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dr. O. Koshkina (Olga)

Feodor Lynen Fellow (Alexander von Humboldt Foundation)

About Me

I am an expert in colloid and polymer chemistry. My main goal is to develop efficient colloidal particles for imaging and therapy, linking their molecular design with function. I obtained my M.Sc.-equivalent (Dipl.-Chem.) in biomedical chemistry from the University of Mainz, Germany, and Ph.D. in colloid and polymer chemistry from the Technical University of Berlin, together with Fraunhofer IMM and Federal Institute for Materials Research. Connecting chemistry with biomedical research, I did my postdoc at the Tumor Immunology Lab at Radboud University Medical Center in Nijmegen (NL). There, I developed novel imaging agents with unique structure for imaging cancer immunotherapies with ultrasound and 19F Magnetic Resonance Imaging. Subsequently, at Max Planck Institute for Polymer Research and collaborative Max-Planck-Twente Center, I expanded my work to the assembly of colloidal particles to supraparticles, developing new pathways to tailor-made colloidal materials. I received a prestigious Feodor Lynen Fellowship for Experienced Researchers from Alexander von Humboldt Foundation to start building my group at the University of Twente. 

 

 

 

 

 

 

Expertise

Engineering & Materials Science
Ethers
Imaging Techniques
Magnetic Resonance
Milk
Nanoparticles
Chemistry
Nanoparticle
Medicine & Life Sciences
Flotillins
Nanoparticles

Research

The main goal of my research is to develop polymeric and colloidal materials for biomedical use, from molecular design and understanding their properties, to their interactions with biomolecules and cells. Therefore, we synthesize tailor-made polymers, assemble them to nanocarriers, characterize their properties, and correlate them to function. We work with variety of techniques, including anionic polymerization, micro- and miniemulsion technique, static and dynamic light scattering (SLS, DLS) and small angle neutron scattering (SANS). Current research directions include polymeric colloids for future application in quantitative heteronuclear Magnetic Resonance Imaging (19F, 31P). We further work on nanocarriers for ultrasound imaging, optoacoustics and drug delivery. 

My vision is that this interdisciplinary approach will lead to powerful therapies in the future.

Publications

Recent
Bona, B. L. , Koshkina, O., Chirizzi, C., Dichiarante, V., Metrangolo, P., & Baldelli Bombelli, F. (2023). Multibranched-Based Fluorinated Materials: Tailor-Made Design of 19F-MRI Probes. Accounts of Materials Research, 4(1), 71-85. https://doi.org/10.1021/accountsmr.2c00203
Verbeelen, M., White, P. B., Staal, A. H. J., Swider-Cios, E., R.g, K., Van Riessen, N. K., Cadiou, C., Chuburu, F., Srinivas, M. , & Koshkina, O. (2021). Encapsulation of Paramagnetic Chelates in Perfluorocarbon-loaded Fractal Nanoparticles Enables Modulation of Fluorine-19 and Proton Magnetic Resonance Imaging Signal. ChemRxiv. https://doi.org/10.26434/chemrxiv-2021-wr46c
Hoogendijk, E., Swider, E., Staal, A. H. J., White, P. B., Van Riessen, N. K., Glaßer, G., Lieberwirth, I., Musyanovych, A., Serra, C. A., Srinivas, M. , & Koshkina, O. (2020). Continuous-Flow Production of Perfluorocarbon-Loaded Polymeric Nanoparticles: From the Bench to Clinic. ACS applied materials & interfaces, 12(44), 49335-49345. https://doi.org/10.1021/acsami.0c12020, https://doi.org/10.1021/acsami.0c12020
Staal, A. H. J., Becker, K. , Tagit, O., van Riessen, N. K. , Koshkina, O., Veltien, A., Bouvain, P., Cortenbach, K. R. G., Scheenen, T., Flögel, U., Temme, S., & Srinivas, M. (2020). In vivo clearance of 19F MRI imaging nanocarriers is strongly influenced by nanoparticle ultrastructure. Biomaterials, 261, [120307]. https://doi.org/10.1016/j.biomaterials.2020.120307, https://doi.org/10.1016/j.biomaterials.2020.120307
Koshkina, O., White, P. B., Staal, A. H. J., Schweins, R., Swider, E., Tirotta, I., Tinnemans, P., Fokkink, R., Veltien, A., van Riessen, N. K., van Eck, E. R. H., Heerschap, A., Metrangolo, P., Baldelli Bombelli, F., & Srinivas, M. (2020). Nanoparticles for “two color” 19F magnetic resonance imaging: Towards combined imaging of biodistribution and degradation. Journal of colloid and interface science, 565, 278-287. https://doi.org/10.1016/j.jcis.2019.12.083, https://doi.org/10.1016/j.jcis.2019.12.083
Koshkina, O. , Lajoinie, G., Baldelli Bombelli, F., Swider, E., Cruz, L. J., White, P. B., Schweins, R., Dolen, Y., van Dinther, E. A. W., van Riessen, N. K., Rogers, S. E., Fokkink, R., Voets, I. K., van Eck, E. R. H., Heerschap, A. , Versluis, M. , de Korte, C. L. , Figdor, C. G., de Vries, I. J. M., & Srinivas, M. (2019). Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and 19 F MRI Applied to In Vivo Cell Tracking. Advanced functional materials, 29(19), [1806485]. https://doi.org/10.1002/adfm.201806485
Swider, E., Staal, A. H. J., van Riessen, N. K., Jacobs, L., White, P. B., Fokkink, R., Janssen, G. J., Van Dinther, E. , Figdor, C. G., De Vries, I. J. M. , Koshkina, O., & Srinivas, M. (2018). Design of triphasic poly(lactic-co-glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications. RSC advances, 8(12), 6460-6470. https://doi.org/10.1039/c7ra13062g, https://doi.org/10.1039/c7ra13062g

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Visiting Address

University of Twente
Drienerlolaan 5
7522 NB Enschede
The Netherlands

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Mailing Address

University of Twente
P.O. Box 217
7500 AE Enschede
The Netherlands

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