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R. Bansal PhD (Ruchi)

Associate Professor

About Me

Ruchi obtained her Bachelor’s and Master’s degree in Biochemistry from Delhi University, India. In 2012, She obtained her PhD from the Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen. Her PhD project was focused on designing of novel strategies to target interferon gamma and its signaling domain to the target pathogenic cells in the chronic diseases (liver fibrosis and cancer). During the last stages of her PhD, she received two prestigious grants Sheila Sherlock research fellowship (from European association for the study of liver diseases, EASL) and The Ruth and Richard Julin’s Foundation Swedish research grant for postdoctoral research at the Karolinska Institute, Stockholm, Sweden. Her research project was focused on “Pathogenesis of Hepatitis C virus (HCV)-induced and alcohol-induced liver diseases”. In October 2012, she started as a senior postdoctoral researcher at the Department of Biomaterials Science and Technology at the University of Twente. In 2014, she received the prestigious VENI grant (from NWO, ZonMw) to pursue her research on “Development of novel targeted nano-therapeutics for the treatment of liver diseases”. She has received several awards and research grants for pursuing her research. Since 2016, she is appointed as an Assistant professor and has established her independent research group "Translational Liver Research" at the Department of Medical Cell BioPhysics, the University of Twente.

Expertise

Liver
Therapeutics
Neoplasms
Liver Cirrhosis
Fibrosis
Stellate Crystal
Interferon-Gamma
Hepatic Stellate Cells

Research

My research group, Translational Liver Research, focuses on multiple research lines from
understanding the underlying disease mechanisms and cellular crosstalk, identification of new therapeutic and diagnostic targets, designing of novel cell‐specific (nano)therapeutics (and theranostics), development of new in vitro culture systems, in vivo (preclinical animal models) and ex vivo platforms (including 3D microtissues, 3D bioprinted models and microfluidic based organ‐on‐a‐chip models) human patient mimic models. The group broadly focusses on fibrotic and inflammatory liver diseases, and (liver) cancer.  

Publications

Recent
Zuchowska, A. , Bansal, R. , & le Gac, S. (2021). The presence of an ECM capsule around liver tumor models blocks the penetration of (Nano)-Drugs. In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Ojha, T., Hu, Q., Colombo, C., Wit, J., van Geijn, M., van Steenbergen, M. J. , Bagheri, M., Königs-Werner, H., Buhl, E. M. , Bansal, R., Shi, Y., Hennink, W. E. , Storm, G., Rijcken, C. J. F. , & Lammers, T. (2021). Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges. Biotechnology journal, 16(6), [2000212]. https://doi.org/10.1002/biot.202000212
Zuchowska, A. , Bansal, R. , & le Gac, S. (2021). The presence of an ECM capsule around liver tumor models blocks the penetration of (Nano)-Drugs. 637-638. Paper presented at 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021, Palm Springs, California, United States.
Kalloor Joseph, F. , Steenbergen, W. , & Bansal, R. (2021). Ultrasound and LED-based photoacoustic system for preclinical imaging of liver fibrosis. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2021 [116422I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11642). SPIE Press. https://doi.org/10.1117/12.2577720
Bansal, R., Mandrekar, P., Mohanty, S. K., & Weiskirchen, R. (2020). Editorial: Macrophages in Liver Disease. Frontiers in Immunology, 11, 1754. https://doi.org/10.3389/fimmu.2020.01754
Mostafa, A. M. R. H. , Bansal, R. , & Prakash, J. (2020). Targeting Fibroblasts in Fibrosis and Cancer. In J. Brenneman, & M. R. Iyer (Eds.), Anti-fibrotic Drug Discovery (pp. 307-339). (RSC Drug Discovery Series; Vol. 2020-January, No. 73). Royal Society of Chemistry. https://doi.org/10.1039/9781788015783-00307
ten Hove, M. , Pater, L. , Storm, G., Weiskirchen, S., Weiskirchen, R. , Lammers, T. , & Bansal, R. (2020). The hepatic lipidome: From basic science to clinical translation. Advanced drug delivery reviews, 159, 180-197. https://doi.org/10.1016/j.addr.2020.06.027
Ortiz-Perez, A., Donnelly, B., Temple, H., Tiao, G. , Bansal, R., & Mohanty, S. K. (2020). Innate Immunity and Pathogenesis of Biliary Atresia. Frontiers in Immunology, 11, [329]. https://doi.org/10.3389/fimmu.2020.00329
Mohanty, S. K., Lobeck, I., Donnelly, B., Dupree, P., Walther, A., Mowery, S., Coots, A., Bondoc, A., Sheridan, R. M., Poling, H. M., Temple, H., McNeal, M., Sestak, K. , Bansal, R., & Tiao, G. (2020). Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia. Hepatology, 71(4), 1316-1330. https://doi.org/10.1002/hep.30907
Ortiz-Perez, A. , Zuchowska, A. , Blondé, J. B. , Bansal, R. , & Le Gac, S. (2020). Modelling the tumor micro-environment in hepatocellular carcinoma using multi-cellular spheroids. In Proceedings of MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 937-938). (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences). The Chemical and Biological Microsystems Society.
Nijland, H. , & Bansal, R. (2020). Therapeutic Targeting of Hepatic Macrophages. Current Tissue Microenvironment Reports, 1, 113-120. https://doi.org/10.1007/s43152-020-00008-7
Morsink, M. A. J., Willemen, N. G. A. , Leijten, J. , Bansal, R., & Shin, S. R. (2020). Immune organs and immune cells on a chip: An overview of biomedical applications. Micromachines, 11(9), [849]. https://doi.org/10.3390/MI11090849

UT Research Information System

Google Scholar Link

Education

I have successfully completed my University teaching qualification (UTQ)/Basis Kwalificatie Onderwijs (BKO) in 2017, and English proficiency assessment (C1/C2) in 2019.

Since 2015, I am an organizer, coordinator and teacher of Controlled Drug and Gene delivery Master course (5EC). Due to the excellent performance of Controlled Drug and Gene delivery master course (graded 8.3 by students). This course was included in BME NVAO accreditation in 2018 and received positive remarks. In upcoming years, I will be develop myself further by coordinating M1 bachelor module, and will coordinate and teach Biochemistry master course. 

I actively participate as a tutor for bachelor’s M1, M5 and M11 modules. I supervise bachelor and master students during their internships and thesis assignments. I have also served as an advisor for ATLAS students and as a master Honor’s program supervisor. 

Affiliated Study Programmes

Bachelor

Master

Other

Courses

Projects

Ongoing projects:

  • ATX-Liver.Evaluation of Novel Autotaxin Inhibitors for the Treatment of Liver Diseases, funded by TKI-HTSM grant.
  • Chemokine receptor CCR2 and CCR8 peptide antagonists as a promising treatment for nonalcoholic steatohepatitis (NASH), funded by EASL.
  • Healing wounds with Phototherapy, funded by the Pioneers in Healthcare (PIHC) project grant.
  • Metabolic reprogramming of fatty liver diseases, funded by the Twente University RadBoudumc Opportunities (TURBO) grant.
  • Bioactive liposomes for the treatment of non-alcoholic steatohepatitis (NASH), funded by the Phospholipid research council grant.
  • Novel and Versatile Theranostics for diagnosis and therapy of liver fibrosis, funded by BOOSTER project (UT-WWU), Cross-border Collaboration UT Twente-WWU Muenster On Imaging for Diagnosis and Therapy.
  • MDR-Phage - Small molecules that promote bacterial killing in phagocytes, funded by the NWO-TTW NACTAR grant.
  • NanoNASH program, Joint Co-PI with Prof. Gert Storm, funded by NUS: 
  • Lipoxygenases: From dissecting mechanism to targeted therapeutics for the treatment of non-alcoholic steatohepatitis (NASH), funded by the DAAD-PRIME.

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Contact Details

Visiting Address

University of Twente
Drienerlolaan 5
7522 NB Enschede
The Netherlands

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Mailing Address

University of Twente
P.O. Box 217
7500 AE Enschede
The Netherlands

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