Carré

dr.ir. R.B.M. Schasfoort (Richard)

Researcher
TNW-BET-AST
Carré C4429
r.b.m.schasfoort@utwente.nl
+31534893962
Business card

Richard B.M. Schasfoort (1959) graduated in 1984 as a biotechnology major from the University of Groningen. He defended his PhD thesis for a new approach to biosensor operation in 1989. He is founder of the company IBIS Technologies BV after selling his shares of Bio-intermediair BV in 1996. He developed at IBIS Technologies the Surface Plasmon Resonance imaging (SPRi) platform. In 2002, Richard started the Biochip group at the University of Twente after receiving the VIDI grant from NWO. He is co-author of > 100 peer reviewed papers and editor of the two Handbooks of Surface Plasmon Resonance (2008 and 2017).  In the chair Medical Cell BioPhysics of Prof. Leon Terstappen, he investigates single cell binding and secretion fingerprinting of cancer cells. Since the Corona outbreak in March 2020, he changed his focus to antibody profiling using SPRi of patients with COVID19 and cooperated with the hospital Medical Spectrum Twente/Medlon. Triggered by cumbersome analyzes with COVID-19 patients, the focus is currently on developing a device with which the concentration and affinity of antibodies can be measured simultaneously in a plug & play manner.

Expertise

  • Biochemistry, Genetics and Molecular Biology

    • Surface Plasmon Resonance
    • Antibody
    • Density
    • Surface Property

  • Chemistry

    • Procedure
    • Ligand
    • Electron Affinity

  • Immunology and Microbiology

    • Cells

Organisations

Publications

2024

A nanowell platform to identify, sort and expand high antibody-producing cells (2024)Scientific reports, 14(1). Article 9457. Abali, F., Schasfoort, R., Nijland, S., Wittenberns, J., Tibbe, A. G. J., den Hartog, M., Boon, L. & Terstappen, L. W. M. M.https://doi.org/10.1038/s41598-024-60054-1Gradient Method to Determine the Avidity of Cell Binding (2024)Research in medical & engineering sciences, 11(1), 1157-1159. Schasfoort, R. B. M., van de Vosse, D. & van Weperen, J.https://doi.org/10.31031/RMES.2024.11.000752

2023

Gradient method for accurate affinity determinations (2023)Analytical biochemistry, 667. Article 115085. Schasfoort, R. B. M.https://doi.org/10.1016/j.ab.2023.115085

2022

Kinetic characterization of SPR-based biomarker assays enables quality control, calibration free measurements and robust optimization for clinical application (2022)Analytical biochemistry, 658. Article 114918. Hendriks, J., Schasfoort, R. B. M., Huskens, J., Saris, D. B. F. & Karperien, M.https://doi.org/10.1016/j.ab.2022.114918High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease Severity (2022)Frontiers in Immunology, 13. Article 867716. Hendriks, J., Schasfoort, R., Koerselman, M., Dannenberg, M., Cornet, A. D., Beishuizen, A., van der Palen, J., Krabbe, J., Mulder, A. H. L. & Karperien, M.https://doi.org/10.3389/fimmu.2022.867716Surface Plasmon Resonance Imaging (SPRi) and Photonic Integrated Circuits (PIC) for COVID-19 Severity Monitoring (2022)COVID, 2(3), 389-397. Steglich, P. & Schasfoort, R. B. M.https://doi.org/10.3390/covid2030027

2021

Presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection (2021)Biosensors & bioelectronics, 183. Article 113165. Schasfoort, R. B. M., van Weperen, J., van Amsterdam, M., Parisot, J., Hendriks, J., Koerselman, M., Karperien, M., Mentink, A., Bennink, M., Krabbe, H., Terstappen, L. W. M. M. & Mulder, A. H. L.https://doi.org/10.1016/j.bios.2021.113165High throughput surface plasmon resonance imaging method for clinical detection of presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection (2021)MethodsX, 8. Article 101432. Schasfoort, R. B. M., van Weperen, J., van Amsterdam, M., Parisot, J., Hendriks, J., Koerselman, M., Karperien, M., Mentink - Leusink, A., Bennink, M., Krabbe, H., Terstappen, L. W. M. M. & Mulder, A. H. L.https://doi.org/10.1016/j.mex.2021.101432

2020

IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice (2020)Frontiers in Immunology, 11. Article 1516. Shinde, P., Howie, H. L., Stegmann, T. C., Hay, A. M., Waterman, H. R., Szittner, Z., Bentlage, A. E. H., Kapp, L., Lissenberg-Thunnissen, S. N., Dekkers, G., Schasfoort, R. B. M., Ratcliffe, S. J., Smolkin, M. E., Vidarsson, G., Schoot, C. E. v. d., Hudson, K. E. & Zimring, J. C.https://doi.org/10.3389/fimmu.2020.01516Cancer-ID: Toward identification of cancer by tumor-derived extracellular vesicles in blood (2020)Frontiers in oncology, 10. Article 608. Rikkert, L. G., Beekman, P., Caro, J., Coumans, F. A. W., Enciso-Martinez, A., Jenster, G., Le Gac, S., Lee, W., van Leeuwen, T. G., Loozen, G. B., Nanou, A., Nieuwland, R., Offerhaus, H. L., Otto, C., Pegtel, D. M., Piontek, M. C., van der Pol, E., de Rond, L., Roos, W. H., … Terstappen, L. W. M. M.https://doi.org/10.3389/fonc.2020.00608

Research profiles

Address

University of Twente

Carré (building no. 15), room C4429
Hallenweg 23
7522 NH Enschede
Netherlands

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