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R. Bansal PhD (Ruchi)

Associate Professor

About Me

Ruchi obtained her Bachelor’s and Master’s degree in Biochemistry from Delhi University, India. In 2012, she obtained her PhD from the University of Groningen, the Netherlands focused on designing of novel strategies to target nanobiologicals to key pathogenic cells in the chronic diseases (liver fibrosis and cancer). During the last stages of her PhD, she received two prestigious grants Sheila Sherlock research fellowship (from European association for the study of liver diseases, EASL) and The Ruth and Richard Julin’s Foundation Swedish research grant to pursue her postdoctoral research at the Karolinska Institute, Stockholm, Sweden. Her research project was focused on “Understanding the fundamental disease mechanisms behind Hepatitis C virus (HCV)-induced and alcohol-induced liver diseases”. In October 2012, she moved to the Netherlands and started as a senior postdoctoral researcher at the Department of Biomaterials Science and Technology at the University of Twente. Her aim was to combine fundamental disease understanding to identify new disease targets to develop (nano)biotherapeutics against liver diseases. In 2014, she received the prestigious VENI grant (from ZonMw, NWO) to pursue her research on “Development of novel targeted nano-therapeutics for the treatment of liver diseases”. From 2016-2019, she was an appointed as an Assistant Professor at the Department of Biomaterials Science and Technology. In 2019, she moved to the Department of Medical Cell BioPhysics, University of Twente where established her research group "Translational Liver Research". She has received several awards, published >60 publications, and  obtained several research grants for pursuing her research. She has also served as a young academy board member, faculty council member and Twente graduate school award jury member. She participate in editorial board of several journals, evaluation committees and advisory boards.

Expertise

Chemistry
Stellate Crystal
Medicine & Life Sciences
Fibrosis
Hepatic Stellate Cells
Interferon-Gamma
Liver
Liver Cirrhosis
Macrophages
Myofibroblasts

Research

My research group, Translational Liver Research, focuses on multiple research lines: 1) understanding the underlying disease mechanisms and cellular crosstalk, 2) identification of new therapeutic and diagnostic targets, 3) non-invasive detection methods and single-cell analysis, 4) designing of novel cell‐specific (nano)therapeutics (and theranostics), and 5) development of new in vitro culture systems and in vivo (preclinical animal models). The group broadly focuses on fibrotic and inflammatory liver diseases, and (liver) cancer. 

Publications

Recent
Ojha, T., Hu, Q., Colombo, C., Wit, J., van Geijn, M., van Steenbergen, M. J. , Bagheri, M., Königs-Werner, H., Buhl, E. M. , Bansal, R., Shi, Y., Hennink, W. E. , Storm, G., Rijcken, C. J. F. , & Lammers, T. (2021). Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges. Biotechnology journal, 16(6), [2000212]. https://doi.org/10.1002/biot.202000212
Kalloor Joseph, F. , Steenbergen, W. , & Bansal, R. (2021). Ultrasound and LED-based photoacoustic system for preclinical imaging of liver fibrosis. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2021 [116422I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11642). SPIE Press. https://doi.org/10.1117/12.2577720
Zuchowska, A. , Bansal, R. , & le Gac, S. (2021). The presence of an ECM capsule around liver tumor models blocks the penetration of (Nano)-Drugs. In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 637-638)
Mohanty, S. K., Donnelly, B., Temple, H. , Ortiz-Perez, A., Mowery, S., Lobeck, I., Dupree, P., Poling, H. M., McNeal, M., Mourya, R., Jenkins, T. , Bansal, R., Bezerra, J., & Tiao, G. (2021). High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants. Hepatology, 74(2), 864-878. https://doi.org/10.1002/hep.31745
Nijland, H. , & Bansal, R. (2020). Therapeutic Targeting of Hepatic Macrophages. Current Tissue Microenvironment Reports, 1, 113-120. https://doi.org/10.1007/s43152-020-00008-7
ten Hove, M. , Pater, L. , Storm, G., Weiskirchen, S., Weiskirchen, R. , Lammers, T. , & Bansal, R. (2020). The hepatic lipidome: From basic science to clinical translation. Advanced drug delivery reviews, 159, 180-197. https://doi.org/10.1016/j.addr.2020.06.027
Mohanty, S. K., Lobeck, I., Donnelly, B., Dupree, P., Walther, A., Mowery, S., Coots, A., Bondoc, A., Sheridan, R. M., Poling, H. M., Temple, H., McNeal, M., Sestak, K. , Bansal, R., & Tiao, G. (2020). Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia. Hepatology, 71(4), 1316-1330. https://doi.org/10.1002/hep.30907
Ortiz-Perez, A. , Zuchowska, A. , Blondé, J. B. , Bansal, R. , & Le Gac, S. (2020). Modelling the tumor micro-environment in hepatocellular carcinoma using multi-cellular spheroids. In Proceedings of MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 937-938). (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences). The Chemical and Biological Microsystems Society.
Ortiz-Perez, A., Donnelly, B., Temple, H., Tiao, G. , Bansal, R., & Mohanty, S. K. (2020). Innate Immunity and Pathogenesis of Biliary Atresia. Frontiers in Immunology, 11, [329]. https://doi.org/10.3389/fimmu.2020.00329
Bansal, R., Mandrekar, P., Mohanty, S. K., & Weiskirchen, R. (2020). Editorial: Macrophages in Liver Disease. Frontiers in Immunology, 11, 1754. https://doi.org/10.3389/fimmu.2020.01754
Morsink, M. A. J., Willemen, N. G. A. , Leijten, J. , Bansal, R., & Shin, S. R. (2020). Immune organs and immune cells on a chip: An overview of biomedical applications. Micromachines, 11(9), [849]. https://doi.org/10.3390/MI11090849

UT Research Information System

Google Scholar Link

Education

I have successfully completed my University teaching qualification (UTQ)/Basis Kwalificatie Onderwijs (BKO) in 2017, and English proficiency assessment (C1/C2) in 2019.

Since 2015, I am an organizer, coordinator and teacher of Controlled Drug and Gene delivery Master course (5EC). Due to the excellent performance of Controlled Drug and Gene delivery master course (graded 8.3 by students). This course was included in BME NVAO accreditation in 2018 and received positive remarks. I am coordinating M1 bachelor module, and Biochemistry master course. 

I also supervise capita selecta, bachelor and master students during their internships and thesis assignments. I have also served as an advisor for ATLAS students and as a master Honor’s program supervisor. 

Affiliated Study Programmes

Bachelor

Master

Other

Courses Academic Year  2021/2022

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.
 

Courses Academic Year  2020/2021

Projects

Ongoing projects:

  • ATX-Liver.Evaluation of Novel Autotaxin Inhibitors for the Treatment of Liver Diseases, funded by TKI-HTSM grant.
  • Chemokine receptor CCR2 and CCR8 peptide antagonists as a promising treatment for nonalcoholic steatohepatitis (NASH), funded by EASL.
  • Healing wounds with Phototherapy, funded by the Pioneers in Healthcare (PIHC) project grant.
  • Metabolic reprogramming of fatty liver diseases, funded by the Twente University RadBoudumc Opportunities (TURBO) grant.
  • Bioactive liposomes for the treatment of non-alcoholic steatohepatitis (NASH), funded by the Phospholipid research council grant.
  • Novel and Versatile Theranostics for diagnosis and therapy of liver fibrosis, funded by BOOSTER project (UT-WWU), Cross-border Collaboration UT Twente-WWU Muenster On Imaging for Diagnosis and Therapy.
  • MDR-Phage - Small molecules that promote bacterial killing in phagocytes, funded by the NWO-TTW NACTAR grant.
  • NanoNASH program, Joint Co-PI with Prof. Gert Storm, funded by NUS: 
  • Lipoxygenases: From dissecting mechanism to targeted therapeutics for the treatment of non-alcoholic steatohepatitis (NASH), funded by the DAAD-PRIME.

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Contact Details

Visiting Address

University of Twente
Drienerlolaan 5
7522 NB Enschede
The Netherlands

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Mailing Address

University of Twente
P.O. Box 217
7500 AE Enschede
The Netherlands

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