiological measurements through biophysical modeling (2025)[Thesis › PhD Thesis - Research UT, graduation UT] (Accepted/In press). Doorn, N.https://publication-online.com/p/nina-doorn/Automated inference of disease mechanisms in patient-hiPSC-derived neuronal networks (2025)Communications Biology, 8(1). Article 768. Doorn, N., van Putten, M. J. A. M. & Frega, M.https://doi.org/10.1038/s42003-025-08209-2
2024
Breaking the burst: Unveiling mechanisms behind fragmented network bursts in patient-derived neurons (2024)Stem cell reports, 19(11), 1583-1597. Doorn, N., Voogd, E. J. H. F., Levers, M. R., van Putten, M. J. A. M. & Frega, M.https://doi.org/10.1016/j.stemcr.2024.09.001CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability (2024)Brain, 139(4). Hommersom, M., Doorn, N., Puvogel, S., Lewerissa, E. I., Mordelt, A., Ciptasari, U., Kampshoff, F., Dillen, L., van Beusekom, E., Oudakker, A., Kogo, N., Dolga, A. M., Frega, M., Schubert, D. & van Bokhoven, H.https://doi.org/10.1093/brain/awae330Unraveling Dravet Syndrome: Exploring the complex effects of sodium channel mutations on neuronal networks (2024)Science Progress, 107(1). Doorn, N.https://doi.org/10.1177/00368504231225076
2023
Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells (2023)Journal of neural engineering, 20(6), 1741-2552. Article 066038. Voogd, E. J. H. F., Doorn, N., Levers, M. R., Hofmeijer, J. & Frega, M.https://doi.org/10.1088/1741-2552/ad17f3An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome (2023)Stem cell reports, 18(8), 1686-1700. Doorn, N., Hugte, E. J. H. v., Ciptasari, U., Mordelt, A., Meijer, H. G. E., Schubert, D., Frega, M., Nadif Kasri, N. & Putten, M. J. A. M. v.https://doi.org/10.1016/j.stemcr.2023.06.003Modeling the role of the thalamus in resting-state functional connectivity: Nature or structure (2023)PLoS Computational Biology, 19(8), e1011007. Article e1011007. Cabrera-Álvarez, J., Doorn, N., Maestú, F. & Susi, G.https://doi.org/10.1371/journal.pcbi.1011007
2021
Inter-device reproducibility of transcutaneous bilirubin meters (2021)Pediatric Research, 89(4), 770-775. Dam-Vervloet, A. J., van Erk, M. D., Doorn, N., Lip, S. G. J., Timmermans, N. A., Vanwinsen, L., de Boer, F. A., van Straaten, H. L. M. & Bosschaart, N.https://doi.org/10.1038/s41390-020-01118-6
Research profiles
News on utwente.nl
Won the 2022 graduation award: https://www.utoday.nl/news/71838/vijf-masterstudent-beloond-met-graduation-award
Address
University of Twente
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Hallenweg 5
7522 NH Enschede
Netherlands
University of Twente
Technohal 3384
P.O. Box 217
7500 AE Enschede
Netherlands
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