After obtaining my Bachelor's degree in Technical Medicine, I continued with a Masters in Biomedical Engineering at the University of Twente. I quickly became intrigued by mathematics and neuroscience and decided to do my master thesis in the field of computational neuroscience. Currently, I am a PhD Candidate in the Clinical Neurophysiology group, where I aim to use computational models to integrate multiscale neuro-electrophysiological data of patients with monogenic neurodevelopmental disorders.
Organisations
Publications
2024
Breaking the burst: Unveiling mechanisms behind fragmented network bursts in patient-derived neurons (2024)Stem cell reports, 19(11), 1583-1597. Doorn, N., Voogd, E. J. H. F., Levers, M. R., van Putten, M. J. A. M. & Frega, M.https://doi.org/10.1016/j.stemcr.2024.09.001CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability (2024)Brain, 139(4). Hommersom, M., Doorn, N., Puvogel, S., Lewerissa, E. I., Mordelt, A., Ciptasari, U., Kampshoff, F., Dillen, L., van Beusekom, E., Oudakker, A., Kogo, N., Dolga, A. M., Frega, M., Schubert, D. & van Bokhoven, H.https://doi.org/10.1093/brain/awae330Unraveling Dravet Syndrome: Exploring the complex effects of sodium channel mutations on neuronal networks (2024)Science Progress, 107(1). Doorn, N.https://doi.org/10.1177/00368504231225076
2023
Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells (2023)Journal of neural engineering, 20(6), 1741-2552. Article 066038. Voogd, E. J. H. F., Doorn, N., Levers, M. R., Hofmeijer, J. & Frega, M.https://doi.org/10.1088/1741-2552/ad17f3An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome (2023)Stem cell reports, 18(8), 1686-1700. Doorn, N., Hugte, E. J. H. v., Ciptasari, U., Mordelt, A., Meijer, H. G. E., Schubert, D., Frega, M., Nadif Kasri, N. & Putten, M. J. A. M. v.https://doi.org/10.1016/j.stemcr.2023.06.003Modeling the role of the thalamus in resting-state functional connectivity: Nature or structure (2023)PLoS Computational Biology, 19(8), e1011007. Article e1011007. Cabrera-Álvarez, J., Doorn, N., Maestú, F. & Susi, G.https://doi.org/10.1371/journal.pcbi.1011007
2021
Inter-device reproducibility of transcutaneous bilirubin meters (2021)Pediatric Research, 89(4), 770-775. Dam-Vervloet, A. J., van Erk, M. D., Doorn, N., Lip, S. G. J., Timmermans, N. A., Vanwinsen, L., de Boer, F. A., van Straaten, H. L. M. & Bosschaart, N.https://doi.org/10.1038/s41390-020-01118-6
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